Side Effects of polyethylene glycol-electrolyte solution (peg-es): A Synthesis of Findings from 2 Studies

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Original Abstract of the Article

Main Research Findings

Polyethylene glycol-electrolyte solution (PEG-ES) has been shown to be more comfortable and less damaging to the rectal lining compared to traditional soap suds or tap water enemas for constipation treatment in healthy volunteers. 1

In a study comparing the efficacy and safety of PEG-ES versus polyethylene glycol-3350 for treating fecal impaction in pediatric patients, both PEG-based treatments were effective, but PEG-ES was more frequently associated with diarrhea and vomiting, while PEG-3350 was more commonly associated with abdominal pain. 2

Reasons for Side Effects

Soap suds and tap water enemas can damage the surface epithelium of the rectum, which may contribute to discomfort and a stronger defecation stimulus. 1

Common Side Effects

Diarrhea

PEG-ES can cause diarrhea. 2

Vomiting

PEG-ES can cause vomiting. 2

Abdominal Pain

Polyethylene glycol-3350 can cause abdominal pain. 2

Side Effect Management

Diarrhea

If diarrhea occurs, make sure to stay hydrated. Consult a doctor if symptoms persist.

Vomiting

If vomiting occurs, make sure to stay hydrated. Consult a doctor if symptoms persist.

Abdominal Pain

Consult a doctor if abdominal pain occurs.

Comparison Between Studies

Research Similarities

Both studies indicated that PEG-ES is effective in treating constipation.

Research Differences

The first study found that PEG-ES was more comfortable and less damaging to the rectal lining compared to soap suds or tap water enemas for healthy volunteers. 1

The second study showed that PEG-ES was as effective as polyethylene glycol-3350 for treating fecal impaction in children, but it was more frequently associated with diarrhea and vomiting. 2

Real-World Application Considerations

While PEG-ES can be an effective treatment for constipation, it may cause side effects such as diarrhea and vomiting. 2

It is essential to consult a doctor before using PEG-ES and monitor for any side effects.

Limitations of Current Research

These studies were conducted on healthy volunteers or children with fecal impaction, and it is unclear whether the findings are applicable to other populations.

Future Research Directions

Further research is needed to determine the most effective populations for PEG-ES treatment for constipation and to investigate the long-term safety and efficacy of PEG-ES.

Conclusion

PEG-ES may be an effective treatment for constipation, and it may be more comfortable and less damaging to the rectal lining than soap suds or tap water enemas. 1 However, it can cause side effects such as diarrhea and vomiting, so it is essential to consult a doctor before using it.

Literature analysis of 2 papers
Positive Content
1
Neutral Content
0
Negative Content
1
Article Type
1
0
0
0
2
1.

Safety and effectiveness of large-volume enema solutions.

Author: SchmelzerMarilee, SchillerLawrence R, MeyerRichard, RugariSusan M, CasePatti

Greater returns
Epithelium loss
Uncomfortable

This study compared the effectiveness and side effects of different enema solutions. Soapsuds and tap water enemas were more effective than a polyethylene glycol electrolyte solution, but were also more uncomfortable and caused damage to the rectal lining.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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