Effects of carbamazepine: A Synthesis of Findings from 9 Studies

  1. Home
  2. Effects of carbamazepine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of carbamazepine: A Synthesis of Findings from 9 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of carbamazepine: A Synthesis of Findings from 9 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Findings

Carbamazepine (CBZ) is a commonly used anti-epileptic drug, but several studies suggest it may have adverse effects on cognitive and neurophysiologic functions. 6 compared the effects of CBZ and levetiracetam (LEV) in healthy volunteers using a randomized, double-blind crossover design. The study found LEV produced fewer adverse neuropsychological and neurophysiologic effects than CBZ at the dosages and timeframes used in this study. 4 evaluated the effects of CBZ, remacemide, and placebo on actual driving performance in a three-way, double-blind, cross-over driving study. This study showed CBZ can produce mild but sufficient impairment to put epileptic patients at risk when driving, at least during initiation therapy.

The 8 study found that withdrawal of CBZ and valproate in patients with well-controlled epilepsy resulted in improvement in verbal memory, indicating these drugs may have negative effects on this cognitive function. 7 compared the effects of oxcarbazepine (OXC) and CBZ on driving ability in a double-blind, randomized crossover trial with healthy volunteers. Both drugs had negative effects on driving, but the study found CBZ had a more pronounced impact on driving performance than OXC.

Benefits and Risks

Benefit Summary

LEV may have fewer negative effects on cognitive function and driving performance compared to CBZ. It is an effective treatment for epilepsy. 6 , 4

Risk Summary

CBZ may negatively impact cognitive function, neurophysiologic function, and driving performance. While an effective treatment for epilepsy, its impact on cognitive function is a concern. 6 , 4 , 1

Comparison of Studies

Similarities

These studies consistently suggest CBZ can negatively impact cognitive function and neurophysiologic function. All utilized a double-blind crossover design, providing a common research approach.

Differences

The studies differed in the drugs and specific outcomes evaluated. 6 compared LEV to CBZ on cognitive function, while 4 compared CBZ, remacemide, and placebo on actual driving performance. 1 compared CBZ and phenytoin on cognitive function.

Consistency and Contradictions in Findings

These studies consistently indicate that CBZ may negatively impact cognitive function, neurophysiologic function, and driving performance. However, the extent of this impact and how it compares to other medications varies across studies, suggesting further research is needed.

Practical Applications and Considerations

Individuals taking CBZ for epilepsy may need to be cautious about driving, including obtaining a driver's license. Consulting a physician to assess driving safety is essential. If drowsiness or a decline in concentration occurs while driving, pulling over to rest is vital for safety. 4

Limitations of Current Research

These studies were conducted on healthy volunteers, thus further research is needed to understand CBZ's effects on epileptic patients. The studies were relatively short-term, requiring longer-term studies to assess lasting effects. 6 , 4 , 1

Future Research Directions

Research on epileptic patients is needed to evaluate CBZ's long-term effects. Research should focus on identifying methods to mitigate the negative cognitive effects of CBZ.

Conclusion

CBZ is an effective anti-epileptic drug, but it may have negative impacts on cognitive function, neurophysiologic function, and driving performance. LEV may have fewer negative cognitive effects than CBZ and could be considered a safer option. Patients with epilepsy should consult with their physician to select the appropriate medication for their individual needs. Consultation with a physician is essential to assess driving safety when obtaining a driver's license.

Literature analysis of 9 papers
Positive Content
5
Neutral Content
2
Negative Content
2
Article Type
9
0
0
0
9
1.

Comparative cognitive effects of carbamazepine and phenytoin in healthy adults.

Author: MeadorK J, LoringD W, AllenM E, ZamriniE Y, MooreE E, AbneyO L, KingD W

Cognitive impairment

Both carbamazepine and phenytoin impaired cognitive function in healthy adults, but the differences in effects between the two drugs were not clinically significant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Controlled release carbamazepine: cognitive side effects in patients with epilepsy.

Author: AldenkampA P, AlphertsW C, MoerlandM C, OttevangerN, Van ParysJ A

Improved cognitive function
Cognitive side effects

Controlled-release carbamazepine was more effective at controlling cognitive side effects in epilepsy patients than standard carbamazepine. This may be due to the smoothing effect of controlled-release on serum concentration fluctuations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults.

Author: RamsayR E, WilderB J, BergerJ R, BruniJ

LDH elevation
SGOT elevation
WBC elevation

Carbamazepine and phenytoin were equally effective in treating epileptic patients. Both drugs had similar rates of side effects and complete control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual traffic.

Author: RamaekersG, LamersJ, VerheyF, MuntjewerffD, MobbsE, SandersN, LewisM, LocktonA

Impaired driving performance

Remacemide, an antiepileptic drug, does not affect driving performance. Carbamazepine, another antiepileptic drug, can impair driving performance, particularly during initiation therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Effects of gabapentin and carbamazepine on the EEG and cognition in healthy volunteers.

Author: SalinskyMartin C, BinderLawrence M, OkenBarry S, StorzbachDaniel, AronCarey R, DodrillCarl B

Neurotoxicity detection
Cognitive dysfunction

This study investigates the effects of gabapentin and carbamazepine on neurophysiologic and cognitive measures in healthy volunteers. The goal is to identify objective methods for detecting neurotoxicity associated with antiepileptic drug therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam.

Author: MeadorK J, GevinsA, LoringD W, McEvoyL K, RayP G, SmithM E, MotamediG K, EvansB M, BaumC

Neuropsychological effects

Levetiracetam (LEV) produced fewer untoward neuropsychological and neurophysiologic effects than carbamazepine (CBZ) in healthy adults.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

7.

Effects of oxcarbazepine and carbamazepine on driving ability: a double-blind, randomized crossover trial with healthy volunteers.

Author: KaussnerYvonne, Kenntner-MabialaRamona, HoffmannSonja, KlattJan, TracikFerenc, KrügerHans-Peter

Less impact on driving (than carbamazepine)
Negative impact on driving

Both oxcarbazepine (OXC) and carbamazepine (CBZ) negatively affected driving performance. CBZ had a more pronounced negative effect on driving performance than OXC.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Improvement in verbal memory after withdrawal of carbamazepine and valproate in patients with well-controlled epilepsy: a randomized, double-blind study.

Author: HessenE, LossiusM I, GjerstadL

Improved verbal memory

A randomized, double-blind, placebo-controlled study of 124 epilepsy patients assessed the effects of carbamazepine and valproate withdrawal on verbal memory. While withdrawal of both drugs resulted in slight improvement in verbal memory, the impact on daily life function remains uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effects of lacosamide and carbamazepine on human motor cortex excitability: a double-blind, placebo-controlled transcranial magnetic stimulation study.

Author: LangNicolas, RothkegelHolger, PeckoltHannes, DeuschlGünther

Lacosamide effect on neuronal excitability
Transcranial magnetic stimulation

Lacosamide (LCM) and carbamazepine (CBZ) are antiepileptic drugs that affect neuronal voltage-gated sodium channels. Patch-clamp studies showed significant differences in their effects on neuronal membrane excitability, while transcranial magnetic stimulation (TMS) can describe drug-induced changes at the system level of the human cerebral cortex.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.