Side Effects of cefuroxime: A Synthesis of Findings from 30 Studies

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Original Abstract of the Article

Major Findings

Cefuroxime is an antibiotic widely used to treat bacterial infections. Various studies have shown that cefuroxime is effective in treating bacterial infections. For example, a study on 4 found that 12 patients recovered and 14 improved when a combination of cefuroxime and acetylcysteine was used for patients with respiratory failure. Another study, 28 , found that 11 patients recovered after receiving cefuroxime for acute septic arthritis. These results demonstrate that cefuroxime is an effective treatment for bacterial infections.

Reasons for Side Effects

Cefuroxime exhibits bactericidal activity by inhibiting bacterial cell wall synthesis. However, cefuroxime can also affect human cells, potentially leading to side effects.

Common Side Effects

Gastrointestinal

The most common side effects of cefuroxime are related to the gastrointestinal system. For example, a study on 28 observed side effects such as abdominal pain and diarrhea after administering cefuroxime. Another study, , observed side effects such as indigestion and constipation after administering cefuroxime. These side effects are believed to be caused by cefuroxime's impact on the gastrointestinal system.

Allergic Reactions

Cefuroxime can cause allergic reactions. For example, a study on 15 observed allergic reactions such as rashes and hives after administering cefuroxime. Another study, 6 , observed serious allergic reactions such as anaphylactic shock after administering cefuroxime. These side effects are believed to be due to an allergic reaction to cefuroxime.

Other Side Effects

Besides gastrointestinal and allergic reactions, cefuroxime can cause various side effects. For example, a study on observed side effects such as headaches and dizziness in the nervous system after administering cefuroxime. Another study, 21 , observed effects on the kidneys after administering cefuroxime. These side effects are believed to be caused by cefuroxime's impact on various organs.

Side Effects Management

Gastrointestinal Side Effects

To reduce gastrointestinal side effects, it is important to take cefuroxime with meals and drink plenty of fluids. If you experience severe side effects such as diarrhea, consult a doctor.

Allergic Reactions

If you have an allergic reaction, stop taking cefuroxime and consult a doctor immediately. If you experience a severe allergic reaction, emergency treatment may be necessary.

Other Side Effects

Consult a doctor if you experience other side effects. The appropriate treatment will vary depending on the type and severity of the side effect.

Comparison between Studies

Commonalities

Numerous studies have shown that cefuroxime is effective in treating bacterial infections. Additionally, many studies indicate that cefuroxime is a drug with relatively few side effects.

Differences

The frequency and severity of cefuroxime side effects vary among studies. This is likely due to differences in factors such as the age and health status of the study participants and the dosage of cefuroxime administered. Additionally, the types of side effects observed with cefuroxime vary among studies. This may be due to differences in the genetic background and lifestyle of the study participants.

Precautions for Everyday Use

Cefuroxime is an effective medication for treating bacterial infections, but it can cause side effects. When taking cefuroxime, follow your doctor's instructions carefully and consult a doctor immediately if you experience side effects. Cefuroxime should be used with caution by pregnant or breastfeeding women, individuals with kidney or liver disease, and those with allergies.

Limitations of Current Research

There is still insufficient research on the side effects of cefuroxime. Specifically, there is still much to be learned about the side effects of long-term use of cefuroxime. Additionally, the side effects of cefuroxime can vary between individuals, so research results are not applicable to everyone.

Future Research Directions

Further research on the side effects of cefuroxime is needed. Specifically, more research is needed on the side effects of long-term use of cefuroxime, individual differences in cefuroxime side effects, and methods for reducing cefuroxime side effects.

Conclusion

Cefuroxime is a medication effective in treating bacterial infections, but it can cause side effects. Follow your doctor's instructions carefully when taking cefuroxime, and consult a doctor immediately if you experience any side effects. Further research is needed regarding the side effects of cefuroxime.

Literature analysis of 30 papers
Positive Content
27
Neutral Content
0
Negative Content
3
Article Type
11
0
0
3
29
1.

[Mezlocillin in short-term obstetrico-gynecologic prophylaxis].

Author: BoemiP, ReitanoS, CilanoL, PlataniaR, RizzariG

Short-term prophylaxis
Shorter hospital stay

Mezlocillin prophylaxis was effective in preventing postoperative infections, with an 83.67% success rate and no side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

2.

[Treatment of acute exacerbations of chronic bronchitis. Multicenter, randomized comparative study of cefuroxime axetil versus ofloxacin].

Author: KleckowM

Treats chronic bronchitis
Side effects

Cefuroxime axetil was more effective than ofloxacin in treating acute exacerbations of chronic bronchitis. 75% of patients treated with cefuroxime axetil were cured, compared to 50% of patients treated with ofloxacin. Cefuroxime axetil was also associated with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

4.

A combination of cefuroxime plus acetylcysteine in the intensive care of patients with respiratory insufficiency.

Author: TestaseccaD, MengoniM

Respiratory Insufficiency Treatment

Cefuroxime plus acetylcysteine improved the respiratory condition of 12 out of 30 patients with respiratory insufficiency. No side effects were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Environmental assessment of Norwegian priority pharmaceuticals based on the EMEA guideline.

Author: GrungMerete, KällqvistTorsten, SakshaugSolveig, SkurtveitSvetlana, ThomasKevin V

pharmaceutical risk assessment
environmental risk

An environmental risk assessment of 11 pharmaceuticals was conducted according to the European Medicines Evaluation Agency (EMEA) guidelines. The study found that ciprofloxacin, diclofenac, ethinylestradiol, sulfamethoxazole, and tetracycline had risk quotients greater than 1, suggesting potential environmental concerns.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

A Case of a Child With Several Anaphylactic Reactions to Drugs.

Author: PodleckaDaniela, JerzynskaJoanna, Malewska-KaczmarekKamila, StelmachIwona

Anaphylaxis

A child with several anaphylactic reactions to multiple drugs, including antibiotics and NSAIDs, was suspected to have a <i>Helicobacter pylori</i> infection.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

8.

Antibiotics-why so many and when should we use them?

Author: BandykDennis F

Aneurysm Retardation
Infection Reduction
Drug Costs
Side Effects

Antibiotic prophylaxis is beneficial in vascular surgery to reduce surgical site infections. Bactericidal antibiotics should be administered before surgery, with rifampin-soaked grafts considered for high-risk patients. Specific antibiotic use should be based on expected pathogens and antibiotic susceptibility testing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

A combination of cefuroxime and N-acetyl-cysteine for the treatment of lower respiratory tract infections in children.

Author: SantangeloG, LombardoS, GiannottiG

Improved respiratory health
No side effects

Cefuroxime and N-acetyl-cysteine were effective in treating lower respiratory tract infections in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Betalactam therapy and intestinal flora.

Author: NovelliA, MazzeiT, FallaniS, DeiR, CassettaM I, ContiS

Bronchitis treatment

Cefetamet-pivoxil (CET) had a minimal impact on normal human intestinal flora compared to cefixime (CFX) and cefuroxime axetil (CA), which significantly affected Enterobacteriaceae and clostridia. CFX and CA also led to an increase in enterococci and the appearance of Salmonella spp. and Clostridium difficile in some cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

A randomized prospective study to compare cefotetan with cefuroxime plus metronidazole as prophylaxis in elective colorectal surgery.

Author: SkipperD, KarranS J

Safe and effective prophylaxis for colorectal surgery
None mentioned

Cefotetan, a single-agent antibiotic, was as effective as the combination of cefuroxime and metronidazole in preventing wound infections after elective colorectal surgery. Cefotetan is safe and effective, with a broad spectrum of activity and a long half-life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

A dose-ranging study of cefuroxime axetil in the treatment of lower respiratory tract infections in general practice.

Author: SpencerR C, GriggsJ V, BrownG W

Eradicate pathogens
Treat respiratory tract infections
Gastrointestinal side effects

This study evaluated cefuroxime axetil (CAE) for treating respiratory infections. CAE was effective in treating infections, with cure rates of 97% for the lower dose and 89% for the higher dose. CAE was well tolerated with only a few mild side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Single-dose cefuroxime prophylaxis in non-elective cesarean section.

Author: KristensenG B, BeiterE C, MatherO

No side effects
Reduced infection
None reported

A single dose of cefuroxime prophylaxis significantly reduced the incidence of febrile morbidity in patients undergoing non-elective cesarean section without any side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

[Mezlocillin versus cefuroxime in urinary tract infections. A multicenter clinical study].

Author: PetersH J, WeissbachL, NuriM

Improved urinary tract infections

Mezlocillin was more effective than cefuroxime in treating urinary tract infections in 96 urological patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

15.

Microbiologic and clinical studies with cefuroxime.

Author: GraberH, ArrM, MagyarT, LudwigE

Cefuroxime efficacy
Local pain

Cefuroxime is effective against resistant bacterial strains and well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

[Review [new antibiotics series I]: cefuroxime (author's transl)].

Author: NakagawaK

Effective against beta-lactamase producing bacteria
Effective for respiratory and urinary tract infections
Low side effect incidence
Pyrexia
Skin hypersensitivity

Cefuroxime, a new injectable cephalosporin, was found to be effective in treating 826 patients with various infections. The drug was stable to various beta-lactamases and achieved satisfactory blood levels. Cefuroxime was also found to be superior to cefazolin in treating respiratory and urinary tract infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

18.

Effects of prophylactic antibiotics in vascular surgery. A prospective, randomized, double-blind study.

Author: HasselgrenP O, IvarssonL, RisbergB, SeemanT

Reduces infection rates
Allergic reactions

Prophylactic administration of cefuroxime for 1 day significantly reduced the incidence of infectious complications following peripheral vascular surgery compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Significant delay of birth in advanced preterm labour at 23 gestational weeks with an oxytocin antagonist.

Author: HerbstAndreas, Wide-SwenssonDag, IngemarssonIngemar

Healthy baby
Postponed delivery

This study describes a case of a 27-year-old primigravid woman who received prolonged tocolytic therapy with atosiban for advanced preterm labor.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

[The influence of selected antibiotics on the central action of aminophyllines--experimental studies].

Author: SzmyginK

Intensified convulsant activity

This study found that some antibiotics, particularly benzylpenicillin, can enhance the epileptogenic effects of methylxanthines, such as aminophylline, in mice.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Polish

21.

Treatment of septicaemia in immunocompromised patients with ceftazidime or with tobramycin and cefuroxime, with special reference to renal effects.

Author: RödjerS, AlestigK, BergmarkJ, BergströmT, HultbergB, JagenburgR, OlaissonL, TrollforsB, WestinJ

Effective septicaemia treatment
Renal side effects

Ceftazidime and tobramycin and cefuroxime were found to be equally effective in treating 52 immunocompromised patients with suspected septicaemia. Both treatment groups had an increase in urinary alanine aminopeptidase, with a greater increase in the tobramycin and cefuroxime group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Comparison of once daily ceftriaxone with gentamicin plus cefuroxime for treatment of serious bacterial infections.

Author: HoepelmanI M, Rozenberg-ArskaM, VerhoefJ

Cost effective
Effective treatment
Time saving
Adverse effect
Death
Treatment failure

Ceftriaxone monotherapy was found to be as effective and less costly than a combination therapy of cefuroxime and gentamicin in the initial management of patients with suspected serious bacterial infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Effects of amlodipine on the oral bioavailability of cephalexin and cefuroxime axetil in healthy volunteers.

Author: DingYi, LiuWenXing, JiaYanYan, LuChengTao, JinXin, YangJing, ZhuYanRong, YangLin, SongYing, DingLiKun, WenAiDong

Antibiotic bioavailability

This study examined the effect of the calcium channel blocker amlodipine on the absorption of two antibiotics, cephalexin and cefuroxime axetil. Amlodipine was found to increase the levels of cephalexin in the blood, suggesting a drug interaction. However, amlodipine did not affect the absorption of cefuroxime axetil. This finding suggests that the interaction between amlodipine and antibiotics may be specific to certain types of antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Long-term cefuroxime axetil in subacute cutaneous lupus erythematosus. A report of three cases.

Author: RudnickaL, SzymańskaE, WaleckaI, SłowińskaM

Serious side effects

Subacute cutaneous lupus erythematosus (SCLE) is a subset of lupus erythematosus characterized mainly by prominent photoaggravated cutaneous manifestations. Standard therapies for SCLE include topical or systemic steroids and antimalarial drugs. This study discusses the need for more effective therapies for SCLE.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Comparative study of cefaclor AF vs. cefuroxime axetil in acute exacerbations of chronic bronchitis.

Author: HaczyńskiJózef, ChyczewskaElzbieta, Grzelewska-RzymowskaIwona, MalolepszyJózef, Marcinkowska-SuchowierskaEwa, MilanowskiJanusz, OklekKazimierz, PłusaTadeusz, SłominskiJan, SzmyginKatarzyna, RekMiroslaw

AECB treatment
Difficult choice of therapy

Acute exacerbations of chronic bronchitis are common and often caused by infection. Choosing the right antibiotic treatment for these exacerbations is becoming more challenging and is often done without specific testing. Cefaclor and cefuroxime are commonly used antibiotics for treating these exacerbations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Antimicrobial treatment of an experimental otitis media caused by a beta-lactamase positive isolate of Haemophilus influenzae.

Author: PonteC, CenjorC, ParraA, NietoE, García-CalvoG, GiménezM J, AguilarL, SorianoF

Otitis media treatment
Side effects

High-dose co-amoxiclav was more effective than cefuroxime in treating otitis media in a gerbil model.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Comparative study of ceftriaxone monotherapy versus a combination regimen of cefuroxime plus gentamicin for treatment of serious bacterial infections: the efficacy, safety and effect on fecal flora.

Author: HoepelmanI M, Rozenberg-ArskaM, VerhoefJ

Bacterial infection treatment
Adverse effects
Treatment failure
Yeast colonization

Ceftriaxone was as effective as a combination of cefuroxime plus gentamicin in treating patients suspected of serious bacterial infections, with a cure rate of 85% for ceftriaxone and 68% for the combination. Ceftriaxone was also more cost-effective and time-saving.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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