Side Effects of labetalol: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major Research Findings

Labetalol is an effective treatment for chronic hypertension during pregnancy, as evidenced by several studies. 12 found that labetalol was superior to nifedipine in controlling blood pressure. 18 demonstrated that labetalol is also effective for treating hypertensive emergencies during pregnancy.

Reasons for Side Effects

Labetalol is a drug that combines both beta-blocker and alpha-blocker effects. As a result, it has the potential to affect the heart, blood vessels, and other organs. While the occurrence of side effects varies from person to person, they are generally mild and temporary.

Common Side Effects

Dizziness

Labetalol can cause dizziness by lowering blood pressure. 12 reported dizziness in some patients who took labetalol.

Headache

Labetalol can cause headaches. 12 reported headaches in some patients who took labetalol.

Fatigue

Labetalol can cause fatigue. 12 reported fatigue in some patients who took labetalol.

Breathing difficulties

Labetalol can cause breathing difficulties by constricting the bronchi. 3 reported breathing difficulties in some patients who took labetalol.

Bradycardia

Labetalol can slow down the heart rate. 3 reported bradycardia in some patients who took labetalol.

Side Effect Management

Dizziness

When taking labetalol, be careful to get up slowly after sitting or lying down. If you feel dizzy, consult your doctor.

Headache

If your headache is severe, consult your doctor. They may prescribe a different medication to help alleviate the headache.

Fatigue

While taking labetalol, make sure to get enough rest. If you are experiencing severe fatigue, consult your doctor.

Breathing difficulties

If you experience breathing difficulties while taking labetalol, consult your doctor immediately.

Bradycardia

If you experience bradycardia while taking labetalol, consult your doctor immediately.

Comparison Across Studies

Commonalities

Numerous studies have shown that labetalol is effective for treating hypertension during pregnancy. However, side effects can vary from person to person.

Differences

The frequency and severity of labetalol side effects vary depending on the study. Furthermore, studies differ in their comparisons of labetalol with other medications.

Considerations for Real-World Application

Labetalol is an effective medication for treating hypertension during pregnancy, but it does carry the risk of side effects. When taking labetalol, it is crucial to consult your doctor, discuss the potential side effects, and understand them.

Current Research Limitations

Research on the side effects of labetalol remains insufficient. In particular, more research is needed on the effects of labetalol on the fetus.

Future Research Directions

Further research is necessary to gain a deeper understanding of the side effects of labetalol. Research focusing on elucidating the effects of labetalol on the fetus is particularly important.

Conclusion

Labetalol is an effective medication for treating hypertension during pregnancy, but it does carry the risk of side effects. When taking labetalol, it is crucial to consult your doctor, discuss the potential side effects, and understand them. Research on the side effects of labetalol remains insufficient. Further research is needed to better understand the safety and efficacy of labetalol.

Literature analysis of 20 papers
Positive Content
18
Neutral Content
2
Negative Content
0
Article Type
7
3
2
1
20
2.

Neonatal side effects of maternal labetalol treatment in severe preeclampsia.

Author: HeidaKarst Y, ZeemanGerda G, Van VeenTeelkien R, HulzebosChristian V

PE treatment
Neonatal bradycardia
Neonatal hypoglycemia
Neonatal hypotension

This study analyzed the possible association between intrauterine labetalol exposure and neonatal side effects such as hypotension, bradycardia, and hypoglycemia. Labetalol is often used in severe preeclampsia (PE).

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Comparison of intravenous labetalol and hydralazine for severe hypertension in pregnancy in Northeastern Nigeria: A randomized controlled trial.

Author: MuhammadSagir, UsmanHadiza, DawhaYahaya Musa, YahyaAnisah, YekeenAyoola, BakoBabagana

Lowered blood pressure

Both intravenous hydralazine and labetalol are effective for acute blood pressure control in pregnancy with a similar safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Efficacy of nifedipine versus hydralazine in the management of severe hypertension in pregnancy: A randomised controlled trial.

Author: AdebayoJoshua Adeniyi, NwaforJohnbosco Ifunanya, LawaniLucky Osaheni, EsikeChidi Ochu, OlaleyeAyodele Adegbite, AdieleNnabugwu Alfred

Effective BP control

Oral nifedipine and intravenous hydralazine showed comparable efficacy in controlling blood pressure in pregnant women with severe hypertension. Nifedipine required fewer doses to achieve target blood pressure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

First-line antihypertensive treatment for severe hypertension in pregnancy: A systematic review and network meta-analysis.

Author: AlavifardSepand, ChaseRebecca, JanoudiGhayath, ChaumontAndréanne, LanesAndrea, WalkerMark, GaudetLaura

Nifedipine for hypertension

This systematic review and network meta-analysis found that oral nifedipine is a superior first-line treatment for severe hypertension in pregnancy compared to hydralazine, without an increased risk of caesarean delivery or maternal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Labetalol Versus Nifedipine as Antihypertensive Treatment for Chronic Hypertension in Pregnancy: A Randomized Controlled Trial.

Author: WebsterLouise M, MyersJenny E, Nelson-PiercyCatherine, HardingKate, CruickshankJ Kennedy, Watt-CooteIngrid, KhalilAsma, WiesenderCornelia, SeedPaul T, ChappellLucy C

Hypertension control

This study looked at the effects of two different drugs, labetalol and nifedipine, on blood pressure in pregnant women with high blood pressure. The study found that both drugs were effective in controlling blood pressure, but that nifedipine was associated with a lower central aortic pressure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial.

Author: SharmaKathryn J, GreeneNaomi, KilpatrickSarah J

BP control
Fewer side effects
None reported

In 25 women with persistent postpartum hypertension, both oral labetalol and extended-release nifedipine were effective in controlling blood pressure. Labetalol achieved control more often with the starting dose and had fewer side effects compared to nifedipine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Oral nifedipine vs. intravenous labetalol for treatment of pregnancy-induced severe pre-eclampsia.

Author: ShiD-D, YangF-Z, ZhouL, WangN

Reduced blood pressure

Oral nifedipine and intravenous labetalol are both effective and safe for reducing blood pressure to target levels in patients with severe pre-eclampsia. There was no significant difference in time taken to achieve effective blood pressure control between the two groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Neonatal haemodynamic effects following foetal exposure to labetalol in hypertensive disorders of pregnancy.

Author: ThewissenLiesbeth, PistoriusLou, BaertsWim, NaulaersGunnar, Van BelFrank, LemmersPetra

Lower maternal blood pressure
Prolong pregnancy

This study investigated the neonatal effects of fetal exposure to labetalol on cerebral oxygenation and extraction. Maternal labetalol treatment is often used to lower maternal blood pressure and prolong pregnancy. While there is conflicting evidence regarding specific neonatal side effects of labetalol, this study aimed to clarify the impact on cerebral oxygenation and extraction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

16.

Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis.

Author: ShekharS, GuptaN, KirubakaranR, PareekP

Pregnancy hypertension control

Nifedipine, labetalol, and hydralazine are recommended for treating severe hypertension during pregnancy. However, despite lacking evidence, labetalol is often preferred over nifedipine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Impedance cardiography assessed treatment of acute severe pregnancy hypertension: a randomized trial.

Author: MorrisRachael, SunesaraImran, DarbyMarie, NovotnySarah, KipronoLuissa, BautistaLeody, SawardeckerSandip, BofillJames, AndersonBelinda, MartinJames N

Blood pressure reduction
Safe

Intravenous labetalol and hydralazine performed similarly in reducing acute-onset severe hypertension in pregnant women, without causing significant hemodynamic changes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial.

Author: ShekharShashank, SharmaChanderdeep, ThakurSita, VermaSuresh

Blood pressure control

A randomized controlled trial of 60 pregnant women with hypertensive emergency found that oral nifedipine lowered blood pressure more quickly than intravenous labetalol. Neither treatment was associated with serious adverse maternal or perinatal effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

[Clinical efficacy and perinatal outcome of nifedipine for severe preeclampsia: meta-analysis].

Author: LiuQian-qian, YuYan-hong, GongShi-peng, HuangLi-ping

Preeclampsia treatment
Headache
Nausea
Palpitation

Nifedipine is associated with greater effective control of blood pressure and prolongation of gestation, with no additional neonatal respiratory distress syndrome or perinatal deaths, compared with other antihypertensives for women with severe preeclampsia.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : Chinese

20.

Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy.

Author: GiannubiloStefano R, BezzeccheriValeria, CecchiStefano, LandiBeatrice, BattistoniGiovanna I, VitaliPaola, CecchiLucia, TranquilliAndrea L

Fetal growth restriction
Fetal worsening

Labetalol treatment during pregnancy may be associated with a higher rate of intrauterine growth restriction and fetal worsening in women with gestational hypertension and mild preeclampsia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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