Side Effects of cetirizine injection: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Main research findings

Cetirizine has been shown to inhibit the effects of various substances involved in allergic reactions, such as histamine, bradykinin, and platelet-activating factor (PAF). 5 , 4 Furthermore, cetirizine has been reported to inhibit urticarial reactions induced by the patient's own serum in patients with chronic urticaria. 5 , 4 Cetirizine has been shown to have an effect on suppressing swelling and redness of the skin caused by histamine (urticaria) and may be effective in treating chronic urticaria. 4

Reasons for side effects

Cetirizine acts as a histamine H1 receptor antagonist, suppressing allergic reactions caused by histamine. However, cetirizine can act on histamine H1 receptors that exist in various cells and tissues, which can lead to unintended side effects. 4 Cetirizine may also act on receptors other than the histamine H1 receptor, which is thought to be the cause of side effects. 3

Common side effects

Drowsiness

Cetirizine can cause drowsiness in some patients. 6 Cetirizine is said to have fewer drowsiness side effects compared to first-generation antihistamines. 6

Dry mouth

Cetirizine can cause dry mouth. 4

Gastrointestinal symptoms

Cetirizine can cause gastrointestinal symptoms. 4

Headache

Cetirizine can cause headache. 4

Fatigue

Cetirizine can cause fatigue. 4

Countermeasures for side effects

Drowsiness

If you experience drowsiness, adjust the time you take cetirizine or consult your doctor. 6

Dry mouth

If you experience dry mouth, drink plenty of fluids. 4

Gastrointestinal symptoms

If you experience gastrointestinal symptoms, consult your doctor. 4

Headache

If you have a severe headache, consult your doctor. 4

Fatigue

If you experience persistent fatigue, consult your doctor. 4

Comparison between studies

Common points

Multiple studies have shown that cetirizine is effective in suppressing urticarial reactions caused by histamine. 5 , 4

Differences

Different results have been reported regarding the side effects of cetirizine in different studies. 6 , 4 For example, drowsiness side effects have been reported in some studies, while others have not. 6

Precautions for real-life application

Cetirizine is an effective medication for alleviating allergy symptoms, but there is also a risk of side effects. 6 , 4 It is important to follow your doctor's instructions and adhere to the dosage when taking cetirizine. 6 , 4 Also, if you experience side effects such as drowsiness while taking cetirizine, be careful with activities such as driving or operating machinery. 6

Limitations of current research

Research on the side effects of cetirizine is still insufficient. 6 , 4 Further research is needed, especially on long-term side effects. 6

Future research directions

Further research is needed on long-term side effects of cetirizine and the effects and side effects of cetirizine in specific patient populations. 6 , 4 Also, research is needed on appropriate methods of use to maximize the efficacy of cetirizine and minimize the risk of side effects. 6

Conclusion

Cetirizine is an effective medication for alleviating allergy symptoms, but there is also a risk of side effects. 6 , 4 It is important to follow your doctor's instructions and adhere to the dosage when taking cetirizine. 6 , 4 Also, if you experience side effects such as drowsiness while taking cetirizine, be careful with activities such as driving or operating machinery. 6

Literature analysis of 11 papers
Positive Content
11
Neutral Content
0
Negative Content
0
Article Type
7
0
0
2
11
1.

Management of flu-like syndrome with cetirizine in patients with relapsing-remitting multiple sclerosis during therapy with interferon beta: Results of a randomized, cross-over, placebo-controlled pilot study.

Author: LandiDoriana, AlbaneseMaria, ButtariFabio, MonteleoneFabrizia, BoffaLaura, RossiSilvia, MottaCaterina, PumaElisa, CentonzeDiego

Improved IFNβ tolerance

This study hypothesized that cetirizine, a second-generation histamine H1 receptor antagonist, might improve interferon beta (IFNβ)-induced flu-like syndrome (FLS) in patients with relapsing-remitting multiple sclerosis (RRMS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effect of oral antihistamine on local injection site reactions with self-administered glatiramer acetate.

Author: PardoGabriel, BoutwellChristine, ConnerJill, DenneyDouglas, Oleen-BurkeyMerriKay

Reduced LISR

This study evaluated the efficacy of cetirizine, an oral antihistamine, in reducing local injection site reactions (LISRs) associated with glatiramer acetate therapy for multiple sclerosis. While cetirizine slightly decreased the number of LISRs, the difference was not statistically significant. Both groups showed a significant reduction in mean LISR score during the treatment period.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Desferal (desferrioxamine)--a novel activator of connective tissue-type mast cells.

Author: ShalitM, TedeschiA, MiadonnaA, Levi-SchafferF

Positive control in skin testing
Allergic side effects
Local histamine release

Desferal is an iron-chelating agent that has allergic side effects. In a study, Desferal induced histamine release from rat peritoneal MCs but had no effect on mouse bone marrow-derived MCs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Cetirizine in the treatment of chronic urticaria.

Author: JuhlinL

Urticaria treatment

Cetirizine, an antihistamine, was found to effectively reduce the incidence of spontaneous and provoked urticaria. In two studies, cetirizine was significantly more effective than placebo in reducing the incidence of erythema, wheals, and pruritus, and also inhibited reactions to injected histamine, kallikrein, and synthetic platelet-activating factor.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effect of cetirizine on cutaneous reactions to PAF, kallikrein and serum in patients with chronic urticaria.

Author: JuhlinL, RihouxJ P

Effective antihistamine
Well tolerated

Cetirizine markedly reduced the weal and flare induced by platelet activating factor, kallikrein, histamine and the patient's own serum.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Comparison between cetirizine and terfenadine: time-response study.

Author: RandazzoL, ValenciaM, Olivé-PérezA

Inhibits histamine response

Cetirizine 10mg showed a longer duration of peripheral antihistaminic effect than terfenadine 60mg. Both were well-tolerated and did not cause sedation or anticholinergic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Desferal (desferrioxamine)--a novel activator of connective tissue-type mast cells.

Author: ShalitM, TedeschiA, MiadonnaA, Levi-SchafferF

Positive control in skin testing
Allergic side effects
Local histamine release

Desferal is an iron-chelating agent that has allergic side effects. In a study, Desferal induced histamine release from rat peritoneal MCs but had no effect on mouse bone marrow-derived MCs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Cetirizine in the treatment of chronic urticaria.

Author: JuhlinL

Urticaria treatment

Cetirizine, an antihistamine, was found to effectively reduce the incidence of spontaneous and provoked urticaria. In two studies, cetirizine was significantly more effective than placebo in reducing the incidence of erythema, wheals, and pruritus, and also inhibited reactions to injected histamine, kallikrein, and synthetic platelet-activating factor.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effect of cetirizine on cutaneous reactions to PAF, kallikrein and serum in patients with chronic urticaria.

Author: JuhlinL, RihouxJ P

Effective antihistamine
Well tolerated

Cetirizine markedly reduced the weal and flare induced by platelet activating factor, kallikrein, histamine and the patient's own serum.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines.

Author: MonroeE W, DalyA F, ShalhoubR F

Allergic disease treatment

This review concluded that while the histamine-induced wheal and flare test can assess dose-response relations for antihistamines, it is not reliable for predicting or comparing their clinical efficacy in seasonal allergic rhinitis and chronic idiopathic urticaria.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

New treatments for allergic rhinitis.

Author: TkachykS J

Allergic rhinitis treatment
Growth retardation

This review highlights new treatments for allergic rhinitis, including newer antihistamines, intranasal steroid sprays, antileukotrienes, and immunotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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