Side Effects of phenoxybenzamine: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Key Research Findings

Phenoxybenzamine is an alpha-blocker used to treat a variety of conditions, including benign prostatic hyperplasia (BPH), causalgia, neuropathic pain, pheochromocytoma, and Raynaud's phenomenon. 17 , 23 , 15 , 7 , Research has shown that phenoxybenzamine is effective in treating these conditions.

Reasons for Side Effects

Phenoxybenzamine is an alpha-blocker, so it relaxes smooth muscle in blood vessels and other organs. 13 This action can cause side effects such as low blood pressure, erectile dysfunction, and difficulty urinating.

Common Side Effects

Orthostatic Hypotension

Phenoxybenzamine can cause orthostatic hypotension because it dilates blood vessels. 23 , 15 , 26 This occurs when blood pressure drops suddenly when changing positions.

Erectile Dysfunction

Phenoxybenzamine can cause erectile dysfunction because it dilates blood vessels. 23 , 15 , 20 This occurs when blood flow to the penis is reduced.

Difficulty Urinating

Phenoxybenzamine can cause difficulty urinating because it relaxes the bladder sphincter. 13 This occurs when the resistance in the urethra decreases and urine cannot be excreted properly.

Other Side Effects

Phenoxybenzamine can also cause side effects such as nasal congestion, dry mouth, indigestion, and fatigue. , 22 These side effects are usually mild and temporary.

Countermeasures for Side Effects

Orthostatic Hypotension

To prevent orthostatic hypotension, get up slowly when taking phenoxybenzamine. It is also important to drink plenty of fluids.

Erectile Dysfunction

If you experience erectile dysfunction, consult your doctor.

Difficulty Urinating

If you experience difficulty urinating, consult your doctor.

Comparison Between Studies

Commonalities in Studies

Many studies have shown that while phenoxybenzamine is effective for a variety of conditions, it can cause side effects such as orthostatic hypotension, erectile dysfunction, and difficulty urinating.

Differences Between Studies

Studies have shown that the incidence and types of side effects of phenoxybenzamine vary. This is thought to be due to differences in the diseases studied, the age, sex, and health status of the patients, and other factors.

Cautions for Real-Life Application

It is important to use phenoxybenzamine under the guidance of a doctor because it can be effective for a variety of conditions while also causing side effects. In particular, if you are elderly or have underlying conditions such as heart disease, kidney disease, or liver disease, consult your doctor before taking phenoxybenzamine. Also, phenoxybenzamine should not be taken by pregnant or breastfeeding women.

Limitations of Current Research

Research on the side effects of phenoxybenzamine is still insufficient. Further research is needed, especially on long-term side effects.

Future Research Directions

To reduce the incidence of phenoxybenzamine side effects, it is necessary to develop safer drugs and improve administration methods.

Conclusion

Phenoxybenzamine is a drug that can be effective for a variety of conditions, but it can also cause side effects. When taking phenoxybenzamine, follow your doctor's instructions carefully and consult your doctor immediately if you experience any side effects.

Keywords
Benefit Keywords
Hemodynamic stability
Postoperative recovery
Reduced costs
1
Haemodynamic instability prevention
Pheochromocytoma treatment
2
Colorectal adenocarcinoma treatment
3
Tumor resection
4
Adrenal mass treatment
5
Endocrine hypertension treatment
7
Volume expansion
8
Lower arterial pressure
Pheochromocytoma management
9
Blood pressure control
10
Improved urinary flow
Reduced cardiovascular side effects
11
Bladder neck obstruction treatment
12
BPH treatment
Erectile dysfunction treatment
Stress incontinence treatment
13
Prostate volume reduction
Quality of life improvement
Symptom improvement
14
CRPS treatment
15
Improved obstructive symptoms
Reduced prostatic volume
16
Alpha-adrenoceptor antagonist
BPH treatment
Urethral obstruction
17
Antipsychotic efficacy
No extrapyramidal side effects
18
Antipsychotic effect
19
Erectile dysfunction treatment
20
Fewer side effects
Treat erectile dysfunction
21
Pain management
Reduced side effects
22
Effective for causalgia
23
Treats Raynaud's syndrome
24
Detrusor dyssynergia treatment
Phenoxybenzamine efficacy
26
Benign prostatic obstruction treatment
27
Risk Keywords
Side effects
1
Alpha-blocker risks
2
Harmful side effects
3
Blood pressure increase
4
Hypocortisolism
Hypotension
5
Carcinogenicity
6
Drug side effects
7
Postural hypotension
Tachycardia
8
Postoperative a1 blockade
Side effects
9
Dizziness
Headache
Hypotension
11
Side effects
Symptom relapse
14
Diarrhea
Headache
Impotence
Nausea
Orthostatic dizziness
15
Postural hypotension
16
Cardiovascular side effects
17
Extrapyramidal side effects
19
Hypertension
20
Arteriopathy
21
Side effects
22
Ejaculatory problems
Orthostatic hypotension
23
Dizziness
Erectile dysfunction
Nasal congestion
24
Urinary incontinence
25
Drowsiness
Ejaculatory failure
Fatigue
Mouth dryness
Nasal congestion
Nausea
Palpitations
Retrograde ejaculation
Vomiting
26
Alpha-blocking effects
27
Literature analysis of 27 papers
Positive Content
25
Neutral Content
0
Negative Content
2
Article Type
1
0
0
8
27
2.

Pheochromocytoma: a review on preoperative treatment with phenoxybenzamine or doxazosin.

Author: van der ZeeP A, de BoerA

Haemodynamic instability prevention
Pheochromocytoma treatment
Alpha-blocker risks

This review analyzes the current evidence of the benefits and risks of phenoxybenzamine and doxazosin, two alpha-blockers used in the preoperative treatment of pheochromocytoma to prevent haemodynamic instability during surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Functional Module Connectivity Map (FMCM): a framework for searching repurposed drug compounds for systems treatment of cancer and an application to colorectal adenocarcinoma.

Author: ChungFeng-Hsiang, ChiangYun-Ru, TsengAi-Lun, SungYung-Chuan, LuJean, HuangMin-Chang, MaNianhan, LeeHoong-Chien

Colorectal adenocarcinoma treatment
Harmful side effects

This study presents a novel method, Functional Module Connectivity Map (FMCM), for repurposing drugs for complex diseases, specifically colorectal adenocarcinoma. FMCM identifies promising drug candidates with minimal side effects and demonstrates its effectiveness in repurposing drug discovery for various diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

[Preoperative α-receptor block in patients with pheochromocytoma? Against].

Author: GroebenH

Tumor resection
Blood pressure increase

This study investigated the need for α-receptor blockade before surgery for catecholamine-producing tumors. While α-receptor blockade is still recommended, the study found no significant difference in blood pressure or hypertensive episodes between patients treated with and without α-receptor blockade. The study suggests that with improvements in surgical techniques and short-acting substances to control hemodynamics, the need for α-receptor blockade may be re-evaluated.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

5.

[Preoperative and postoperative management of adrenal masses].

Author: ParagliolaR M, RicciatoM P, GalloF, De RosaA, IanniF, LocantoreP, SenesP, PontecorviA, CorselloS M

Adrenal mass treatment
Hypocortisolism
Hypotension

This paper describes the management of adrenal masses, including preoperative and postoperative care. It highlights the importance of careful management to avoid complications such as hypocortisolism and hypertensive crisis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

6.

Epidemiologic evaluation of pharmaceuticals with limited evidence of carcinogenicity.

Author: FriedmanGary D, JiangSheng-Fang, UdaltsovaNatalia, QuesenberryCharles P, ChanJames, HabelLaurel A

Carcinogenicity

This study evaluated 9 pharmaceuticals classified as probably or possibly carcinogenic to humans for evidence of carcinogenicity in patients receiving them. Some supportive evidence was found for carcinogenicity of griseofulvin, metronidazole, and phenytoin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

7.

Endocrine arterial hypertension: therapeutic approach in clinical practice.

Author: MazzaA, ArmigliatoM, ZamboniS, RempelouP, RubelloD, PessinaA C, CasigliaE

Endocrine hypertension treatment
Drug side effects

This review provides an overview of the therapeutic approaches for endocrine arterial hypertension in clinical practice. Treatment options include surgery, pharmacologic blood pressure control, and management of hypertensive crises.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

[Effects of doxazosin mosylate and phenoxybenzamine in preoperative volume expansion of pheochromocytoma: a comparative study in 38 cases].

Author: PanDong-liang, LiHan-zhong, JiZhi-gang, ZengZheng-pei

Volume expansion
Postural hypotension
Tachycardia

Doxazosin mosylate was less effective than phenoxybenzamine for preoperative volume expansion in patients with pheochromocytoma but had a significantly lower rate of side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

9.

Efficacy and safety of doxazosin for perioperative management of patients with pheochromocytoma.

Author: Prys-RobertsCedric, FarndonJohn R

Lower arterial pressure
Pheochromocytoma management
Postoperative a1 blockade
Side effects

Doxazosin, a specific α1-adrenoceptor antagonist, was as effective as phenoxybenzamine in managing pheochromocytoma preoperatively but with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Rapid preparation of a patient with pheochromocytoma with labetolol and magnesium sulfate.

Author: PoopalalingamR, ChinE Y

Blood pressure control

Rapid perioperative control of blood pressure in a patient with pheochromocytoma was achieved using high doses of labetolol and a magnesium sulfate infusion, enabling safe laparoscopic resection of the tumor.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Alpha adrenergic blockers in the treatment of benign hyperplasia of the prostate.

Author: KumarV L, DewanS

Improved urinary flow
Reduced cardiovascular side effects
Dizziness
Headache
Hypotension

Benign prostatic hyperplasia (BPH) is a common condition in men. This paper reviews the pharmacological properties and efficacy of alpha adrenergic receptor blockers in the treatment of BPH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Adrenoceptor pharmacology: urogenital applications.

Author: RuffoloR R, HiebleJ P

BPH treatment
Erectile dysfunction treatment
Stress incontinence treatment

Alpha1-adrenoceptor antagonists, initially developed as antihypertensive drugs, are now widely used for benign prostatic hyperplasia (BPH). The article discusses the role of alpha1-adrenoceptor subtypes in BPH and other conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Comparative study of therapeutic effect of dibenyline, finasteride, and combination drugs for symptomatic benign prostatic hyperplasia.

Author: KuoH C

Prostate volume reduction
Quality of life improvement
Symptom improvement
Side effects
Symptom relapse

This prospective study found that medical treatment is effective in treating symptomatic benign prostatic hyperplasia (BPH), with combination dibenyline and finasteride providing a weak synergistic clinical effect without additive side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Medical management of benign prostatic hyperplasia: a review.

Author: MagohaG A

Improved obstructive symptoms
Reduced prostatic volume
Postural hypotension

Alpha adrenergic antagonists and 5-alpha reductase inhibitors are effective in treating benign prostatic hyperplasia (BPH). Alpha antagonists relax the smooth muscle component of prostatic obstruction, while 5-alpha reductase inhibitors reduce prostate volume.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

The use of alpha-adrenoceptor antagonists in the pharmacological management of benign prostatic hypertrophy: an overview.

Author: HiebleJ P, RuffoloR R

Alpha-adrenoceptor antagonist
BPH treatment
Urethral obstruction
Cardiovascular side effects

Alpha-adrenoceptor antagonists represent a useful pharmacological approach to the treatment of BPH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Experience with buccal phentolamine mesylate for impotence.

Author: ZorgniottiA W

Erectile dysfunction treatment
Hypertension

Oral or buccal administration of phentolamine can effectively treat impotence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

[Prostaglandin E1--the pharmacologic prosthesis].

Author: de BoccardG A, RochatC H

Fewer side effects
Treat erectile dysfunction
Arteriopathy

Prostaglandin E1 is an effective and safe treatment for erectile failure, offering an excellent alternative to a prosthetic implant.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

22.

[Pharmacotherapy of cancer pain. 3. Adjuvant drugs.].

Author: ChernyN I, PortenoyR K, RaberM, ZenzM

Pain management
Reduced side effects
Side effects

Adjuvant analgesics can be used to treat various types of pain, but they should not be used as a substitute for opioids and nonopioids.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

24.

Treatment of Raynaud's syndrome with adrenergic alpha-blockade with or without beta-blockade.

Author: CleophasT J, van LierH J, FennisJ F, van 't LaarA

Treats Raynaud's syndrome
Dizziness
Erectile dysfunction
Nasal congestion

Alpha-blockade is effective in treating Raynaud's syndrome. Adding beta-blockade counteracts fluid retention and reduces heart rate, without causing hypotension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Urinary incontinence secondary to drugs.

Author: KirulutaH G, AndrewsK

Urinary incontinence

Urinary incontinence can be a side effect of neuroleptics, antihypertensive agents, and drugs used to treat neurogenic bladder obstruction. These drugs may act peripherally or centrally.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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