Effects of isocarboxazid: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Major Research Findings

Isocarboxazid, a monoamine oxidase inhibitor (MAOI), has been studied for its effects on various aspects of health. One study found that isocarboxazid can lead to a loss of appetite and weight loss. Additionally, research indicates that isocarboxazid can affect blood pressure and pulse, with a dose-related lowering of systolic blood pressure observed in both inpatient and outpatient settings. 10 Notably, the response to isocarboxazid might vary depending on the type of depression, with a higher dose showing greater antidepressant effects in non-melancholic depression. 11 Furthermore, the study found that the response to isocarboxazid can be predicted by factors like platelet MAO activity, standing diastolic blood pressure, and psychomotor irregularity. 3 In a case report, long-term use of isocarboxazid revealed potential relapse, side effects, and the importance of monitoring MAO inhibition. Another case report highlighted the risk of central nervous system toxicity after abruptly switching from one MAOI to another, emphasizing the need for careful transitions. 19

Benefits and Risks

Benefits Summary

Isocarboxazid may be a beneficial treatment for depression, particularly for those who haven't responded well to other antidepressants. 14 1

Risks Summary

Isocarboxazid can cause side effects such as loss of appetite, weight loss, and decreased blood pressure and pulse. 10 It's crucial to consult with a doctor and follow their instructions when taking isocarboxazid, especially concerning potential interactions with other medications. 14

Comparison Across Studies

Commonalities Across Studies

Consistent findings suggest that isocarboxazid may be a viable treatment for depression, but it can also lead to side effects and interactions with other medications. 14 2

Differences Across Studies

The effectiveness of isocarboxazid may vary depending on the type of depression. 11 14 Additionally, for older adults, SSRIs may be a more suitable treatment option compared to isocarboxazid. 2

Consistency and Contradictions in Results

Research consistently highlights the potential benefits of isocarboxazid for depression while also acknowledging the possibility of side effects and interactions. 14 2 These findings emphasize the importance of careful consideration and monitoring when using this medication.

Implications for Daily Life

Isocarboxazid should be taken under a doctor's supervision. 14 2 It's crucial to consult with your physician and follow their instructions, particularly regarding potential interactions with other medications. 14

Limitations of Current Research

The current research on isocarboxazid is not exhaustive. 14 Further research is needed to fully understand its effectiveness and side effects.

Future Research Directions

More research is needed to comprehensively investigate the effectiveness and side effects of isocarboxazid. 14 Additionally, further research is required to understand the interactions between isocarboxazid and other medications. 14

Conclusion

Isocarboxazid holds potential benefits for depression treatment, but it's important to be aware of its possible side effects and interactions. 14 2 Consulting with a doctor and following their guidance is crucial when considering isocarboxazid. 14

Literature analysis of 21 papers
Positive Content
18
Neutral Content
1
Negative Content
2
Article Type
1
1
1
4
21
2.

Recent pharmacologic advances in antidepressant therapy for the elderly.

Author: PreskornS H

Effective depression treatment
Wide therapeutic index
Potential drug interactions

Selective serotonin reuptake inhibitors may be the best choice for treating depression in the elderly due to their broad spectrum of activity, wide therapeutic index, and fewer serious side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Assessing treatment response to the monoamine oxidase inhibitor isocarboxazid.

Author: GillerE, BialosD, HarknessL, RiddleM

Treats depression
Side effects

Isocarboxazid effectively inhibited platelet MAO and improved symptoms of depression in patients with atypical depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.

Author: LevantB, MoehlenkampJ D, MorganK A, LeonardN L, ChengC C

Antidepressant effect
Dopamine receptor activation

This study found that monoamine oxidase inhibitors (MAOIs) interact with a novel binding site labeled by [3H]quinpirole, a dopamine agonist. This site may be associated with D2-like dopamine receptors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Predictors of response to monoamine oxidase inhibitors: do they exist?

Author: DavidsonJ R, GillerE L, ZisookS, HelmsM J

Effective for depression
Not specified

In a double-blind study of 130 depressed outpatients, MAOIs were more effective than placebo in treating depression, particularly for patients who were female, had not been previously hospitalized, and had experienced precipitating events. However, the presence of distinct quality (unclear meaning) was associated with decreased improvement in the MAOI group and greater improvement in the placebo group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition.

Author: KlegerisA, McGeerP L

Antineurotoxic action

Deprenyl, a monoamine oxidase B (MAO-B) inhibitor, has neuroprotective effects independent of its MAO-B inhibition activity. It reduces the secretion of neurotoxic products from stimulated human monocytic cells. Deprenyl may have utility in neurodegenerative diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Monoamine oxidase inhibitors and elective surgery.

Author: EbrahimZ Y, O'HaraJ, BordenL, TetzlaffJ

Surgical safety

This study found that patients taking isocarboxazid, a monoamine oxidase inhibitor, could safely undergo elective surgery with appropriate anesthetic management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Comparative effects of seven antidepressant regimes on appetite, weight and carbohydrate preference.

Author: HarrisB, YoungJ, HughesB

Improved depression
Increased appetite
Increased weight
None mentioned

The combination of trimipramine and isocarboxazid significantly increased appetite, carbohydrate preference, and weight in patients. Improvement in Hamilton score was linked to weight gain in patients who had lost appetite, suggesting a potential benefit of this treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

The effects of isocarboxazid on blood pressure and pulse.

Author: DavidsonJ, TurnbullC D

Blood pressure reduction
Bradycardia
Orthostatic hypotension

Isocarboxazid lowered systolic blood pressure in both inpatient and outpatient settings. The reduction was significant and dose-related. Isocarboxazid also produced bradycardia in outpatients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

An evaluation of two doses of isocarboxazid in depression.

Author: DavidsonJ, MillerR, TurnbullC D, BelyeaM, StricklandR

Antidepressant effect
Anticholinergic effect

Isocarboxazid was studied in depressed patients at two doses (30 mg/day and 50 mg/day) for 4 weeks. The higher dose was more effective in non-melancholic depression, but there was no overall difference between the doses. Side effects were similar, with a possible anticholinergic effect at the higher dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

[Effects of beta-phenylethylamine derivatives on the central nervous system. (5) The effect of intracerebral administration of tyramine on head twitching in mice pre-treated with isocarboxazid].

Author: SakuradaS

Serotonin was identified as the mediator for head-twitches induced by tyramine in isocarboxazide pretreated mice.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

13.

Body weight changes associated with psychopharmacology.

Author: VaninaYelena, PodolskayaAnna, SedkyKarim, ShahabHasan, SiddiquiAbufarah, MunshiFiroz, LippmannSteven

Weight loss possible
Weight gain possible

This review discusses changes in body weight associated with various psychopharmaceuticals. Many psychotropic drugs with antipsychotic, mood stabilizing, and antidepressant properties are associated with weight gain. Others, such as fluoxetine, isocarboxazid, nefazadone, topiramate, and psychostimulants, may cause weight loss. Careful monitoring and consideration of alternative therapies are essential.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Current place of monoamine oxidase inhibitors in the treatment of depression.

Author: ShulmanKenneth I, HerrmannNathan, WalkerScott E

Mood disorder treatment
Drug interactions

Monoamine oxidase inhibitors (MAOIs) can be effective for treating challenging mood disorders, but their use has declined due to safety concerns and lack of marketing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Differential responses of rat hepatic microsomal carboxylesterase isozymes to glucocorticoids and pregnenolone 16 alpha-carbonitrile.

Author: HosokawaM, HattoriK, SatohT

Glucocorticoids and pregnenolone 16 alpha-carbonitrile induced different responses in hepatic microsomal carboxylesterase isozymes in rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

[Irreversible, non-selective monoamine oxidase inhibitors].

Author: CastbergIngrid, SpigsetOlav

Adverse effects
Interactions

This article discusses the adverse effects, interactions, and precautions associated with irreversible, non-selective monoamine oxidase (MAO) inhibitors, a class of antidepressants still prescribed in Norway despite their potential for serious adverse reactions.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Norwegian

18.

Prescribing patterns and safety monitoring of duloxetine using the Danish Register of Medicinal Product Statistics as a source.

Author: JohansenAnja Nygaard, StenzhornAnnette Aalykke, RosenzweigMary, ThirstrupSteffen, GazeraniParisa

Drug safety monitoring

Monitoring the safety and use patterns of medicines after they are marketed is essential. The Danish Health and Medicines Authority utilizes the Register of Medicinal Product Statistics (RMPS) for this purpose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Central nervous system toxicity after abrupt monoamine oxidase inhibitor switch: a case report.

Author: SaffermanA Z, MasiarS J

Not applicable
Central nervous system toxicity

This case report describes a patient who experienced acute central nervous system toxicity after switching from phenelzine to isocarboxazid, both monoamine oxidase inhibitors.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Antidepressants versus placebo for people with bulimia nervosa.

Author: BacaltchukJ, HayP

Antidepressant efficacy
Antidepressant discontinuation
Antidepressant side effects

This review evaluated the use of antidepressant medications compared to placebo for the treatment of bulimia nervosa. The review found that antidepressants were clinically effective for the treatment of bulimia nervosa, resulting in a greater remission rate compared to placebo. However, there was a higher rate of dropouts in the antidepressant groups. No differential effect regarding efficacy and tolerability among different classes of antidepressants was demonstrated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants.

Author: GrossM D

Anorgasmy treatment
Impotence treatment

Bethanechol, a cholinergic drug, effectively relieved impotence in two men and anorgasmy in one woman, without any reported side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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