Side Effects of choline magnesium trisalicylate: A Synthesis of Findings from 8 Studies

  1. Home
  2. Side Effects of choline magnesium trisalicylate
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of choline magnesium trisalicylate: A Synthesis of Findings from 8 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of choline magnesium trisalicylate: A Synthesis of Findings from 8 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Choline magnesium trisalicylate (CMT) has been shown to be effective in treating rheumatoid arthritis. 7 , 5 , 3 It can reduce pain and swelling in joints, and decrease the duration of morning stiffness. 7 CMT has also been found to be more effective in reducing the number of swollen joints compared to acetylsalicylic acid (ASA), with fewer side effects. 5 Additionally, CMT shows potential in managing metastatic bone pain, though further research is needed. 8

Reasons for Side Effects

CMT, being a salicylate, can cause irritation to the stomach lining, leading to increased exfoliation of gastric mucosal cells. 2 This irritation can contribute to several side effects.

Common Side Effects

Tinnitus

Tinnitus is a common side effect associated with CMT use. 2 , 3 It often resolves when the dosage is reduced. 3

Nausea

Nausea is another potential side effect of CMT. 2 Lowering the dosage may help alleviate this symptom. 3

Increased Fecal Blood Loss

CMT can lead to increased fecal blood loss, indicating potential gastrointestinal irritation. 2

Pruritus

Pruritus (itching) has been reported in some patients taking CMT. 3

Gastrointestinal Side Effects

Minor gastrointestinal side effects are also possible with CMT use. 3

Side Effect Countermeasures

Tinnitus

Reducing the dosage of CMT can often alleviate tinnitus. 3

Nausea

Lowering the CMT dosage can help reduce nausea. 3

Pruritus

If pruritus occurs, consider reducing the dosage of CMT. 3

Gastrointestinal Side Effects

Adjusting the dosage of CMT may help manage gastrointestinal side effects. 3

Comparison between Studies

Common Points of Studies

Several studies have shown CMT's effectiveness in treating rheumatoid arthritis. 7 , 5 , 3 The studies consistently demonstrate CMT's ability to reduce joint pain and swelling, and improve morning stiffness. 7

Differences between Studies

The frequency of side effects reported in different studies varies. 5 , 3 For instance, one study found a 16.3% incidence of side effects while another reported 32.1%. 5

Points to Note Regarding Application to Real Life

While CMT shows promise in treating rheumatoid arthritis, it's important to be aware of potential side effects. 7 , 5 , 3 Before starting CMT, consult with your doctor to discuss the potential risks and benefits. 2 If you experience any side effects, report them to your doctor immediately. 2

Limitations of Current Research

Research on CMT is still limited. 7 , 5 , 3 More research is needed, especially regarding the long-term effects and safety of CMT. 2

Future Research Directions

Long-term studies to evaluate the efficacy and safety of CMT are crucial. 2 Research should also explore the effects of CMT when used in combination with other rheumatoid arthritis medications. 7 , 5 , 3

Conclusion

CMT shows potential as a treatment option for rheumatoid arthritis. 7 , 5 , 3 However, be aware of possible side effects and discuss them with your doctor before starting CMT. 2 Further research is needed to fully understand the long-term effects and safety of CMT. 2

Literature analysis of 8 papers
Positive Content
6
Neutral Content
1
Negative Content
1
Article Type
4
0
0
0
8
1.

The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers.

Author: PenttiläJ, SyvälahtiE, HinkkaS, KuuselaT, ScheininH

Anticholinergic side effects

Reboxetine, despite its low antimuscarinic activity in vitro, had distinct effects on the HF power of RRI, consistent with anticholinergic activity in vivo. Amitriptyline had a measurable anticholinergic effect in the salivary glands, but not in the heart.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

The effect of the non-steroidal anti-inflammatory drug choline magnesium trisalicylate on gastric mucosal cell exfoliation.

Author: MitchellK G, HearnsJ, CreanG P

Gastric irritation
Increased bleeding
Nausea
Tinnitus

Both choline magnesium trisalicylate (CMT) and aspirin caused gastric mucosal cell exfoliation. However, CMT was associated with more side effects, including tinnitus, nausea, and increased faecal blood loss.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Clinical evaluation of choline magnesium trisalicylate in rheumatoid arthritis.

Author: ModyG M, NaidooP D, SinghT G

Improved indices of inflammation
Gastrointestinal side effects
Pruritus
Tinnitus

Choline magnesium trisalicylate (CMT) was effective in reducing inflammation in patients with rheumatoid arthritis. Tinnitus was the most common side effect, which resolved with dose reduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Efficacy and safety of a non-acetylated salicylate, choline magnesium trisalicylate, in the treatment of rheumatoid arthritis.

Author: RothwellK G

Lower GI side effects
Similar or greater improvement

CMT showed similar or greater improvement in rheumatoid arthritis compared to ASA with fewer gastrointestinal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Clinical comparative evaluation of choline magnesium trisalicylate and acetylsalicylic acid in rheumatoid arthritis.

Author: BlechmanW J, LechnerB L

Lower side effect incidence
Reduced symptom severity

Choline magnesium trisalicylate is as effective as acetylsalicylic acid in treating rheumatoid arthritis but has a lower incidence of adverse side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

A comparison of choline magnesium trisalicylate and acetylsalicylic acid in patients with rheumatoid arthritis.

Author: Le GallezP, BirdH A, WrightV

Side effects

Choline magnesium trisalicylate (3.0 g/day) and enteric-coated acetylsalicylic acid (3.0 g/day) were compared in a double-blind, crossover study in patients with rheumatoid arthritis. There was no significant clinical difference between the two treatments. There was also no clear difference in the side-effects profile, but the number of patients recruited was small.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Once-daily treatment of rheumatoid arthritis with choline magnesium trisalicylate.

Author: MannC C, BoyerJ T

Effective for rheumatoid arthritis

Once-daily treatment with choline magnesium trisalicylate (CMT) was as effective as twice-daily treatment in controlling rheumatoid arthritis symptoms. Side effects were similar in both regimens.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.

Author: JohnsonJ R, MillerA J

Bone pain relief

Choline magnesium trisalicylate (CMT) significantly relieved bone pain caused by metastatic cancer in 26 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.