Side Effects of cenobamate: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Major Findings

Cenobamate is an antiseizure medication (ASM) approved for the treatment of focal seizures in adults. 6 , 9 , 11 , 1 Cenobamate has been shown to be effective in reducing seizure frequency, particularly in those with refractory or highly active focal seizures. 1 , 10 Additionally, cenobamate is effective as an adjunctive therapy in pediatric patients with focal epilepsy. 7

Reasons for Side Effects

The side effects of cenobamate are likely due to its dual mechanism of action: inhibition of voltage-gated sodium channels and positive allosteric modulation of the GABAA receptor. 9 , 11 This can affect the balance of neurotransmitters in the brain, leading to various side effects.

Common Side Effects

Somnolence

Somnolence is one of the most common side effects reported with cenobamate. 9 This is likely due to the drug's effect on the GABAA receptor, which can suppress neuronal activity. 9

Dizziness

Dizziness is another commonly reported side effect. 9 This could be related to the drug's effects on the central nervous system.

Headache

Headache is also a reported side effect, possibly due to the drug's impact on neuronal activity. 9

Nausea

Nausea is another potential side effect. 9 This could be linked to the drug's effects on the gastrointestinal system.

Fatigue

Fatigue is also a reported side effect. 9 This could be due to the drug's effects on the central nervous system.

Strategies for Managing Side Effects

Somnolence

Adjusting the dosage or timing of cenobamate administration can help manage somnolence.

Dizziness

Adjusting the dosage or timing of cenobamate administration can help manage dizziness. It is essential to be cautious to prevent falls.

Headache

Adjusting the dosage or timing of cenobamate administration can help manage headaches. Over-the-counter pain relievers may also be helpful.

Nausea

Adjusting the dosage or timing of cenobamate administration can help manage nausea. Additionally, dietary modifications or medication might help.

Fatigue

Adjusting the dosage or timing of cenobamate administration can help manage fatigue. Getting enough rest is crucial.

Comparison Across Studies

Commonalities

Several studies have found cenobamate to be effective in treating focal seizures. 6 , 9 , 11 , 1 Research has also identified cenobamate's dual mechanism of action: sodium channel inhibition and GABAA receptor modulation. 9 , 11 Common side effects associated with cenobamate include somnolence, dizziness, headache, nausea, and fatigue. 9

Differences

Variations in study populations and design result in differences in findings regarding cenobamate's effectiveness and side effects. For instance, 10 demonstrates the effectiveness of cenobamate in treating refractory epilepsy, while 8 shows its effectiveness in adolescents and young adults with focal seizures. Additionally, 3 suggests a potential for alopecia as a side effect. These differences highlight the need for continued research into cenobamate's effectiveness and side effects.

Considerations for Real-World Application

While cenobamate is an effective treatment for focal seizures, it can cause side effects. It is crucial to adhere to a doctor's instructions and take the appropriate dosage. If any side effects, such as somnolence or dizziness, occur, avoid activities such as driving or operating machinery.

Limitations of Current Research

Research on cenobamate is still ongoing and limited. More research is needed, particularly on the long-term effects and side effects of cenobamate.

Future Research Directions

Further research is needed to evaluate the long-term effects and side effects of cenobamate, as well as its efficacy in treating different types of seizures. Additionally, research is required to investigate the effectiveness and side effects of cenobamate when used concurrently with other medications.

Conclusion

Cenobamate is an effective treatment for focal seizures, but it can cause side effects. It is essential to follow a doctor's instructions and take the appropriate dosage. If you experience any side effects, consult your doctor.

Literature analysis of 11 papers
Positive Content
10
Neutral Content
0
Negative Content
1
Article Type
1
0
0
2
11
1.

Adjunctive cenobamate in highly active and ultra-refractory focal epilepsy: A "real-world" retrospective study.

Author: Peña-CeballosJavier, MoloneyPatrick B, MunteanuTudor, DoyleMichael, ColleranNiamh, LigganBrenda, BreenAnnette, MurphySinead, El-NaggarHany, Widdess-WalshPeter, DelantyNorman

Seizure Control

Cenobamate shows efficacy and tolerability in a real-world cohort of patients with severe drug-resistant focal epilepsy, including those with highly active and ultra-refractory epilepsy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effects of cenobamate on cognitive performance of epilepsy patients.

Author: SchuetzElisa, WagnerKathrin, MetternichBirgitta, PapadopoulouGeorgia, KravalisKristina, HeersMarcel, Martínez-LizanaEva, Castillo-RodriguezMaria, AltenmüllerDirk-Matthias, Schulze-BonhageAndreas, HirschMartin

Epilepsy treatment
Seizure control
Cognitive impairment

The effects of cenobamate on cognition are unclear. Further research is needed to determine if adjunctive treatment with cenobamate is associated with changes in cognitive performance.

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Antiseizure Medication-Induced Alopecia: A Literature Review.

Author: Pitton RissardoJamir, Fornari CapraraAna Leticia, CasaresMaritsa, SkinnerHolly J, HamidUmair

Alopecia

This literature review examines alopecia as a side effect of antiseizure medications (ASMs). Valproate, lamotrigine, and carbamazepine are the most frequently reported ASMs associated with alopecia. Alopecia is typically diffuse, non-scarring, and often reversible after ASM dose adjustments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Onset of efficacy and adverse events during Cenobamate titration period.

Author: SteinhoffBernhard J, Ben-MenachemElinor, BrandtChristian, García MoralesIrene, RosenfeldWilliam E, SantamarinaEstevo, SerratosaJosé M

Focal seizure control
Treatment-emergent adverse events

This post hoc analysis of cenobamate, an antiseizure medication, investigated the onset of efficacy and the characteristics of treatment-emergent adverse events (TEAEs) during cenobamate titration. The analysis provides insights into the clinical profile of cenobamate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Cenobamate for the treatment of focal epilepsy.

Author: DhirA

Focal-onset seizures treatment
Side effects

Cenobamate, a new drug for focal-onset seizures, showed superior efficacy over placebo. It has mild to moderate side effects, but DRESS syndrome is a rare potential risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Cenobamate, a Sodium Channel Inhibitor and Positive Allosteric Modulator of GABA<sub>A</sub> Ion Channels, for Partial Onset Seizures in Adults: A Comprehensive Review and Clinical Implications.

Author: LatimerDustin R, EdinoffAmber N, RuffRachel D, RooneyKelsey C, PennyKayla M, PatelShaan B, SabbenahalliSuresh, KayeAdam M, CornettElyse M, ViswanathOmar, UritsIvan, KayeAlan D

Improved quality of life
Reduced seizures
Dizziness
Somnolence

This abstract discusses the potential of cenobamate, a newly approved drug for treating partial-onset seizures, in epilepsy management. Cenobamate's dual mechanism of action and low toxicity profile make it a promising addition to antiepileptic therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy.

Author: AgasheShruti, WorrellGregory, BrittonJeffrey, NoeKatherine, RitaccioAnthony, WirrellElaine C, NickelsKatherine C, CascinoGregory D, BurkholderDavid

Epilepsy treatment
Hypersensitivity reactions

This study evaluated the efficacy of cenobamate (CNB) in drug-refractory patients with genetic generalized epilepsies (GGE) or combined generalized and focal epilepsies (CGFE).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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