Side Effects of cidofovir injection: A Synthesis of Findings from 4 Studies

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Original Abstract of the Article

Main Research Findings

Several studies have shown that cidofovir is effective in treating recurrent respiratory papillomatosis (RRP). 1 , 2 . Local cidofovir injections can help reduce RRP symptoms and delay recurrence. 2 . Local cidofovir injections are expected to reduce the number of surgeries used to treat RRP. 2 , 3 .

Reasons for side effects

Side effects of cidofovir may be related to the mechanism of action and administration of the drug. Cidofovir is a drug that inhibits the replication of viral DNA. This mechanism of action is effective in treating viral infections, but it can also affect human cells. In addition, local injection of cidofovir can cause inflammation and pain at the injection site.

Common side effects

Hepatotoxicity

Hepatotoxicity from local cidofovir injections has been reported in two cases. 1 . Hepatotoxicity may be related to the dose and duration of cidofovir administration. 1 .

Inflammation at the injection site

Local cidofovir injections can cause inflammation at the injection site. 2 , 1 .

Vocal fold scarring

Long-term administration of cidofovir can lead to vocal fold scarring. 2 . Vocal fold scarring can lead to vocal fold dysfunction.

Side effects countermeasures

Hepatotoxicity

To reduce the risk of hepatotoxicity, it is important to adjust the dose of cidofovir appropriately. 1 . Regular monitoring of liver function is also necessary.

Inflammation at the injection site

Rest and cold compresses after injection are effective in reducing inflammation at the injection site. 2 .

Vocal fold scarring

To reduce the risk of vocal fold scarring, the dose and duration of cidofovir administration should be minimized. 2 . Regular vocal fold examinations are also important.

Comparison between studies

Commonalities of studies

All three studies show that local cidofovir injections are effective in treating RRP. 1 , 2 , 3 .

Differences between studies

The dose, duration of cidofovir administration, number of patients, follow-up period, etc. vary among the studies. Also, the study methods are different. 1 , 2 , 3 .

Precautions for application in real life

Local cidofovir injections are an effective way to treat RRP, but there is a risk of side effects. 1 , 2 . It is important to consult your doctor and understand the risks and benefits of local cidofovir injections before receiving them.

Limitations of current research

There is still not enough research on local cidofovir injections. 1 , 2 , 3 . In particular, data on long-term side effects are lacking. 2 . Also, there is no clear conclusion yet on the optimal dose and duration of local cidofovir injections. 1 , 2 .

Future research directions

Further research is needed to clarify the safety and efficacy of local cidofovir injections. 1 , 2 , 3 . In particular, research on long-term side effects is needed. 2 . Also, research is needed to determine the optimal dose and duration of local cidofovir injections. 1 , 2 .

Conclusion

Local cidofovir injections are an effective way to treat RRP. 1 , 2 , 3 . However, there is also a risk of side effects. 1 , 2 . It is important to consult your doctor and understand the risks and benefits of local cidofovir injections before receiving them. 1 , 2 .

Literature analysis of 4 papers
Positive Content
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Neutral Content
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Negative Content
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Article Type
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4
1.

Effectiveness of cidofovir intralesional treatment in recurrent respiratory papillomatosis.

Author: WierzbickaMałgorzata, JackowskaJoanna, BartochowskaAnna, JózefiakAgata, SzyfterWitold, KędziaWitold

Effective RRP treatment
Safe RRP treatment
Hepatic toxicity

This study presented results of recurrent respiratory papillomatosis (RRP) treatment with surgical excision and cidofovir intralesional use. Cidofovir was effective in 18 out of 32 patients and safe, and should be considered in those patients who experienced disease relapse.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

[Intralesional cidofovir injections for recurrent laryngeal papillomatosis: first results].

Author: NeumannK, PudszuhnA, WelzelC, Bartel-FriedrichS, PassmannM

Cidofovir, a nucleoside analog, is being investigated as a treatment for recurrent laryngeal papillomatosis, a benign disease of the larynx caused by human papilloma virus (HPV) infection. Intralesional injection of cidofovir is being evaluated in pilot studies.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

4.

Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.

Author: TaskintunaI, RahhalF M, ArevaloJ F, MunguiaD, BankerA S, De ClercqE, FreemanW R

Effective for CMV retinitis
Hypotony
Iritis

Intravitreal injections of 10 micrograms of cidofovir were found to be effective in treating cytomegalovirus retinitis, but may be associated with iritis and hypotony.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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