Side Effects of pretomanid: A Synthesis of Findings from 5 Studies

  1. Home
  2. Side Effects of pretomanid
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of pretomanid: A Synthesis of Findings from 5 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of pretomanid: A Synthesis of Findings from 5 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Pretomanid is a new drug used to treat multidrug-resistant tuberculosis (MDR-TB). 4 The bedaquiline-pretomanid-linezolid regimen has been reported to have 90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events with 1200 mg of linezolid daily has been high. 3 Pretomanid is a new nitroimidazole drug used to treat multidrug-resistant pulmonary tuberculosis. 4

Reasons for Side Effects

Side effects of drugs containing pretomanid can be caused by a variety of factors, including the drug's mechanism of action, dosage, individual patient differences, and interactions with other drugs. 3

Common Side Effects

QT Prolongation

QT prolongation has been reported as a side effect of drugs containing pretomanid. QT prolongation can cause heart attacks and other heart-related complications by affecting the electrical activity of the heart. QT prolongation has been reported as a side effect of drugs containing pretomanid.

Side Effects Countermeasures

QT Prolongation

QT prolongation has been reported as a side effect of drugs containing pretomanid. QT prolongation can cause heart attacks and other heart-related complications by affecting the electrical activity of the heart. To prevent QT prolongation, doctors should regularly monitor the patient's heart function. Also, other medications that may affect the patient's heart should be carefully managed.

Comparison Between Studies

Commonalities in Studies

Multiple studies have shown that pretomanid is an effective drug for the treatment of MDR-TB. 3 4 However, it has also been shown that pretomanid can cause side effects such as QT prolongation.

Differences in Studies

Further research is needed on the optimal dose and duration of treatment for pretomanid. 3 Side effects of drugs containing pretomanid are influenced by many factors, including individual physical characteristics and other medications being taken.

Precautions for Real-Life Applications

Pretomanid is an effective drug for the treatment of MDR-TB, but you need to be aware of the risk of side effects. If you are taking medications containing pretomanid, you should follow your doctor's instructions and see your doctor regularly to detect side effects early.

Limitations of Current Research

The long-term effects and safety of pretomanid have not yet been adequately studied. Further research is needed on the optimal dose and duration of treatment for pretomanid. 3

Future Research Directions

Further research is needed to evaluate the long-term effects and safety of pretomanid. Further research is needed to determine the optimal dose and duration of treatment for pretomanid. 3

Conclusion

Pretomanid is a new drug that is effective for the treatment of MDR-TB. 3 However, pretomanid can cause side effects such as QT prolongation. If you are taking medications containing pretomanid, you should follow your doctor's instructions and see your doctor regularly to detect side effects early.

Literature analysis of 5 papers
Positive Content
2
Neutral Content
1
Negative Content
2
Article Type
2
0
0
0
4
1.

Cognitive effects of pregabalin in healthy volunteers: a double-blind, placebo-controlled trial.

Author: SalinskyMartin, StorzbachDaniel, MunozSonia

Cognitive dysfunction

This study investigated the cognitive effects of pregabalin, an antiepileptic drug (AED), in healthy volunteers over 12 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Bedaquiline-Pretomanid-Linezolid Regimens for Drug-Resistant Tuberculosis.

Author: ConradieFrancesca, BagdasaryanTatevik R, BorisovSergey, HowellPauline, MikiashviliLali, NgubaneNosipho, SamoilovaAnastasia, SkornykovaSergey, TudorElena, VariavaEbrahim, YablonskiyPetr, EverittDaniel, WillsGenevieve H, SunEugene, OlugbosiMorounfolu, EgiziErica, LiMengchun, HolstaAlda, TimmJuliano, BatesonAnna, CrookAngela M, FabianeStella M, HuntRobert, McHughTimothy D, TweedConor D, ForaidaSalah, MendelCarl M, SpigelmanMelvin,

Drug-resistant TB efficacy
Adverse events

This study aimed to determine the appropriate dose and duration of linezolid treatment to minimize toxic effects while maintaining efficacy against highly drug-resistant tuberculosis in the bedaquiline-pretomanid-linezolid regimen.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Pretomanid dose selection for pulmonary tuberculosis: An application of multi-objective optimization to dosage regimen design.

Author: LyonsMichael A

Optimized TB drug regimens
Drug resistance
Drug-related adverse events

A multi-objective optimization approach to dose selection was developed as a conceptual and computational framework for clinical testing of novel TB regimens. The phase IIa studies for pretomanid demonstrated the approach with Pareto optimized dosing that best minimized sputum bacillary load and the probability of drug-related adverse events.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.

Author: ConradieFrancesca, DiaconAndreas H, NgubaneNosipho, HowellPauline, EverittDaniel, CrookAngela M, MendelCarl M, EgiziErica, MoreiraJoanna, TimmJuliano, McHughTimothy D, WillsGenevieve H, BatesonAnna, HuntRobert, Van NiekerkChristo, LiMengchun, OlugbosiMorounfolu, SpigelmanMelvin,

Favorable outcome
Myelosuppression
Peripheral neuropathy

This study found that a combination of bedaquiline, pretomanid, and linezolid led to a favorable outcome in 90% of patients with highly drug-resistant forms of tuberculosis. However, the study also observed some associated toxic effects, including peripheral neuropathy and myelosuppression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.