Side Effects of phentermine and topiramate: A Synthesis of Findings from 27 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of phentermine and topiramate: A Synthesis of Findings from 27 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Major Research Findings

Phentermine/topiramate combination has been shown to be effective in treating obesity. 7 indicates that the combination of phentermine/topiramate results in an average weight loss of 8-10 kg. 1 reviews clinical evidence on weight loss and metabolic effects associated with the use of this product, suggesting its effectiveness. 12 shows that the combination drug phentermine/topiramate is effective in reducing weight compared to other anti-obesity drugs.

Reasons for Side Effects

Phentermine/topiramate is a medication that works by suppressing appetite. This is achieved by acting on neurotransmitters in the brain. Neurotransmitters are chemical substances that transmit information within the brain. Phentermine/topiramate works by acting on these neurotransmitters to suppress appetite and promote weight loss. 4 explains that the combination drug of phentermine and topiramate suppresses appetite by acting on neurotransmitters in the brain.

Common Side Effects

Tachycardia

Tachycardia is one of the side effects of the combination drug of phentermine and topiramate. 5 mentions the increased resting heart rate as a side effect of the combination drug of phentermine and topiramate. 12 also mentions that the combination drug of phentermine and topiramate can potentially affect the heart rate.

Metabolic Acidosis

Metabolic acidosis is one of the side effects of the combination drug of phentermine and topiramate. 5 mentions mild metabolic acidosis as a side effect of the combination drug of phentermine and topiramate.

Mental and Cognitive Impairment

Mental and cognitive impairment is one of the side effects of the combination drug of phentermine and topiramate. 5 mentions mental and cognitive impairment as a side effect of the combination drug of phentermine and topiramate.

Teratogenesis

The combination drug of phentermine and topiramate may cause birth defects in infants if taken by pregnant women. 5 mentions that the combination drug of phentermine and topiramate may cause teratogenesis.

Countermeasures for Side Effects

Tachycardia

Tachycardia caused by the combination drug of phentermine and topiramate is usually mild and improves when the drug is stopped. 5 mentions the increased resting heart rate as a side effect of the combination drug of phentermine and topiramate.

Metabolic Acidosis

Metabolic acidosis caused by the combination drug of phentermine and topiramate is usually mild and improves when the drug is stopped. 5 mentions mild metabolic acidosis as a side effect of the combination drug of phentermine and topiramate.

Mental and Cognitive Impairment

Mental and cognitive impairment caused by the combination drug of phentermine and topiramate is usually mild and improves when the drug is stopped. 5 mentions mental and cognitive impairment as a side effect of the combination drug of phentermine and topiramate.

Teratogenesis

Pregnant women should not take the combination drug of phentermine and topiramate. 5 mentions that the combination drug of phentermine and topiramate may cause teratogenesis.

Comparison Between Studies

Common Points

These studies indicate that the combination drug of phentermine and topiramate is effective in treating obesity. These studies also indicate that the combination drug of phentermine and topiramate is effective in reducing weight compared to other anti-obesity drugs.

Differences in Studies

These studies have employed different study designs to obtain detailed information about the side effects of the combination drug of phentermine and topiramate. 1 reviews clinical evidence related to the side effects of the combination drug of phentermine and topiramate. 5 provides more detailed information on the side effects of the combination drug of phentermine and topiramate.

Points to Note Regarding Application in Real Life

The combination drug of phentermine and topiramate is an effective drug for treating obesity, but there is a risk of side effects. When taking the combination drug of phentermine and topiramate, it is important to follow your doctor's instructions. Also, before taking it, you need to consult your doctor about whether you are pregnant or have the possibility of becoming pregnant.

Limitations of Current Research

Research on the long-term safety and effectiveness of the combination drug of phentermine and topiramate is still limited. 12 mentions the lack of research on the long-term safety and effectiveness of the combination drug of phentermine and topiramate.

Directions for Future Research

Further research on the long-term safety and effectiveness of the combination drug of phentermine and topiramate is needed. 12 mentions the need for research on the long-term safety and effectiveness of the combination drug of phentermine and topiramate.

Conclusion

The combination drug of phentermine and topiramate is an effective drug for treating obesity. However, there is a risk of side effects. When taking the combination drug of phentermine and topiramate, it is important to follow your doctor's instructions.

Literature analysis of 27 papers
Positive Content
21
Neutral Content
3
Negative Content
3
Article Type
1
0
0
18
26
1.

A review of the metabolic effects of controlled-release Phentermine/Topiramate.

Author: KiortsisDimitrios N

Metabolic effects
Weight loss
Adverse events

Phentermine/topiramate controlled-release (Qsymia®) has recently been approved for chronic weight management. This article reviews the available clinical evidence on its weight loss, metabolic effects, and adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Combination phentermine/topiramate for obesity treatment in primary care: a review.

Author: XiongGlen L, GaddeKishore M

Obesity management
Weight loss
Cognitive side effects
Heart rate issues
Psychiatric side effects

Phentermine/topiramate (Qsymia) is a weight loss drug that can achieve clinically meaningful weight loss (5%) and improve weight-related health problems. This drug may be a useful tool for primary care providers to manage obesity. However, special precautions and close monitoring are needed, especially for women who are pregnant or could become pregnant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

New drug therapies for the treatment of overweight and obese patients.

Author: MahgereftehBabak, VigueMichael, FreestoneZachary, SilverScott, NguyenQuang

Obesity

This abstract discusses the growing public health crisis of obesity, its associated healthcare costs, and the need for effective interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Update on pharmacology of obesity: benefits and risks.

Author: Cabrerizo GarcíaLucio, Ramos-LevíAna, Moreno LoperaCarmen, Rubio HerreraMiguel A

Obesity treatment
Weight loss
Side effects

This review examines the current landscape of medications for obesity treatment, highlighting the challenges and opportunities in this field. While orlistat is the only available drug in Europe, the US has recently approved lorcaserin and the combination phentermine/topiramate, both with varying levels of effectiveness and potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Tolerability and safety of the new anti-obesity medications.

Author: HainerVojtech, Aldhoon-HainerováIrena

Cardiometabolic risk reduction
Weight loss
Heart rate elevation
Side effects
Valvulopathy

This review compares two new anti-obesity medications, phentermine/topiramate extended-release (PHEN/TPM ER) and lorcaserin. PHEN/TPM ER showed superior weight loss compared to lorcaserin, while lorcaserin had a lower incidence of adverse effects. Both drugs were well-tolerated, but serious safety concerns include elevated resting heart rate, teratogenicity, mild metabolic acidosis, and psychiatric/cognitive events for PHEN/TPM ER, and valvulopathy, cognitive impairment, psychiatric disorders, and hypoglycemia for lorcaserin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

New medications for obesity management: changing the landscape of obesity treatment.

Author: Boulghassoul-PietrzykowskaNadia, FranceschelliJennifer, StillChristopher

Weight loss

This review article summarizes the current and future pharmacological approaches to treating obesity, including medications that can be used alongside lifestyle modifications for achieving weight loss.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Pharmacotherapy for obesity.

Author: JooJong Kil, LeeKyu Sup

Weight loss
Side effects

This article reviews currently available anti-obesity drugs, including short-term and long-term options. The article discusses the mechanisms of action, efficacy, and side effects of each drug, emphasizing the importance of considering side effects when choosing treatment for obesity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

A randomized, placebo-controlled crossover trial of phentermine-topiramate ER in patients with binge-eating disorder and bulimia nervosa.

Author: SaferDebra L, AdlerSarah, DalaiShebani Sethi, BentleyJason P, ToyamaHannah, PajaritoSarah, NajarianThomas

Binge eating treatment

This study investigated the efficacy and safety of phentermine/topiramate ER (PHEN/TPM-ER) for binge eating disorder (BED) or bulimia nervosa (BN) in a crossover randomized controlled trial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

9.

The cardiovascular safety of antiobesity drugs-analysis of signals in the FDA Adverse Event Report System Database.

Author: GorelikEinat, GorelikBoris, MasarwaReem, PerlmanAmichai, Hirsh-RaccahBruria, MatokIlan

Valvular disorders

Lorcaserin was associated with a significantly greater proportion of reports of valvular disorders. No safety signal was detected for valvulopathy, pulmonary hypertension, or other cardiovascular events with recently approved antiobesity drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Pharmacotherapy for Obesity.

Author: SaundersKatherine H, ShuklaAlpana P, IgelLeon I, KumarRekha B, AronneLouis J

Obesity treatment
Contraindications
Drug interactions
Side effects

This article reviews clinical indications, mechanisms of action, dosing/administration, side effects, drug interactions and contraindications for the six most widely prescribed obesity medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

New pharmacological treatments for the management of obesity.

Author: HurtRyan T, Edakkanambeth VarayilJithinraj, EbbertJon O

Obesity treatment
Reduced cardiovascular risk
Weight reduction
Adverse side effects
Lack of efficacy

This article reviews the pharmacology, clinical efficacy, and safety of two new medications for obesity, lorcaserin and phentermine/topiramate extended release (ER), in comparison to older and current medications. The authors highlight the challenges in developing effective and safe medications for obesity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Anti-obesity drugs.

Author: RankinWayne, WittertGary

Obesity treatment

Obesity is a growing global health problem that is associated with many serious health conditions. This review examines recent advances in the development of medications for weight loss. It also discusses the limitations of currently available and emerging agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Safety and tolerability of medications approved for chronic weight management.

Author: FujiokaKen

weight management
side effects

This paper reviewed 5 medications that are approved for chronic weight management and their mechanisms of action, risk profiles, and safety issues.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

FDA-Approved Pharmacotherapy for Weight Loss Over the Last Decade.

Author: IdreesZarwa, CancarevicIvan, HuangLi

Weight loss
Obesity complications

This review examines the safety and efficacy of five FDA-approved medications for obesity treatment: orlistat, phentermine/topiramate, naltrexone/bupropion, liraglutide, and semaglutide. While all medications were found to be effective in inducing weight loss, semaglutide may have superior efficacy. However, long-term safety and efficacy data are still lacking.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Effectiveness of anti-obesity medications approved for long-term use in a multidisciplinary weight management program: a multi-center clinical experience.

Author: CalderonGerardo, Gonzalez-IzundeguiDaniel, ShanKuangda L, Garcia-ValenciaOscar A, CifuentesLizeth, CamposAlejandro, Collazo-ClavellMaria L, ShahMeera, HurleyDaniel L, Abu LebdehHaitham S, SharmaMayank, SchmitzKristine, ClarkMatthew M, GrotheKaren, MundiManpreet S, CamilleriMichael, Abu DayyehBarham K, Hurtado AndradeMaria D, MokademMohamad A, AcostaAndres

Obesity treatment
Side effects

The effectiveness and side effects of anti-obesity medications (AOMs) are being evaluated in real-world multidisciplinary clinical practice settings to assess their applicability beyond controlled clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

19.

Phentermine-topiramate extended release for the dual treatment of obesity and sleep-related eating disorder: a case report.

Author: GrunvaldEduardo, DeCondeJennifer

Weight reduction
Sleep-related eating disorder

This review explores the challenges of treating obesity and eating disorders together, specifically focusing on the use of phentermine-topiramate extended release for weight reduction and the management of sleep-related eating disorder.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles.

Author: KrentzA J, FujiokaK, HompeschM

Obesity prevention
Weight loss
Cardiovascular toxicity
Neuro-psychiatric issues
Pulmonary hypertension
Stroke

This review explores the history of anti-obesity pharmacotherapy and the challenges of developing safe and effective weight loss medications. It discusses how the withdrawal of several drugs due to serious side effects has influenced the regulatory landscape for new anti-obesity drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview.

Author: Telci CakliliOzge, CesurMustafa, MikhailidisDimitri P, RizzoManfredi

Obesity management
Drug side effects

This review explores six anti-obesity drugs: liraglutide, semaglutide, tirzepatide, orlistat, phentermine/topiramate, and bupropion/naltrexone. All drugs have been approved by the FDA for weight reduction except tirzepatide which is still under evaluation. These medications offer promising results for managing obesity and reducing associated complications due to their efficacy and tolerable safety profiles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

A Rare Case of Phentermine-Induced Nonischemic Cardiomyopathy.

Author: DamaniDevanshi, HassanMariam, MahapatraSwati, PrakashSwathi, AlhaririSara, BiesJared, TrivediBhavi, EdwardsBrian P

Heart failure
Phentermine use

This case report highlights the potential for phentermine to precipitate heart failure, even in a young, relatively healthy person.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

24.

A Comparison of New Pharmacological Agents for the Treatment of Obesity.

Author: NufferWesley, TrujilloJennifer M, MegyeriJade

Obesity treatment
Gastrointestinal side effects

Four new pharmacological agents for managing overweight and obesity have been approved: phentermine/topiramate ER, naltrexone/bupropion, liraglutide, and lorcaserin. Phentermine/topiramate ER had the best overall average weight loss, followed by naltrexone/bupropion, liraglutide, and lorcaserin. Most side effects were gastrointestinal in nature, with liraglutide having the highest reported rates and lorcaserin the lowest.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Pharmacotherapy for weight loss: the cardiovascular effects of the old and new agents.

Author: WalterC P, BleskeB E, DorschM P

Weight loss
Cardiovascular effects

The cardiovascular effects of weight loss pharmacotherapy agents are being reviewed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

Pharmacotherapy in Conjunction with a Diet and Exercise Program for the Treatment of Weight Recidivism or Weight Loss Plateau Post-bariatric Surgery: a Retrospective Review.

Author: SchwartzJennifer, ChaudhryUmer I, SuzoAndrew, DurkinNicholas, WehrAllison M, ForemanKathy S, TychonievichKristen, MikamiDean J, NeedlemanBradley J, NoriaSabrena F

Improved obesity management
Weight loss
Weight loss plateau
Weight recidivism

Bariatric surgery is effective for obesity but weight recidivism and plateau are common problems. This report describes the use of two pharmacotherapies alongside diet and exercise for patients experiencing these issues.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

[Drug control of appetite].

Author: MakoundouV, GolayA

Appetite control
Fewer side effects
Obesity management

Drugs that control appetite are crucial for managing obesity. New research is focusing on developing drugs with fewer side effects and novel mechanisms of action. Polypill products combining multiple drugs show promising results.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

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