Side Effects of coding (therapy): A Synthesis of Findings from 3 Studies

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Original Abstract of the Article

Major findings

Side effects of antidepressants are a common occurrence and can impact the successful treatment outcome in individuals with major depressive disorder (MDD). 2 studied the impact of antidepressant side effects on treatment success. They found that the burden of side effects, even as early as 4 days after treatment initiation, is associated with poorer treatment outcomes. However, the frequency or intensity of side effects did not impact the treatment outcome.

Reasons for side effects

Antidepressants work by balancing neurotransmitter levels in the brain, which in turn improves mood. However, these neurotransmitters also affect various bodily functions besides mood, which can lead to side effects. For instance, serotonin, a neurotransmitter targeted by antidepressants, is involved in appetite, sleep, and mood, so antidepressants targeting serotonin can cause side effects like loss of appetite or insomnia.

Common side effects

Digestive System

Digestive system issues are common side effects of antidepressants. 2 reported that many patients with depression who took antidepressants experienced digestive side effects such as nausea, vomiting, constipation, diarrhea, and loss of appetite.

Nervous System

Antidepressants can also lead to nervous system side effects. 2 reported that many patients with depression who took antidepressants experienced nervous system side effects, including headache, dizziness, drowsiness, insomnia, and tremors. It's important to note that while most studies regarding cognitive side-effects following ECT for treating depression report transient forms of cognitive disturbances, 1 highlights that there are significant differences among individual patients in experiencing cognitive side effects.

Other side effects

Other side effects of antidepressants include weight gain, sexual dysfunction, sweating, and dry mouth. 2 reported that many patients with depression who took antidepressants experienced these side effects.

Measures against side effects

Digestive System

Dietary therapy can help alleviate digestive side effects caused by antidepressants. This involves eating easily digestible foods and avoiding spicy and greasy foods. Maintaining adequate hydration is also crucial. If you experience severe digestive side effects, consult your doctor to discuss changing medications or adjusting dosage.

Nervous System

Lifestyle changes and consulting a doctor are essential to alleviate nervous system side effects caused by antidepressants. This includes maintaining a regular routine, ensuring adequate sleep, engaging in moderate exercise, maintaining a balanced diet, and managing stress levels. If you experience severe nervous system side effects, consult your doctor to discuss changing medications or adjusting dosage.

Other side effects

It is important to consult a doctor to alleviate other side effects caused by antidepressants. Your doctor can explain the cause and management of side effects and provide appropriate advice. If necessary, they may change your medication or adjust the dosage.

Comparison between studies

Common points of the studies

All three studies indicate that side effects of antidepressants and ECT can affect the effectiveness of depression treatment. They also suggest that the frequency and severity of side effects may vary from patient to patient.

Differences between the studies

The three studies differ in their study subjects and methods, leading to different results. The study 3 examined the effectiveness of combining traditional Chinese medicine with antidepressants. The study 1 examined the predictive factors of cognitive impairment following ECT. The study 2 examined the relationship between antidepressant side effects and treatment success rates.

Points to note regarding application to real life

Antidepressants are expected to improve symptoms of depression, but they also carry the risk of side effects. When taking antidepressants, it is essential to fully understand the side effects, consult with your doctor, and choose an appropriate treatment method. If you experience side effects, do not hesitate to consult your doctor.

Limitations of current research

Research on the side effects of antidepressants is still insufficient. In particular, more research is needed on long-term side effects and side effects in specific populations.

Future research directions

To advance research on the side effects of antidepressants, long-term follow-up studies and research on the mechanisms of side effects are essential. Research on side effects in specific populations is also needed.

Conclusion

Antidepressants are effective medications for treating depression, but they also carry the risk of side effects. If you experience side effects, it is important to consult your doctor. Research on the side effects of antidepressants is still insufficient. Future research may lead to better ways to reduce side effects.

Literature analysis of 3 papers
Positive Content
2
Neutral Content
1
Negative Content
0
Article Type
2
0
1
1
3
1.

Psychotic depressive subtype and white mater hyperintensities do not predict cognitive side effects in ECT: A systematic review of pretreatment predictors.

Author: van KesselMike A, van der VlugtJoris J B, SpaansHarm-Pieter, MurreJaap M J, VerwijkEsmée

Cognitive side effects

Psychotic features and white matter hyperintensities are not predictive of cognitive side-effects following ECT. Further studies are needed to identify pretreatment patient characteristics that predict cognitive side-effects following ECT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report.

Author: BraundTaylor A, TillmanGabriel, PalmerDonna M, GordonEvian, RushA John, HarrisAnthony W F

Depression treatment
Side effects
Treatment outcome

This study looks at the frequency, intensity, and burden of side effects associated with antidepressant medications in people with major depressive disorder (MDD). The study found that the burden of side effects was associated with poorer treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial.

Author: LiXin, LiXiuyu, GongMan, LiChaoqun, LiJing, ZhouChao, HeTingting

Improved PDD treatment

The combination of modified Xiaochaihu Decoction and mirtazapine was more effective in treating PDD than modified Xiaochaihu Decoction alone. The total effective rate of the combined group (96.7%) was significantly higher than the control group (78.6%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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