Side Effects of nicotine nasal spray: A Synthesis of Findings from 9 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of nicotine nasal spray: A Synthesis of Findings from 9 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Main Research Findings

Nicotine nasal spray has proven to be effective in smoking cessation. 2 It delivers nicotine rapidly, which may help alleviate withdrawal symptoms associated with quitting. 1 However, long-term success rates remain low, particularly in hard-core smokers. 5

Reasons for Side Effects

Side effects of nicotine nasal spray are often attributed to the direct contact of nicotine with the nasal mucosa. This can lead to irritation and inflammation as nicotine is a vasoconstrictor and neuro-stimulant. 3

Common Side Effects

Nasal irritation

Nasal irritation is a common side effect, manifesting as runny nose, sneezing, or congestion. 2 8 It's more prevalent during the initial stages of treatment. 8

Eye irritation

Nicotine's effects on the nasal mucosa can extend to the eyes, causing irritation. 3

Dizziness

Nicotine can affect the inner ear, leading to dizziness, lightheadedness, unsteadiness, or a spinning sensation. 3

Nausea

Nicotine's effects on the digestive system can result in nausea, stomach upset, or vomiting. 3

Other

Other reported side effects include headache, indigestion, fatigue, insomnia, and sweating. 9

Countermeasures for Side Effects

Nasal irritation

To alleviate nasal irritation, consider reducing the dosage or increasing the interval between uses. 2 Blowing your nose thoroughly before application might also help. 8

Eye irritation

Applying eye drops before using the nasal spray may help reduce eye irritation. 3

Dizziness

If dizziness is a concern, rest before using the nasal spray. 3 It's advisable to avoid standing up immediately after application.

Nausea

To minimize nausea, try eating or drinking something before using the nasal spray. 3 Avoid lying down for a while after application.

Other

If you experience any side effects, consult your doctor or pharmacist.

Comparison between Studies

Commonalities of Studies

Studies consistently show that nicotine nasal spray can increase smoking cessation success rates. 2 However, it's not effective for everyone. 5

Differences in Studies

Variations in the effectiveness and side effects of nicotine nasal spray across studies may be due to differences in participant characteristics, the type of nasal spray used, and the dosage administered. 8

Points to note about application to real life

It's crucial to understand the potential risks of side effects before using nicotine nasal spray. 3 It's also essential to use it under the guidance of a doctor. 4

Limitations of Current Research

Research on nicotine nasal spray is still limited, and much is unknown about its long-term safety and efficacy. 5

Future research directions needed

Further research is needed to evaluate the long-term safety and effectiveness of nicotine nasal spray. 5 Research on methods to mitigate side effects is also essential. 8

Conclusion

Nicotine nasal spray holds promise as a smoking cessation aid, but it's important to be aware of the potential side effects. 2 Consult a doctor for guidance on using this medication. 4

Literature analysis of 9 papers
Positive Content
6
Neutral Content
1
Negative Content
2
Article Type
5
0
0
0
9
1.

Effect of nicotine nasal spray on smoking cessation. A randomized, placebo-controlled, double-blind study.

Author: HjalmarsonA, FranzonM, WestinA, WiklundO

Smoking cessation
Side effects

This study evaluated the efficacy and safety of nicotine nasal spray for smoking cessation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial.

Author: SchneiderN G, OlmsteadR, ModyF V, DoanK, FranzonM, JarvikM E, SteinbergC

Smoking cessation
Side effects

Nicotine nasal spray (NNS) was significantly more effective than placebo in helping smokers quit. NNS increased success rates at all time points, with 18% of NNS users remaining abstinent after one year.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

3.

The effect of nicotine on perceptual, ocular motor, postural, and vegetative functions at rest and in motion.

Author: ZinglerV C, DeneckeK, JahnK, von MeyerL, KrafczykS, KramsM, ElfontR, BrandtT, StruppM, GlasauerS

Dizziness
Nausea
Nicotine-induced nystagmus

Nicotine causes dizziness, nausea, and nystagmus in a dose-dependent manner. These effects may be intensified by motion stimulation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

[Nasal nicotine spray in smoking cessation. Results of a multicenter study].

Author: Jiménez RuizC A, Flórez MartínS, Ramos PinedaA, LorzaJ J, Hernández-MezquitaM A, Solano ReinaS, Barrueco FerreroM

Smoking cessation
Intolerance to medication
Nasal irritation
Rhinorrhea
Tearing

A nicotine nasal spray combined with psychological support was moderately effective in helping people quit smoking. About 35% of participants were abstinent after six months. The nasal spray caused several side effects, including nasal irritation and rhinorrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Spanish

5.

Recycling of hard-core smokers with nicotine nasal spray.

Author: TønnesenP, MikkelsenK, NørregaardJ, JørgensenS

Short-term efficacy
Smoking cessation
Low long-term success
Nicotine side effects

Nicotine nasal spray was effective for short-term smoking cessation, but long-term success rates were low, with 6% of participants still abstaining after one year. The study found no significant difference in success rate between ad libitum and fixed dosing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial.

Author: SchneiderN G, OlmsteadR, ModyF V, DoanK, FranzonM, JarvikM E, SteinbergC

Smoking cessation
Side effects

Nicotine nasal spray (NNS) was significantly more effective than placebo in helping smokers quit. NNS increased success rates at all time points, with 18% of NNS users remaining abstinent after one year.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

7.

Effect of nicotine nasal spray on smoking cessation. A randomized, placebo-controlled, double-blind study.

Author: HjalmarsonA, FranzonM, WestinA, WiklundO

Smoking cessation
Side effects

This study evaluated the efficacy and safety of nicotine nasal spray for smoking cessation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Nicotine nasal spray for smoking cessation: pattern of use, side effects, relief of withdrawal symptoms, and cotinine levels.

Author: HurtR D, DaleL C, CroghanG A, CroghanI T, Gomez-DahlL C, OffordK P

Nicotine nasal spray effective
Nicotine nasal spray reduces withdrawal symptoms
Irritant side effects

Nicotine nasal spray effectively reduced smoking rates and provided relief from withdrawal symptoms, despite significant irritant side effects during the initial days of use. These side effects decreased within the first week, suggesting that subjects continued to use the spray despite the initial discomfort.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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