Side Effects of lamotrigine: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Main research findings

Lamotrigine is a commonly used anti-epileptic drug. Several studies have been conducted on the side effects of lamotrigine, but the results vary. Some studies have reported cardiac side effects, while others have not found any evidence of cardiac side effects. 3 . Other studies have found that lamotrigine has fewer side effects compared to other antiepileptic drugs, and is particularly effective in controlling seizures. . Some studies have suggested ways to mitigate the side effects of lamotrigine. . Research on the side effects of lamotrigine will continue in the future.

Reasons for side effects

The reasons for the side effects of lamotrigine are not yet fully understood. Lamotrigine works by adjusting the balance of neurotransmitters in the brain to reduce seizures, but it is speculated that side effects may occur in this process. The side effects of lamotrigine vary from person to person, and may be influenced by age, sex, health status, dosage, etc.

Common side effects

Skin side effects

Common side effects of lamotrigine include skin side effects. . Skin rashes, and in rare cases, serious side effects such as Stevens-Johnson syndrome and toxic epidermal necrolysis, may occur. .

Cardiac side effects

Lamotrigine may cause cardiac side effects. 3 . However, cardiac side effects do not occur in all patients, and the severity of side effects varies from person to person. Cardiac side effects include changes in heart rate, arrhythmias, chest pain, etc. 3 .

Neurological side effects

Lamotrigine may also cause neurological side effects. 1 . Neurological side effects include dizziness, headache, drowsiness, tremors, and decreased attention and concentration. 1 .

Side effect countermeasures

Skin side effect countermeasures

If you experience skin side effects, consult your doctor. Your doctor may discontinue lamotrigine or switch to a different medication if necessary. . It is also important to use a moisturizer and avoid exposure to ultraviolet light to reduce skin side effects.

Cardiac side effect countermeasures

If you experience cardiac side effects, consult your doctor immediately. Cardiac side effects can be life-threatening if they become severe. Your doctor will examine your heart condition and may discontinue lamotrigine or switch to a different medication if necessary. 3 .

Neurological side effect countermeasures

If you experience neurological side effects, consult your doctor. Your doctor may adjust your lamotrigine dosage or add other medications if necessary. 1 . It is also important to get enough rest and avoid alcohol and caffeine to reduce neurological side effects.

Comparison between studies

Commonalities between studies

Studies on the side effects of lamotrigine have all found that there are side effects, but the severity and frequency of side effects vary depending on the study. Also, the specific symptoms of side effects may differ depending on the study.

Differences between studies

There is some variation in the results of studies on the cardiac side effects of lamotrigine. 3 . 7 . This may be due to differences in study subjects and methods.

Precautions for application in real life

It is important to understand the risks of side effects when taking lamotrigine. Lamotrigine is an effective drug for controlling seizures, but it can cause side effects. Consult your doctor immediately if you experience any abnormalities while taking lamotrigine.

Limitations of current research

There is not enough research on the side effects of lamotrigine. Therefore, not all side effects of lamotrigine have been identified.

Future research directions

Further research on the side effects of lamotrigine is needed. In particular, research on the long-term side effects of lamotrigine and the cardiac side effects of lamotrigine is needed.

Conclusion

Lamotrigine is a widely used anti-epileptic drug, but it is important to understand the risk of side effects. Consult your doctor immediately if you experience any abnormalities while taking lamotrigine. Further research on the side effects of lamotrigine is needed.

Literature analysis of 8 papers
Positive Content
7
Neutral Content
0
Negative Content
1
Article Type
0
0
0
2
8
1.

Unusual side effects of lamotrigine therapy.

Author: DasKrishna B, HarrisChris, SmythDiane P L, CrossJ Helen

Chorea
Cognitive decline
Eye movement abnormalities
Tremor
Unsteadiness

Two case reports suggest that lamotrigine may cause unusual side effects such as eye movement abnormalities, involuntary movements, and behavioral changes. These side effects resolved upon discontinuation of the medication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

[Cardiac side effects and ECG changes with lamotrigine?--A clinical study].

Author: SteinhoffB J, StodieckS R, TiecksF P, WedelR, PolatschekB

Lamotrigine safe

Lamotrigine (LTG) did not show any evidence of clinically significant cardiac side effects in a prospective study of 20 patients with epilepsy. ECG abnormalities were observed in a few patients, but these were not considered clinically significant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

4.

Lamotrigine add-on therapy for drug-resistant focal epilepsy.

Author: PanebiancoMariangela, BresnahanRebecca, MarsonAnthony G

Reduced seizures
Adverse effects

This updated Cochrane review examines the effectiveness and adverse effects of lamotrigine as an add-on therapy for epilepsy, a common neurological disorder affecting 0.5% to 1% of the population. Lamotrigine can reduce seizures but may have some side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Clinical impact of therapeutic drug monitoring for newer anti-seizure medications in patients with epilepsy: A real-world observation study.

Author: LimSiew-Na, WuTony, ChangChun-Wei, Johnny TsengWei-En, ChengMei-Yun, HsiehHsiang-Yao, LeeChih-Hong, LinWey-Ran, LiuChun-Jing, ChenPo-Ru, LinChia-Ni

Epilepsy management
TDM effectiveness

This study found that therapeutic drug monitoring (TDM) for newer anti-seizure medications (ASMs) can benefit clinical decision-making in epilepsy patients. TDM led to medication adjustments in 64.2% of cases, resulting in improved seizure control and fewer ASM-related side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Normalization and cross-sectional validation of an extended Adverse Event Profile (E AEP) in a large cohort of patients with epilepsy.

Author: HelmstaedterChristoph, MeschedeCarolin, MastaniSandra, Moskau-HartmannSusanna, RademacherMichael, von WredeRandi, WittJuri-Alexander

ASM side effect monitoring

This abstract discusses the need for additional symptoms to be assessed in the Liverpool Adverse Event Profile (L AEP), a tool for monitoring anti-seizure medication side effects, and the importance of normative data to better interpret patients' complaints.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Therapeutic Approach for Trigeminal Neuralgia: A Systematic Review.

Author: RanaMuhammad Haseeb, KhanAbdul Ahad Ghaffar, KhalidImran, IshfaqMuhammad, JavaliMukhatar Ahmed, BaigFawaz Abdul Hamid, KotaMohammad Zahir, KhaderMohasin Abdul, HameedMohammad Shahul, ShaikSharaz, DasGotam

Trigeminal neuralgia treatment
Drug side effects

Carbamazepine and oxcarbazepine are considered the first-line drugs for treating classical trigeminal neuralgia (TN). Lamotrigine and baclofen can be used as second-line options if the first-line drugs are ineffective or cause intolerable side effects. While anticonvulsants are effective in managing TN, more research is needed on other drugs, combination therapies, and newer formulations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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