Effects of oxytocin injection: A Synthesis of Findings from 19 Studies

  1. Home
  2. Effects of oxytocin injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of oxytocin injection: A Synthesis of Findings from 19 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of oxytocin injection: A Synthesis of Findings from 19 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Oxytocin is a hormone that plays various physiological roles in mammals. The effects of oxytocin injections vary greatly depending on the research subject and the method of administration. For example, in neonatal mice, oxytocin has been shown to play a role in promoting sensory experience-dependent plasticity. This was revealed by the fact that oxytocin administration could restore excitatory synaptic transmission in the sensory cortex that had been suppressed by sensory deprivation. 18

On the other hand, in pregnant mares, oxytocin induces labor by promoting cervical dilation. 17 This effect may be even more effective when used in combination with prostaglandin E2. In addition, oxytocin administration is expected to have an effect of reducing postpartum hemorrhage. 13 However, there are concerns about the effects of oxytocin administration on the fetus. 2 For example, labor induction by oxytocin administration may increase the risk of fetal asphyxia and umbilical cord rupture. Moreover, oxytocin administration increases the concentration of oxytocin in the milk of dairy cows, but oxytocin is broken down by heating and digestion, reducing the amount of oxytocin in the milk and having no effect on the stability of oxytocin in the milk. 16

In addition, in rats, oxytocin has been shown to promote gastric contraction. 3 This effect is obtained by administering oxytocin to the nucleus of the solitary tract in the medulla oblongata, and it occurs via the vagus nerve. Furthermore, oxytocin has been reported to suppress vomeronasal activity and reduce pup-directed aggression in male mice. 7

In various studies, oxytocin has been shown to affect neural circuitry and sensory perception in the brain. However, its effects vary greatly depending on the research subject and the method of administration, so further research is needed.

Benefits and Risks

Benefit Summary

Oxytocin is a hormone that plays various physiological roles, and its effects vary depending on the research subject and the method of administration. Oxytocin has been shown to promote sensory experience-dependent plasticity in neonatal mice. It is also expected to promote cervical dilation and induce labor in pregnant mares. Additionally, oxytocin is expected to have the effect of reducing postpartum hemorrhage.

Risk Summary

Oxytocin administration may increase the risk of fetal asphyxia and umbilical cord rupture. Moreover, oxytocin administration increases the concentration of oxytocin in the milk of dairy cows, but oxytocin is broken down by heating and digestion, reducing the amount of oxytocin in the milk. Additionally, in rats, oxytocin has been shown to promote gastric contraction.

Research Comparisons

Research Similarities

In various studies, oxytocin has been shown to affect neural circuitry and sensory perception in the brain.

Research Differences

The effects of oxytocin vary greatly depending on the research subject and the method of administration. For example, in neonatal mice, oxytocin has been shown to promote sensory experience-dependent plasticity, while in pregnant mares, it is expected to promote cervical dilation and induce labor. Moreover, oxytocin administration is expected to have an effect of reducing postpartum hemorrhage, but there are also concerns about its effects on the fetus.

Consistency and Discrepancies in Results

Oxytocin has been shown to affect neural circuitry and sensory perception in the brain in various studies, but its effects vary greatly depending on the research subject and the method of administration. Therefore, further research is needed to determine the specific mechanisms by which oxytocin exerts its effects.

Considerations for Real-World Applications

Oxytocin is a hormone that plays various physiological roles, and its effects vary depending on the research subject and the method of administration. Therefore, when administering oxytocin, it is important to understand its effects and risks carefully and make decisions with caution.

Limitations of Current Research

There is still not enough research on the effects of oxytocin. In particular, further research is needed to determine the specific mechanisms by which oxytocin exerts its effects.

Future Research Directions

To better understand the effects of oxytocin, research using various research subjects and methods of administration is needed. In addition, research at the molecular level is needed to understand the mechanisms by which oxytocin exerts its effects.

Conclusion

Oxytocin is a hormone that plays various physiological roles, and its effects vary depending on the research subject and the method of administration. Further research is needed to better understand the effects of oxytocin.

Literature analysis of 19 papers
Positive Content
15
Neutral Content
1
Negative Content
3
Article Type
3
0
0
1
18
1.

Pharmacodynamic effects of oral oxymorphone: abuse liability, analgesic profile and direct physiologic effects in humans.

Author: BabalonisShanna, LofwallMichelle R, NuzzoPaul A, WalshSharon L

Pain relief
Abuse potential
Respiratory depression

Oxymorphone is a semisynthetic μ-opioid agonist marketed as a prescription analgesic. This study compared the pharmacodynamic effects of oxymorphone and oxycodone in opioid abusers. Oxymorphone was less potent than oxycodone on most pharmacodynamic measures, but at higher doses, its abuse liability was similar to oxycodone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Clinical Experiences and Mechanism of Action with the Use of Oxytocin Injection at Parturition in Domestic Animals: Effect on the Myometrium and Fetuses.

Author: Marcet-RiusMíriam, Bienboire-FrosiniCécile, Lezama-GarcíaKarina, Domínguez-OlivaAdriana, Olmos-HernándezAdriana, Mora-MedinaPatricia, Hernández-ÁvalosIsmael, Casas-AlvaradoAlejandro, GazzanoAngelo

Reduced labor duration
Dystocia
Fetus asphyxia
Meconium staining
Ruptured umbilical cord

This review examines the effects of oxytocin on myometrial activity during parturition and its potential benefits and risks for the fetus in domestic animals. Oxytocin can reduce labor duration, but excessive or inappropriate administration can increase dystocia and other adverse fetal outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

[Multicenter, Randomized, Double-Blind, and Positive Drug-Controlled Clinical Trial on Prevention of Postpartum Hemorrhage after Vaginal Delivery with Ergometrine Maleate].

Author: LiTao, WeiQiang, WuLin, ChenMeng, ZhangLi-Ping, ZhangQian, LiuXing-Hui

Improved safety
Reduced postpartum hemorrhage

Ergometrine maleate injection combined with oxytocin injection was more effective in preventing postpartum hemorrhage after vaginal delivery compared to oxytocin injection alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

5.

Effect of exogenous administration of oxytocin on postpartum follicular dynamics, oestrous rate and ovulation in Nili-Ravi buffaloes.

Author: MurtazaSaeed, SattarAbdul, AhmadNasim, Jamil AhmadMuhammad, AkhtarSaleem, AhmadEjaz, AhmadTanveer, OmerTalha

Shortened PEI
Delayed ovulation

Exogenous oxytocin administration in buffaloes shortens the postpartum oestrous interval but delays ovulation. A higher dose of oxytocin stimulates the growth of small, medium, and total follicles in postpartum buffaloes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Peripheral oxytocin injection modulates vomeronasal sensory activity and reduces pup-directed aggression in male mice.

Author: NakaharaThiago S, CamargoAntonio P, MagalhãesPedro H M, SouzaMateus A A, RibeiroPedro G, Martins-NettoPaulo H, CarvalhoVinicius M A, JoséJuliana, PapesFabio

Reduced aggression

This study examined the role of the hormone oxytocin in controlling social behaviors in male mice. Oxytocin was found to reduce both the activity of the vomeronasal organ, which detects scents, and aggressive behavior towards pups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Oxytocin in the dorsal raphe nucleus antagonizes the inhibition of maternal care induced by food deprivation.

Author: FujisakiMotoyuki, NakamuraAyane, MuroiYoshikage, IshiiToshiaki

Maternal Care

Oxytocin in the dorsal raphe nucleus (DRN) was found to be necessary for maternal care in food-deprived dams, but not in fed dams.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Repeated trans-cervical embryo recoveries in Santa inês ewes subjected to short- or long-term superovulatory treatment regimens.

Author: OliveiraM E F, ZambriniF N, Souza-FabjanJ M G, BartlewskiP M, GuimarãesJ D, BrandãoF Z, FonsecaJ F

Embryo collection
Superovulation response

This study compared the outcomes of different estrous synchronization and superovulatory protocols in ewes. The results suggest that longer synchronization and superovulation protocols might not improve the number of embryos produced, but could affect embryo quality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.

Language : English

10.

Is there an interest in repeating the vaginal administration of dinoprostone (Propess®), to promote induction of labor of pregnant women at term? (RE-DINO): study protocol for a randomized controlled trial.

Author: Coste MazeauP, HessasM, MartinR, EyraudJ-L, MargueritteF, AubardY, SalleeC, SireF, GauthierT

Cervical Ripening

This study examines the use of dinoprostone (Propess®) for cervical ripening in labor induction. It explores the uncertainty surrounding the use of a second dinoprostone pessary versus oxytocin when labor doesn't start within 24 hours, aiming to inform best practices for achieving vaginal delivery.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

The ventromedial hypothalamus oxytocin induces locomotor behavior regulated by estrogen.

Author: NaritaKazumi, MurataTakuya, MatsuokaSatoshi

Enhanced estrogen effect
Increased locomotor activity

Oxytocin, acting through its receptor in the ventromedial hypothalamus, induces running behavior in rats. Estrogen enhances this effect by upregulating the oxytocin receptor. These findings suggest that oxytocin plays a role in the locomotor activity of female rats during proestrus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Method for collecting mouse milk without exogenous oxytocin stimulation.

Author: MuranishiYuki, ParryLaurent, AverousJulien, TerrisseAnne, MaurinAnne-Catherine, ChaverouxCédric, MesclonFlorent, CarraroValérie, BruhatAlain, FafournouxPierre, JousseCéline

Milk production
Dam behavior changes
Dam physiology changes
Milk content modification

Maternal milk composition is crucial for offspring health, but collecting mouse milk for research often involves oxytocin injections, which can alter milk content and dam behavior. This article describes a new procedure for collecting mouse milk without oxytocin injection. This non-invasive, low-cost method provides sufficient milk for various biological analyses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Systematic prophylactic oxytocin injection and the incidence of postpartum hemorrhage: A before-and-after study.

Author: GarabedianC, SimonM, ClossetE, Ducloy-BouthorsA-S, SchaffarA, DeruelleP, GautierS, DepretS, SubtilD

Moderate PPH reduction

Routine injection of 5 units of oxytocin reduces the risk of moderate postpartum haemorrhage (PPH) but does not affect the risk of severe PPH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

14.

Nicolau syndrome following intramuscular injection of oxytocin in pregnant women: report of two cases.

Author: SeremetSila, TuranEnver, ErdemirAsli Turgut

Nicolau syndrome

Nicolau syndrome, a rare complication of intramuscular drug injections, can occur after intramuscular oxytocin injection.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Double-blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital.

Author: MusaAbdulkarim O, IjaiyaMunir'deen A, SaiduRakiya, AboyejiAbiodun P, JimohAbiodun A, AdesinaKikelomo T, AbdulIshaq F

Effective for AMTSL
Good alternative to oxytocin
Transient side effects

A double-blind randomized control trial found that oral misoprostol was as effective as intramuscular oxytocin for active management of the third stage of labor. Adverse effects associated with misoprostol were transient and self-limiting.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Effect of oxytocin injection to milching buffaloes on its content & stability in milk.

Author: PullakhandamRaghu, PalikaRavindranadh, VemulaSudershan Rao, PolasaKalpagam, BoindalaSesikeran

Milk contamination

Oxytocin (OT) injections are commonly used in dairy farming in India to induce milk letdown. This study investigated the OT content in milk samples from buffaloes with and without OT injections and assessed the stability of OT in milk during heating and gastrointestinal digestion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices.

Author: ZhengJing-Jing, LiShu-Jing, ZhangXiao-Di, MiaoWan-Ying, ZhangDinghong, YaoHaishan, YuXiang

Improved cortical development
Potential autism therapy

Sensory experience plays a crucial role in the development of neural circuits. This study reveals a new form of plasticity in neonatal mice, where early sensory experience regulates the development of all sensory cortices via oxytocin signaling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi).

Author: IqbalZafar, RahmanZia Ur, MuhammadFaqir, KhaliqTanweer, AnwarHaseeb, AwaisMian Muhammad, SadafSaima

Oxidative stress

This study evaluated the adverse effects of oxytocin on biomarkers of oxidative stress in buffaloes. Oxytocin administration before each milking resulted in increased oxidative stress biomarkers in the treatment group compared to the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.