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Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs.

Author: ChananaPriyanka, ChoudharySupriti, KumarAnil

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Orexin neuropeptides are regulators of transition between wakefulness and sleep. Orexin receptor antagonists are being developed as novel strategies for the treatment of sleep disorders.
Paper Details　
Original Abstract of the Article :
The pharmacological management of insomnia has lately become a challenge for researchers worldwide. As per the third International Classification of Sleep disorders (ICSD-3) insomnia can be defined as a state with repeated difficulty in sleep initiation, duration, consolidation, or quality that occu...See full text at original site
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引用元：
https://doi.org/10.1016/j.pharep.2015.09.002

データ提供：米国国立医学図書館（NLM）

Orexin Antagonists: A Novel Approach to Insomnia Treatment

[Insomnia] is a common sleep disorder that can significantly impact quality of life. This study reviews the [emerging role] of [orexin antagonists] in the treatment of insomnia. The authors explore the mechanisms of action of orexin antagonists and their potential advantages over conventional insomnia treatments.

New Hope for Insomnia Sufferers

This study is like a traveler discovering a new and promising path through the desert of insomnia. The authors highlight the potential of orexin antagonists as a novel therapeutic strategy for insomnia, offering a promising alternative to conventional treatments with their associated side effects. Orexin antagonists target the [orexin neuropeptides], which play a crucial role in regulating the transition between wakefulness and sleep, potentially providing a more targeted and effective approach to insomnia treatment.

Dr. Camel's Conclusion

This study suggests that the quest for better insomnia treatments may be leading to a new oasis of hope. By targeting the orexin system, we can potentially develop medications that effectively address insomnia without the drawbacks of conventional therapies. This research, like a camel caravan navigating a challenging landscape, offers a promising direction for future insomnia treatments.
Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2020-01-06
Further Info :

Pubmed ID

26922522

DOI: Digital Object Identifier

10.1016/j.pharep.2015.09.002

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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