Side Effects of pitavastatin: A Synthesis of Findings from 24 Studies

  1. Home
  2. Side Effects of pitavastatin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of pitavastatin: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of pitavastatin: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Pitavastatin has been shown to be associated with a lower risk of muscle toxicity compared to other statins. 17 , 23 , 22 . It is selectively distributed to the liver and excreted into bile without metabolic modification, leading to minimal metabolism by cytochrome P450 and a reduced potential for drug-drug interactions. 23 . Moreover, pitavastatin has been found not to adversely affect glucose metabolism. 11 .

Pitavastatin, like other statins, has been shown to be effective in treating high cholesterol. 23 . By lowering LDL cholesterol levels, it can help prevent the progression of atherosclerosis and reduce the risk of cardiovascular events. 11 .

Pitavastatin has been suggested to have an effect on suppressing cancer cell growth, although its mechanism is not fully understood. 5 . It has shown potential to inhibit the growth of ovarian cancer cells and may even enhance the effectiveness of anticancer drugs like paclitaxel. 12 , 3 . Additionally, pitavastatin has shown potential to suppress the growth of breast cancer cells and enhance the effectiveness of anticancer drugs like doxorubicin/cyclophosphamide. 1 .

Reasons for Side Effects

Pitavastatin, like other statins, can cause side effects such as muscle toxicity, liver toxicity, and neurotoxicity. 7 . These side effects are likely due to a complex interplay of its pharmacological action, individual patient characteristics, and genetic background.

Common Side Effects

Muscle Pain

Pitavastatin, like other statins, can cause muscle pain. 17 , 18 , 22 . Muscle pain may be caused by inhibition of CYP3A4, an enzyme involved in pitavastatin metabolism. 18 . Muscle pain occurs in about 1-5% of patients taking pitavastatin. 14 . It may develop a few weeks to months after starting pitavastatin. 14 . Muscle pain usually improves when pitavastatin is stopped. 14 .

Liver Function Impairment

Pitavastatin, like other statins, can cause liver function impairment. 14 . Liver function impairment occurs in about 1% of patients taking pitavastatin. 14 . It may develop a few weeks to months after starting pitavastatin. 14 . Liver function impairment usually improves when pitavastatin is stopped. 14 .

Neurotoxicity

Pitavastatin, like other statins, can cause neurotoxicity. 14 . Neurotoxicity occurs in about 1% of patients taking pitavastatin. 14 . It may develop a few weeks to months after starting pitavastatin. 14 . Neurotoxicity usually improves when pitavastatin is stopped. 14 .

Side Effect Management

Muscle Pain

If muscle pain develops, stop taking pitavastatin and consult your doctor. 14 . If the pain is mild, you may be able to resume taking pitavastatin. 14 . However, if the pain is severe, you may need to stop taking pitavastatin and switch to a different medication. 14 .

Liver Function Impairment

If liver function impairment develops, stop taking pitavastatin and consult your doctor. 14 . If the impairment is mild, you may be able to resume taking pitavastatin. 14 . However, if the impairment is severe, you may need to stop taking pitavastatin and switch to a different medication. 14 .

Neurotoxicity

If neurotoxicity develops, stop taking pitavastatin and consult your doctor. 14 . If the neurotoxicity is mild, you may be able to resume taking pitavastatin. 14 . However, if the neurotoxicity is severe, you may need to stop taking pitavastatin and switch to a different medication. 14 .

Comparison Between Studies

Commonalities

Multiple studies have shown that pitavastatin is associated with a lower risk of muscle toxicity compared to other statins. 17 , 23 , 22 .

Differences

While pitavastatin has shown potential for suppressing cancer cell growth, the mechanisms involved are not entirely understood. 5 . Some studies suggest that pitavastatin may be superior to other statins in terms of its anti-cancer effects. 5 . However, it is not definitive to say that pitavastatin is more effective than other statins in cancer treatment. 5 .

Precautions for Real-World Application

Pitavastatin, like other statins, can cause muscle pain, liver function impairment, and neurotoxicity. 14 . When taking pitavastatin, it is important to be aware of these potential side effects and consult with your doctor regularly. 14 . It is also important to consult with your doctor before taking pitavastatin due to the possibility of drug interactions. 17 , 22 .

Limitations of Current Research

There are still aspects of pitavastatin's side effects that remain unclear. 14 . Specifically, it is not definitively established whether pitavastatin is more effective than other statins in cancer treatment. 5 . Further research on the side effects of pitavastatin is needed.

Future Research Directions

Pitavastatin has been shown to have a lower risk of muscle toxicity compared to other statins. 17 , 23 , 22 . It has also shown potential for suppressing cancer cell growth. 5 . However, further research is needed to support these findings. 5 . Additionally, research on reducing the side effects of pitavastatin is necessary.

Conclusion

Pitavastatin has been shown to be effective in treating high cholesterol. 23 . It has been associated with a lower risk of muscle toxicity compared to other statins. 17 , 23 , 22 . It has also shown potential for suppressing cancer cell growth. 5 . However, there are still aspects of pitavastatin's side effects that remain unclear. 14 . When taking pitavastatin, it is important to be aware of these potential side effects and consult with your doctor regularly.

Literature analysis of 24 papers
Positive Content
22
Neutral Content
0
Negative Content
2
Article Type
2
0
0
8
24
4.

Interaction of the pitavastatin with model membranes.

Author: ShurshalovaGuzel S, ScheidtHolger A, FischerMarkus, HusterDaniel, AganovAlbert V, KlochkovVladimir V

Lowered LDL cholesterol
Statin intolerance

This report investigated the interaction of pitavastatin, a statin drug, with model membranes using solid-state NMR spectroscopy. The study found that pitavastatin localizes at the lipid/water interface of the membrane, suggesting a potential explanation for its side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Atorvastatin associated with gamma glutamyl transpeptidase elevation in a hyperlipidemia patient: A case report and literature review.

Author: XuYan, WuYanqing

Atorvastatin GGT elevation

A case report describes a 47-year-old male who experienced gamma glutamyl transpeptidase (GGT) elevation induced by atorvastatin. The patient's GGT level returned to normal within 6 weeks of cessation of atorvastatin. This case highlights the importance of monitoring liver function tests in patients on statin therapy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins.

Author: HirotaTakeshi, FujitaYuito, IeiriIchiro

Hypercholesterolemia treatment
Skeletal muscle toxicity

This abstract provides information about statins, a class of drugs used to lower cholesterol levels. It discusses the different mechanisms by which various statins are metabolized and transported in the body, highlighting the potential for drug interactions and muscle toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Recent advances in synthetic pharmacotherapies for dyslipidaemias.

Author: SirtoriCesare R, YamashitaShizuya, GrecoMaria Francesca, CorsiniAlberto, WattsGerald F, RuscicaMassimiliano

Elevated HDL-C
Reduced LDL-C
Reduced triglycerides

This review highlights the need for new oral agents targeting classical lipid targets. Pitavastatin, bempedoic acid, pemafibrate, eicosapentaenoic ethyl ester, gemcabene, anacetrapib, and probucol are promising options that address hypercholesterolemia and hypertriglyceridemia with good efficacy and potential safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

A randomized controlled trial of eicosapentaenoic acid in patients with coronary heart disease on statins.

Author: WatanabeTetsu, AndoKaoru, DaidojiHyuma, OtakiYoichiro, SugawaraShigeo, MatsuiMotoyuki, IkenoEiichiro, HironoOsamu, MiyawakiHiroshi, YashiroYoshinori, NishiyamaSatoshi, ArimotoTakanori, TakahashiHiroki, ShishidoTetsuro, MiyashitaTakehiko, MiyamotoTakuya, KubotaIsao,

CHD prevention
Plaque regression
CHD residual risk

This study investigated whether adding eicosapentaenoic acid (EPA) to high-dose pitavastatin (PTV) could reinforce coronary plaque regression and stabilization. Further research is needed to determine the clinical significance of this approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Statin Therapy: Review of Safety and Potential Side Effects.

Author: RamkumarSatish, RaghunathAjay, RaghunathSudhakshini

Cardiovascular disease prevention
Statin side effects

This article reviews the current medical literature regarding the safety of statins, commonly prescribed medications for reducing LDL cholesterol and cardiovascular risk. It discusses both the benefits and potential adverse effects of long-term statin use, providing a comprehensive overview of the safety profile of these drugs.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Drug-drug interactions that interfere with statin metabolism.

Author: HirotaTakeshi, IeiriIchiro

Atherosclerotic disease prevention
Myotoxic side effects

Statins are effective in treating and preventing atherosclerotic diseases but can cause myotoxic side effects. The myotoxicity is associated with CYP 3A4 inhibition, which increases the plasma concentration of simvastatin, lovastatin, and atorvastatin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

The effects of pitavastatin on glucose metabolism in patients with type 2 diabetes with hypercholesterolemia.

Author: DaidoHisashi, HorikawaYukio, TakedaJun

Reduced fasting blood glucose

Pitavastatin did not worsen insulin resistance in Japanese patients with type 2 diabetes complicated by hypercholesterolemia. However, it elicited a significant decrease in fasting blood glucose in the obese group with BMI ≥ 25.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Effect of pitavastatin on vascular reactivity in hypercholesterolemic rabbits.

Author: AlmeidaEros Antonio de, OzakiMichiko Regina

Reduced cholesterol
Reduced plasma lipids
Reduced tissue lipid peroxidation
Reversed endothelial dysfunction

The study evaluated the effect of pitavastatin on vascular reactivity in hypercholesterolemic rabbits. The study found that pitavastatin, starting at a 0.5 mg dose, was effective in reverting endothelial dysfunction in hypercholesterolemic rabbits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.

Author: MatsumotoTetsuya, FujitaMasatoshi, SawamuraTatsuya, KakinoAkemi, SatoYuko, FujitaYoshiko, MatsudaHaruo, NakanishiMamoru, UchidaKagehiro, NakaeIzuru, KandaHiroshi, YoshidaAkira, MiwaKunihisa, HayashiHideki, MitsunamiKenichi, HorieMinoru

LDL-C reduction
Oxidative stress reduction
Statin pleiotropic effects

Pitavastatin, a statin, was found to reduce LDL-C, LOX-1 ligand, and triacylglycerols in patients with hypercholesterolemia. These findings suggest that pitavastatin may have beneficial effects on oxidative stress.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions.

Author: ShitaraYoshihisa, SugiyamaYuichi

Hypercholesterolemia treatment
Myopathy
Rhabdomyolysis

This review discusses the pharmacokinetic aspects of statins, a class of drugs used to lower cholesterol, and the potential for pharmacokinetic alterations to cause myotoxic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

[Pharmacological and pharmacokinetic features and clinical effects of pitavastatin (Livalo Tablet)].

Author: YamazakiHiroyuki, FujinoHideki, KanazawaMizuho, TamakiTaro, SatoFumiyasu, SuzukiMikio, KitaharaMasaki

Cholesterol reduction
Reduced drug interaction
Triglyceride reduction
Side effects

Pitavastatin is a medication used to lower cholesterol levels. This study reviewed the development and effectiveness of pitavastatin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

24.

New drugs for the treatment of hypercholesterolaemia.

Author: IglesiasPedro, DíezJuan J

Improved lipid profiles
Reduced cholesterol levels

This review discusses the various lipid-lowering drugs used to reduce the risk of coronary heart disease. The review highlights two new statins, rosuvastatin and pitavastatin, which are more potent than other available statins and have a lower risk of muscle toxicity. The review also discusses the use of ezetimibe, a selective cholesterol absorption inhibitor, and colesevelam, a bile acid sequestrant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.