Major research findings

Estazolam is a benzodiazepine drug that has been found to be effective in treating insomnia in various studies. It has been shown to improve sleep quality and increase total sleep time. 7 showed that in a study of elderly insomniacs, estazolam significantly reduced sleep latency, nocturnal awakenings, and wake time after sleep onset, increasing total sleep time by an average of 63 minutes. This study also found that estazolam did not adversely affect daytime performance or anterograde memory. 3 showed that in a study comparing estazolam and flurazepam, both were significantly superior to placebo in terms of sleep improvement, but estazolam had fewer side effects than flurazepam. 4 showed that in a study comparing estazolam, flurazepam, and placebo, estazolam and flurazepam were significantly superior to placebo in terms of sleep improvement, but estazolam had fewer side effects than flurazepam, such as fatigue and lethargy. 8 showed that in a study comparing the effects of Imovane (zolpidem) and estazolam on sleep, there were no statistically significant differences in sleep onset time, total sleep time, nocturnal awakenings, feelings after awakening, dreams, drug side effects, and sleep quality. However, Imovane was more effective than estazolam in terms of sleep onset time and total sleep time.

Reasons for side effects

Estazolam is a benzodiazepine drug that is thought to promote sleep by acting on GABA_A receptors to inhibit the activity of the central nervous system. 12 However, this effect can cause side effects such as drowsiness, dizziness, and impaired concentration. There are also concerns about the development of dependence and tolerance with long-term use.

Common side effects

Drowsiness

Drowsiness is the most common side effect of estazolam. 6 3 4 Many studies have reported drowsiness after taking estazolam. 14 This side effect is more likely to occur in older adults and patients with impaired liver function. 7

Dizziness

Estazolam can disrupt balance and increase the risk of dizziness and falls. 15 This side effect is more likely to occur in older adults and patients who consume alcohol.

Impaired concentration

Estazolam can impair concentration. 16 15 This side effect should be considered when performing tasks that require concentration, such as driving or operating machinery.

Memory impairment

Estazolam can cause memory impairment. 7 15 This side effect is more likely to occur in older adults and patients who consume alcohol.

Dependence

Estazolam can lead to dependence and tolerance with long-term use. 13 To prevent this side effect, it is important to take estazolam as directed by your doctor and not discontinue use without consulting your doctor.

Countermeasures for side effects

Drowsiness countermeasures

If you experience severe drowsiness after taking estazolam, it is important to take safety precautions, such as refraining from driving or operating machinery. 15 Taking estazolam at a time when you are less likely to feel drowsy or adjusting the dosage can also be effective. 2 Consult your doctor to find the right approach for you.

Dizziness countermeasures

While taking estazolam, you should be careful when walking because the risk of falls is increased. 15 Also, be very careful on slippery surfaces or steps, and use handrails whenever possible.

Countermeasures for impaired concentration

Avoid tasks that require concentration while taking estazolam. 16 Be particularly careful when driving or operating machinery.

Countermeasures for memory impairment

While taking estazolam, it is important to make an effort to remember important things, such as by taking notes. 7 Consult your doctor to find the right approach for you.

Countermeasures for dependence

Estazolam can lead to dependence and tolerance with long-term use. 13 To prevent this side effect, it is important to take estazolam as directed by your doctor and not discontinue use without consulting your doctor. 10 Also, consult your doctor if you experience signs of dependence.

Comparison between studies

Commonalities of studies

Multiple studies have reported that estazolam improves sleep while also experiencing side effects such as drowsiness and dizziness. 3 4 8

Differences in studies

Studies comparing estazolam to other sleep medications have reported that estazolam has fewer side effects than other sleep medications. 3 4 However, the side effects of estazolam may vary depending on the individual, dosage, and duration of use. 2

Points to note about applying research to real life

Estazolam is an effective drug for the treatment of insomnia, but it also carries the risk of side effects. 15 In particular, older adults, patients with impaired liver function, and those who consume alcohol are more likely to experience side effects. 7 If you take estazolam, consult your doctor for appropriate dosage and administration instructions. 11 Also, if you experience side effects such as drowsiness, dizziness, or impaired concentration while taking the medication, it is important to take safety precautions such as refraining from driving or operating machinery. 15

Limitations of current research

There has not been enough research on the long-term effects of estazolam. 13 The side effects of estazolam may vary depending on the individual, dosage, and duration of use. 2 In addition, there has not been enough research on the interactions between estazolam and other drugs.

Future research directions

Further research is needed on the long-term effects of estazolam and its interactions with other drugs. 13 Development of new treatment methods to reduce the side effects of estazolam is also expected. 17

Conclusion

Estazolam is an effective drug for the treatment of insomnia, but it also carries the risk of side effects. 15 If you take estazolam, consult your doctor for appropriate dosage and administration instructions. 11 Also, if you experience side effects while taking the medication, consult your doctor to find the right approach for you.