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Tolerability and Efficacy of Clindamycin/Tretinoin versus Adapalene/Benzoyl Peroxide in the Treatment of Acne Vulgaris.

Author: AschoffRoland, HaaseRocco, KuskeMarvin, MöllerSebastian

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared two common acne treatments: clindamycin 1%-tretinoin 0.025% (CT) and benzoyl peroxide 2.5%-adapalene 0.1% (BA). Both treatments reduced acne lesions, but CT was better tolerated than BA, with less dryness, irritation, and burning. While both treatments increased skin moisture loss, BA caused significant dryness and redness. Patients reported higher satisfaction with CT and were more likely to continue using it. Overall, both treatments were effective, but CT was better tolerated.
Paper Details　
Original Abstract of the Article :
Acne vulgaris is the most common dermatological disorder worldwide, causing significant physical and psychological morbidity. Topical combination therapy has shown superior efficacy compared to monotherapy, especially when combined with retinoids. Few studies have directly compared combined formulat...See full text at original site
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引用元：
https://doi.org/10.36849/JDD.2021.5641

データ提供：米国国立医学図書館（NLM）

Acne Vulgaris: Finding the Right Treatment for a Common Skin Condition

Acne vulgaris is a common skin condition that affects millions of people, particularly adolescents. It's like a pesky sandstorm that disrupts the serenity of the skin, leaving behind blemishes and discomfort. This study investigates the efficacy and tolerability of two topical combination therapies for acne.

Topical Combination Therapies: A Comparison

The researchers compared the efficacy and tolerability of clindamycin 1%-tretinoin 0.025% (CT) and benzoyl peroxide 2.5%-adapalene 0.1% (BA). Both treatments showed significant reductions in acne lesions, but CT was found to be better tolerated, with fewer side effects such as dryness and irritation. It's like having two different types of camel saddles: one comfortable and effective, the other offering a less desirable ride.

Personalized Approach to Acne Treatment

This study emphasizes the importance of considering individual patient needs and preferences when choosing acne treatments. It's about finding the right combination of ingredients and delivery methods that effectively manage acne without causing unnecessary discomfort. It's like selecting the perfect camel and saddle for your journey through the desert of acne.

Dr.Camel's Conclusion

This research suggests that CT is a promising treatment option for acne vulgaris, offering effective results with good tolerability. By understanding the different treatment options and considering individual needs, patients can find the best approach to managing this common skin condition. It's like navigating the desert with a trusty camel, ensuring a smooth and comfortable journey toward clear skin.
Date :
  1. Date Completed 2021-07-08
  2. Date Revised 2021-07-08
Further Info :

Pubmed ID

33683070

DOI: Digital Object Identifier

10.36849/JDD.2021.5641

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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