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Antipsychotic-Induced Weight Gain: Dose-Response Meta-Analysis of Randomized Controlled Trials.

Author: DavisJohn M, HamzaTasnim, LeuchtStefan, SalantiGeorgia, Schneider-ThomaJohannes, SiafisSpyridon, WuHui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This meta-analysis investigated the dose-response relationship between second-generation antipsychotics and weight gain in adults with acute exacerbation of schizophrenia or negative symptoms. Most drugs produced mild weight gain compared to placebo, but significant weight gain was observed with some drugs. Dose-response curves varied, with some showing an initial increase in weight that plateaued at higher doses, while others showed no plateau or even bell-shaped curves. This information is important for informing dosing decisions in clinical practice.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Weight gain is among the most important side-effects of antipsychotics. It is, however, unclear whether it is associated with antipsychotic doses. We aimed to fill this gap with a dose-response meta-analysis. METHODS: We searched multiple electronic databases (last update search June 20...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077426/

データ提供：米国国立医学図書館（NLM）

Antipsychotic-Induced Weight Gain: A Dose-Dependent Journey

The use of antipsychotic medications can be a double-edged sword, offering relief from mental health conditions while potentially leading to unwanted side effects, such as weight gain. This meta-analysis investigates the dose-response relationship between antipsychotic medications and weight gain in adults with schizophrenia. The research aims to determine the extent to which antipsychotic doses contribute to weight gain, providing valuable insights for clinical decision-making.

Understanding the Weight Gain Landscape

This meta-analysis offers a comprehensive overview of the dose-response relationship between antipsychotics and weight gain, providing valuable insights for clinicians. The findings highlight the importance of careful dose titration and monitoring for weight changes when prescribing these medications, particularly for patients with a higher risk of weight gain. This research helps us navigate the complex terrain of antipsychotic treatment, seeking to maximize benefits while minimizing potential side effects.

Navigating the Desert of Antipsychotic Treatment

This research is like a carefully crafted map guiding us through the desert of antipsychotic treatment, helping us navigate the complexities of dose-response relationships and weight management. The study offers valuable insights into the potential risks and benefits of antipsychotic medications, allowing us to make informed decisions about treatment strategies.

Dr.Camel's Conclusion

This meta-analysis is like a compass guiding us through the complex world of antipsychotic medications, helping us understand the impact of dosage on weight gain. The findings emphasize the importance of careful dose titration and monitoring for weight changes, ensuring the best possible outcomes for patients seeking relief from mental health conditions.

Date :
  1. Date Completed 2022-05-10
  2. Date Revised 2023-02-09
Further Info :

Pubmed ID

35137229

DOI: Digital Object Identifier

PMC9077426

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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