Effects of cenobamate: A Synthesis of Findings from 23 Studies

  1. Home
  2. Effects of cenobamate
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of cenobamate: A Synthesis of Findings from 23 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of cenobamate: A Synthesis of Findings from 23 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Cenobamate is a newly approved anti-epileptic drug for the treatment of focal seizures in adults. 23 , 19 , 10 , 20 Several studies have shown that cenobamate can significantly reduce the frequency of focal seizures, and this effect may be observed after two weeks of treatment. 22 Cenobamate is thought to work by inhibiting persistent sodium currents and acting as a positive allosteric modulator of GABAA receptors. 19 Some studies have shown that cenobamate is effective in reducing the frequency of seizures in patients whose seizures are not controlled with other medications. 15 Cenobamate has been shown to eliminate seizures in around 20% of patients with drug-resistant focal seizures. 20 Cenobamate has also been shown to be more cost-effective than other third-generation anti-seizure medications. 20 In patients who are seizure-free, cenobamate may allow for the reduction or discontinuation of other anti-seizure medications. 2 Cenobamate may also have neuroprotective effects. 20 Cenobamate has been shown to affect a range of cognitive and behavioral functions. 13 Cenobamate may reduce neuronal excitability through a combined action on sodium currents and GABAAR-mediated synapse responses. 13

Benefits and Risks

Benefit Summary

Cenobamate has been shown to be effective in reducing the frequency of seizures in patients with drug-resistant focal seizures. 15 In patients who are seizure-free, cenobamate may allow for the reduction or discontinuation of other anti-seizure medications. 2 Cenobamate may also have neuroprotective effects. 20 Cenobamate has also been shown to be more cost-effective than other third-generation anti-seizure medications. 20

Risk Summary

Cenobamate can cause a number of side effects, including fatigue, dizziness, and sleepiness. 2 Cenobamate may cause drug reaction with eosinophilia and systemic symptoms (DRESS), which is a serious skin reaction. 14 Cenobamate may increase the risk of suicidal thoughts and behaviors. 20 Cenobamate may be addictive. 20

Comparison Across Studies

Commonalities

Many studies have shown that cenobamate may be an effective treatment for focal seizures in adults. 23 , 15 , 22 , 12 , 11 , 7 Many studies suggest that cenobamate works by inhibiting sodium currents and acting as a positive allosteric modulator of GABAA receptors. 19 , 10 Many studies have shown that cenobamate is effective in reducing the frequency of seizures in patients whose seizures are not controlled with other medications. 15 , 22 , 7 Many studies have shown that cenobamate is more cost-effective than other third-generation anti-seizure medications. 20

Differences

Some studies have shown that cenobamate may allow for the reduction or discontinuation of other anti-seizure medications in patients who are seizure-free. 2 Other studies have shown that cenobamate may have neuroprotective effects. 20 Some studies have shown that cenobamate may affect a range of cognitive and behavioral functions. 13 Cenobamate may reduce neuronal excitability through a combined action on sodium currents and GABAAR-mediated synapse responses. 13

Consistency and Contradictions in Findings

There is a consistent amount of evidence from many studies indicating that cenobamate may be an effective treatment for focal seizures in adults. 23 , 15 , 22 , 12 , 11 , 7 However, there are some contradictions in research findings regarding the rate of side effects from cenobamate, particularly DRESS. 14 Some studies have suggested that cenobamate may be addictive. 20

Considerations for Real-World Application

Cenobamate shows promise as a potential treatment for patients with focal seizures, especially those who have not responded well to other anti-seizure medications. 15 However, cenobamate can cause serious side effects, and therefore should be used with caution. 14 It is important to consult with a doctor before starting cenobamate.

Limitations of Current Research

More research is needed to understand the long-term effects of cenobamate. 20 More research is needed to determine if cenobamate can lead to the reduction or discontinuation of other anti-seizure medications. 2 More research is also needed to evaluate the neuroprotective effects of cenobamate. 20 Further research is also needed to investigate if cenobamate may affect a range of cognitive and behavioral functions. 13

Future Research Directions

Future research should investigate the long-term effects of cenobamate, the potential for cenobamate to allow for the reduction or discontinuation of other anti-seizure medications, the neuroprotective effects of cenobamate, and the potential for cenobamate to affect a range of cognitive and behavioral functions.

Conclusion

Cenobamate is a newly approved anti-epileptic drug for the treatment of focal seizures in adults. 23 , 19 , 10 , 20 It has the potential to be a promising treatment for patients with focal seizures, especially those who have not responded well to other anti-seizure medications. 15 However, it is important to use cenobamate with caution as it can cause serious side effects. 14 Consult with a doctor before starting cenobamate.

Literature analysis of 23 papers
Positive Content
23
Neutral Content
0
Negative Content
0
Article Type
4
3
2
6
23
1.

Adjunctive Cenobamate for Focal-Onset Seizures in Adults: A Systematic Review and Meta-Analysis.

Author: LattanziSimona, TrinkaEugen, ZaccaraGaetano, StrianoPasquale, Del GiovaneCinzia, SilvestriniMauro, BrigoFrancesco

Enhanced sodium inactivation
GABA<sub>A</sub> receptor modulation

Cenobamate is a novel antiseizure medication with a dual mechanism of action. It enhances the inactive state of voltage-gated sodium channels and acts as a positive allosteric modulator of GABA<sub>A</sub> receptors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Dose reduction and discontinuation of concomitant antiseizure medications after initiating cenobamate: A retrospective review.

Author: BeckerDanielle A, DemkoSarah A

Reduce ASM dose
Seizure-free
Fatigue

Cenobamate is a new antiseizure medication that allows for dose reduction or elimination of other antiseizure medications in some patients. In this study, 50% of patients discontinued at least one other antiseizure medication while taking cenobamate. The most common side effect was fatigue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy.

Author: AgasheShruti, WorrellGregory, BrittonJeffrey, NoeKatherine, RitaccioAnthony, WirrellElaine C, NickelsKatherine C, CascinoGregory D, BurkholderDavid

Epilepsy treatment
Hypersensitivity reactions

This study evaluated the efficacy of cenobamate (CNB) in drug-refractory patients with genetic generalized epilepsies (GGE) or combined generalized and focal epilepsies (CGFE).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non-Japanese.

Author: YangEunsol, SunwooJung, HuhKi Young, KimYu Kyong, LeeSeungHwan, JangIn-Jin, YuKyung-Sang

Focal seizure treatment
Good safety profile

This study evaluated the pharmacokinetics (PKs) and safety of cenobamate in healthy Japanese subjects. The study found that cenobamate was rapidly absorbed and eliminated, with systemic exposure comparable to that in non-Japanese subjects. The single dose of cenobamate was well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Long-Term Efficacy and Safety From an Open-Label Extension of Adjunctive Cenobamate in Patients With Uncontrolled Focal Seizures.

Author: KleinPavel, AboumatarSami, BrandtChristian, DongFang, KraussGregory L, MizneSarah, Sanchez-AlvarezJuan Carlos, SteinhoffBernhard J, VillanuevaVicente

Long-term efficacy
Safe treatment
Dizziness
Somnolence

Long-term treatment with cenobamate (CNB) was associated with sustained efficacy in patients with uncontrolled focal seizures. No new safety issues were identified during 48 months of treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Onset of efficacy and adverse events during Cenobamate titration period.

Author: SteinhoffBernhard J, Ben-MenachemElinor, BrandtChristian, García MoralesIrene, RosenfeldWilliam E, SantamarinaEstevo, SerratosaJosé M

Focal seizure control
Treatment-emergent adverse events

This post hoc analysis of cenobamate, an antiseizure medication, investigated the onset of efficacy and the characteristics of treatment-emergent adverse events (TEAEs) during cenobamate titration. The analysis provides insights into the clinical profile of cenobamate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Use of cenobamate for the treatment of focal epilepsy: an Italian expert opinion paper.

Author: VillaniFlavio, CianciVittoria, Di BonaventuraCarlo, Di GennaroGiancarlo, GalimbertiCarlo Andrea, GuerriniRenzo, La NeveAngela, MecarelliOriano, PietrafusaNicola, SpecchioNicola, VigevanoFederico, PeruccaEmilio

Focal-onset seizure treatment

Cenobamate, a new antiseizure medication (ASM), has been recently approved for the adjunctive treatment of focal-onset seizures in adults with epilepsy. This study provides an overview of the regulatory approval process and the potential role of cenobamate in epilepsy management.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Cost-effectiveness of cenobamate for focal seizures in people with drug-resistant epilepsy.

Author: LaskierVicki, Agyei-KyerematengKenneth K, EddyAlex E, PatelDilip, MulheronStuart, JamesSamuel, ThomasRhys H, SanderJosemir W

Cost-effective
Seizure control

Cenobamate was found to be cost-effective compared to brivaracetam, eslicarbazepine, lacosamide, and perampanel in treating drug-resistant focal seizures. Cenobamate improved QALYs and was less costly than the comparators, making it a potential cost-effective adjunctive antiseizure medication.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Long-term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program.

Author: SanderJosemir W, RosenfeldWilliam E, HalfordJonathan J, SteinhoffBernhard J, BitonVictor, ToledoManuel

Effective
Well-tolerated
Adverse events

Cenobamate demonstrated consistently high retention rates, suggesting its potential as an effective and well-tolerated treatment option for people with drug-resistant focal seizures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Efficacy and safety of cenobamate in patients with uncontrolled focal seizures: A meta-analysis.

Author: ZhangLanlan, WangJuan, WangChengzhong

focal seizures
seizure reduction
cenobamate adverse events

A systematic review of two randomized placebo-controlled trials (RCTs) with a total of 658 patients found that cenobamate demonstrated favorable efficacy for treatment of uncontrolled focal seizures. A significantly larger proportion of patients allocated to cenobamate achieved 50% seizure reduction compared to placebo. Cenobamate was well tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Cognitive and behavioral effects of the anti-epileptic drug cenobamate (YKP3089) and underlying synaptic and cellular mechanisms.

Author: SongWoo Seok, ChoYoung Seon, OhSung Pyo, YoonSang Ho, KimYoung Sook, KimMyoung-Hwan

Epilepsy treatment
Cognitive impairment
Seizure control

Cenobamate is a new anti-seizure medication that reduces neuronal excitability by acting on GABA A receptors and voltage-gated sodium channels. In animal studies, cenobamate was found to improve memory performance, enhance inhibitory signals in the brain, and suppress excitatory signals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Cenobamate tablets as a treatment for focal-onset seizures in adults.

Author: SteinhoffBernhard J

Epilepsy treatment
Drug reaction

This review explores the pharmacological profile and clinical trial data for cenobamate (CNB), a new antiseizure medication (ASM) for focal-onset seizures. While CNB demonstrates promising efficacy, the review also highlights the occurrence of drug-related reactions with eosinophilia and systemic symptoms, emphasizing the importance of careful titration strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Pharmacokinetics of Cenobamate: Results From Single and Multiple Oral Ascending-Dose Studies in Healthy Subjects.

Author: VernilletLaurent, GreeneStephen A, KaminMarc

Seizure treatment

This review summarizes the pharmacokinetics, safety, and tolerability of cenobamate, a newly approved antiepileptic drug, in healthy subjects. The results show that cenobamate is generally well tolerated and has a long terminal half-life, making once-daily dosing possible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?

Author: GuignetMichelle, CampbellAmanda, WhiteH Steve

Epilepsy treatment

Cenobamate (CBM) is a new anti-seizure medication (ASM) that is effective in treating partial onset seizures in adults. CBM is different from other ASMs because it appears to have two mechanisms of action: it blocks sodium channels and increases GABA activity. In preclinical studies, CBM showed greater seizure protection than other similar drugs, suggesting that it may be a valuable treatment for patients with epilepsy that is resistant to other therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Cenobamate (YKP3089) and Drug-Resistant Epilepsy: A Review of the Literature.

Author: RissardoJamir Pitton, Fornari CapraraAna Letícia

Cost-effectiveness
Epilepsy treatment
Seizure freedom
Abuse potential
Suicidality risk

Cenobamate (CNB) is a novel anti-seizure medication that has shown high efficacy in managing focal onset seizures, with a significant proportion of individuals with drug-resistant epilepsy achieving seizure freedom. However, it has a slow and complex titration and maintenance phase, and its potential for abuse and suicidality risk needs further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Cenobamate for the treatment of focal epilepsy.

Author: DhirA

Focal-onset seizures treatment
Side effects

Cenobamate, a new drug for focal-onset seizures, showed superior efficacy over placebo. It has mild to moderate side effects, but DRESS syndrome is a rare potential risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.