Side Effects of cefprozil: A Synthesis of Findings from 18 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Key Findings

Cefprozil is a new, orally bioavailable, cephalosporin with significant activity against the bacteria commonly associated with upper and lower respiratory tract infection, and skin and soft tissue infections. 16 Its absorption and elimination dynamics suggest once- or twice-daily dosing. 16 Cefprozil has a low rate of gastrointestinal and dermatologic side effects associated with its administration, suggesting that it may have a significant role in the management of patients with these infections. 16

Reasons for Side Effects

Antibiotics, such as cefprozil, work by inhibiting or killing bacterial growth to treat infections. However, antibiotics can affect the normal bacterial flora in the body, in addition to bacteria causing infections. Imbalances in the normal bacterial flora can lead to side effects such as gastrointestinal symptoms and allergic reactions. 15 Additionally, cefprozil can affect liver function and blood cell counts in some patients. 11 5

Common Side Effects

Gastrointestinal

Many patients who take cefprozil have reported gastrointestinal side effects such as diarrhea, nausea, and vomiting. 13 3 10 4 12 6 8 7 9 17

Blood

Some patients who take cefprozil have reported blood abnormalities such as leukopenia, eosinophilia, and thrombocytosis. 2 3 11 5 8 9

Liver

Some patients who take cefprozil have reported liver function abnormalities such as elevated GOT (AST) and GPT (ALT) levels. 11 10 7

Side Effect Management

Gastrointestinal

If you experience gastrointestinal side effects from cefprozil, you may need to consider dietary changes or medication. 13

Blood

If you suspect blood abnormalities due to cefprozil, you should have a blood test and receive appropriate treatment if necessary. 2

Liver

If you suspect liver function abnormalities due to cefprozil, you should have a liver function test and receive appropriate treatment if necessary. 11

Comparison Between Studies

Similarities

Many studies have shown that cefprozil is effective for treating respiratory tract infections and skin and soft tissue infections. 2 13 3 4 5 16 10 12 6 8 7 9 17 Additionally, some reports suggest that cefprozil has fewer gastrointestinal side effects compared to other cephalosporin antibiotics. 13 16

Differences

The frequency and types of side effects reported for cefprozil vary between studies. 2 13 3 11 5 10 4 12 6 8 7 9 17 This may be due to differences in the patient populations studied and research methods.

Cautions for Real-World Applications

While cefprozil appears to be effective for treating respiratory tract infections and skin and soft tissue infections, it is important to consider the risk of side effects. 16 Always follow your doctor's instructions when taking cefprozil, and avoid stopping or changing the dosage without consulting your doctor. 15 If you experience any adverse effects while taking cefprozil, consult your doctor immediately. 15

Limitations of Current Research

Research on cefprozil is still limited. 15 In particular, further research is needed to assess the safety of long-term cefprozil use. 15

Future Research Directions

Further research is needed on the safety of long-term cefprozil use, and comparative studies of cefprozil with other antibiotics. 16

Conclusion

Cefprozil is an effective oral cephalosporin antibiotic for treating respiratory tract infections and skin and soft tissue infections. 16 However, it is important to consider the risk of side effects when taking cefprozil. 16 Always follow your doctor's instructions when taking cefprozil. 15

Literature analysis of 18 papers
Positive Content
18
Neutral Content
0
Negative Content
0
Article Type
3
1
1
3
18
1.

Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis.

Author: LattanziSimona, BrigoFrancesco, TrinkaEugen, ZaccaraGaetano, CagnettiClaudia, Del GiovaneCinzia, SilvestriniMauro

Anti-seizure properties
Abuse liability

Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, shows promise as a new therapeutic option for epilepsy. CBD exhibits anti-seizure properties through multiple mechanisms, including modulation of ionic channels and neurotransmitter transporters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Comparative efficacy and safety of cefprozil and cefaclor in the treatment of acute uncomplicated urinary tract infections.

Author: ChristensonJ C, GoochW M, HerrodJ N, SwensonE

Once-daily dosing
Treats UTIs
Leucopenia
Nausea
Vomiting
Yeast infections

Cefprozil, a new oral cephalosporin, was found to be as effective as cefaclor in treating acute, uncomplicated urinary tract infections. In a study of 98 patients, clinical and bacteriological responses were comparable for both antibiotics. Leucopenia, nausea, and vaginal yeast infections were slightly more common in the cefprozil group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Comparative efficacy and safety of cefprozil (BMY-28100) and cefaclor in the treatment of acute group A beta-hemolytic streptococcal pharyngitis.

Author: ChristensonJ C, SwensonE, GoochW M, HerrodJ N

Once daily dosage
Treats strep throat
Leukopenia
Nausea

Cefprozil, a once-a-day cephalosporin, was comparable to cefaclor in treating acute group A beta-hemolytic streptococcal pharyngitis. Cefprozil was associated with more side effects, including nausea and leukopenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

[Clinical study on cefprozil in pediatrics].

Author: IwaiN, MiyazuM, NakamuraH, KasaiK

Effective antibiotic
Safe for children
Elevated eosinophils
Elevated platelets

Cefprozil (CFPZ) demonstrated excellent clinical efficacy and a high bacteriological eradication rate in treating pediatric infections, particularly against Gram-positive bacteria. No significant side effects were observed, except for elevated eosinophil counts in 3 patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

6.

[Clinical studies on cefprozil granules in pediatrics].

Author: NakazawaS, SatoH, NaritaA, SuzukiH, MatsumotoK, NiinouK

Effective
Pediatric antibiotic
Well-tolerated
Eosinophilia

Cefprozil (CFPZ) granules demonstrated high clinical efficacy and a good bacteriological eradication rate in treating various pediatric infections, with no significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

7.

[Laboratory and clinical studies on cefprozil granules in pediatrics].

Author: AkitaH, SatoY, IwataS, SunakawaK

Effective
Pediatric antibiotic
Well-tolerated
Eosinophilia
GOT/GPT elevation

Cefprozil (CFPZ) granules were effective in treating pediatric patients with various infections, achieving a 95.1% clinical efficacy rate and an 84.6% bacteriological eradication rate. While two patients showed elevated liver enzymes and eosinophilia, the overall side effect profile was favorable.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

10.

[Laboratory and clinical studies of cefprozil in pediatric field].

Author: NishimuraT, TabukiK, AokiS, TakagiM

Effective for bacterial infections
Safe for children
Elevated liver enzymes
Eosinophilia
Loose stool

Cefprozil (CFPZ), an oral cephalosporin, demonstrated excellent clinical efficacy and good bacteriological efficacy in pediatric patients with various infections, with only mild side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

11.

[Laboratory and clinical studies on cefprozil in the field of pediatrics].

Author: HayakawaF, KunoK, OgawaA, NakaoY, AndoY, AndoH

Effective antibiotic
Safe for children
Elevated liver enzymes
Elevated platelets

Cefprozil (CFPZ) demonstrated superior antibacterial activity against Gram-positive cocci compared to cefaclor and against E. coli compared to ampicillin. In pediatric patients with acute infections, CFPZ achieved a 100% clinical efficacy rate and 56% bacteriological efficacy rate with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

13.

Comparative trial of cefprozil vs. amoxicillin clavulanate potassium in the treatment of children with acute otitis media with effusion.

Author: ArguedasA G, ZaleskaM, StutmanH R, BlumerJ L, HainsC S

Otitis media treatment
Loose stools

Cefprozil was found to be an effective treatment for acute otitis media with effusion in children, with lower gastrointestinal side effects and a more convenient twice-a-day dosing schedule compared to amoxicillin clavulanate potassium. 8.3% of patients treated with cefprozil and 22.5% of patients treated with amoxicillin clavulanate potassium experienced treatment failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Clinical Outcomes of Failing to Dose-Reduce Cephalosporin Antibiotics in Older Adults with CKD.

Author: BathiniLavanya, JandocRacquel, KuwornuPaul, McArthurEric, WeirMatthew A, SoodManish M, BattistellaMarisa, MuandaFlory T, LiuAiden, JainArsh K, GargAmit X

Cephalosporin side effects

This retrospective cohort study of 9,347 elderly CKD patients receiving cephalosporin antibiotics found no association between the dose of cephalosporin and the risk of side effects, treatment failure, or mortality. This suggests that dose reduction may not be necessary for elderly patients with CKD. However, further research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Oral cephalosporins: newer agents and their place in therapy.

Author: ThompsonE M, ShaughnessyA F

Alternative to IM antibiotics
Effective treatment
Low side effects
Twice-daily dosing
Expensive

Cefprozil, cefpodoxime, and loracarbef, three new oral cephalosporins, are effective and well-tolerated alternatives to traditional antibiotics for common community-acquired infections.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Cefprozil.

Author: StutmanH R

Treats infections
Dermatologic side effects
Gastrointestinal side effects

Cefprozil is a new, orally bioavailable cephalosporin that is effective against common respiratory and skin infections. It is well-tolerated with low rates of gastrointestinal and dermatologic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Properties of azithromycin that enhance the potential for compliance in children with upper respiratory tract infections.

Author: PowersJ L

Antibiotic
Azithromycin

Azithromycin is an effective antibiotic for community-acquired infections, particularly in children.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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