Effective treatment of peptic ulcer: A Synthesis of Findings from 50 Studies

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Original Abstract of the Article

Main Research Findings

Peptic ulcers are sores that develop in the lining of the stomach or duodenum. These sores are caused by damage from stomach acid and digestive enzymes. 47 defines refractory peptic ulcers as those that do not heal after 8 to 12 weeks of medical treatment or are associated with complications despite medical treatment. Recurrent peptic ulcers are peptic ulcers that recur after the ulcer has healed. Given the number of deaths due to peptic ulcer-related complications and the long-term complications of medical treatment (increased incidence of fractures), it is unclear whether medical or surgical intervention is the better treatment option for people with recurrent or refractory peptic ulcers.

One of the causes of peptic ulcers is Helicobacter pylori infection. Research shows that eradicating H. pylori can be effective in treating peptic ulcers. Studies 33 , 17 , 30 , 32 , 36 , 34 , 18 , 15 , 24 , 50 , 48 show that eradication of H. pylori is associated with higher peptic ulcer healing rates and lower recurrence rates.

Treatments for peptic ulcers include drug therapy, such as antacids and H2 receptor antagonists, H. pylori eradication therapy, and surgery. 10 compared the 4-week healing rates of duodenal and gastric ulcers treated with antacids and ranitidine (Zantac). The study found that 74% of duodenal ulcers healed with ranitidine therapy, compared with 63% with antacids, though this difference was not statistically significant. For gastric ulcers, the healing rates were 58% with ranitidine and 35% with antacids, but again, this difference was not statistically significant. While there was no significant difference between the two therapies in terms of symptomatic relief in the duodenal ulcer group, ranitidine produced significantly better results in the gastric ulcer group. No side effects were noted in either group.

Proton pump inhibitors (PPIs) are also commonly used in peptic ulcer treatment. Research has shown that PPIs can be effective in preventing bleeding and rebleeding in peptic ulcers. 43 , 44 , 46 , 26 , 40 studies suggest PPIs reduce the risk of bleeding and rebleeding by suppressing gastric acid secretion, which promotes ulcer healing.

Treatment options for peptic ulcers vary depending on the type of ulcer, severity, and cause. Treatment for refractory or recurrent ulcers may include H. pylori eradication, long-term PPI therapy, or surgery. Each of these treatments comes with advantages and disadvantages. It is essential to choose the most appropriate treatment based on the patient's condition.

Treatment Summary

10 compared antacids and ranitidine for duodenal and gastric ulcer treatment. Ranitidine demonstrated higher healing rates for duodenal ulcers and better symptom relief for gastric ulcers.

33 showed that a 1-week low-dose proton pump inhibitor-based triple therapy is sufficiently effective for eradicating H. pylori and healing ulcers.

43 , 44 , 46 , 26 , 40 showed that PPIs are effective in preventing bleeding and rebleeding in peptic ulcers.

17 , 30 , 32 , 36 , 34 , 18 , 15 , 24 , 50 , 48 showed that eradicating H. pylori is an effective treatment option for peptic ulcers.

Benefits and Risks

Benefits Summary

Eradicating H. pylori can improve the healing rates and reduce the recurrence of peptic ulcers. 17 , 30 , 32 , 36 , 34 , 18 , 15 , 24 , 50 , 48 .

PPIs can effectively prevent bleeding and rebleeding in peptic ulcers. 43 , 44 , 46 , 26 , 40 .

Risk Summary

Treatment for peptic ulcers includes drug therapy, H. pylori eradication therapy, and surgery, each with advantages and disadvantages. Selecting the appropriate treatment for each patient is crucial. 47 .

Fracture incidence may increase as a long-term complication of medical treatment. 47 .

Comparison of Research

Research Similarities

Many studies indicate that H. pylori eradication and PPIs are effective treatments for peptic ulcers.

Research Differences

There are variations in the effectiveness of H. pylori eradication and PPIs, treatment selection criteria, and potential side effects across different studies.

Consistency and Contradictions in Results

There are still many challenges in treating peptic ulcers. Numerous studies demonstrate the effectiveness of H. pylori eradication and PPIs. However, the optimal treatment option depends on the patient's specific condition. Therefore, it is crucial to choose the most suitable treatment approach for each individual patient.

Application in Real-Life, Things to Keep in Mind

Treatment for peptic ulcers depends on the type, severity, and underlying cause of the ulcer. If you experience symptoms of a peptic ulcer, do not self-treat. Instead, consult a medical professional for proper diagnosis and treatment.

Limitations of Current Research

Research on peptic ulcer treatment requires long-term follow-up studies and larger-scale investigations. Developing a better understanding of the mechanisms that cause peptic ulcers and discovering new treatment options are also critical areas of focus.

Future Research Directions

Further research is needed in peptic ulcer treatment, particularly in developing more effective treatments, preventing long-term complications, and personalizing treatment plans for individual patients.

Conclusion

Peptic ulcers are sores in the lining of the stomach or duodenum caused by damage from stomach acid and digestive enzymes. Treatment options include drug therapy, H. pylori eradication therapy, and surgery. It is essential to select the most appropriate treatment for each individual based on their condition.

If you experience symptoms of a peptic ulcer, seek medical attention for proper diagnosis and treatment.

Treatment List

  • Antacids
  • Ranitidine
  • Proton Pump Inhibitors (PPIs)
  • Helicobacter pylori eradication therapy
  • Surgery
Keywords
Benefit Keywords
Prevents complications
Ulcer healing
1
Prevents relapse
Ulcer healing
2
Ulcer treatment
3
Ulcer healing
4
Ulcer healing
5
Ulcer relapse prevention
6
Peptic ulcer treatment
7
Effective ulcer treatment
Reduced medication use
8
Ulcer treatment
9
Improved healing
Symptomatic relief
10
Improved duodenitis
Symptomatic improvement
Ulcer healing
11
Faster ulcer healing
Relief of night-time pain
12
Eradication of Helicobacter pylori
Ulcer healing
13
Reduced rebleeding
14
Improved understanding of peptic ulcer disease treatment
15
Decreased bleeding
Reduced surgery need
16
Improved peptic ulcer disease treatment
17
Omeprazole-based triple therapy effective
Omeprazole-based triple therapy safe
18
Improved understanding of peptic ulcer disease treatment
19
Improved peptic ulcer disease treatment
20
Ulcer healing
21
Improved peptic ulcer disease treatment
22
Improved peptic ulcer disease treatment
23
Increased roxithromycin concentration
24
Cost-effectiveness
25
Improved therapeutic outcomes
26
Improved outcomes for peptic ulcer bleeding
28
Reduced acid-reducing medication use
Reduced dyspepsia
29
H. pylori eradication
30
Peptic ulcers treatment
31
Dyspepsia relief
H. pylori eradication
32
H. pylori eradication
Ulcer healing
33
Prevention of recurrent bleeding
34
Prevention of recurrent bleeding
35
H. pylori eradication
Reduced costs
36
Effective H. pylori eradication
38
Peptic ulcer treatment
39
Ulcer bleeding treatment
40
Peptic ulcer disease treatment
41
Peptic ulcer bleeding treatment
42
Faster acid control
43
Reduced rebleeding
44
Improved peptic ulcer disease treatment
45
Peptic ulcer treatment
47
Increased H. pylori eradication
48
Improved dyspeptic symptoms
Prevents peptic ulcer
Reduced risk of gastric cancer
49
High efficiency
50
Risk Keywords
Liver damage
Ulcer recurrence
1
Asymptomatic recurrence
Ulcer recurrence
2
Relapse
4
Relapse rates
5
Increased serum creatinine
11
Side effects
18
Helicobacter pylori eradication
21
N/A
25
Lack of randomized comparison
28
Increased acid-peptic related costs
29
Side effects
33
Efficacy of H. pylori eradication unknown
34
Efficacy of H. pylori eradication unknown
35
Increased mortality
No benefit
37
Peptic ulcer disease
45
Treatment complications
47
Higher cost
49
Literature analysis of 50 papers
Positive Content
48
Neutral Content
1
Negative Content
1
Article Type
43
5
3
3
50
1.

Maintenance treatment of recurrent peptic ulcer by cimetidine.

Author: BodemarG, WalanA

Prevents complications
Ulcer healing
Liver damage
Ulcer recurrence

Cimetidine was significantly more effective than placebo in preventing peptic ulcer recurrence and complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Very long-term treatment of peptic ulcer with cimetidine.

Author: CargillJ M, SaundersJ H, PedenN, WormsleyK G

Prevents relapse
Ulcer healing
Asymptomatic recurrence
Ulcer recurrence

Cimetidine was effective in healing peptic ulcers, but relapse occurred in 43% of patients within 6 months of stopping treatment. Continuous treatment for a year prevented relapse in most patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Refractory peptic ulcers.

Author: ArakawaT, KobayashiK, DajaniE Z

Ulcer treatment

Omeprazole (20 mg daily) was more effective than H2-receptor antagonists in treating refractory ulcers, with a refractory incidence of 3% for duodenal ulcers and 11% for gastric ulcers compared to 9% and 20% for H2-receptor antagonists, respectively. Omeprazole's benefit may be due to its strong acid-suppressing action and effectiveness in treating ulcers with normal pharmacologic response to H2-receptor antagonists.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

[The outpatient treatment possibilities for patients with exacerbated peptic ulcer].

Author: IvashkinV T, KalininA V, MinasianG A

Ulcer healing
Relapse

A study comparing hospital and ambulatory treatment for peptic ulcer exacerbation found no significant difference in pain relief or ulcer healing time. However, early relapses were more frequent in hospitalized patients. Outpatient treatment is recommended for patients with mild symptoms, no complications, small ulcers, and good support systems.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

5.

Modern management of peptic ulceration.

Author: SinghP, Colin-JonesD G

Ulcer healing
Relapse rates

Drug therapy has become the standard treatment for most patients with peptic ulceration. The focus has shifted from healing to preventing relapses, which remain high with most drug regimens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

[Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer].

Author: Varas LorenzoM J, López MartínezA, Gordillo BernalJ, Mundet SurrocaJ

Ulcer relapse prevention

A study of 146 patients with recently healed peptic ulcers compared three mucosal protecting drugs for preventing relapses. Zinc acexamate was more effective than magaldrate in preventing relapses, with a possible advantage over aceglutamide aluminum salt, although not statistically significant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

7.

The role of sustained achlorhydria in bleeding peptic ulcer.

Author: AroraA, TandonR K, AcharyaS K, TandonB N

Peptic ulcer treatment

A study of 25 patients with bleeding peptic ulcers found that continuous nasogastric antacid infusion plus cimetidine was more effective in controlling bleeding and reducing the need for surgery compared to ranitidine alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Symptomatic cimetidine treatment of duodenal and prepyloric ulcers.

Author: GustavssonS, AdamiH O, LööfL, NybergA, NyrénO

Effective ulcer treatment
Reduced medication use

A study of 75 patients with duodenal or prepyloric ulcers found that both standard and symptomatic cimetidine treatment regimens were equally effective in relieving symptoms and healing ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Are endoscopic and/or histologic findings in gastroduodenal mucosa a predictor of clinical outcome in peptic ulcer disease? A 1-year follow-up study after initial healing with either cimetidine or medium-dose antacid.

Author: JönssonK A, BodemarG, NorrbyK, WalanA, TyskC

Ulcer treatment

A study comparing cimetidine with antacids for treating duodenal or prepyloric ulcers found that cimetidine was more effective in relieving symptoms in patients with prepyloric ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

A comparison of 4-week peptic ulcer healing rates following treatment with antacids and ranitidine.

Author: BezuidenhoutD J, PeroldJ G, AdamsG

Improved healing
Symptomatic relief

In a study of 88 patients with stomach and duodenal ulcers, ranitidine and an antacid (Gelusil) were compared for effectiveness in healing ulcers. Ranitidine healed 74% of duodenal ulcers and 58% of stomach ulcers, while Gelusil healed 63% of duodenal ulcers and 35% of stomach ulcers. Although ranitidine showed a slight improvement in healing rates, these differences were not statistically significant. Both treatments were well tolerated with no reported side effects. Ranitidine was found to be significantly better at relieving symptoms for those with stomach ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

The relationship between active peptic ulcer, endoscopic duodenitis and symptomatic state after treatment with cimetidine.

Author: DanielssonA, EkB, NyhlinH, SteenL

Improved duodenitis
Symptomatic improvement
Ulcer healing
Increased serum creatinine

The study found that cimetidine was significantly more effective than placebo in healing peptic ulcers, with 82.6% of patients in the cimetidine group showing ulcer healing compared to 48.0% in the placebo group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Antacid/anticholinergic, cimetidine, and placebo in treatment of active peptic ulcers.

Author: StrömM, GotthardR, BodemarG, WalanA

Faster ulcer healing
Relief of night-time pain

Cimetidine and a combination of antacids and an anticholinergic drug were both effective in healing duodenal ulcers, while placebo was not. Cimetidine relieved nighttime ulcer pain more quickly than the antacid/anticholinergic combination.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Lansoprazole treatment of Helicobacter pylori-positive peptic ulcers.

Author: KohliY, KatoT, AzumaT, ItoS, HiraiM

Eradication of Helicobacter pylori
Ulcer healing

This study compared different treatments for Helicobacter pylori (Hp) infection in patients with gastric or duodenal ulcers. All treatments healed ulcers similarly, but combination therapy (lansoprazole, amoxicillin/clarithromycin, and metronidazole) was most effective at eradicating Hp. No significant side effects were reported. The study suggests that combination therapy is the most effective and safe option for patients with persistent Hp infection and peptic ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Eradication of Helicobacter pylori reduces the possibility of rebleeding in peptic ulcer disease.

Author: RokkasT, KaramerisA, MavrogeorgisA, RallisE, GiannikosN

Reduced rebleeding

A study of 31 patients with a history of duodenal ulcer bleeding found that eradication of Helicobacter pylori significantly reduced the risk of rebleeding. Patients were randomized to receive either omeprazole alone (group O) or omeprazole plus amoxicillin (group O+A) for two weeks. H. pylori eradication was achieved in 13.3% of group O and 81.3% of group O+A (p < .001). All five rebleeding events occurred in group O, and only in patients where eradication had failed. No rebleeding occurred in group O+A.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Treatment of Helicobacter pylori reduces the rate of rebleeding in peptic ulcer disease.

Author: GrahamD Y, HeppsK S, RamirezF C, LewG M, SaeedZ A

Improved understanding of peptic ulcer disease treatment

This study aimed to determine if eradicating Helicobacter pylori infection in patients with peptic ulcers who had experienced bleeding would reduce the risk of future bleeding. Patients who had their ulcers healed after receiving either ranitidine alone or ranitidine plus triple therapy to eradicate H. pylori were followed up with endoscopy and no maintenance medication was given after healing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

A comparison of omeprazole and placebo for bleeding peptic ulcer.

Author: KhurooM S, YattooG N, JavidG, KhanB A, ShahA A, GulzarG M, SodiJ S

Decreased bleeding
Reduced surgery need

Omeprazole significantly reduced the rate of further bleeding and the need for surgery in patients with bleeding peptic ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study.

Author: LindT, Veldhuyzen van ZantenS, UngeP, SpillerR, BayerdörfferE, O'MorainC, BardhanK D, BradetteM, ChibaN, WrangstadhM, CederbergC, IdströmJ P

Improved peptic ulcer disease treatment

Eradicating Helicobacter pylori bacteria is a potential cure for many people with peptic ulcers. Treatment regimens using omeprazole along with two antibiotics have achieved eradication rates above 90%. However, the best combination of antibiotics, dosage, and treatment duration are still being studied to determine the most effective approach.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Omeprazole-based dual and triple therapy for the treatment of Helicobacter pylori infection in peptic ulcer disease: a randomized trial.

Author: PieramicoO, ZanettiM V, InnerhoferM, MalfertheinerP

Omeprazole-based triple therapy effective
Omeprazole-based triple therapy safe
Side effects

Triple therapy with omeprazole, amoxicillin, and clarithromycin for 1 week achieved the highest eradication rate of Helicobacter pylori infection compared to dual therapy with omeprazole and amoxicillin for 2 weeks. All therapies were well-tolerated with similar side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Lansoprazole, amoxicillin, and clarithromycin triple therapy in vagotomized patients with dyspeptic complaints. A randomized, double-blind, placebo-controlled, clinical study without pretreatment diagnostic upper endoscopy.

Author: LindsetmoR O, JohnsenR, RevhaugA

Improved understanding of peptic ulcer disease treatment

This study examines whether eradicating Helicobacter pylori improves symptoms in patients who have had vagotomy (surgery on the vagus nerve) for peptic ulcers and still experience digestive problems.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Dose-response relationship of lansoprazole to gastric acid antisecretory effects.

Author: BlumR A, HuntR H, KiddS L, ShiH, JenningsD E, Greski-RoseP A

Improved peptic ulcer disease treatment

Proton pump inhibitors have been shown to be effective in treating peptic ulcers, particularly those associated with H. pylori bacteria and acid reflux. The success of these medications depends on the strength and duration of acid suppression as well as the length of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Three treatment schemes with colloidal bismuth subcitrate (Q-ULCER) in peptic ulcer with Helicobacter pylori.

Author: SuárezM S, González CansinoJ, Velasco IlizaldeC, SabatierC A, Castillo HernándezJ

Ulcer healing
Helicobacter pylori eradication

The three schemes of treatment were effective for ulcerous healing, but the Helicobacter pylori eradication was only observed in 47.3% of the patients studied. In a study of 53 patients suffering from gastroduodenal peptic ulcer with Helicobacter pylori, the highest clearing index (52.6%) was obtained in group III.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Therapeutic news on Helicobacter pylori from Budapest and Wien.

Author: RicciC, GattaL, MiglioliM, VairaD

Improved peptic ulcer disease treatment

Helicobacter pylori is a common infection linked to gastroduodenal diseases. Eradicating it not only heals duodenal ulcers but also prevents recurrence and complications. This review analyzed various treatment regimens for H. pylori, with over 10,000 patients studied, though only 10-15% had peptic ulcer disease. While many regimens were evaluated, no definitive "optimal" treatment emerged. Proton pump inhibitors are a common treatment approach, with a one-week regimen (The Maastricht regimen) showing promising results.

CongressA conference or meeting where experts in a specific field gather. It provides opportunities for presentations, discussions, and networking, and serves as a place to share expertise and learn about the latest trends in the industry.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

23.

Decision analysis of histamine H2-receptor antagonist maintenance therapy versus Helicobacter pylori eradication therapy: a randomised controlled trial in patients with continuing pain after duodenal ulcer.

Author: TavakoliM, PrachA T, MalekM, HopwoodD, SeniorB W, MurrayF E

Improved peptic ulcer disease treatment

While many studies focus on the effectiveness and cost-effectiveness of Helicobacter pylori eradication for peptic ulcers, they often emphasize eradication rates rather than symptom management and associated cost savings. Although eradication therapy is successful in clearing the infection, symptoms can persist, leading to additional costs for symptom management.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Pharmacokinetic interaction between proton pump inhibitors and roxithromycin in volunteers.

Author: KeesF, HolstegeA, IttnerK P, ZimmermannM, LockG, SchölmerichJ, GrobeckerH

Increased roxithromycin concentration

Proton pump inhibitors did not alter the systemic bioavailability of roxithromycin but significantly increased its local concentration in the stomach, potentially contributing to the synergistic benefit in Helicobacter pylori eradication therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong.

Author: YouJ H, LeeK K, HoS S, SungJ J, KungN N, YungM, LeeC, YeeG C

Cost-effectiveness
N/A

The study found that ranitidine bismuth citrate with amoxicillin and clarithromycin (RAC) was the least costly regimen for out-patient treatment of H. pylori-related peptic ulcer disease in Hong Kong, while RBC with metronidazole and tetracycline (RMT) was the least costly regimen for in-patient treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer.

Author: JavidG, MasoodiI, ZargarS A, KhanB A, YatooG N, ShahA H, GulzarG M, SodhiJ S

Improved therapeutic outcomes

Endoscopic procedures are now used to treat bleeding ulcers. Additional medications may improve outcomes. Stopping stomach acid is essential for healing ulcers, and proton pump inhibitors, which strongly reduce stomach acid, may be beneficial for patients who have undergone endoscopic treatment for ulcers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Meta-analysis: the efficacy of intravenous H2-receptor antagonists in bleeding peptic ulcer.

Author: LevineJ E, LeontiadisG I, SharmaV K, HowdenC W

Intravenous H2-receptor antagonists are of no value in bleeding duodenal ulcer, although they may be mildly beneficial in bleeding gastric ulcer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

28.

Endoscopic versus operative treatment in high-risk ulcer bleeding patients - results of a randomised study.

Author: ImhofMichael, OhmannChristian, RöherHans-Dietrich, GlutigHolger,

Improved outcomes for peptic ulcer bleeding
Lack of randomized comparison

The best way to treat bleeding ulcers in high-risk patients is still being debated. These patients are at higher risk of death if the bleeding recurs in the hospital. Two treatment approaches are being considered: surgery as the initial treatment or endoscopic treatment alone. While studies have shown similar improvements with both approaches, there is no randomized study directly comparing them.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

A randomized controlled trial of test-and-treat strategy for Helicobacter pylori: clinical outcomes and health care costs in a managed care population receiving long-term acid suppression therapy for physician-diagnosed peptic ulcer disease.

Author: AllisonJames E, HurleyLeo B, HiattRobert A, LevinTheodore R, AckersonLynn M, LieuTracy A

Reduced acid-reducing medication use
Reduced dyspepsia
Increased acid-peptic related costs

Routine testing and treating for Helicobacter pylori (HP) in patients with physician-diagnosed peptic ulcer disease (PUD) does not reduce acid-peptic-related costs and has a modest effect in reducing clinical symptoms and use of acid-reducing medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

[Four different treatment protocols for Helicobacter pylori infection--a clinical pilot study].

Author: CavaljugaSemra, GornjakovićSrdan, PotkonjakDubravka

H. pylori eradication

This study compared four different triple-drug treatments for Helicobacter pylori infection in patients with peptic ulcers. The most effective treatment was omeprazole, clarithromycin, and metronidazole (OCM), achieving a 91.7% eradication rate with minimal partial eradication (8.3%) and no persistent infection. While other combinations were also effective, the OCM regimen was recommended as the first-line treatment for H. pylori infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Croatian

31.

Maintenance treatment is not necessary after Helicobacter pylori eradication and healing of bleeding peptic ulcer: a 5-year prospective, randomized, controlled study.

Author: LiuChen-Chiung, LeeChia-Long, ChanChung-Chuan, TuTien-Chien, LiaoChien-Chung, WuChi-Hwa, ChenTzen-Kwan

Peptic ulcers treatment

This 5-year study aimed to determine whether long-term medication for ulcers is necessary after successfully treating and healing bleeding ulcers caused by H pylori bacteria. While it's generally accepted that further medication isn't needed for simple ulcers after H pylori treatment, the need for ongoing treatment in cases of bleeding ulcers remains unclear.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

One-day quadruple therapy compared with 7-day triple therapy for Helicobacter pylori infection.

Author: LaraLuis F, CisnerosGerardo, GurneyMichael, Van NessMichael, JarjouraDavid, MoauroBetty, PolenAnn, RuteckiGregory, WhittierFrederick

Dyspepsia relief
H. pylori eradication

A 1-day, 4-drug regimen was found to be statistically similar to a 7-day, 3-drug regimen for the eradication of Helicobacter pylori in patients with dyspepsia and a positive urea breath test.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

One-week low-dose triple therapy without anti-acid treatment has sufficient efficacy on Helicobacter pylori eradication and ulcer healing.

Author: HsuChia-Chang, LuSheng-Nan, ChangchienChi-Sin

H. pylori eradication
Ulcer healing
Side effects

This study investigated the efficacy of a one-week low-dose proton pump inhibitor-based triple therapy for the eradication of Helicobacter pylori and healing of peptic ulcers. The study found that continuing antisecretory drug therapy beyond one week was not necessary for eradication efficacy or ulcer healing, with eradication rates of 87.2% and 97.1% in the group that stopped antisecretory therapy after one week.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

H. pylori eradication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer.

Author: GisbertJ P, KhorramiS, CarballoF, CalvetX, GenéE, Dominguez-MuñozJ E

Prevention of recurrent bleeding
Efficacy of H. pylori eradication unknown

Peptic ulcers are a common cause of bleeding in the upper digestive system, and H. pylori bacteria are a major cause of ulcers. While medications to reduce stomach acid have been the standard treatment for preventing future bleeding, it is unclear how effective eliminating H. pylori is in preventing ulcers from bleeding again.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

H. pylori eradication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer.

Author: GisbertJ P, KhorramiS, CarballoF, CalvetX, GenéE, Dominguez-MuñozJ E

Prevention of recurrent bleeding
Efficacy of H. pylori eradication unknown

Peptic ulcers are a common cause of bleeding in the upper digestive system, and H. pylori bacteria are a major cause of ulcers. While medications to reduce stomach acid have been the standard treatment for preventing future bleeding, it is unclear how effective eliminating H. pylori is in preventing ulcers from bleeding again.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Effectiveness and pharmaceutical cost of sequential treatment for Helicobacter pylori in patients with non-ulcer dyspepsia.

Author: De FrancescoV, Della ValleN, StoppinoV, AmorusoA, MuscatielloN, PanellaC, IerardiE

H. pylori eradication
Reduced costs

Halving the clarithromycin dose did not affect the eradication rate of Helicobacter pylori with the 10-day sequential regimen in patients with non-ulcer dyspepsia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

The effect of octreotide as an adjunct treatment in active nonvariceal upper gastrointestinal bleeding.

Author: NikolopoulouVassiliki N, ThomopoulosKonstantin C, KatsakoulisEvangelos C, VasilopoulosApostolos G, MargaritisVassilios G, VagianosConstantin E

Increased mortality
No benefit

Octreotide did not offer significant benefits in treating patients with acutely bleeding benign peptic ulcers or visible vessels. There was no significant difference in rebleeding rates, surgical intervention rates, mortality rates, or hospital stay between octreotide and placebo groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Seven-day therapy for Helicobacter pylori in the United States.

Author: VakilN, LanzaF, SchwartzH, BarthJ

Effective H. pylori eradication

A 7-day triple therapy using rabeprazole, clarithromycin, and amoxicillin is as effective as 10-day therapies in eradicating Helicobacter pylori in patients with and without peptic ulcer disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Helicobacter pylori eradication as the sole treatment for gastric and duodenal ulcers.

Author: ArkkilaPerttu Et, SeppäläKari, KosunenTimo U, SipponenPentti, MäkinenJudit, RautelinHilpi, FärkkiläMartti

Peptic ulcer treatment

This study investigates whether eliminating H. pylori bacteria alone, without long-term acid-reducing medication, is enough to heal peptic ulcers. It also examines the effect of using NSAIDs (nonsteroidal anti-inflammatory drugs) and aspirin on ulcer recurrence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Pantoprazole infusion as adjuvant therapy to endoscopic treatment in patients with peptic ulcer bleeding: prospective randomized controlled trial.

Author: ZargarShowkat Ali, JavidGul, KhanBashir Ahmad, YattooGhulam Nabi, ShahAltaf Hussain, GulzarGhulam Mohammad, SodhiJaswinder Singh, MujeebSheikh Abdul, KhanMushtaq Ahmad, ShahNisar Ahmad, ShafiHakim Mohamad

Ulcer bleeding treatment

The study investigated whether administration of pantoprazole infusion would improve the outcome in ulcer bleeding following successful endoscopic therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Pharmacoeconomic comparison of Helicobacter pylori eradication regimens.

Author: SancarMesut, IzzettinFikret Vehbi, Apikoglu-RabusSule, BesisikFatih, TozunNurdan, DulgerGul

Peptic ulcer disease treatment

The study discussed the cost-effectiveness of Helicobacter pylori eradication treatment for the treatment of peptic ulcer disease, noting the need for further research to clarify the relative cost-effectiveness of various eradication regimens.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.

Author: WeiKou-Liang, TungShui-Yi, SheenCheng-Han, ChangTe-Shen, LeeI-Lin, WuCheng-Shyong

Peptic ulcer bleeding treatment

The study aimed to assess whether the use of oral esomeprazole would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

43.

Effect of intravenous application of esomeprazole 40 mg versus pantoprazole 40 mg on 24-hour intragastric pH in healthy adults.

Author: HartmannDirk, EickhoffAxel, DamianUlrich, RiemannJuergen F, SchillingDieter

Faster acid control

Esomeprazole 40 mg intravenously provided faster and more pronounced intragastric acid control than pantoprazole 40 mg intravenously in H. pylori-negative patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

44.

Randomized trial comparing pantoprazole infusion, bolus and no treatment on gastric pH and recurrent bleeding in peptic ulcers.

Author: HungWai-Ka, LiVicky K M, ChungChi-Kin, YingMarcus W L, LooChing-Kong, LiuCecilia K T, LamBilly Y K, ChanMiranda C M

Reduced rebleeding

Pantoprazole, either as an infusion or bolus, decreased rebleeding after endoscopic treatment for bleeding peptic ulcer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

[Role of anti-secretory treatment in addition to Helicobacter pylori eradication triple therapy in the treatment of peptic ulcer].

Author: JungJi Min, ShimKi-Nam, OhHee Jung, NaYoun Ju, JungHae Sun, JungSung-Ae, YooKwon

Improved peptic ulcer disease treatment
Peptic ulcer disease

This study investigated whether it is more effective to give medications that reduce stomach acid (anti-secretory therapy) before or after eliminating H. pylori bacteria in people with peptic ulcers. The study aimed to determine whether this additional treatment improves outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Korean

46.

Intermittent versus continuous pantoprazole infusion in peptic ulcer bleeding: a prospective randomized study.

Author: YükselIlhami, AtasevenHilmi, KöklüSeyfettin, ErtuğrulIbrahim, BaşarOmer, OdemişBülent, IbişMehmet, SaşmazNurgül, SahinBurhan

This study compares two methods of using pantoprazole, a medication that reduces stomach acid, to prevent bleeding from peptic ulcers after endoscopic treatment: 1) giving the medication continuously and 2) giving it intermittently. The study aims to determine which approach is more effective in preventing bleeding from recurring.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Medical versus surgical treatment for refractory or recurrent peptic ulcer.

Author: GurusamyKurinchi Selvan, PallariElena

Peptic ulcer treatment
Treatment complications

Ulcers in the stomach or duodenum that don't heal with medication or those that cause problems despite treatment are called refractory or recurrent ulcers. While these ulcers can be fatal or lead to long-term health problems from medication, the best treatment, surgery or continued medication, is unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori.

Author: HajiaghamohammadiAli Akbar, ZargarAli, OveisiSonia, SamimiRasoul, ReisianSedigheh

Increased H. pylori eradication

Adding licorice to a clarithromycin-based triple regimen for Helicobacter pylori (H. pylori) eradication increased eradication rates, particularly in patients with peptic ulcer disease. The study involved 120 patients with positive rapid urease test, who were randomly assigned to receive either a standard triple regimen or the triple regimen plus licorice.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

49.

The cost effectiveness of Helicobacter pylori population screening-economic evaluation alongside a randomised controlled trial with 13-year follow-up.

Author: HøghMaria Bomme, KronborgChristian, HansenJane Møller, Schaffalitzky de MuckadellOve B

Improved dyspeptic symptoms
Prevents peptic ulcer
Reduced risk of gastric cancer
Higher cost

Population screening and eradication of Helicobacter pylori was not cost-effective in improving quality of life and was more expensive than not screening. Further research is needed to evaluate the long-term impact of this intervention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

[The efficacy and safety of quadruple therapy without bismuth (concomitant therapy) in the treatment of patients with Helicobacter pylori - associated gastric and duodenal peptic ulcer disease].

Author: VelievA M, MaevI V, AndreevD N, DichevaD T, ZaborovskiiA V, LobanovaE G, BektemirovaL G

High efficiency

Quadruple therapy without bismuth was more effective than triple therapy in eradicating Helicobacter pylori infection in patients with gastric or duodenal ulcer in Russia. The eradication rate was 92.1% (PP) for quadruple therapy without bismuth, compared to 78.4% (PP) for triple therapy. The frequency of side effects was 24.2% for quadruple therapy without bismuth, compared to 18.5% for triple therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

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