Effects of methocarbamol: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Main Research Findings

Methocarbamol is a muscle relaxant commonly used for the treatment of muscle spasms and pain. Numerous studies have investigated its efficacy and safety.

For instance, a study ( 2 ) found that methocarbamol was as effective as diazepam for acute low back pain, while another study ( 24 ) suggested that methocarbamol is beneficial for treating myofascial low back pain. Additionally, a study ( 8 ) indicated that methocarbamol might be effective for managing muscle cramps in patients with cirrhosis.

However, a study ( 6 ) revealed a possible increased risk of opioid overdose when methocarbamol is used in conjunction with opioids. Another study ( 19 ) suggested that methocarbamol might inhibit the metabolism of opioids, requiring caution when used with opioids.

Furthermore, a study ( 13 ) discovered that methocarbamol inhibits sodium channels in mouse muscles, leading to reduced muscle force.

Benefits and Risks

Benefits Summary

Methocarbamol holds the potential to be effective in treating conditions like acute low back pain, myofascial low back pain, and muscle cramps in patients with cirrhosis.

Risks Summary

Methocarbamol might elevate the risk of opioid overdose when used with opioids. It may also inhibit the metabolism of opioids, necessitating careful consideration when used in combination with these medications.

Comparison of Studies

Commonalities

Many studies have indicated that methocarbamol could be effective for managing muscle spasms and pain. It is generally considered a safe medication.

Differences

The effects and risks associated with methocarbamol can vary across studies. For instance, research findings regarding the potential for methocarbamol to increase the risk of opioid overdose when used alongside opioids are inconsistent.

Consistency and Contradictions in Findings

While methocarbamol might be beneficial for treating muscle spasms and pain, further research is warranted to clarify its effects and risks.

Cautions for Real-Life Applications

It is crucial to adhere to a physician's instructions when using methocarbamol. Notably, individuals taking opioids should consult their physician before using methocarbamol.

Limitations of Current Research

Current research on the effects and risks of methocarbamol is insufficient. Further investigation, particularly focusing on the potential for methocarbamol to increase the risk of opioid overdose when combined with opioids, is needed.

Future Research Directions

Large-scale clinical trials are required to comprehensively understand the effects and risks of methocarbamol. Research involving patients using opioids is also crucial to investigate the potential for methocarbamol to increase the risk of opioid overdose in these individuals.

Conclusion

Methocarbamol might be effective for treating muscle spasms and pain, but further research is essential to solidify its effects and risks. Following a physician's instructions is critical when using this medication.

Literature analysis of 24 papers
Positive Content
17
Neutral Content
3
Negative Content
4
Article Type
4
0
0
4
24
2.

Methocarbamol versus diazepam in acute low back pain in the emergency department: a randomised double-blind clinical trial.

Author: SharifiMeisam, AbdorazzaghnejadAli, YazdchiMahtab, BahreiniMaryam

Pain relief
Drowsiness
Low back pain

This clinical trial compared the efficacy and adverse effects of methocarbamol and diazepam for acute low back pain in the emergency department. The study found that both drugs significantly reduced pain scores after 60 minutes, with diazepam showing slightly greater pain reductions. However, diazepam was associated with a higher risk of drowsiness. The study concluded that both methocarbamol and diazepam can be effective for acute low back pain, but clinicians should consider the potential for drowsiness with diazepam.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Nerve block with liposomal bupivacaine yields fewer complications and similar pain relief when compared to an interscalene catheter for arthroscopic shoulder surgery: a randomized controlled trial.

Author: WallKevin C, ElphingstoneJoseph, PaulKyle D, ArguelloAlexandra, PandeyAkash, QureshiHamza, McGwinGerald, MacBethLisa, FeinsteinJoel, MomayaAmit, PonceBrent, BrabstonEugene

Pain relief

This study aims to compare the complication rates and pain relief of liposomal bupivacaine brachial plexus nerve block to a conventional interscalene catheter (ISC) in patients undergoing arthroscopic shoulder surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Identifying Clinically Relevant Drug-Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection.

Author: MianoTodd A, WangLei, LeonardCharles E, BrensingerColleen M, ActonEmily K, DawwasGhadeer K, BilkerWarren B, SopranoSamantha E, NguyenThanh Phuong Pham, WoodyGeorge, YuElmer, NeumanMark, LiLang, HennessySean

Buprenorphine DDIs
Methadone DDIs

This study performed high-throughput screening for clinically relevant drug-drug interactions (DDIs) with methadone or buprenorphine using pharmacoepidemiologic and pharmacokinetic approaches. Statistically significant DDIs were identified, including gabapentinoids with either methadone or buprenorphine, baclofen with methadone, and benzodiazepines with methadone. Pharmacokinetic screening identified two potential DDIs (clonidine and fluconazole with buprenorphine).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.

Author: KhanNazleen F, BykovKatsiaryna, BarnettMichael L, GlynnRobert J, VineSeanna M, GagneJoshua J

Opioid overdose risk

This study compared the risk of opioid overdose in patients on long-term opioid therapy who concurrently initiate skeletal muscle relaxants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Treatment of Muscle Cramps in Patients With Cirrhosis of Liver: A Systematic Review.

Author: KaliaShivam, NathPreetam, PathakMona, AnandAnil C

Muscle cramp relief

Muscle cramps are common in patients with cirrhosis of the liver and significantly impact quality of life. This study aimed to systematically review available therapeutic options for muscle cramps in patients with cirrhosis of the liver. The review focuses on providing evidence-based management protocols due to the scarcity of trials on treatment options in the literature.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Efficacy of Methocarbamol for Acute Pain Management in Young Adults With Traumatic Rib Fractures.

Author: DeloneyLindsay P, Smith CondeniMelanie, CarterCassandra, PrivetteAlicia, LeonStuart, ErikssonEvert A

Opioid sparing
Rib fracture pain relief

This study found that methocarbamol, a non-opioid muscle relaxant, significantly reduced daily opioid requirements in young adults with rib fractures. The addition of methocarbamol to the pain control regimen resulted in a 35% decrease in cumulative opioid exposure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

13.

Methocarbamol blocks muscular Na<sub>v</sub> 1.4 channels and decreases isometric force of mouse muscles.

Author: ZhangYaxin, OttoPhilipp, QinLu, EiberNane, HashemolhosseiniSaid, KrögerStephan, BrinkmeierHeinrich

Muscle relaxation
Na+ channel inhibition

This study provides evidence for peripheral actions of methocarbamol on skeletal muscle. Methocarbamol, at 2 mM, decreased the decay of endplate currents, slowed the decay of endplate potentials and reduced tetanic force of soleus muscles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

[Myofascial chronic pelvic pain in women : A retrospective evaluation of the effects of specific diagnostics and therapy].

Author: SchwagerusL, DörnerK, BenderS, MüllerK, BitterlichN, RothkötterH-J, GüntherO

Chronic pelvic pain treatment

Specific diagnostics and therapy can be effective for myofascial chronic pelvic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

16.

Opioid prescribing practices after posterior spinal arthrodesis for adolescent idiopathic scoliosis.

Author: HarrisAndrew B, PuvanesarajahVarun, MarracheMajd, GottlichCaleb P, RaadMicheal, SkolaskyRichard L, NjokuDolores B, SponsellerPaul D, JainAmit

Opioid compliance
Opioid overdose

Most opioid prescriptions after posterior spinal fusion in adolescent idiopathic scoliosis patients comply with CDC guidelines, but variations in prescribing practices exist, highlighting the need for standardization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Multimodal analgesia for craniotomy.

Author: BanVin Shen, BhojaRavi, McDonaghDavid L

Improved pain control
Multimodal analgesia
Reduced opioid use

Multimodal analgesia, including acetaminophen and gabapentinoids, scalp blocks, and intraoperative dexmedetomidine, may be beneficial in reducing postoperative opioid requirements and improving pain control in craniotomy patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Randomized-controlled trial of methocarbamol as a novel treatment for muscle cramps in cirrhotic patients.

Author: Abd-ElsalamSherief, ArafaMona, ElkadeemMahmoud, ElfertAsem, SolimanShaimaa, ElkhalawanyWalaa, BadawiRehab

Effective for cramps
Safe
Well tolerated
Drowsiness
Dry mouth

This study evaluated the efficacy and safety of methocarbamol in controlling muscle cramps in cirrhotic patients. Methocarbamol showed a significant decrease in the frequency and duration of cramps. Few side effects of methocarbamol were recorded, including dry mouth and drowsiness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Impact of Medicine Withdrawal on Reporting of Adverse Events Involving Therapeutic Alternatives: A Study from the French Spontaneous Reporting Database.

Author: PageotCécile, BezinJulien, SmithAndy, ArnaudMickael, SalvoFrancesco, HaramburuFrançoise, BégaudBernard, ParienteAntoine,

The withdrawal of drugs from the market is often studied by looking at how people switch to other medications. However, this study explores how the reporting of side effects changes when people switch to new drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Uptake and Disposition of Select Pharmaceuticals by Bluegill Exposed at Constant Concentrations in a Flow-Through Aquatic Exposure System.

Author: ZhaoJian-Liang, FurlongEdward T, SchoenfussHeiko L, KolpinDana W, BirdKyle L, FeifarekDavid J, SchwabEric A, YingGuang-Guo

Pharmaceutical effects on fish

Temazepam and methocarbamol were the most frequently detected pharmaceuticals in bluegill sunfish exposed to environmentally relevant concentrations in a flow-through exposure system.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

23.

Complex mixtures, complex responses: Assessing pharmaceutical mixtures using field and laboratory approaches.

Author: SchoenfussHeiko L, FurlongEdward T, PhillipsPat J, ScottTia-Marie, KolpinDana W, Cetkovic-CvrljeMarina, LestebergKelsey E, RearickDaniel C

Fish population impact

This study assessed the effects of pharmaceuticals in laboratory exposures of fathead minnows and added environmental complexity through effluent exposures. The results suggest that effluents containing waste streams from pharmaceutical formulation facilities can adversely impact fish populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

24.

[Methocarbamol in acute low back pain. A randomized double-blind controlled study].

Author: EmrichOliver M D, MilachowskiKlaus A, StrohmeierMartin

LBP treatment

Methocarbamol is a muscle relaxant used to treat low back pain. This study reevaluated data from a 2002 study on the efficacy of methocarbamol for low back pain associated with myofascial components.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

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