Side Effects of propantheline: A Synthesis of Findings from 19 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of propantheline: A Synthesis of Findings from 19 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Findings

Propantheline is an anticholinergic medication that is often used to treat bladder problems, including overactive bladder and urinary retention. 8 It is also used to relax the esophagus for diagnostic tests such as esophagography. 6 While propantheline can be effective in treating these conditions, it is important to be aware of the potential side effects.

Reasons for Side Effects

Propantheline works by blocking the action of acetylcholine, a neurotransmitter that plays a role in the parasympathetic nervous system. The parasympathetic nervous system controls many bodily functions, including digestion, urination, and heart rate. By blocking acetylcholine, propantheline can disrupt these functions, leading to side effects.

Common Side Effects

Dry Mouth

Propantheline can cause dry mouth as a common side effect. This is because it blocks acetylcholine, which is involved in saliva production. 6 1

Visual Disturbances

Propantheline can also cause visual disturbances, such as blurred vision and difficulty focusing. This is because it can constrict the pupils of the eyes. 6

Difficulty Urinating

Since propantheline relaxes the bladder, it can lead to difficulty urinating or urinary retention. 6

Constipation

Propantheline can slow down the movement of the digestive system, which can cause constipation. 6

Tachycardia

Propantheline can increase heart rate, a condition known as tachycardia. 6

Other Potential Side Effects

Other less common side effects reported with propantheline include dizziness, confusion, and sweating. 6

Countermeasures for Side Effects

Dry Mouth

To manage dry mouth, try drinking plenty of fluids and sucking on sugar-free candies or chewing sugar-free gum.

Visual Disturbances

If you experience visual disturbances, avoid activities that require clear vision, such as driving or operating machinery.

Difficulty Urinating

If you have trouble urinating, consult your doctor. They may recommend adjustments to your medication or suggest alternative treatments.

Constipation

To prevent constipation, eat a high-fiber diet, drink plenty of fluids, and consider using over-the-counter laxatives if necessary.

Tachycardia

If you experience rapid heartbeat, consult your doctor. They may adjust your medication or recommend other treatments.

Other Potential Side Effects

If you experience any other concerning side effects, contact your doctor for advice.

Comparison Between Studies

Commonalities of Studies

Many studies have shown that propantheline is effective in treating bladder problems and relaxing the esophagus for diagnostic procedures. 8 6

Differences Between Studies

The frequency and severity of side effects reported with propantheline can vary between studies. Some studies have reported more significant side effects than others.

Points to Note for Application in Real Life

Propantheline can be a useful medication for treating bladder problems and facilitating diagnostic procedures. However, it's crucial to discuss any concerns about side effects with your doctor. They can help you weigh the benefits and risks of propantheline and determine if it's the right treatment for you. It's also important to remember that propantheline is contraindicated in people with glaucoma, severe heart or circulatory problems, or urinary obstruction. 6

Limitations of Current Research

While there is a significant body of research on propantheline, more research is needed to fully understand the long-term effects and the potential for side effects in specific patient populations.

Future Research Directions

Future research should focus on understanding the long-term effects of propantheline, evaluating the risk of side effects in different populations, and exploring alternative treatments that may have fewer side effects.

Conclusion

Propantheline is an effective medication for treating certain bladder problems and aiding in diagnostic procedures. However, it's important to be aware of the potential side effects and discuss any concerns with your doctor. Your doctor can help you make an informed decision about whether propantheline is the right treatment for you.

Literature analysis of 19 papers
Positive Content
16
Neutral Content
0
Negative Content
3
Article Type
4
0
0
2
18
1.

[Propantheline bromide is effective against dog drooling].

Author: GyldenløveMette, ThyssenJacob P

Polydipsia

This case report describes a puppy that accidentally ingested a large amount of propantheline bromide, an anticholinergic drug. The puppy experienced severe thirst, which resolved after three days.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : Danish

2.

Comparison of risk of neurovascular and cardiovascular side effects between tiotropium and other anticholinergic agents.

Author: AlzayerReem, HughesJeffery, ParsonsRichard, LeeYa Ping

Cardiovascular risk
Neurovascular risk

Inhaled anticholinergic drugs were associated with a higher risk of neurovascular or cardiovascular side effects compared to oral anticholinergic drugs, except for stroke and hypertension. However, oral anticholinergic drugs also had potential adverse impacts on health.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Double-blind evaluation of glucagon and propantheline bromide (pro-banthine) for hypotonic duodenography.

Author: BertrandG, LinscheerW G, RahejaK L, WoodsR F

Gastrointestinal hypotonia

Glucagon is more effective than propantheline bromide in reducing hypotonia of the upper gastrointestinal tract.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Gastrointestinal radiography with glucagon.

Author: MillerR E, ChernishS M, BrunelleR L

Predictable length of action
Rapid onset
Nausea
Vomiting

Glucagon is effective for hypotonic diagnostic examinations of the upper gastrointestinal tract and colon. It can be given intramuscularly or intravenously, and has a rapid onset and predictable length of action depending on the dose given.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Blood levels and management of lithium treatment.

Author: CrammerJ L, RosserR M, CraneG

Antimanic effect
Prophylactic effect
Hypothyroidism
Obesity
Polyuria
Thirst

Lithium plasma levels fluctuate after ingestion, making single measurements unreliable for dose adjustments. Common side effects include thirst and hypothyroidism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Studies on the effect and mode of action of flavoxate in human urinary bladder and sphincter.

Author: PedersenE

Neurogenic bladder treatment
Side effects

Flavoxate and propantheline were compared for their clinical effects on voiding disturbances in hyperactive neurogenic bladders. Both drugs increased bladder capacity, but flavoxate did not increase residual urine, unlike propantheline. Flavoxate had fewer side effects than propantheline.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

The use of Pro-Banthine to induce gastrointestinal hypotonia.

Author: MerloR B, StoneM, BaugusP, MartinM

Minimal side effects
Relaxes GI tract

Pro-Banthine, a medication used to induce gastrointestinal hypotonia, was found to be an effective alternative to glucagon when contraindicated or unavailable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Oxybutinin versus propantheline in the management of detrusor instability. A patient-regulated variable dose trial.

Author: HolmesD M, MontzF J, StantonS L

Detrusor instability treatment
Side effects

Oxybutinin hydrochloride and propantheline bromide are both effective in treating detrusor instability. In a randomized crossover trial of 23 women, oxybutinin hydrochloride was associated with subjective improvement in 14 patients, while propantheline bromide showed improvement in 11 patients. Oxybutinin significantly delayed the first desire to void and increased maximum cystometric capacity. Propantheline also increased maximum cystometric capacity. Three patients stopped treatment due to side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with gastric hypersecretory states.

Author: JensenR T, CollenM J, McArthurK E, HowardJ M, MatonP N, ChernerJ A, GardnerJ D

Gastric acid hypersecretion treatment
Breast changes
Impotence

Ranitidine is a more potent H2-histamine receptor antagonist than cimetidine. It is effective in controlling gastric acid hypersecretion and does not cause the antiandrogen side effects that can occur with high doses of cimetidine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Anticholinergic medication for the unstable bladder: prospective trials of imipramine/propantheline versus penthienate and oxybutynin versus penthienate.

Author: ClarkeB

Improved urinary symptoms
Unstable bladder treatment
Side effects

Imipramine/propantheline, oxybutynin, and penthienate bromide were compared for treating unstable bladder symptoms. All drugs improved urinary symptoms and urodynamic changes, but penthienate was more effective than imipramine/propantheline and equivalent to oxybutynin. Side effects were common, particularly with oxybutynin. However, none of the drugs consistently and objectively prevented uninhibited detrusor contractions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Urinary urge incontinence: randomised crossover trials of penthienate versus placebo and propantheline.

Author: CoombesG M, MillardR J

Improved bladder capacity
Reduced frequency
Reduced incontinence
Dry mouth
Urinary retention

Penthienate (5 mg three times a day) was more effective than both placebo and propantheline (15 mg three times a day) in treating primary idiopathic detrusor instability. This was observed both objectively and subjectively.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Hypotonic duodenography with glucagon. A clinical comparison study.

Author: CarsenG M, FinbyN

Effective for duodenography
More side effects than Pro-Banthine

Glucagon was found to be a valuable agent for hypotonic duodenography, with fewer side effects than Pro-Banthine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Oxybutynin versus propantheline in patients with multiple sclerosis and detrusor hyperreflexia.

Author: GajewskiJ B, AwadS A

Improved bladder function
Side effects

Oxybutynin was found to be more effective than propantheline in treating detrusor hyperreflexia in patients with multiple sclerosis. While both drugs had comparable neurological, urological, and urodynamic status before treatment, oxybutynin led to better symptomatic responses in a larger percentage of patients. Side effects were experienced by 21% of patients taking oxybutynin and 27% taking propantheline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The use of neurolept analgesia for gastro-intestinal endoscopy.

Author: RubinJ, BryerJ V, Brock-UtneJ G, MoshalM G

Improved tolerance of gastrointestinal endoscopy
Reduced side effects

Neurolept analgesia with droperidol and fentanyl without topical anaesthesia was found to be the most tolerable and well-tolerated regimen for gastro-intestinal endoscopy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Pirenzepine and propantheline effects on esophageal pressure responses to bethanechol.

Author: HassanM, DaltonC B, CastellJ A, CastellD O

Less anticholinergic side effects

Pirenzepine, an antisecretory anticholinergic drug, showed no significant anticholinergic side effects on esophageal smooth muscle, unlike propantheline. It demonstrated a moderate effect on LES pressure and no significant change in peristaltic amplitudes, suggesting no release of cholinergic inhibition.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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