Effective treatment of nausea: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Major Research Findings

Nausea and vomiting are common side effects of cancer treatment, especially chemotherapy. While standard antiemetic medications are available, they don’t always fully eliminate these symptoms, leading to a significant impact on the quality of life of patients. This has spurred research into various alternative and complementary treatments to manage these symptoms effectively. 20 delves into the effectiveness of cannabinoids as an adjunct to standard antiemetic therapy. The review indicates that while cannabinoids may potentially offer benefits, the evidence for their efficacy in managing chemotherapy-induced nausea and vomiting remains uncertain due to the low certainty of the available evidence. Furthermore, the use of cannabinoids is likely to increase adverse effects. 11 investigates acupressure as a non-pharmacological treatment for chemotherapy-related nausea and vomiting. The research shows highly suggestive evidence of a positive effect from acupressure, prompting further investigation into its potential as an adjuvant therapy. 12 explores electroacupuncture for managing chemotherapy-induced nausea and vomiting. The research indicates that electroacupuncture might be beneficial, but further research is necessary to identify the most effective acupoints and their applications. 17 examines acupuncture as an adjunctive treatment for chemotherapy-induced nausea and vomiting. Similar to electroacupuncture, the study suggests that acupuncture might offer benefits, but further research is warranted to confirm its efficacy. 14 reviews pharmacological interventions for managing chemotherapy-induced nausea and vomiting in children. The study highlights the potential effectiveness of 5-HT3 antagonists in preventing and treating these symptoms in children, and it recommends further research to optimize antiemetic regimens for children undergoing chemotherapy. 28 evaluates the effect of peppermint-lemon aromatherapy on nausea and vomiting, as well as quality of life, in children with leukemia undergoing chemotherapy. This study suggests that peppermint-lemon aromatherapy might be a helpful alternative method for improving quality of life and managing chemotherapy-induced nausea and vomiting in children with leukemia. 24 explores the use of olanzapine for treating chronic nausea and vomiting in patients with advanced cancer, unrelated to chemotherapy. The study suggests that olanzapine might be effective in managing these symptoms in such patients. 8 investigates auricular acupressure for reducing chemotherapy-induced nausea and vomiting in children with cancer. While the study shows that auricular acupressure is acceptable to children and parents, it concludes that further research with a larger sample size is needed to definitively establish its efficacy. 25 assesses acupressure for managing nausea and vomiting in palliative care patients with advanced cancer. This study found that acupressure at the pericardium 6 site didn’t show any significant benefit over a placebo for these patients. 7 reviews aromatherapy for the treatment of postoperative nausea and vomiting. The review suggests that isopropyl alcohol inhalation might be more effective than a saline placebo for reducing postoperative nausea and vomiting, but less effective than standard antiemetic medications. 10 presents a study protocol for a randomized placebo-controlled trial investigating the use of an overshadowing technique to prevent anticipatory nausea and vomiting in pediatric cancer patients. Overshadowing aims to reduce the intensity and duration of nausea and vomiting by minimizing anticipatory anxiety. 3 evaluates encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. The study concludes that ginger doesn’t provide additional benefit for reducing the prevalence or severity of acute or delayed nausea and vomiting when used in conjunction with standard antiemetic medications. 9 compares the effectiveness of olanzapine and metoclopramide for managing breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy. The study suggests that olanzapine is more effective than metoclopramide in controlling breakthrough nausea and vomiting in patients receiving highly emetogenic chemotherapy. 26 examines the use of aprepitant for preventing chemotherapy-induced nausea and vomiting in women. The study finds that combining aprepitant with palonosetron and dexamethasone offers increased antiemetic efficacy in women with gastrointestinal cancer who consume little or no alcohol. 16 investigates the preliminary effects of massage and inhalation aromatherapy on chemotherapy-induced acute nausea and vomiting. The study suggests that both massage and inhalation aromatherapy might be promising non-pharmacological approaches for managing chemotherapy-induced nausea and vomiting. 6 evaluates the efficacy and safety of gabapentin for preventing chemotherapy-induced nausea and vomiting. The study suggests that gabapentin might be effective in preventing nausea and vomiting in patients undergoing chemotherapy. 18 reviews the use of corticosteroids for managing nausea and vomiting in adult patients with advanced cancer, unrelated to chemotherapy, radiotherapy, or surgery. The study highlights that while corticosteroids are often used for these conditions, there is little objective evidence to support their efficacy. 2 evaluates acupressure at the pericardium 6 (Neiguan) acupoint for managing chemotherapy-induced nausea and vomiting. This study suggests that acupressure at this specific acupoint might be effective in managing chemotherapy-induced nausea and vomiting. 27 reviews the use of food-based interventions for managing nausea and vomiting in patients undergoing chemoradiotherapy. The review suggests that dietary modifications might be a potential avenue for improving the symptom experience. 23 presents the results of a randomized clinical trial investigating the use of bimodal release ondansetron for treating vomiting caused by acute gastroenteritis in adolescents and adults. This study suggests that bimodal release ondansetron might be effective for managing vomiting in these patients. 19 investigates the use of sumatriptan nasal powder for reducing nausea associated with migraine. This study suggests that sumatriptan nasal powder might be more effective than sumatriptan tablets for managing migraine-related nausea. 15 suggests that latent inhibition, a technique that involves repeated exposure to a stimulus without an outcome, could effectively and ethically reduce nocebo nausea.

Treatment Summary

Several treatments have been investigated for managing nausea and vomiting associated with cancer treatment, including standard antiemetics, cannabinoids, acupressure, electroacupuncture, acupuncture, aromatherapy, ginger, olanzapine, gabapentin, and corticosteroids. 20 、 11 、 12 、 17 、 14 、 28 、 24 、 8 、 25 、 7 、 3 、 9 、 26 、 16 、 6 、 18 、 2

Benefits and Risks

Benefit Summary

Research indicates that various methods, including acupuncture, aromatherapy, acupressure, and olanzapine, might offer benefits alongside standard antiemetics in managing nausea and vomiting. 11 、 12 、 17 、 24 、 8 、 2

Risk Summary

While cannabinoids may potentially offer benefits, they are also associated with an increased risk of adverse effects. 20 、 14

Research Comparison

Research Similarities

Many studies suggest that combining various methods with standard antiemetic therapy may lead to improved management of nausea and vomiting. 11 、 12 、 17 、 24 、 8 、 2

Research Differences

The specific treatments identified as effective and their levels of effectiveness vary between studies. 11 、 12 、 17 、 24 、 8 、 2

Consistency and Contradictions of Findings

While some research findings are consistent, there are also contradictions. For instance, cannabinoids show potential for managing nausea and vomiting, but they are also linked to an increased risk of adverse effects. 20 、 14

Practical Application Considerations

It is important to consider that while various methods might offer additional benefits alongside standard antiemetics, they are not without risks. Consulting with healthcare professionals is essential for individualizing treatment plans and assessing potential risks and benefits. 20

Current Research Limitations

Research on treatments for nausea and vomiting remains limited. There is a need for more extensive research, particularly focusing on long-term effects and safety evaluations. 20

Future Research Directions

Further research on treatments for nausea and vomiting is necessary. This includes studies that evaluate the long-term efficacy and safety of various treatments. Research focused on identifying the most effective treatments for individual patients is also crucial. 20

Conclusion

Nausea and vomiting are challenging side effects for cancer patients undergoing chemotherapy. While research is ongoing, there is a need for more comprehensive understanding of various treatments, their effectiveness, and their safety profiles. Patients experiencing these symptoms should consult with their healthcare providers to discuss available options and find the most effective treatment plan for their individual needs. 20

Treatment List

Cannabinoids, Acupuncture, Aromatherapy, Acupressure, Ginger, Olanzapine, Gabapentin, Corticosteroids

Literature analysis of 28 papers
Positive Content
24
Neutral Content
1
Negative Content
3
Article Type
19
7
8
9
28
1.

Comparison of intravenous granisetron with metoclopramide in the treatment of chemotherapy-induced emesis.

Author: ChiouT J, WeiC H, HsiehR K, FanF S, LiuJ H, ChenP M

Reduces nausea and vomiting

This study evaluated the effect of granisetron, a 5HT3 receptor antagonist, on antiemesis in patients receiving cisplatin-based chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

The effects of P6 acupressure in the prophylaxis of chemotherapy-related nausea and vomiting in breast cancer patients.

Author: MolassiotisA, HelinA M, DabbourR, HummerstonS

Chemotherapy-induced nausea reduction

This study evaluated the effectiveness of acupressure at the Pericardium 6 (Neiguan) acu-point in managing chemotherapy-induced nausea and vomiting, suggesting its potential to enhance the effectiveness of antiemetics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting.

Author: ZickSuzanna M, RuffinMack T, LeeJulia, NormolleDaniel P, SidenRivka, AlrawiSara, BrennerDean E

Ineffective for CINV

Ginger provides no additional benefit for reduction of the prevalence or severity of acute or delayed chemotherapy-induced nausea and vomiting (CINV) when given with 5-HT3 receptor antagonists and/or aprepitant.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

4.

Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood.

Author: PhillipsRobert S, GopaulShireen, GibsonFaith, HoughtonElizabeth, CraigJean V, LightKate, PizerBarry

Reduced nausea
Reduced vomiting
Side effects

5-HT(3) antagonists with dexamethasone added were effective in preventing chemotherapy-induced nausea and vomiting in children, but further research with validated, age-appropriate measures is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Droperidol for treatment of nausea and vomiting in palliative care patients.

Author: DormanSaskie, PerkinsPaul

Nausea and vomiting treatment

This study discusses the use of droperidol, an antipsychotic medication, for treating nausea and vomiting in patients with terminal illnesses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a pilot study.

Author: CruzFelipe Melo, de Iracema Gomes CuberoDaniel, TarantoPatrícia, LernerTatiana, LeraAndrea Thaumaturgo, da Costa MirandaMichele, da Cunha VieiraMariana, de Souza FêdeAngelo Bezerra, SchindlerFernanda, CarrascoMércia Maleckas, de AfonsecaSamuel Oliveira, PinczowskiHélio, del GiglioAuro

CINV prevention
Chemotherapy-induced nausea and vomiting

A trial is evaluating the efficacy and safety of gabapentin in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Aromatherapy for treatment of postoperative nausea and vomiting.

Author: HinesSonia, SteelsElizabeth, ChangAnne, GibbonsKristen

Postoperative nausea treatment
Less effective than drugs

This review of nine studies examined the effect of aromatherapy on postoperative nausea and vomiting. Isopropyl alcohol vapor inhalation was found to be more effective than placebo in reducing the proportion of participants requiring rescue anti-emetics, but less effective than standard anti-emetic drugs. There is currently no reliable evidence for the use of peppermint oil.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Reduction in nausea and vomiting in children undergoing cancer chemotherapy by either appropriate or sham auricular acupuncture points with standard care.

Author: YehChao Hsing, ChienLung-Chang, ChiangYi Chien, LinSu Wen, HuangChen Kuan, RenDianxu

CINV treatment
Small sample size

Auricular acupressure is acceptable to children and their parents to prevent/treat CINV, but there were no statistically significant differences between the AAP and SAP groups in the prevention/treatment of CINV.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy.

Author: NavariRudolph M, NagyCindy K, GraySarah E

Reduced nausea and vomiting

Olanzapine was significantly better than metoclopramide in the control of breakthrough emesis and nausea in patients receiving highly emetogenic chemotherapy.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Overshadowing as prevention of anticipatory nausea and vomiting in pediatric cancer patients: study protocol for a randomized controlled trial.

Author: GeigerFriedemann, WolfgramLevke

Nausea and vomiting prevention

This study aims to investigate whether a technique called overshadowing can help prevent anticipatory nausea and vomiting in cancer patients receiving chemotherapy. The study will also assess the impact of overshadowing on anxiety levels, treatment adherence, and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

The effectiveness and cost-effectiveness of acupressure for the control and management of chemotherapy-related acute and delayed nausea: Assessment of Nausea in Chemotherapy Research (ANCHoR), a randomised controlled trial.

Author: MolassiotisA, RussellW, HughesJ, BreckonsM, Lloyd-WilliamsM, RichardsonJ, HulmeC, BrearleyS, CampbellM, GarrowA, RyderWd

Acupressure efficacy
Chemotherapy side effects

Chemotherapy-induced nausea and vomiting remain a challenge to manage. Acupressure, a non-pharmacological therapy, shows promising evidence for reducing these symptoms and warrants further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Efficacy and safety of electroacupuncture with different acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial.

Author: ChenBo, HuShu-xiang, LiuBao-hu, ZhaoTian-yi, LiBo, LiuYan, LiMing-yue, PanXing-fang, GuoYong-ming, ChenZe-lin, GuoYi

Electroacupuncture
Chemotherapy-induced nausea and vomiting

Electroacupuncture was found to be beneficial for controlling chemotherapy-induced nausea and vomiting (CINV), with potential for further investigation to identify the most effective acupoint for treating CINV.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Drugs for the treatment of nausea and vomiting in adults in the emergency department setting.

Author: FurykJeremy S, MeekRobert A, Egerton-WarburtonDiana

This research examines the optimal drug treatment of nausea and vomiting in adult patients presenting to emergency departments (EDs). The study highlights the diverse causes of nausea and vomiting in ED settings and the lack of consensus on the best treatment approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood.

Author: PhillipsRobert S, FriendAmanda J, GibsonFaith, HoughtonElizabeth, GopaulShireen, CraigJean V, PizerBarry

Improved quality of life
Reduced nausea
Reduced vomiting
Steroid side effects

5-HT3 antagonists are effective in patients who are to receive emetogenic chemotherapy, with granisetron or palonosetron possibly better than ondansetron. Adding dexamethasone improves control of vomiting, although the risk-benefit profile of adjunctive steroid remains uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Latent Inhibition Reduces Nocebo Nausea, Even Without Deception.

Author: QuinnV F, LiveseyE J, ColagiuriB

Reduced nocebo nausea

This study tested whether ‘latent inhibition’ could reduce nocebo nausea in healthy adults. The study found clear evidence of conditioned nocebo nausea that was eradicated by latent inhibition following pre-exposure to placebo stimulation. The study also found that open pre-exposure was just as effective for reducing nocebo nausea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

The Preliminary Effects of Massage and Inhalation Aromatherapy on Chemotherapy-Induced Acute Nausea and Vomiting: A Quasi-Randomized Controlled Pilot Trial.

Author: ZorbaPinar, OzdemirLeyla

Reduced nausea severity
Reduced nausea/retching incidence

Massage and inhalation aromatherapy seemed promising regarding the management of chemotherapy-induced nausea and vomiting (CINV), with nausea severity significantly lower in the massage and inhalation aromatherapy groups than in the control group. Nausea and retching incidence was reduced in the aromatherapy groups compared with that in the control group.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Effect of acupuncture in prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: study protocol for a randomized controlled trial.

Author: LiQi-Wei, YuMing-Wei, YangGuo-Wang, WangXiao-Min, WangHuan, ZhangChen-Xi, XueNa, XuWei-Ru, FuQi, YangZhong, YangLin

Nausea and vomiting are common and upsetting side effects of chemotherapy for cancer patients. While medications have improved, there are challenges in using these medications. Acupuncture is a potential non-drug treatment for these symptoms but more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy, radiotherapy, or surgery).

Author: Vayne-BossertPetra, HaywoodAlison, GoodPhillip, KhanSohil, RickettKirsty, HardyJanet R

Nausea treatment
Corticosteroid side effects

Nausea is a common symptom in people with advanced cancer, affecting up to 70% of patients. While nausea can be caused by treatments like chemotherapy, radiation, or surgery, a significant number of people experience nausea unrelated to these treatments. Nausea can cause emotional distress and worsen quality of life for cancer patients. While corticosteroids are commonly used for nausea, their exact mechanism for relieving nausea is unknown. They also have potential side effects. Despite widespread use, there is limited evidence on how effective they are for nausea not related to cancer treatment. Further research is needed to understand their effects and determine if there are better options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

AVP-825 (Sumatriptan Nasal Powder) Reduces Nausea Compared to Sumatriptan Tablets: Results of the COMPASS Randomized Clinical Trial.

Author: LiptonRichard B, McGinleyJames S, ShulmanKenneth J, SilbersteinStephen D, WirthR J, BuseDawn C

Migraine treatment

Nausea is a common and debilitating symptom of migraine that can make it difficult to take medication or lead to poor treatment outcomes. While nausea is often a part of migraine itself, it can also be caused by migraine medications. Reducing nausea and minimizing medication-related nausea are important goals in treating migraine attacks.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Are cannabinoids effective for the management of chemotherapy induced nausea and vomiting?

Author: MoralesMariaignacia, CorsiOscar, PeñaJosé

None mentioned
Increased adverse effects

The addition of cannabinoids to standard antiemetic regimes may not benefit patients with chemotherapy-induced nausea and vomiting. The evidence is very low, and cannabinoids may increase adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Spanish

21.

A randomized open-label study of guideline-driven antiemetic therapy versus single agent antiemetic therapy in patients with advanced cancer and nausea not related to anticancer treatment.

Author: HardyJanet, SkermanHelen, GlarePaul, PhilipJennifer, HudsonPeter, MitchellGeoffrey, MartinPeter, SpruytOdette, CurrowDavid, YatesPatsy

Nausea/vomiting treatment

This study compared the effectiveness of etiology-based guideline-driven antiemetic regimens and an empiric approach using single agents for managing nausea/vomiting (N/V) in patients with advanced cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Olanzapine for the prevention and treatment of cancer-related nausea and vomiting in adults.

Author: SutherlandAnna, NaessensKatrien, PluggeEmma, WareLynda, HeadKaren, BurtonMartin J, WeeBee

Reduced nausea
Reduced vomiting
Adverse events
Fatigue
Somnolence

Oral olanzapine, when used as an antiemetic for cancer patients, likely doubles the chance of not experiencing nausea or vomiting during chemotherapy compared to placebo. However, it may increase the risk of other adverse events, particularly somnolence and fatigue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Bimodal Release Ondansetron for Acute Gastroenteritis Among Adolescents and Adults: A Randomized Clinical Trial.

Author: SilvermanRobert A, HouseStacey L, MeltzerAndrew C, HahnBarry, LovatoLuis M, AvarelloJahn, MillerJoseph B, KalfusIra N, FathiReza, RadayGilead, PlasseTerry F, YanEric C

Nausea and vomiting relief

Vomiting from gastroenteritis (stomach flu) is often treated with anti-nausea medications given through a vein. If effective oral treatments were available, people might not need intravenous fluids or medications. Additionally, a long-lasting oral medication could provide longer relief from nausea and vomiting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Olanzapine for the Treatment of Advanced Cancer-Related Chronic Nausea and/or Vomiting: A Randomized Pilot Trial.

Author: NavariRudolph M, PywellCameron M, Le-RademacherJennifer G, WhitePatrick, DodgeAndrew B, AlbanyCostantine, LoprinziCharles L

Emesis reduction
Improved appetite
Improved well-being
Nausea relief
Sedation

Olanzapine at 5 mg/d effectively controlled nausea and emesis in patients with advanced cancer, improving other symptoms and quality-of-life parameters, without significant adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Does acupressure help reduce nausea and vomiting in palliative care patients? A double blind randomised controlled trial.

Author: PerkinsPaul, ParkinsonAnne, ParkerRebecca, BlakenAlison, AkyeaRalph K

Acupressure ineffective

A double-blind randomized controlled trial was conducted to determine whether acupressure at the pericardium 6 site could help in the treatment of nausea and vomiting suffered by palliative care patients with advanced cancer. 57 patients were randomized to receive either active or placebo acupressure wristbands. The study found that there was no difference in any of the outcome measures between the two groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Effect of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Women: A Randomized Clinical Trial.

Author: WangDe-Shen, HuMing-Tao, WangZhi-Qiang, RenChao, QiuMiao-Zhen, LuoHui-Yan, JinYing, FongWilliam Pat, WangShu-Bin, PengJie-Wen, ZouQing-Feng, TanQiong, WangFeng-Hua, LiYu-Hong

Increased antiemetic efficacy
Well tolerated

A phase 3, double-blind, placebo-controlled randomized clinical trial of 248 women with gastrointestinal cancer found that the combination of aprepitant with palonosetron and dexamethasone provided increased antiemetic efficacy in the FOLFOX or FOLFIRI chemotherapy regimen and was well tolerated. The complete response (CR) rate was significantly higher in the aprepitant group than in the control group (87.0% vs 66.7%).

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review.

Author: MolassiotisA, ZhaoI Y, CrichtonM, OlverI, FleuryM, GiustiR, ScotteF, AffrontiM L

Improved nausea

Dietary modifications may help improve nausea and vomiting in cancer patients, but further research is needed to determine their effectiveness.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Effect of peppermint-lemon aromatherapy on nausea-vomiting and quality of life in pediatric patients with leukemia: A randomized controlled trial.

Author: ŞancıYağmur, YıldızSuzan, AyçiçekAli, MöhürNaciye

Nausea-vomiting management
Quality of life

In children with leukemia undergoing chemotherapy, inhalation aromatherapy with peppermint-lemon was effective in managing chemotherapy-induced nausea-vomiting symptoms and improving quality of life compared to placebo and control groups.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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