Effects of fluorouracil topical: A Synthesis of Findings from 6 Studies

  1. Home
  2. Effects of fluorouracil topical
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of fluorouracil topical: A Synthesis of Findings from 6 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of fluorouracil topical: A Synthesis of Findings from 6 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Fluorouracil topical medication has shown effectiveness in treating various skin conditions, including actinic keratosis, odontogenic keratocyst, and cutaneous warts. 2 evaluated the pharmacokinetics of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis, finding that systemic absorption, while usually low, can vary depending on the specific skin disease, product formulation, and other factors. 1 compared a new 0.5% fluorouracil topical cream with a vehicle control for the treatment of actinic keratosis, demonstrating that the active treatment applied once daily for 1, 2, or 4 weeks was more effective than the control in reducing lesion counts and achieving lesion clearance. A case report in 5 highlights the successful treatment of a recurrent mandibular keratocyst using a combination of enucleation, diode laser, and 5-Fluorouracil topical application, indicating the potential of this approach for managing such cysts.

Benefits and Risks

Benefit Summary

Fluorouracil topical medication offers potential benefits in treating various skin conditions, including actinic keratosis, odontogenic keratocyst, and cutaneous warts. Research suggests its effectiveness in reducing lesions and improving overall condition. 2 , 1 , 5 The development of new formulations like microsphere-based fluorouracil cream has further enhanced its safety and efficacy profile. 1

Risk Summary

Fluorouracil topical medication can cause side effects such as skin inflammation and irritation. The absorption rate can vary depending on the specific skin disease and product formulation. 2 While typically mild and resolving upon cessation of treatment, serious side effects can occur. It's crucial to adhere to medical guidance when using this medication.

Comparison Across Studies

Commonalities

All these studies demonstrate the potential effectiveness of fluorouracil topical medication in treating diverse skin conditions. They also generally suggest its safety as a treatment approach. However, it's important to be aware that the absorption rate of fluorouracil can vary, emphasizing the need for careful monitoring.

Differences

The studies differ in their focus on specific skin conditions, fluorouracil formulations, and treatment protocols. For example, 2 focuses on the pharmacokinetic evaluation of two fluorouracil topical creams, while 1 evaluates a new microsphere-based formulation. 5 showcases a unique approach to treating a specific type of cyst. These variations underscore the need for tailored treatment plans and careful consideration of individual factors.

Consistency and Contradictions

While the studies consistently demonstrate the potential of fluorouracil topical medication in treating skin conditions, they also highlight the variability in absorption and the possibility of side effects. This underscores the importance of consulting a healthcare professional to determine the suitability of this treatment for individual cases and to manage any potential side effects.

Practical Applications and Precautions

Fluorouracil topical medication can be a valuable tool for managing certain skin conditions, but it's crucial to use it under medical guidance. It's important to be aware of the potential side effects and to carefully monitor any reactions. Consultation with a healthcare professional is essential to determine the appropriateness of this treatment for individual cases and to develop an appropriate treatment plan.

Limitations of Current Research

These studies provide valuable insights into the effectiveness and safety of fluorouracil topical medication. However, they have limitations. The long-term safety and efficacy data are limited, and the variability in absorption and side effects across individuals requires further investigation. Additionally, some studies focus on specific skin conditions and formulations, necessitating broader research to establish comprehensive evidence.

Future Research Directions

Future research should focus on addressing the current limitations, such as expanding long-term safety and efficacy studies, exploring individual variability in absorption and side effects, and conducting comprehensive research across a wider range of skin conditions and formulations. This will provide a more robust understanding of fluorouracil topical medication's role in managing various skin conditions.

Conclusion

Fluorouracil topical medication presents a promising treatment option for various skin conditions, offering potential benefits in reducing lesions and improving overall condition. However, it's crucial to use this medication under medical guidance, being aware of potential side effects and individual variations in absorption. Further research is needed to address current limitations and expand our knowledge of its long-term safety and efficacy. Consultation with a healthcare professional is vital to determine the suitability of this medication for individual cases and to develop a safe and effective treatment plan.

Literature analysis of 6 papers
Positive Content
6
Neutral Content
0
Negative Content
0
Article Type
2
1
1
2
5
1.

Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic keratosis.

Author: JorizzoJoseph, StewartDaniel, BuckoAlicia, DavisSteven A, EspyPaul, HinoPeter, RodriguezDavid, SavinRonald, StoughDow, FurstKatharine, ConnollyMargaret, LevySharon

Actinic keratosis treatment
Facial irritation

A new 0.5% fluorouracil topical cream was more effective than a vehicle control in treating actinic keratosis (AK). The treatment was effective for 1, 2, or 4 weeks, with longer durations resulting in greater efficacy. The cream was generally well tolerated, with side effects limited to facial irritation that resolved quickly.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis.

Author: LevyS, FurstK, ChernW

Treats AK
Facial irritation

Topical 0.5% fluorouracil cream was found to have minimal systemic absorption and was well tolerated in patients with actinic keratosis (AK). Plasma concentrations of fluorouracil were detectable in 3 of 10 patients treated with 0.5% fluorouracil, compared to 9 of 10 patients treated with 5% fluorouracil.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Solar-induced epidermal tumors in the elderly.

Author: BeachamB E

Actinic keratosis treatment
Bowen's disease treatment
Solar lentigo treatment

Solar lentigo, actinic keratosis, and Bowen's disease are common solar-induced epidermal tumors in the elderly. Treatment options for these conditions include cryosurgery, topical medications such as 5-fluorouracil and tretinoin, and excision. The use of sunscreen products is an important preventive measure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Combined conservative treatment of a recurrent mandibular keratocyst by enucleation, diode laser, 5-Fluorouracil and dental implants: a case report with 18 years-follow up.

Author: BerberiAntoine, AounGeorges, HjeijBouchra, HosnMaissa Aboul

Keratocyst treatment

Odontogenic keratocysts are common and have a high recurrence rate. This case report describes a successful treatment of a recurrent odontogenic keratocyst using a combination of surgical enucleation, topical 5-Fluorouracil, and diode laser application.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

6.

Topical treatments for cutaneous warts.

Author: KwokChun Shing, GibbsSam, BennettCathy, HollandRichard, AbbottRachel

Clear warts
Blistering
Pain
Scarring

Salicylic acid significantly increased the chance of clearance of warts, especially for hand warts. Cryotherapy did not demonstrate a significant difference in effectiveness compared to placebo or salicylic acid.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.