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Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.

Author: ArevaloJ F, BankerA S, De ClercqE, FreemanW R, MunguiaD, RahhalF M, TaskintunaI

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Intravitreal injections of 10 micrograms of cidofovir were found to be effective in treating cytomegalovirus retinitis, but may be associated with iritis and hypotony.
Paper Details　
Original Abstract of the Article :
The authors have shown that long-term treatment of cytomegalovirus (CMV) retinitis with 20-microgram intravitreal injections of cidofovir (HPMPC) is highly effective but may be associated with iritis and profound hypotony. They evaluated the efficacy and safety of 10-microgram intravitreal injection...See full text at original site
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引用元：
https://doi.org/10.1016/s0161-6420(97)30188-2

データ提供：米国国立医学図書館（NLM）

Low-Dose Intravitreal Cidofovir: A New Path Through the Desert of CMV Retinitis

Cytomegalovirus (CMV) retinitis, a serious complication for individuals with acquired immune deficiency syndrome (AIDS), can be a daunting challenge. This research explores the effectiveness of low-dose intravitreal cidofovir (HPMPC) in treating CMV retinitis, offering a potentially safer and more tolerable alternative to higher doses. The study meticulously compared the efficacy and safety of 10-microgram injections to the previously established 20-microgram injections, akin to a desert explorer carefully evaluating different routes through a challenging terrain.

Low-Dose Cidofovir: A More Navigable Path for CMV Retinitis Treatment

The study's findings suggest that low-dose cidofovir may be an effective and well-tolerated treatment option for CMV retinitis. This is akin to discovering a smoother path through a treacherous desert landscape, offering a less burdensome journey. The research provides valuable insights for managing CMV retinitis in individuals with AIDS, potentially improving their quality of life.

Navigating the Desert of CMV Retinitis: Finding the Right Treatment Strategy

This research sheds light on the potential benefits of low-dose cidofovir in treating CMV retinitis. However, just as navigating a desert requires careful planning and consideration, selecting the right treatment for CMV retinitis requires close collaboration between the patient and their physician. A careful assessment of individual risk factors, treatment goals, and potential side effects is essential in choosing the optimal treatment path.

Dr. Camel's Conclusion

This study explores the vast landscape of CMV retinitis treatment with a keen eye for safer and more effective solutions. The findings provide valuable insights into the potential benefits of low-dose cidofovir, offering a glimmer of hope for individuals facing this challenging condition.

Date :
  1. Date Completed 1997-07-14
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

9186448

DOI: Digital Object Identifier

10.1016/s0161-6420(97)30188-2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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