Main Research Findings

Flurbiprofen ophthalmic solution has been shown to effectively reduce ocular pain. A study involving 105 patients undergoing radial keratotomy found that flurbiprofen significantly reduced pain compared to a control group, with effects seen as early as 2 hours after surgery and lasting up to 7 days. Importantly, this study also demonstrated that flurbiprofen did not negatively impact corneal sensitivity. 1

Reasons for Side Effects

Flurbiprofen ophthalmic solution is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are chemicals that contribute to pain and inflammation. Side effects are thought to be related to this mechanism of action.

Common Side Effects

Eye Irritation

The most common side effect of flurbiprofen ophthalmic solution is eye irritation. In the study mentioned above, about 16% of patients experienced eye irritation, most of which was transient. This irritation is likely due to the flurbiprofen stimulating the cornea. 1

Vision Problems

Flurbiprofen ophthalmic solution can also cause temporary vision problems. This is likely due to its effects on corneal sensitivity and transparency.

Allergic Reactions

Flurbiprofen ophthalmic solution can cause allergic reactions in some individuals. Symptoms of an allergic reaction can include eye swelling and itching, rash, and difficulty breathing. If you experience an allergic reaction, stop using the medication immediately and consult your doctor.

Side Effect Management

Eye Irritation Management

To help manage eye irritation, gently close your eyes after instillation or apply a cold compress. If irritation is severe, discontinue use and consult your doctor.

Vision Problem Management

If you experience vision problems, discontinue use and consult your doctor.

Allergic Reaction Management

If you experience an allergic reaction, stop using the medication immediately and consult your doctor.

Comparison Between Studies

Commonalities in Studies

Multiple studies have shown that flurbiprofen ophthalmic solution is effective in reducing ocular pain. These studies have also confirmed that flurbiprofen ophthalmic solution does not negatively affect corneal sensitivity.

Differences in Studies

The incidence and severity of side effects can vary between studies, and these results should be interpreted cautiously. Further research is needed to evaluate the effectiveness and safety of flurbiprofen ophthalmic solution.

Cautions for Everyday Use

While flurbiprofen ophthalmic solution has been shown to be effective in reducing ocular pain, it is important to remember that there are potential side effects. If you experience eye irritation, vision problems, or allergic reactions, discontinue use and consult your doctor. Also, if you are taking other medications, be sure to discuss flurbiprofen ophthalmic solution with your doctor to ensure it is safe to use.

Limitations of Current Research

Long-term safety and efficacy data for flurbiprofen ophthalmic solution are still limited. More research is needed.

Future Research Directions

Additional research is needed to evaluate the long-term safety and efficacy of flurbiprofen ophthalmic solution. It is also important to investigate potential drug interactions and evaluate effectiveness and safety in specific populations.

Conclusion

Flurbiprofen ophthalmic solution has been shown to be effective in reducing ocular pain. 1 It is a promising option for managing post-surgical ocular pain. However, it is important to be aware of potential side effects. If you are considering using flurbiprofen ophthalmic solution, be sure to discuss it with your doctor to ensure it is the right option for you.