Effects of lamotrigine: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Major Research Findings

Lamotrigine has shown a range of potential benefits in several studies, including improved cognitive function, mood enhancement, and seizure control. 7 demonstrated that lamotrigine led to enhanced cognitive activation in healthy volunteers, as measured by simple reaction time tasks. 3 found that lamotrigine significantly reduced seizure frequency in epilepsy patients compared to placebo. These findings suggest that lamotrigine may have a broad impact on cognitive function, mood, and seizure control.

Benefits and Risks

Benefits Summary

Lamotrigine holds promise for improving cognitive function, mood, and seizure control. 7 found that lamotrigine improved cognitive activation in healthy volunteers. It also showed positive effects on mood. 9 suggested that lamotrigine had significantly fewer negative impacts on cognition and behavior compared to topiramate. Additionally, lamotrigine is a potential treatment for seizures in epilepsy patients. 3 showed that lamotrigine significantly reduced seizure frequency in epilepsy patients compared to placebo.

Risks Summary

Potential side effects of lamotrigine include dizziness, drowsiness, nausea, and skin rash. 3 reported that approximately 5% of patients experienced rash as a side effect. Lamotrigine can also interact with other medications. It is crucial to consult with a doctor before taking lamotrigine.

Comparison Between Studies

Similarities Between Studies

Across multiple studies, lamotrigine has consistently demonstrated beneficial effects on cognitive function, mood, and seizure control. 7 , 3 , 9 and other studies suggest that lamotrigine may have a positive impact on cognitive activation, mood enhancement, and seizure reduction. 6 found that lamotrigine had fewer negative cognitive and behavioral effects compared to carbamazepine.

Differences Between Studies

The specific situations in which lamotrigine is effective and the frequency of side effects can vary between studies. For instance, 7 demonstrated cognitive activation in healthy volunteers, while 3 focused on seizure control in epilepsy patients. These differences may be attributed to variations in study designs and participant populations.

Consistency and Contradictions in Results

Several studies have produced consistent findings regarding the effects of lamotrigine. However, some studies have indicated that the effects of lamotrigine may be limited or that the risk of side effects is higher. 3 found that lamotrigine reduced seizure frequency in epilepsy patients, but some experienced rash as a side effect. These contradictions could be explained by differences in study design and the participant population.

Implications for Everyday Life

Lamotrigine shows potential to improve cognitive function, mood, and seizure control. However, it can also cause side effects. It is essential to take lamotrigine as directed by a doctor. Before taking lamotrigine, consult with a doctor to discuss your symptoms and potential interactions with other medications.

Limitations of Current Research

Research on lamotrigine is still ongoing and needs further exploration. Long-term effects and the effectiveness of lamotrigine in diverse populations need more study. In addition, further investigation is necessary to understand the interactions between lamotrigine and other drugs.

Future Research Directions

Further research should focus on the long-term effects of lamotrigine, its effectiveness in various patient populations, interactions with other medications, risk of side effects, and optimized administration methods. These studies will help us to better understand the safety and efficacy of lamotrigine.

Conclusion

Lamotrigine shows promise for improving cognitive function, mood, and seizure control, as indicated by multiple studies. It may be beneficial for treating epilepsy, bipolar disorder, and other mental health conditions. However, lamotrigine can cause side effects. Therefore, it is crucial to take lamotrigine as directed by a doctor. Before taking lamotrigine, consult with a doctor to discuss your symptoms and potential interactions with other medications.

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
9
1
0
0
10
1.

Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy.

Author: RamsayR E, PellockJ M, GarnettW R, SanchezR M, ValakasA M, WarginW A, LaiA A, HubbellJ, ChernW H, AllsupT

Safe epilepsy treatment
Not specified

Lamotrigine, an antiepileptic drug, showed linear pharmacokinetics and did not induce its own metabolism in 11 patients on stable antiepileptic drug regimens. No significant medical, neurological, or hematological changes were observed, and no subjective effects were detected.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans.

Author: CohenA F, LandG S, BreimerD D, YuenW C, WintonC, PeckA W

Effective anticonvulsant

Lamotrigine, a new anticonvulsant, showed linear pharmacokinetics with oral doses up to 240 mg. Repeated administration did not demonstrate autoinduction of metabolism. No clinically significant side effects were observed during a 7-day study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, cross-over trial.

Author: MessenheimerJ, RamsayR E, WillmoreL J, LeroyR F, ZielinskiJ J, MattsonR, PellockJ M, ValakasA M, WombleG, RisnerM

Improved overall clinical status
Reduced seizure frequency
CNS-related side effects
Rash

This study evaluated the efficacy and safety of lamotrigine (LTG), a new antiepileptic drug (AED), in patients with refractory partial seizures. LTG significantly decreased seizure frequency and improved overall patient clinical status. Adverse experiences were generally minor and most frequently were CNS-related.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosage.

Author: HamiltonM J, CohenA F, YuenA W, HarkinN, LandG, WeatherleyB C, PeckA W

Cognitive function
Seizure treatment
Eye movement disturbance
Psychomotor impairment

Lamotrigine (LTG) and carbamazepine (CBZ) are drugs that are used to treat seizures. This study found that CBZ, but not LTG, had negative effects on psychomotor function, including eye movements and balance. These effects were related to the levels of CBZ in the blood.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults.

Author: MartinR, KuznieckyR, HoS, HetheringtonH, PanJ, SinclairK, GilliamF, FaughtE

Tolerable AEDs
Cognitive effects

Topiramate had significant adverse cognitive effects in healthy adults, while gabapentin and lamotrigine had minimal effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Differential cognitive and behavioral effects of carbamazepine and lamotrigine.

Author: MeadorK J, LoringD W, RayP G, MurroA M, KingD W, PerrineK R, VazquezB R, KiolbasaT

Fewer cognitive side effects

Lamotrigine significantly reduced cognitive and behavioral side effects compared to carbamazepine at therapeutic doses in healthy adults.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers.

Author: AldenkampA P, ArendsJ, BootsmaH P R, DiepmanL, HulsmanJ, LambrechtsD, LeenenL, MajoieM, SchellekensA, de VochtJ

Improved cognitive activation
Reduced cognitive complaints
Tiredness/sedation

Lamotrigine improved cognitive activation and mood in healthy volunteers, while valproate had the opposite effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia.

Author: KremerIlana, VassAgnes, GorelikIelena, BarGali, BlanaruMonica, JavittDaniel C, Heresco-LevyUriel

Improved cognition
Improved mood
Reduced positive symptoms

Lamotrigine is a drug used to treat seizures, but it may also help to improve mood and thinking skills in people with bipolar disorder and schizophrenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers.

Author: MeadorK J, LoringD W, VahleV J, RayP G, WerzM A, FesslerA J, OgrockiP, SchoenbergM R, MillerJ M, KustraR P

Improved behavioral effects
Improved cognitive function

Lamotrigine produced fewer untoward cognitive and behavioral effects compared to topiramate in healthy adults. This suggests that lamotrigine might be a better choice for patients who are concerned about cognitive function.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

[Optimizing epilepsy therapy in children and adolescents with lamotrigine].

Author: SiemesH, BrandlU, HelmstädterC, KurlemannG, RatingD, Sälke-KellermannR A, StephaniU, UberallM, Wiemer-KruelA, BergmannL

Effective antiepileptic
Good tolerability
Improved quality of life
CNS side effects
Skin rash

Lamotrigine is an effective antiepileptic drug for children and adolescents with focal and generalized epilepsies, particularly in older school children and adolescents due to its good tolerability. It is effective for various epilepsy diseases, including tuberous sclerosis, juvenile neuronal lipofuscinosis, and Rett syndrome. The most common side effects are vertigo, ataxia, nausea, tremor, and diplopia. The rate of allergic skin rashes has decreased since 1998.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : German

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