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Betalactam therapy and intestinal flora.

Author: CassettaM I, ContiS, DeiR, FallaniS, MazzeiT, NovelliA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cefetamet-pivoxil (CET) had a minimal impact on normal human intestinal flora compared to cefixime (CFX) and cefuroxime axetil (CA), which significantly affected Enterobacteriaceae and clostridia. CFX and CA also led to an increase in enterococci and the appearance of Salmonella spp. and Clostridium difficile in some cases.
Paper Details　
Original Abstract of the Article :
Betalactams, mainly when orally administered, may lead to intestinal flora modifications related to their spectrum of activity, rate of absorption and degradation. therefore it is important to investigate the possible influence of recently developed oral cephem derivatives on normal human microflora...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8618110

データ提供：米国国立医学図書館（NLM）

Betalactam Therapy and Its Impact on Intestinal Flora

This study explores the effects of betalactam antibiotics, particularly those administered orally, on the composition of intestinal flora. The researchers investigated the impact of three oral cephem derivatives – cefetamet-pivoxil (CET), cefixime (CFX), and cefuroxime axetil (CA) – on the normal human microflora in patients with acute exacerbation of chronic bronchitis. They analyzed stool specimens before, during, and after treatment to assess changes in the bacterial composition.

Navigating the Microbial Desert

This research embarks on a journey through the vast and complex ecosystem of the human gut, investigating the impact of betalactam antibiotics on the delicate balance of intestinal flora. The researchers carefully analyzed the changes in bacterial composition before, during, and after treatment, shedding light on the potential consequences of these medications. It's like navigating a desert with a microscope – understanding the intricate relationships between microorganisms and our health requires a close examination of the microbial landscape.

The Importance of Understanding Microbial Ecosystems

This study highlights the importance of understanding the complex interplay between antibiotics and the intestinal flora. The findings demonstrate that different antibiotics can have distinct effects on the composition of gut bacteria, emphasizing the need for careful consideration when prescribing these medications. It's like navigating a desert with a map – understanding the potential impacts of antibiotics on the microbial ecosystem is crucial for maintaining health and well-being.

Dr.Camel's Conclusion

This study delves into the intricate world of intestinal flora and explores the potential impact of betalactam antibiotics on this delicate ecosystem. The researchers provide valuable insights into the distinct effects of different antibiotics on gut bacteria, emphasizing the importance of careful consideration when prescribing these medications. It's a reminder that maintaining the balance of our gut microbiome is crucial for overall health and that antibiotic use should be approached with caution and awareness of its potential consequences.
Date :
  1. Date Completed 1996-06-07
  2. Date Revised 2016-11-23
Further Info :

Pubmed ID

8618110

DOI: Digital Object Identifier

8618110

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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