Effects of omadacycline: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Main research findings

Omadacycline is a new aminomethylcycline antibiotic with a broad spectrum of activity against various bacterial species, including Gram-positive, Gram-negative, anaerobic, and atypical bacterial pathogens. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 It is available as a once-daily intravenous or bioequivalent oral formulation, making it a convenient option for patients. 2 、 6 Omadacycline has shown promising results in treating infections caused by Mycobacterium abscessus. 10 、 11 Additionally, it has been found to have low potential for causing Clostridioides difficile infection and is considered a safe option for cardiovascular health. 16 、 1 、 3 However, it is important to note that omadacycline might have some impact on bone metabolism. 18

Benefits and Risks

Benefit Summary

Omadacycline provides a broad spectrum of activity against various bacterial species, offering a potential solution for multidrug-resistant infections. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 The once-daily dosage regimen simplifies treatment for patients, reducing the burden of frequent medication administration. 2 、 6 Omadacycline is considered a promising option for treating infections caused by Mycobacterium abscessus. 10 、 11 Additionally, its low propensity to cause Clostridioides difficile infection and favorable cardiovascular safety profile make it a potentially advantageous choice for certain patients. 16 、 1 、 3

Risk Summary

Omadacycline might have an impact on bone metabolism, warranting caution, especially for pregnant and breastfeeding women. 18 Similar to other antibiotics, omadacycline can cause adverse effects such as allergic reactions and gastrointestinal issues. 6

Comparison of Studies

Similarities

Multiple studies demonstrate omadacycline’s effectiveness against a broad spectrum of bacteria. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 Many studies highlight the convenient once-daily administration, reducing the burden for patients. 2 、 6

Differences

The methods used to assess omadacycline’s efficacy and safety vary across studies. For example, some research focuses on its effectiveness against Mycobacterium abscessus infections, while others examine its impact on the cardiovascular system. 10 、 11 、 3 Additionally, the patient population and study designs differ, requiring cautious interpretation of the results.

Consistency and Contradictions

Omadacycline has demonstrated consistent effectiveness against a broad spectrum of bacterial species in numerous studies. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 Research also supports its favorable cardiovascular safety profile. 3 However, its potential impact on bone metabolism needs further investigation, particularly for pregnant and breastfeeding women. 18

Practical Considerations

While omadacycline shows promise against a broad range of bacteria, it is not effective against all infections. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 Like other antibiotics, omadacycline can cause adverse effects such as allergic reactions and gastrointestinal problems. 6 Pregnant and breastfeeding women should consult their healthcare provider before using omadacycline. 18

Limitations of Current Research

Research on omadacycline is still ongoing, and more studies are needed to fully understand its long-term safety and efficacy. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 Further research is needed to thoroughly understand its potential impact on bone metabolism. 18

Future Research Directions

Long-term studies are necessary to evaluate the safety and efficacy of omadacycline. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 Further investigation is crucial to understand omadacycline’s impact on bone metabolism. 18

Conclusion

Omadacycline is a promising new antibiotic with a wide spectrum of activity against various bacteria. 6 、 10 、 7 、 17 、 13 、 9 、 4 、 5 、 20 、 2 、 15 、 16 、 19 、 11 、 8 、 3 、 1 、 12 、 18 It offers the convenience of once-daily administration, reducing the burden for patients. 2 、 6 However, its potential impact on bone metabolism needs careful consideration, especially for pregnant and breastfeeding women. 18 It is important to consult with a healthcare professional regarding omadacycline usage and follow their guidance.

Literature analysis of 20 papers
Positive Content
19
Neutral Content
0
Negative Content
1
Article Type
1
2
2
5
19
1.

Fecal Pharmacokinetics and Gut Microbiome Effects of Oral Omadacycline versus Vancomycin in Healthy Volunteers.

Author: JoJinhee, HuChenlin, BegumKhurshida, WangWeiqun, LeThanh M, AgyapongSamantha, HansonBlake M, AyeleHossaena, LancasterChris, AlamM Jahangir, Gonzales-LunaAnne J, GareyKevin W

CDI treatment
None reported

Omadacycline showed high fecal concentrations and distinct microbiome changes compared to vancomycin in healthy adults. This suggests that omadacycline may be a promising treatment option for Clostridioides difficile infection (CDI).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.

Author: DarpoBorje, XueHongqi, TanakaS Ken, TzanisEvan

Heart rate increase

Omadacycline, a new antibiotic, was evaluated for its effects on the QT interval in a thorough QT study. Results showed no significant effect on QTc interval at therapeutic and supratherapeutic doses, suggesting a favorable cardiac safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Long-term evaluation of clinical success and safety of omadacycline in nontuberculous mycobacteria infections: a retrospective, multicenter cohort of real-world health outcomes.

Author: El GhaliAmer, MorrisetteTaylor, AlosaimySara, LucasKristen, Tupayachi-OrtizMaria G, VemulaRaaga, WadleCarly, PhilleyJulie V, Mejia-ChewCarlos, HamadYasir, StevensRyan W, ZeuliJohn D, WebbAndrew J, FiskeChristina T, SimonyanAnahit, CiminoChristo L, MammadovaMehriban, UmanaVirginia E, HasbunRodrigo, ButtSaira, MolinaKyle C, ThomasMichael, KaipEmily A, BouchardJeannette, GoreTristan W, HowardCatessa, CabanillaM Gabriela, HolgerDana J, FrensJeremy J, BargerMelissa, OngAaron, CohenKeira A, RybakMichael J

NTM treatment success
OMC efficacy
Drug discontinuation
OMC side effects

This multicenter retrospective study examined the long-term clinical success, safety, and tolerability of omadacycline (OMC) for nontuberculous mycobacteria (NTM) infections. Seventy-five patients were included in the analysis. Three-month clinical success was observed in 80.0% of patients, and adverse events attributable to OMC occurred in 32.0% of patients, leading to drug discontinuation in 9.3% of patients.

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Genome-based characterization of conjugative IncHI1B plasmid carrying carbapenemase genes bla<sub>VIM-1</sub>, bla<sub>IMP-23</sub>, and truncated bla<sub>OXA-256</sub>in Klebsiella pneumoniae NTU107224.

Author: WenLi-Li, KuoPei-Yun, ThuyTran Thi Dieu, DuongTran Thi Thuy, HuangYu-Tsung, HsuehPo-Ren, ChenYu-Chen, KaoCheng-Yen

Antibiotic resistance

This study characterized a multidrug-resistant Klebsiella pneumoniae strain, identifying a plasmid carrying multiple antibiotic resistance genes, including carbapenemase genes, which contribute to the bacterium's virulence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

<i>In Vitro</i> Antimicrobial Activities of Tigecycline, Eravacycline, Omadacycline, and Sarecycline against Rapidly Growing Mycobacteria.

Author: ZhangTingting, DuJian, DongLingling, WangFen, ZhaoLiping, JiaJunnan, WangCongli, ChengMengli, YuXia, HuangHairong

RGM infection treatment
Antimicrobial resistance

This study found that three tetracyclines (eravacycline, omadacycline, and tigecycline) were effective against Mycobacterium abscessus subsp. abscessus, Mycobacterium abscessus subsp. massiliense, and Mycobacterium fortuitum. Omadacycline was most promising for clinical application for M. abscessus infections due to its potent antimicrobial activity, safety, and convenient administration route.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Investigating the immunomodulatory activities of omadacycline.

Author: BryantAmy E, StevensDennis L

Improved outcomes
Reduced lung injury

Antibiotics are not only used to fight infections but also can have an impact on the immune system, particularly on monocytes. This review discusses how antibiotics can modulate the immune response and potentially reduce the risk of tissue injury in patients with lung infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats.

Author: NiakaniSepehr, LiuHattie, LiuWen-Ying, HornerRichard L

OSA treatment

This study found that oxybutynin, a cholinergic agent, is an effective muscarinic-receptor (MR) antagonist at the hypoglossal motor nucleus (HMN) in rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Efficacy and safety of optional parenteral antimicrobial therapy for complicated skin and soft tissue infections: A systematic review and Bayesian network meta-analysis.

Author: LiHuijuan, LiangXueyan, MoGuangyan, GuoSitong, ChenXiaoyu, LiYan

SSTI treatment

This study investigates the efficacy and safety of optional antimicrobial therapy for the treatment of complicated skin and soft tissue infections (cSSTIs). It aims to provide evidence-based guidelines for optimal treatment strategies, particularly considering the increasing prevalence of methicillin-resistant Staphylococcus aureus infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.

Author: LaPlanteKerry L, DhandAbhay, WrightKelly, LauterioMelanie

Antibiotic resistance overcome
Broad spectrum activity
Drug-drug interactions

This review discusses the efficacy, safety, and clinical utility of three new third-generation tetracycline-class antibiotics: eravacycline, omadacycline, and tigecycline. These drugs overcome common mechanisms of tetracycline resistance and exhibit broad-spectrum activity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Omadacycline and <i>Clostridioides difficile</i>: A Systematic Review of Preclinical and Clinical Evidence.

Author: GareyKevin W, RoseWarren, GunterKyle, SerioAlisa W, WilcoxMark H

Antibacterial activity
CDI risk reduction

Omadacycline is a new antibiotic with potent in vitro activity against many bacteria. It is associated with a low risk of causing Clostridium difficile infection (CDI), which is a common and serious complication of antibiotic use.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Real-World, Multicenter Case Series of Patients Treated with Oral Omadacycline for Resistant Gram-Negative Pathogens.

Author: MorrisetteTaylor, AlosaimySara, LagnfAbdalhamid M, FrensJeremy J, WebbAndrew J, VeveMichael P, StevensRyan, BouchardJeannette, GoreTristan W, AnsariIman, RybakMichael J

Effective against resistant bacteria

This report describes early real-world experience with omadacycline, an aminomethylcycline antibiotic, in the treatment of antibiotic-resistant Gram-negative infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Tetracyclines and bone: Unclear actions with potentially lasting effects.

Author: WarnerAmy J, Hathaway-SchraderJessica D, LubkerRena, DaviesChristopher, NovinceChad M

Acne treatment
Gram +/- infection treatment
Bone development disruption
Unclear bone effects

Tetracyclines are a broad-spectrum class of antibiotics that have unclear actions with potentially lasting effects on bone metabolism. Further research is needed to elucidate unclear effects of tetracyclines on the skeleton.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

19.

<i>In Vitro</i> Activity of KBP-7072 against 536 Acinetobacter baumannii Complex Isolates Collected in China.

Author: HanRenru, DingLi, YangYang, GuoYan, YinDandan, WuShi, ZhiPeiyuan, ZhuDemei, LiuQingmei, TanXiaojuan, ZhuYuanju, ZhangJay, LiLi, HuFupin

Antibacterial activity

KBP-7072, a novel expanded-spectrum tetracycline antibacterial agent, showed potent in vitro activity against a collection of 536 Acinetobacter baumannii (A. baumannii) clinical isolates from China. KBP-7072 was effective against all isolates, including carbapenem-resistant strains, and outperformed other tetracyclines, suggesting potential as a treatment option for infections caused by A. baumannii.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Carbapenemase-producing Enterobacterales infections: recent advances in diagnosis and treatment.

Author: LeeYu-Lin, ChenHsien-Meng, HiiIng-Moi, HsuehPo-Ren

CPE diagnosis
Carbapenem resistance

Carbapenem resistance in Enterobacterales is a growing threat to public health. This study reviews recent advances in methods for the identification of carbapenemase-producing Enterobacterales (CPE). The study discusses phenotypic, biochemical, immunochromatographic, proteomic, and molecular-based methods for identifying CPE.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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