Major research findings

Lurasidone is a second-generation antipsychotic used to treat mental illnesses such as schizophrenia and bipolar disorder. Studies have shown that lurasidone has a lower risk of metabolic and cardiac side effects compared to other antipsychotics. In addition, lurasidone may be effective in improving positive, negative, and cognitive symptoms of schizophrenia. 25 , 12

Reasons for side effects

Side effects of lurasidone are thought to occur by inhibiting the action of neurotransmitters such as dopamine and serotonin. 7 . Lurasidone binds to dopamine receptors and serotonin receptors to inhibit the action of these neurotransmitters. Dopamine plays an important role in movement, pleasure, and motivation, so inhibition of dopamine receptors can lead to side effects such as movement disorders, insomnia, and lethargy. Serotonin is important for mood, sleep, and appetite, so inhibition of serotonin receptors can lead to side effects such as depression, anxiety, and digestive symptoms.

Common side effects

Movement disorders

Lurasidone can cause movement disorders. Main symptoms include akathisia, dystonia, and parkinsonism. 3 , 25 , 14 . These symptoms may be caused by inhibition of dopamine receptors. Akathisia is a state of restlessness and inability to sit still. Dystonia is a condition where muscles in the neck, face, arms, and legs contract involuntarily, causing twisting or rigidity. Parkinsonism refers to symptoms like Parkinson's disease, such as slowness of movement, rigidity, and tremors. If you experience any of these movement disorders, it is important to consult a doctor.

Metabolic abnormalities

Lurasidone can cause metabolic abnormalities such as weight gain, lipid abnormalities, and elevated blood sugar levels. 2 , 25 , 13 . These symptoms may be caused by inhibition of dopamine receptors and serotonin receptors. In particular, lurasidone has been reported to have a lower risk of weight gain compared to other second-generation antipsychotics. 25 . However, the risk of metabolic abnormalities varies greatly from person to person, so it is important to monitor your health regularly. Lifestyle changes such as dietary therapy and exercise therapy can also help reduce the risk of metabolic abnormalities.

Digestive symptoms

Lurasidone can cause digestive symptoms such as nausea, vomiting, constipation, and diarrhea. 7 . These symptoms may be caused by inhibition of serotonin receptors. If you are concerned about digestive symptoms, consult your doctor.

Other

Lurasidone has also been reported to have side effects such as headache, drowsiness, dizziness, dry mouth, and visual disturbances. 7 . These symptoms are usually mild and often improve over time, but if you are concerned, consult your doctor.

Side effect management

Management of movement disorders

Management of movement disorders may include reducing the dose of the drug, adding drugs such as anticholinergics, or trying exercise therapy. 3 . If movement disorders are severe, it may be necessary to discontinue lurasidone under the guidance of a doctor.

Management of metabolic abnormalities

Management of metabolic abnormalities may include lifestyle changes such as dietary therapy and exercise therapy, regular monitoring of blood sugar and lipids, and the addition of other medications as needed. 2 . If you are concerned about weight gain or metabolic abnormalities, consult your doctor.

Management of digestive symptoms

Management of digestive symptoms may include lifestyle changes such as dietary therapy and hydration, and the addition of medications such as antiemetics as needed. 7 . If digestive symptoms are severe, consult your doctor.

Comparison between studies

Commonalities of research

Many studies have shown that lurasidone has a lower risk of metabolic and cardiac side effects compared to other second-generation antipsychotics. 25 , 12 , 13 .

Differences in research

Different studies have reported different results for side effects of lurasidone. For example, one study reported that lurasidone may have a high risk of movement disorders, while another study reported that the risk of movement disorders is low. 3 , 25 , 14 . This may be due to differences in research methods and subjects.

Precautions for application in real life

Lurasidone is an effective drug for the treatment of mental illness, but it is important to understand that there is a risk of side effects. 12 . When taking lurasidone, it is important to follow your doctor's instructions and monitor your health regularly. Also, lurasidone can interact with other drugs, so it is important to consult your doctor before taking it.

Limitations of current research

Research on lurasidone is still not sufficient. In particular, further research is needed on long-term side effects and effects on specific populations. 12 .

Future research directions

Lurasidone has been shown to have a lower risk of metabolic and cardiac side effects compared to other antipsychotics, but further research is needed on long-term side effects and effects on specific populations. 12 . Future research should investigate the long-term safety and efficacy of lurasidone, as well as its effects on specific populations.

Conclusion

Lurasidone is an effective drug for the treatment of mental illness, but it is important to understand that there is a risk of side effects. 12 . When taking lurasidone, it is important to follow your doctor's instructions and monitor your health regularly. Also, lurasidone can interact with other drugs, so it is important to consult your doctor before taking it.