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Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults.

Author: FaughtE, GilliamF, HetheringtonH, HoS, KuznieckyR, MartinR, PanJ, SinclairK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Topiramate had significant adverse cognitive effects in healthy adults, while gabapentin and lamotrigine had minimal effects.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To study the acute and steady-state cognitive effects of three new antiepileptic drugs (AEDs): gabapentin, lamotrigine, and topiramate. BACKGROUND: Several newer antiepileptic medications approved recently by the Food and Drug Administration are gaining attention as efficacious alternati...See full text at original site
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引用元：
https://doi.org/10.1212/wnl.52.2.321

データ提供：米国国立医学図書館（NLM）

Cognitive Effects of Antiepileptic Drugs: Navigating the Brain's Desert

The human brain is a vast and intricate landscape, like a sprawling desert with its own unique topography. This study explores the potential impact of [antiepileptic drugs] on [cognitive function], examining how these medications might affect the delicate balance of the brain's processes. It's like navigating a desert landscape, seeking to understand how different conditions can affect the path of cognitive function.

Mapping the Cognitive Landscape

The researchers meticulously examined the effects of [gabapentin, lamotrigine, and topiramate] on various cognitive functions. They found that [topiramate] had a more pronounced impact on certain cognitive abilities, like [attention and word fluency], while the other medications showed minimal effects. It's like mapping the desert with great precision, identifying specific areas where certain drugs might have a greater impact on cognitive function.

Navigating the Desert of Cognitive Health

This study provides valuable insights for doctors and patients who are considering [antiepileptic drugs]. It's a reminder that understanding the potential impact of these medications on the brain is crucial for navigating the desert of cognitive health. It's like ensuring we have the right map and tools to navigate a potentially challenging landscape, making informed decisions about our health and well-being.

Dr.Camel's Conclusion

This research offers a glimpse into the complex interplay between medications and cognitive function. By understanding the potential effects of different drugs, we can better navigate the intricate terrain of the brain, ensuring the best possible outcomes for both health and cognitive well-being. It's a reminder that the desert of cognitive health requires careful observation, and we must be mindful of the potential effects of any medications we choose to take.

Date :
  1. Date Completed 1999-02-16
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

9932951

DOI: Digital Object Identifier

10.1212/wnl.52.2.321

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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