Effects of mycophenolate: A Synthesis of Findings from 5 Studies

  1. Home
  2. Effects of mycophenolate
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of mycophenolate: A Synthesis of Findings from 5 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of mycophenolate: A Synthesis of Findings from 5 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Mycophenolate mofetil has been shown to improve graft survival after organ transplantation, 3 , but its use may be limited by significant adverse effects. 3 An enteric-coated formulation of mycophenolate sodium has been developed to address these issues. 3 However, more pharmacokinetic data on mycophenolic acid release from this formulation is needed. 3

Mycophenolate is also increasingly used for rheumatic diseases, particularly systemic sclerosis (SSc), 5 . However, gastrointestinal adverse effects are a common concern, as gastrointestinal involvement is prevalent in SSc. 5 Other adverse effects include myelosuppression and infection. 5

Long-term use of cyclosporine (CsA) for maintenance immunosuppression after kidney transplantation is associated with chronic transplant nephropathy and adverse effects on blood pressure and lipid profile. 1 Several nonrandomized studies suggest that CsA might be safely withdrawn from immunosuppressive regimens containing mycophenolate mofetil (MMF; CellCept). 1

Calcineurin inhibitor (CNI)-based therapy for kidney transplant recipients is associated with adverse cardiovascular effects, specifically left ventricular diastolic dysfunction. 4 Late withdrawal of CNI or mycophenolate mofetil (MMF) may prevent this progressive dysfunction. 4

The study on simultaneous pancreas-kidney transplantation reported the early and late secondary effects of tacrolimus or cyclosporine-microemulsion (ME) combined with mycophenolate mofetil (MMF) and rATG. 2

Benefits and Risks

Benefit Summary

Mycophenolate has shown benefits in improving graft survival after organ transplantation. 3 It is also used for treating rheumatic diseases, specifically systemic sclerosis (SSc). 5 Research suggests that mycophenolate may reduce the adverse effects associated with cyclosporine, such as chronic transplant nephropathy, blood pressure issues, and lipid profile problems. 1 Additionally, late withdrawal of CNI or mycophenolate mofetil (MMF) may prevent progressive left ventricular diastolic dysfunction in kidney transplant recipients. 4

Risk Summary

Mycophenolate can have adverse effects, including gastrointestinal issues, myelosuppression, and infection. 3 5 These risks are particularly relevant for SSc patients due to the high prevalence of gastrointestinal involvement. 5

Comparison of Studies

Similarities

The studies highlight the crucial role of mycophenolate in immunosuppressive therapy after organ transplantation and its potential benefits in treating rheumatic diseases. They also suggest a potential reduction in adverse effects when mycophenolate is used in combination with other immunosuppressive agents.

Differences

Each study focuses on different aspects of mycophenolate use, including specific disease targets, patient populations, and co-administered medications. 1 focuses on kidney transplant recipients and the potential for safely withdrawing CsA, 5 examines mycophenolate in SSc, and 2 investigates its use in simultaneous pancreas-kidney transplantation. 3 explores the pharmacokinetics of mycophenolate sodium, comparing it to the mofetil formulation. 4 examines the effects of late CNI or MMF withdrawal on echocardiographic parameters in renal transplant recipients.

Consistency and Contradictions

The studies consistently show that mycophenolate is a valuable treatment option for immunosuppression after organ transplantation and for treating certain rheumatic diseases. However, reports on adverse effects vary. While some studies highlight specific adverse effects like those mentioned in 3 , others focus on specific combinations with other drugs, as seen in 1 . A comprehensive evaluation of these findings provides a deeper understanding of mycophenolate's benefits and risks.

Implications for Everyday Life

Mycophenolate is used for various conditions, including organ transplantation and rheumatic diseases. However, due to its potential adverse effects, it should be used under the guidance of a healthcare professional. This is particularly important for patients with pre-existing gastrointestinal issues or those at risk for myelosuppression or infection.

Limitations of Current Research

These studies are specific to certain diseases and treatments, limiting their generalizability. Additionally, variations in study design, sample size, and follow-up duration can make comparing and interpreting results challenging.

Future Research Directions

Further research is needed to understand the long-term effects and safety of mycophenolate. This includes studies investigating optimal dosages and administration methods for different diseases and treatment combinations, along with preventative measures for adverse effects. Additionally, research on the detailed mechanisms by which mycophenolate affects immune cells is crucial.

Conclusion

Mycophenolate has proven to be an effective treatment option for a range of conditions, including organ transplantation and rheumatic diseases. However, potential adverse effects necessitate careful consideration and monitoring. Future research is critical to optimize mycophenolate use, ensuring its benefits are maximized while minimizing risks. Consulting a healthcare professional for personalized guidance is essential before using mycophenolate.

Literature analysis of 5 papers
Positive Content
5
Neutral Content
0
Negative Content
0
Article Type
4
1
1
1
5
1.

Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen in stable kidney transplant recipients: a randomized, controlled study.

Author: AbramowiczDaniel, ManasDerek, LaoMieczyslaw, VanrenterghemYves, Del CastilloDomingo, WijngaardPeter, FungSamson,

Immunosuppression withdrawal
Blood pressure
Lipid profile
Nephropathy

Long-term cyclosporine use can cause chronic transplant nephropathy and other side effects. Studies suggest that cyclosporine might be safely withdrawn from immunosuppressive regimens containing mycophenolate mofetil.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Immunosuppressive drugs after simultaneous pancreas-kidney transplantation.

Author: MalaiseJ, KuypersD R J, ClaesK, EvenepoelP, MaesB, CoosemansW, PirenneJ, VanrenterghemY, Van OphemD, SquiffletJ P,

Effective transplant therapy
Reduced graft loss
Drug discontinuation
Pancreas graft thrombosis

Short-term induction therapy in combined kidney-pancreas transplantation is effective and well tolerated. Tacrolimus causes fewer pancreas graft losses and fewer drug discontinuations due to side effects. When MMF is combined with tacrolimus, dose reductions and discontinuations are common.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Pharmacokinetics of mycophenolate sodium and comparison with the mofetil formulation in stable kidney transplant recipients.

Author: CattaneoDario, CortinovisMonica, BaldelliSara, BittoAlessandra, GottiEliana, RemuzziGiuseppe, PericoNorberto

Graft survival
Organ transplantation
Adverse effects

This study explores the development of an enteric-coated formulation of mycophenolate sodium as an alternative to mycophenolate mofetil to improve graft survival after organ transplantation. While mycophenolate mofetil has proven beneficial, its side effects can be limiting. This formulation addresses those concerns, but further pharmacokinetic data on mycophenolic acid release is needed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Late calcineurin inhibitor withdrawal prevents progressive left ventricular diastolic dysfunction in renal transplant recipients.

Author: MourerJacqueline S, EweSee Hooi, MallatMarko J K, NgArnold C T, RabelinkTon J, BaxJeroen J, DelgadoVictoria, de FijterJohan W

Better blood pressure control
Prevent LV diastolic dysfunction

Late calcineurin inhibitor withdrawal prevented progressive development of left ventricular diastolic dysfunction and facilitated better blood pressure control in stable renal transplant recipients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Safety and effectiveness of mycophenolate in systemic sclerosis. A systematic review.

Author: OmairMohammed A, AlahmadiAbdulaziz, JohnsonSindhu R

SSc treatment
Gastrointestinal side effects
Infection
Myelosuppression

This study evaluated gastrointestinal adverse events of mycophenolate in systemic sclerosis (SSc) and its effectiveness in skin and lung disease. Mycophenolate's gastrointestinal adverse effects may limit its use in SSc.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.