Side Effects of elagolix: A Synthesis of Findings from 9 Studies

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Original Abstract of the Article

Main Research Findings

Elagolix is a new drug developed for the treatment of uterine fibroids and endometriosis. 2 、 8 、 5 、 7 Elagolix is a non-peptide and can be administered orally, unlike conventional GnRH agonists. Elagolix binds to the GnRH receptor and suppresses the production of LH and FSH, thereby suppressing the secretion of female hormones. 3 This effect is expected to improve the symptoms of uterine fibroids and endometriosis. 4 In addition, elagolix is expected to reduce pain caused by endometriosis. 5 The effect of elagolix is dose-dependent, partially suppressing estrogen at low doses and completely suppressing estrogen at high doses. 7 Elagolix is considered an effective and safe drug for the treatment of uterine fibroids and endometriosis. 2 、 4 However, elagolix suppresses estrogen, so it may cause symptoms like menopause. 2 、 7 Also, elagolix has been suggested to increase the risk of osteoporosis. 7 Therefore, it is important to consult your doctor and receive appropriate prescriptions when using elagolix.

Reason for Side Effects

The side effects of elagolix are caused by the suppression of estrogen. Estrogen is a female hormone that plays an important role in the development of female bodies and minds. Estrogen deficiency can lead to symptoms like menopause, osteoporosis, and an increased risk of cardiovascular disease.

Common Side Effects

Menopausal Symptoms

Elagolix can cause menopausal symptoms because it suppresses estrogen. 2 、 7 These symptoms include hot flashes, sweating, insomnia, mood swings, decreased libido, and vaginal dryness.

Osteoporosis

Elagolix has also been suggested to increase the risk of osteoporosis because it suppresses estrogen. 7 Osteoporosis is a disease in which bone density decreases, increasing the risk of fractures. While taking elagolix, get regular bone density scans and, if necessary, be sure to take calcium and vitamin D supplements.

Cardiovascular Disease

Estrogen also has a positive effect on heart health. Suppressing estrogen with elagolix may increase the risk of cardiovascular disease. 7 Cardiovascular diseases include heart disease, stroke, and hypertension. While taking elagolix, pay attention to your heart health and consult your doctor if necessary.

Countermeasures for Side Effects

Hormone Replacement Therapy

Hormone replacement therapy may be used to reduce menopausal symptoms caused by elagolix. 2 Hormone replacement therapy can alleviate menopausal symptoms by supplementing estrogen and progesterone.

Calcium and Vitamin D Intake

It is important to take calcium and vitamin D to reduce the risk of osteoporosis caused by elagolix. 7 Calcium is an essential mineral for bone formation, and vitamin D aids in the absorption of calcium.

Healthy Lifestyle

Maintain a healthy lifestyle to maintain heart health. Quitting smoking, getting regular exercise, and eating a balanced diet are effective ways to reduce the risk of heart disease.

Comparison between Studies

Common Points of Studies

Several studies have shown that elagolix improves the symptoms of uterine fibroids and endometriosis. 2 、 8 、 5 、 4 Elagolix also suppresses estrogen, so it has been suggested to increase the risk of menopausal symptoms and osteoporosis. 2 、 7

Differences in Studies

Different studies have shown different results regarding the effectiveness and side effects of elagolix. This is thought to be due to differences in study subjects and methods. Further research is needed to investigate the effectiveness and side effects of elagolix in more detail.

Precautions for Application in Real Life

Elagolix is a new drug developed for the treatment of uterine fibroids and endometriosis. While elagolix is an effective drug, it also carries the risk of side effects. It is important to consult your doctor and receive appropriate prescriptions when taking elagolix.

Current Limitations of Research

Research on elagolix is still in its early stages, and there is not enough data yet on long-term effectiveness and safety. In addition, the effectiveness and side effects of elagolix may vary from person to person. Therefore, further research is needed to investigate the effectiveness and side effects of elagolix in more detail.

Future Research Directions

Further research on the long-term effectiveness and safety of elagolix is needed in the future. Also, since the effectiveness and side effects of elagolix may vary from person to person, research is needed to establish the optimal treatment method for each patient. In addition, research comparing elagolix to other treatments is also important.

Conclusion

Elagolix is an effective drug for the treatment of uterine fibroids and endometriosis, but it can also increase the risk of menopausal symptoms and osteoporosis. It is important to consult your doctor and receive appropriate prescriptions when taking elagolix. Research on elagolix is still in its early stages, and there is not enough data yet on long-term effectiveness and safety. Further research is needed in the future.

Literature analysis of 9 papers
Positive Content
8
Neutral Content
1
Negative Content
0
Article Type
0
1
2
5
9
1.

Research advances in drug therapy of endometriosis.

Author: ShiJianyou, TanXin, FengGuimei, ZhuoYuan, JiangZhongliang, BandaSrikanth, WangLin, ZhengWei, ChenLu, YuDongke, GuoChun

Endometriosis treatment

This review provides an overview of the pathogenesis of endometriosis and discusses newly reported lead compounds and drugs used to manage the condition. The review explores potential therapeutic targets and the effectiveness of various drugs, highlighting the need for further research and development of more effective and safer treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Oral Gonadotropin-Releasing Hormone Antagonists for the Treatment of Uterine Leiomyomas.

Author: NeblettMichael F, StewartElizabeth A

Amenorrhea
Anemia improvement
Leiomyoma bleeding reduction
Leiomyoma pain reduction
Reduced hypogonadal side effects
Uterine volume reduction
Hypogonadal side effects

This overview reviews the efficacy and safety of oral gonadotropin-releasing hormone (GnRH) antagonists for the management of uterine leiomyomas. Oral GnRH antagonists provide rapid suppression of sex steroids and can reduce leiomyoma-associated heavy menstrual bleeding, pain, and anemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Elagolix treatment in women with heavy menstrual bleeding associated with uterine fibroid: a systematic review and meta-analysis.

Author: MuhammadJuliawati, YusofYusnita, AhmadImran, NorhayatiMohd Noor

Menorrhagia treatment
Hypoestrogenism

This systematic review and meta-analysis evaluated the effectiveness of elagolix for treating menorrhagia in women with uterine fibroids. Elagolix was effective compared to placebo, and the addition of estradiol/norethindrone acetate mitigated the hypoestrogenism associated with elagolix.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

A Clinician's Guide to the Treatment of Endometriosis with Elagolix.

Author: LeylandNicholas, EstesStephanie J, LesseyBruce A, AdvinculaArnold P, TaylorHugh S

Endometriosis pain treatment
Improved quality of life

This review provides an overview of elagolix, highlighting currently available treatment options and the application of this new treatment for women with endometriosis-associated pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Uterine fibroids: an update on current and emerging medical treatment options.

Author: FarrisManuela, BastianelliCarlo, RosatoElena, BrosensIvo, BenagianoGiuseppe

Medical treatment
Uterine fibroid treatment
Liver complications

This article provides a comprehensive review of medical treatments for uterine fibroids, a common gynecological disorder. It discusses the evolution of treatment options, from progestins and GnRH analogues to selective progesterone receptor modulators. The article highlights the progress made in long-term medical management of fibroids, particularly with the use of ulipristal acetate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Elagolix for endometriosis: all that glitters is not gold.

Author: VercelliniPaolo, ViganòPaola, BarbaraGiussy, BuggioLaura, SomiglianaEdgardo,

Endometriosis treatment
Side effects

Elagolix is a new drug approved by the FDA to treat endometriosis. It works by reducing estrogen levels. The amount of pain relief is dose-dependent, and lower doses may result in less pain relief but fewer side effects. The drug is expensive, and long-term use may require additional therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Efficacy of elagolix in the treatment of endometriosis.

Author: PerricosAlexandra, WenzlRené

Bone loss

Elagolix is a new oral GnRH antagonist being developed for the treatment of endometriosis. This review analyzes clinical trials that evaluated the safety and efficacy of elagolix. The drug is well-tolerated and has a favorable side effect profile. Further studies are needed to determine whether elagolix can compete with or surpass established treatments for endometriosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

A peek into the drug development scenario of endometriosis - A systematic review.

Author: GoenkaLuxitaa, GeorgeMelvin, SenMaitrayee

Cost of treatment
Short-term effect
Side-effects

This review summarized the current status and challenges of drug development for endometriosis, considering the limitations of existing medical therapies in terms of cost, side effects, and short-term symptom relief.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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