Effects of ergoloid mesylates: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major Research Findings

Ergoloid mesylates (Hydergine) is a hydrogenated ergot alkaloid preparation used in the treatment of dementia. A critical review of 12 clinical trials found that Hydergine consistently produced statistically significant (p ≤ 0.05) improvement in 13 symptoms associated with dementia. 4 However, due to the small magnitude of the improvement and the lack of evidence for long-term benefits, Hydergine appears to be of minor value in dementia therapy. 4 Ergoloid mesylates is available in various dosage forms, including oral tablets, sublingual tablets, and solutions. 14 Absorption of ergoloid is rapid, with peak levels of approximately 60-80 pg ml-1 mg-1 dose achieved after 0.6 to 1.3 hours. 14 Ergoloid mesylates administration with food reduces the absorption rate. 14 Ergoloid mesylates has been shown to decrease blood pressure. 14 Ergoloid mesylates can inhibit the absorption of other drugs transported by the organic anion transporting polypeptide (OATP-B). 26 Ergoloid mesylates has shown potential for improving symptoms of depression, sleep disturbance, and agitation in alcohol-related encephalopathy. 29

Benefits and Risks

Benefit Summary

Ergoloid mesylates may have some benefits in treating certain symptoms of dementia. 4 It may also help improve cognitive function in older adults. It shows promise in the rehabilitation of patients with ischemic stroke. 1 Ergoloid mesylates may help reduce some of the effects of aging. 5 It could potentially activate antioxidant enzyme systems. 24 Ergoloid mesylates shows promise in the treatment of symptoms related to alcohol-related encephalopathy. 29

Risk Summary

Ergoloid mesylates can lower blood pressure. 14 Ergoloid mesylates can interfere with the absorption of other drugs. 26 Ergoloid mesylates may not be very effective in treating dementia. 4 Ergoloid mesylates may not be very effective in treating Alzheimer's disease. 3

Comparison Between Studies

Similarities Between Studies

Several studies have shown that ergoloid mesylates has the potential to improve various symptoms associated with dementia. 4 However, the degree of improvement was often modest, and long-term benefits have not been conclusively proven. 4

Differences Between Studies

The effectiveness of ergoloid mesylates varies depending on the study. 4 Some studies indicate that ergoloid mesylates can be effective in treating dementia. 29 However, other studies have shown that ergoloid mesylates may not be very effective in treating Alzheimer's disease. 3 While ergoloid mesylates might improve cognitive function in older adults, it may not be effective for treating Alzheimer's disease. 9

Consistency and Contradictions in Results

The results regarding the effectiveness of ergoloid mesylates are inconsistent. Some studies show it to be effective in treating dementia, while others indicate it is not. 4 It is possible that ergoloid mesylates may not be a highly effective treatment for dementia. 4

Considerations for Real-Life Application

Ergoloid mesylates may not be a highly effective treatment for dementia. 4 Ergoloid mesylates can lower blood pressure. 14 Ergoloid mesylates can interfere with the absorption of other medications. 26 Always consult a healthcare professional before taking ergoloid mesylates.

Limitations of Current Research

There is a lack of sufficient research on the effectiveness of ergoloid mesylates, particularly concerning its long-term effects. 4 Further research is necessary to fully understand its potential benefits and risks.

Future Research Directions

More research is needed to investigate the long-term effects of ergoloid mesylates. 4 Additionally, studies focused on understanding the mechanisms of action of ergoloid mesylates are necessary.

Conclusion

Ergoloid mesylates may have some potential for treating certain symptoms of dementia. 4 However, the evidence for its effectiveness is limited, and long-term benefits remain unclear. 4 Ergoloid mesylates can lower blood pressure and interfere with the absorption of other drugs. 14 26 Always consult your doctor before taking ergoloid mesylates.

Literature analysis of 29 papers
Positive Content
25
Neutral Content
4
Negative Content
0
Article Type
4
0
2
6
29
1.

Ergoloids and ischaemic strokes; efficacy and mechanism of action.

Author: ElwanO, HelmyA A, TamawyM E, NaseerM A, BanhawyI E, KaderA A, ElwanF

Cognitive improvement
Improved limb function

Nicergoline and co-dergocrine mesylate, both ergoloid compounds, showed improvements in some aspects of rehabilitation for patients with ischemic stroke, such as limb function and SCAG score. While statistically significant, most improvements were small.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Double-blind clinical and psychologic study of ergoloid mesylates (Hydergine) in subjects with senile mental deterioration.

Author: van Loveren-HuybenC M, EngelaarH F, HermansM B, van der BomJ A, LeeringC, MunnichsJ M

Improves behavior
Improves cognition
Senile mental deterioration

Ergoloid mesylates significantly improved symptoms of senile mental deterioration compared to placebo in residents of old people's homes, with marked individual differences in the degrees of improvement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Drug treatment of Alzheimer's disease. Effects on caregiver burden and patient quality of life.

Author: HollisterL, GruberN

Alzheimer's disease treatment
Improved caregiver burden

Alzheimer's disease is a progressive neurodegenerative disorder that will become more common as the population ages. Although there is no cure for Alzheimer's disease, research is ongoing to find effective treatments to slow disease progression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

An ergot alkaloid preparation (Hydergine) in the treatment of dementia: critical review of the clinical literature.

Author: HughesJ R, WilliamsJ G, CurrierR D

Improved dementia symptoms

Hydergine, a hydrogenated ergot alkaloid preparation, consistently produced statistically significant improvement in 13 symptoms associated with dementia. However, the magnitude of the improvement was small and long-term benefit was not demonstrated, suggesting Hydergine may have limited value in dementia therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Effects of long-term ergoloid mesylates ('Hydergine') administration in healthy pensioners: 5-year results.

Author: HuberF, KöberleS, PresteleH, SpiegelR

Improved subjective complaints
Maintains physical and mental health
None mentioned

Ergoloid mesylates was well-tolerated and showed potential benefits in maintaining physical and mental health in healthy elderly individuals. The study found that the drug improved subjective complaints and led to fewer disease-related drop-outs compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Hydergine for dementia.

Author: OlinJ, SchneiderL, NovitA, LuczakS

Cognitive symptom improvement
Dementia treatment

This meta-analysis reviewed the efficacy of hydergine for treating dementia or age-related cognitive symptoms. Hydergine was found to be more effective than placebo, but the evidence for efficacy in patients with possible or probable Alzheimer's disease was modest.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Lack of efficacy of hydergine in patients with Alzheimer's disease.

Author: ThompsonT L, FilleyC M, MitchellW D, CuligK M, LoVerdeM, ByynyR L

Hydergine-LC, a new formulation of ergoloid mesylates, is being studied for its effectiveness in treating Alzheimer’s disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Co-dergocrine plasma concentrations and blood pressure changes in hypertensive patients during therapy with slow-release co-dergocrine mesylate.

Author: WoodcockB G, HerrmannW, HabedankW D

Reduced blood glucose
Reduced blood pressure
Negligible side effects

Slow-release co-dergocrine mesylate was effective in lowering blood pressure and blood glucose in patients with mild to moderate essential hypertension. The medication was well tolerated with few adverse reactions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

A controlled long-term study with ergoloid mesylates (Hydergine) in healthy, elderly volunteers: results after three years.

Author: SpiegelR, HuberF, KöberleS

Improved health
Improved intelligence
Reduced symptoms

Ergoloid mesylates, compared to placebo, showed potential benefits in healthy elderly volunteers after three years of treatment, including improved cognitive function and cardiovascular parameters.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Bioavailability of ergoloid mesylates liquid capsule.

Author: SchranH F

Two formulations of ergoloid mesylates demonstrated bioequivalence. While the liquid capsule showed slightly higher bioavailability, the differences were considered clinically insignificant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Preparation of ergoloid mesylate submicron emulsions for enhancing nasal absorption and reducing nasal ciliotoxicity.

Author: YuChaoqun, MengJia, ChenJian, TangXing

Ciliotoxicity
Nasal absorption

This study investigates the preparation of ergoloid mesylate submicron emulsions (EMSEs) to enhance nasal absorption and reduce nasal ciliotoxicity. Compared to ergoloid mesylate solution (EMS), EMSE exhibited higher nasal absorption and significantly lower ciliotoxicity in rats, without a significant difference in brain-targeting efficiency.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Pharmacokinetics and bioavailability of ergoloid mesylates.

Author: SchranH F, McDonaldS, LehrR

Dose proportional AUC
Rapid absorption
Decreased blood pressure

Ergoloid mesylates were rapidly absorbed following oral administration, with peak levels reached in 0.6 to 1.3 hours. Food slowed absorption but did not affect the overall amount absorbed. The sublingual tablet formulation did not provide improved bioavailability compared to the swallowed tablet.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Hydergine: interaction with the neurotransmitter systems in the central nervous system.

Author: MarksteinR

Effective for senile mental impairment

Hydergine, an ergot preparation, has been shown to be effective in treating senile mental impairment. It interacts directly with subtypes of alpha-adrenoceptors, dopamine and serotonin receptors. Hydergine has a dualistic effect on central monoaminergic systems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells.

Author: Cedazo-MinguezA, BonecchiL, WinbladB, PostC, WongE H, CowburnR F, BenattiL

Alzheimer's prevention

Nicergoline, an antidementia agent, stimulated alpha-secretase amyloid precursor protein (APP) processing in human neuroblastoma cells by a PKC-dependent mechanism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine).

Author: RosenH J

Improved mental aging symptoms

Dihydrogenated ergot alkaloids (DEA) were significantly more effective than papaverine in improving symptoms associated with mental aging in older adults, particularly confusion, dizziness, unsociability, depressive mood, and mental alertness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

[The effect of an antihypertensive drug during psychological stress. A double-blind study].

Author: RöslerF, WegenerH, EulenbergerD, DahmeB

Reduced blood pressure
Impaired cognitive function

Briserin, a combination drug containing reserpine, clopamide, and dihydroergocristin, effectively reduced blood pressure in hypertensive patients compared to placebo. The medication lowered blood pressure under stress and at rest, with more significant effects in situations with low or medium stress. However, Briserin may impair reaction time, perceptual speed, and short-term memory.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

20.

[Metabolic consequences of long-term antihypertensive treatment with co-dergocrine mesylate/nifedipine in high age groups].

Author: RitterM M, RichterW O, SchwandtP

Effective for hypertension
Safe for lipid metabolism

A combination treatment with co-dergocrine mesilate/nifedipine had no negative impact on lipid metabolism in hypertensive patients.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

21.

Pharmacological treatment of the cognitive side effects of ECT: a review.

Author: KruegerR B, SackeimH A, GamzuE R

Cognitive enhancement
ECT cognitive side effects

Electroconvulsive therapy (ECT) is an effective treatment for psychiatric conditions but often causes temporary cognitive side effects. This paper reviews research on various compounds that may reduce these side effects, including opioids, vasopressin, adrenocorticotropic hormone, neuropeptides, cholinergic agents, nootropics, ergoloid mesylates, calcium-channel blockers, dexamethasone, thyroid hormone, and stimulants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Drug therapy of Alzheimer's disease: realistic or not?

Author: HollisterL E

Symptomatic treatment for Alzheimer's
Specific treatment controversial

Symptomatic treatment of Alzheimer's disease focuses on managing behavioral manifestations, while specific treatment targets potential pathogenetic mechanisms. Ergoloid mesylates are a promising specific treatment option, although further research is needed to clarify its optimal dose, duration, and goals of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Posttranslational changes in band 3 in adult and aging brain following treatment with ergoloid mesylates, comparison to changes observed in Alzheimer's disease.

Author: CoverC C, PoulinJ E, GustafsonM R, WyantT, GambleD N, KayM M

Anion transport increase

Ergoloid mesylates partially reversed age-related changes in brain band 3, including increased breakdown, decreased phosphorylation, and decreased anion transport. It also reduced autoantibodies to a critical anion transport region of band 3, suggesting protection against damage.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Possible supportive effects of co-dergocrine mesylate on antioxidant enzyme systems in aged rat brain.

Author: SözmenE Y, KanitL, KutayF Z, HaririN I

Improved cognitive function
Reduced MAO activity

Hydergine increased superoxide dismutase and catalase activity in aged rat brain, suggesting a potential role in protecting against free radical damage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Hydergine for dementia.

Author: OlinJ, SchneiderL, NovitA, LuczakS

Cognitive symptom treatment
Dementia treatment

Hydergine is a drug used for dementia and age-related cognitive symptoms. Reviews show that it is more effective than placebo, but the evidence for its efficacy in Alzheimer's disease is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine.

Author: LuWen-Jen, HuangJin-Ding, LaiMing-Liang

Drug interactions

This study examined the effect of ergoloid mesylates and ginkgo biloba on ticlopidine pharmacokinetics. Ergoloid mesylates, but not ginkgo biloba, significantly decreased the AUC and C(max) of ticlopidine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Dose-response studies with co-dergocrine mesylate under hypoxia utilizing EEG mapping and psychometry.

Author: SaletuB, GrünbergerJ, LinzmayerL, AndererP

Attenuates hypoxia
Mitigates deterioration
Loss of brain protection

Co-dergocrine mesylate (CDM) mitigated some negative effects of hypoxia on brain function and mental performance, particularly at a 6mg dose. However, the effect was dose-dependent, and higher doses did not always improve outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Efficacy of oral hydergine (ergoloid mesylates) in alcohol related encephalopathy.

Author: DattaK D, EvensonR C, GannonP J, DickE P

Improved depression
Improved sleep
Reduced agitation

Oral hydergine showed significant improvement in symptoms of depression and some improvement in sleep disturbance and agitation in patients with alcohol-related encephalopathy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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