Effects of clindamycin and benzoyl peroxide topical: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have shown that topical clindamycin and benzoyl peroxide combinations are effective in treating mild to moderate acne. 13 , 10 . This combination treatment has been proven more effective than monotherapy, particularly in reducing inflammatory acne lesions. 13 , 10 Furthermore, the efficacy and tolerability of these combinations may vary depending on the severity of acne and patient characteristics. 11 , 4 .

Benefits and Risks

Benefits Summary

Topical clindamycin and benzoyl peroxide combinations offer numerous benefits in treating acne. They effectively reduce inflammatory acne, including papules and pustules. 15 , 10 . The effectiveness of these combinations can vary based on acne severity and patient characteristics. 11 , 4 . These combinations can be a suitable option for those struggling with acne.

Risks Summary

While effective, topical clindamycin and benzoyl peroxide combinations can cause side effects like dry skin, redness, irritation, and itching. 13 . Benzoyl peroxide can also lead to sun sensitivity, so using sunscreen and protecting your skin from UV rays is crucial. 13 . It is essential to be aware of these potential risks and discuss them with a doctor before starting treatment.

Comparison of Studies

Commonalities in Studies

Multiple studies agree on the effectiveness of topical clindamycin and benzoyl peroxide combinations in treating acne. 13 , 10 . These studies generally show that these combinations are more effective than using only one medication. 13 . This evidence reinforces the idea that topical clindamycin and benzoyl peroxide combinations are a viable treatment option for acne.

Differences in Studies

While effective, the specific effects and side effects of these combinations may vary slightly depending on the study. 11 , 4 . Factors like the severity of acne and patient characteristics can influence how the combinations work. 4 . This underscores the importance of personalized treatment plans tailored to individual needs.

Consistency and Inconsistencies in Results

Research consistently suggests that topical clindamycin and benzoyl peroxide combinations are effective in treating acne. 13 , 10 . However, variations exist in the effectiveness and side effects observed across studies. 11 , 4 . It is essential to consider these variations and individualize treatment plans accordingly.

Considerations for Real-Life Application

Topical clindamycin and benzoyl peroxide combinations are a potential treatment option for acne. 13 , 10 . However, potential side effects like dryness, redness, irritation, and itching should be considered. 13 . Also, benzoyl peroxide can increase sun sensitivity, so sunscreen use and sun protection are crucial. 13 . It is important to follow a doctor's instructions and use these medications as directed for safe and effective treatment.

Limitations of Current Research

The amount of research on topical clindamycin and benzoyl peroxide combinations is limited. 13 . More research is needed to understand the long-term effects and safety of these medications. 13 . Further studies are necessary to address these gaps in knowledge.

Future Research Directions

More research on topical clindamycin and benzoyl peroxide combinations is necessary. 13 . Studies focusing on long-term effects and safety are particularly important. 13 . Additionally, future research should consider the impact of acne severity and patient characteristics on treatment efficacy and side effects. 11 , 4 . This will help to personalize treatment plans and ensure optimal outcomes.

Conclusion

Topical clindamycin and benzoyl peroxide combinations can be a valuable treatment option for mild to moderate acne. 13 , 10 . However, it's crucial to be aware of potential side effects and follow a doctor's instructions for safe and effective treatment. 13 . More research is needed to understand the long-term effects of these medications. 13 . If you struggle with acne, consulting a dermatologist for a personalized treatment plan is recommended.

Literature analysis of 22 papers
Positive Content
19
Neutral Content
1
Negative Content
2
Article Type
4
3
4
8
22
2.

Triple-combination clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel for moderate-to-severe acne in children and adolescents: Randomized phase 2 study.

Author: EichenfieldLawrence F, Stein GoldLinda, KircikLeon H, WerschlerWilliam P, BeerKenneth, DraelosZoe D, TanghettiEmil A, PappKim A, BaldwinHilary, LainEdward, SadickNeil, GooderhamMelinda J, KondaAdarsh

Improved acne
Application site dryness
Application site pain

Topical clindamycin phosphate/benzoyl peroxide/adapalene gel (IDP-126) showed superior efficacy and good tolerability in children and adolescents with moderate-to-severe acne. In a post-hoc analysis of 394 pediatric participants, IDP-126 achieved significantly higher treatment success rates and greater lesion reduction compared to vehicle and three dyad combination gels at week 12. The most common treatment-related adverse events were mild to moderate application site pain and dryness.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris.

Author: MavranezouliIfigeneia, DalyCaitlin H, WeltonNicky J, DeshpandeShalmali, BergLaura, BromhamNathan, ArnoldStephanie, PhillippoDavid M, WilcockJane, XuJingyuan, RavenscroftJane C, WoodDamian, RafiqMohammed, FouLinyun, DworzynskiKatharina, HealyEugene

Improved acne
Reduced lesions
Side effects
Treatment discontinuation

Topical pharmacological treatment combinations, chemical peels, and photochemical therapy were most effective for mild-to-moderate acne. For moderate-to-severe acne, topical pharmacological treatment combinations, oral antibiotics combined with topical treatments, oral isotretinoin, and photodynamic therapy were most effective.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Topical dapsone in the treatment of acne: a systematic review.

Author: NicklesMelissa A, LakeEden

Acne treatment
Skin irritation

Dapsone gel offers a safe and promising alternative therapy for patients with difficult to treat acne or those who experience adverse effects to first-line therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Pharmacological interventions for periorificial (perioral) dermatitis in children and adults: a systematic review.

Author: GrayN A, TodB, RohwerA, FinchamL, VisserW I, McCaulM

POD treatment
Severity reduction
Abdominal discomfort
Burning
Erythema
Facial dryness
Herpes simplex infection
Pruritus

This review assessed the efficacy and safety of pharmacological interventions for periorificial dermatitis (POD) in children and adults. The evidence for the effects of oral tetracycline, pimecrolimus cream, azelaic acid gel, praziquantel ointment, and topical clindamycin/benzoyl peroxide on POD was low or very low. Well-designed trials are needed to further investigate treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Topical preparations for the treatment of mild-to-moderate acne vulgaris: systematic review and network meta-analysis.

Author: StuartB, MaundE, WilcoxC, SridharanK, SivaramakrishnanG, RegasC, NewellD, SoulsbyI, TangK F, FinlayA Y, BucherH C, LittleP, LaytonA M, SanterM

Improved acne
Increased withdrawal

Adapalene in combination with BPO may be the most effective treatment for acne but with a slightly higher incidence of withdrawal than monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Tolerability and Efficacy of Clindamycin/Tretinoin versus Adapalene/Benzoyl Peroxide in the Treatment of Acne Vulgaris.

Author: AschoffRoland, MöllerSebastian, HaaseRocco, KuskeMarvin

Acne reduction
Better tolerability (CT)
Effective treatment
Improved skin moisture
Dryness
Erythema
Irritation (BA)
Limited study duration
Skin irritation

This study compared two common acne treatments: clindamycin 1%-tretinoin 0.025% (CT) and benzoyl peroxide 2.5%-adapalene 0.1% (BA). Both treatments reduced acne lesions, but CT was better tolerated than BA, with less dryness, irritation, and burning. While both treatments increased skin moisture loss, BA caused significant dryness and redness. Patients reported higher satisfaction with CT and were more likely to continue using it. Overall, both treatments were effective, but CT was better tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Comparative Trial of Silver Nanoparticle Gel and 1% Clindamycin Gel when Use in Combination with 2.5% Benzoyl Peroxide in Patients with Moderate Acne Vulgaris.

Author: JurairattanapornNathachat, ChalermchaiThep, OphaswongseSuwirakorn, UdompataikulMontree

Anti-inflammation
Antibacterial effect

Silver nanoparticles are a promising alternative to antibiotics in treating acne vulgaris, due to their antibacterial and anti-inflammatory effects. However, clinical studies on the effectiveness of silver nanoparticle gels for acne treatment are limited.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Topical Vehicle Formulations in the Treatment of Acne.

Author: HoffmanLauren K, BhatiaNeal, ZeichnerJoshua, KircikLeon H

Acne treatment
Skin irritation

Novel formulations of topical medications for acne have helped to enhance tolerability and efficacy, leading to less frequent application or co-application of drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Which acne treatment has the best influence on health-related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes.

Author: ChernyshovP V, Tomas-AragonesL, ManolacheL, SvenssonA, MarronS E, EversA W M, BettoliV, JemecG B, SzepietowskiJ C

Improved HRQoL in acne patients

This study analyzes the impact of different acne treatments on health-related quality of life (HRQoL) in patients. Oral isotretinoin showed the best influence on HRQoL, with other effective treatments including oral isotretinoin and norethindrone acetate/ethinyl estradiol, topical clindamycin phosphate/benzoyl peroxide, and adapalene/benzoyl peroxide.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Erythema-directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris.

Author: MicaliG, Dall'OglioF, TedeschiA, LacarrubbaF

Acne treatment

Erythema-directed digital photography is a promising method for assessing the effectiveness and side effects of topical acne treatments. This method was used in three case reports to evaluate acne before and after treatment with clindamycin 1%/tretinoin 0.025%.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Management of Severe Acne Vulgaris With Topical Therapy.

Author: Stein GoldLinda, BaldwinHilary E, LinTina

Severe acne treatment

This study reviewed the available clinical evidence for the use of fixed combination topical therapies to treat severe acne.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Benzoyl peroxide and clindamycin topical skin preparation decreases Propionibacterium acnes colonization in shoulder arthroscopy.

Author: DizayHailey H, LauDiana G, NottageWesley M

Reduced infections

This study investigated whether a benzoyl peroxide and clindamycin preoperative skin preparation reduces the incidence of Propionibacterium acnes colonization during shoulder arthroscopy. P. acnes is a gram-positive anaerobe that can lead to postoperative shoulder infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Light therapies for acne.

Author: BarbaricJelena, AbbottRachel, PosadzkiPawel, CarMate, GunnLaura H, LaytonAlison M, MajeedAzeem, CarJosip

Acne treatment

This abstract discusses the use of light therapies for acne vulgaris, a common skin problem. It highlights the potential benefits of light therapies as an alternative to oral and topical treatments, which can be limited due to ineffectiveness, inconvenience, or side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Systemic exposure to benzoic acid and hippuric acid following topical application of clindamycin 1%/benzoyl peroxide 3% fixed-dose combination gel in Japanese patients with acne vulgaris.

Author: InoHiroko, TakahashiNaoki, SaenzAlessandra Alio, WakamatsuAkira, HashimotoHirofumi, NakaharaNorie, HasegawaSetsuo

Acne vulgaris treatment

This study assessed the pharmacokinetics of benzoyl peroxide (BPO) after repeated application of clindamycin 1%/benzoyl peroxide 3% fixed-dose combination gel (CLDM/BPO3%) in Japanese patients with acne vulgaris. Repeated application resulted in negligible systemic exposure to BPO metabolites, suggesting safety for this patient population.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Treatment of Acne in Pregnancy.

Author: ChienAnna L, QiJi, RainerBarbara, SachsDana L, HelfrichYolanda R

Teratogenic effects

This review provides guidelines for managing acne during pregnancy, emphasizing the safety profile of common therapies. Topical azelaic acid or benzoyl peroxide are recommended as baseline therapy. A combination of topical erythromycin or clindamycin with benzoyl peroxide is recommended for inflammatory acne. Oral erythromycin or cephalexin may be used for a short period for moderate to severe inflammatory acne. Oral retinoids are contraindicated during pregnancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

[Bacterial resistance in acne? A meta-analysis of the controversy].

Author: Alvarez-SánchezMariana, Rodríguez-AyalaErnesto, Ponce-OliveraRosa María, Tirado-SánchezAndrés, Arellano-MendozaMaría Ivonne

Meta-analysis of antibiotic resistance
Antibiotic resistance
Bacterial resistance

Acne is a common skin condition worldwide and can be complex to treat. Bacteria called Propionibacterium acnes play a key role in acne inflammation. Topical antibiotics, especially erythromycin and clindamycin, have been used, but concerns about bacterial resistance are growing. This analysis reviewed research from the past 10 years to investigate this issue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Spanish

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