Effects of luliconazole topical: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Major Research Findings

Luliconazole is a topical antifungal medication that has shown to be effective in treating various fungal infections, including onychomycosis, tinea pedis, tinea cruris, and seborrheic dermatitis. 25 , 9 , 23 , 7 , 10 , 3 , 20 , 11 , 24 , 8 , 2 , 13 , 19 , 15 , 22 , 17 , 21 , 4 , 6 , 12 , 16 , 18 , 1

Benefits and Risks

Benefit Summary

Luliconazole has been shown to be effective in treating various fungal infections, including onychomycosis, tinea pedis, tinea cruris, and seborrheic dermatitis. 25 , 3 , 2 , 6 , 18

Risk Summary

Side effects of luliconazole are generally mild and include skin irritation and redness. 25 , 2 , 6 , 18

Study Comparisons

Commonalities Across Studies

Many studies indicate that luliconazole is effective in treating fungal infections such as onychomycosis. It has also been demonstrated to be more effective than other topical treatments. 25 , 3 , 2 , 6 , 18

Differences Across Studies

Research regarding the effectiveness and safety of luliconazole can vary depending on the targeted condition, treatment method, and evaluation procedures. For example, 25 used luliconazole 5% nail solution daily for 48 weeks, while 2 used luliconazole 1% cream once daily for 14 days, highlighting variations in dosage and duration. Additionally, 10 assessed the use of carbon dioxide laser in combination with luliconazole.

Consistency and Contradictions in Results

Multiple studies have demonstrated the efficacy of luliconazole in treating fungal infections, including onychomycosis. However, research findings can differ depending on factors like the disease, treatment approach, and evaluation methods. Further research is required to understand the extent of luliconazole's effectiveness and potential side effects. 25 , 3 , 2 , 6 , 18 , 10

Practical Application Considerations

Luliconazole is a topical medication that has shown effectiveness in treating fungal infections like onychomycosis. However, research on its effectiveness and safety is still ongoing, and it is important to consult with a physician before using luliconazole. Luliconazole may cause skin irritation, making a patch test before use advisable. 25 , 3 , 2 , 6 , 18

Limitations of Current Research

Research on the effectiveness and safety of luliconazole is still incomplete. The long-term effects of luliconazole use are not fully understood, making further research in this area necessary. Furthermore, various factors can influence the assessment of luliconazole's effectiveness and safety, including patient age, gender, weight, disease severity, and any other medications they are taking. Research that considers these factors is essential. 25 , 3 , 2 , 6 , 18 , 10

Future Research Directions

Further research on luliconazole's effectiveness and safety is required, particularly regarding long-term use. Studies that consider various factors influencing results, as well as research focused on different conditions, combination therapies, and the effects of long-term use are crucial. 25 , 3 , 2 , 6 , 18 , 10

Conclusion

Luliconazole is a topical antifungal medication that has demonstrated effectiveness in treating various fungal infections, including onychomycosis. It has shown to be more effective than other topical treatments. However, research on its effectiveness and safety is still ongoing. Consulting a physician before using luliconazole is essential. A patch test before use is recommended as luliconazole can cause skin irritation. Further research is needed regarding long-term use, including studies considering various factors influencing results, research on different conditions, combination therapies, and the effects of long-term use. 25 , 3 , 2 , 6 , 18 , 10

Literature analysis of 25 papers
Positive Content
24
Neutral Content
0
Negative Content
1
Article Type
4
1
0
3
25
1.

Newfangled Topical Film-Forming Solution for Facilitated Antifungal Therapy: Design, Development, Characterization, and In Vitro Evaluation.

Author: DhimmarBhakti, PokaleRahul, RahamathullaMohamed, HaniUmme, AlshahraniMohammad Y, AlshehriSultan, ShakeelFaiyaz, AlamPrawez, OsmaniRiyaz Ali M, PatilAmit B

Antifungal effect
Sustained release

Luliconazole is a topical antifungal drug that can be used to treat fungal infections. A new alkaline pH-based spray formulation of luliconazole was found to have good compatibility with human skin and provided sustained drug release, suggesting its potential for improved topical antifungal treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Efficacy and safety of once-daily luliconazole 1% cream in patients ≥12 years of age with interdigital tinea pedis: a phase 3, randomized, double-blind,vehicle-controlled study.

Author: JarrattMichael, JonesTerry, AdelglassJeffrey, BuckoAlicia, PollakRichard, Roman-MirandaAmaury, OlinJason T, SwinyerLeonard

Effective treatment for tinea pedis

Luliconazole cream 1% applied once daily for 14 days is well-tolerated and more effective than vehicle in treating tinea pedis.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent.

Author: NiwanoY, KuzuharaN, KodamaH, YoshidaM, MiyazakiT, YamaguchiH

Antifungal activity
Dermatophyte treatment

NND-502, a new antifungal agent, showed strong in vitro and in vivo activity against dermatophytes, demonstrating greater efficacy than existing treatments like lanoconazole and terbinafine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

A randomized, multicenter, double-blind, vehicle-controlled study evaluating the efficacy and safety of luliconazole cream 1% once daily for 7 days in patients aged ≥ 12 years with tinea cruris.

Author: JonesTerry M, JarrattMichael T, Mendez-MoguelInes, PazNelly, GrekinSteven K, Cognata SmithChristina, KaurMandeep

Tinea cruris treatment

Luliconazole cream 1% applied once daily for 7 days was found to be more effective than vehicle in treating tinea cruris. Luliconazole cream 1% was well tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycoses.

Author: KogaHiroyasu, TsujiYuri, InoueKazuyoshi, KanaiKazuo, MajimaToshiro, KasaiTatsuya, UchidaKatsuhisa, YamaguchiHideyo

Dermatomycoses treatment

Luliconazole, a novel topical imidazole antifungal, showed potent in vitro activity against pathogenic fungi implicated in dermatomycoses. Its potency was significantly higher than that of other reference drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Tavaborole, Efinaconazole, and Luliconazole: Three New Antimycotic Agents for the Treatment of Dermatophytic Fungi.

Author: SaundersJacqueline, MakiKayla, KoskiRenee, NyboS Eric

Onychomycosis treatment
Tinea corporis treatment
Tinea cruris treatment
Tinea pedis treatment

New topical agents, efinaconazole, tavaborole, and luliconazole, have been approved for the treatment of fungal infections of the nail bed and epidermis. These agents offer an alternative to oral antifungal medications, which can have side effects and interactions with other medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Dose-finding comparative study of 2 weeks of luliconazole cream treatment for tinea pedis--comparison between three groups (1%, 0.5%, 0.1%) by a multi-center randomised double-blind study.

Author: WatanabeShinichi, TakahashiHisashi, NishikawaTakeji, TakiuchiIwao, HigashiNobuhiko, NishimotoKatsutaro, KagawaSaburo, YamaguchiHideyo, OgawaHideoki

Mycological cure
Tinea pedis treatment
Adverse events

Luliconazole cream, a newly developed imidazolyl antifungal agent, showed efficacy and safety in treating tinea pedis. Higher concentrations of luliconazole cream demonstrated greater mycological cure rates, with low incidence of adverse events.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

In-vitro antifungal susceptibility testing of lanoconazole and luliconazole against Aspergillus flavus as an important agent of invasive aspergillosis.

Author: OmranSaeed Mahdavi, Taghizadeh-ArmakiMojtaba, ZarrinfarHossein, HedayatiMohammad T, AbastabarMahdi, MoqarabzadehVahid, AnsariSaham, SaberSasan, HoseinnejadAkbar, MiriAli, VerweijPaul E, SeyedmousaviSeyedmojtaba

Aspergillus infection

Aspergillus flavus is becoming a common cause of fungal infections. Lanoconazole and luliconazole, which are used to treat fungal skin infections, may also be effective against Aspergillus flavus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent.

Author: UchidaKatsuhisa, NishiyamaYayoi, YamaguchiHideyo

Anti-fungal activity

Luliconazole is a new antifungal drug that is effective against dermatophytes and other fungi. It is as effective as lanoconazole and more effective than terbinafine and bifonazole, two other antifungal drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

The effects of CO<sub>2</sub> laser and topical agent combination therapy for onychomycosis: A meta-analysis.

Author: HanYang, WangYi, ZhangXin-Rui, ChenJuan, LiXiao-Dong

Onychomycosis treatment

This systematic review compares the efficacy and satisfaction rates of combined CO<sub>2</sub> laser and topical treatments versus topical agents alone in patients with onychomycosis. Combined therapy was found to significantly increase efficacy and satisfaction rates compared with topical agents alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

[In vitro Antifungal Activity of Luliconazole against Trichophyton spp].

Author: MaedaJun, NanjohYasuko, KogaHiroyasu, TogaTetsuo, MakimuraKoichi, TsuboiRyoji

Dermatophytosis treatment

This study compared the antifungal activity of luliconazole to that of six other commonly used topical antifungal drugs against Trichophyton rubrum and Trichophyton mentagrophytes, the two most common causes of tinea. Luliconazole was found to be the most potent antifungal drug tested.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

23.

Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species.

Author: AbastabarMahdi, Al-HatmiAbdullah M S, Vafaei MoghaddamMohammad, de HoogG Sybren, HaghaniIman, AghiliSeyed Reza, ShokohiTahereh, HedayatiMohammad Taghi, Daie GhazviniRoshanak, KachueiReza, Rezaei-MatehkolaeiAli, MakimuraKoichi, MeisJacques F, BadaliHamid

Fungal infection treatment

This study evaluated the activity of ten antifungal drugs, including two novel imidazoles, against clinical and environmental Fusarium isolates. Luliconazole and lanoconazole demonstrated significant antifungal activity, suggesting their potential as topical treatments for skin and nail infections caused by Fusarium species.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Novel in vivo observations on double acting points of luliconazole on Trichophyton rubrum: an ultrastructural study.

Author: Wakumoto-NakashimaKeiko, YamadaNanako, MorinoShinichi, YamamotoOsamu

Tinea pedis treatment

Luliconazole, a topical antifungal cream for tinea pedis, was found to cause dramatic morphological changes in Trichophyton rubrum hyphae, suggesting a double-acting mechanism on the plasma membrane and cell wall.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Efficacy and safety of luliconazole 5% nail solution for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study.

Author: WatanabeShinichi, KishidaHiroshi, OkuboAkihiro

Onychomycosis treatment

Luliconazole 5% nail solution demonstrated clinical efficacy in the treatment of distal lateral subungual onychomycosis, achieving a complete cure rate of 14.9% compared to 5.1% with vehicle.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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