Effects of pyridoxine: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Main Research Findings

Pyridoxine (vitamin B6) can affect sleep and dreams. One study found that taking pyridoxine before bed increased the amount of dream content participants recalled. 10 Another study found that pyridoxine may improve dream vividness, bizarreness, emotionality, and color scores. 10 However, pyridoxine deficiency can negatively impact hippocampal function, monoamine levels, and hippocampal neurogenesis. 8

Benefits and Risks

Benefits Summary

Pyridoxine may increase the amount of dream content recalled. 10 It may also improve dream vividness, bizarreness, emotionality, and color scores. 10 Additionally, pyridoxine may help improve cognitive function, increase monoamine levels, and promote hippocampal neurogenesis. 8

Risks Summary

Pyridoxine can cause neurological damage if taken in excessive amounts. 8 Pyridoxine deficiency can lead to impaired cognitive function, decreased monoamine levels, and inhibited hippocampal neurogenesis. 8 Furthermore, pyridoxine may worsen tissue damage and oxidative stress induced by high-intensity interval training (HIIT). 4

Research Comparisons

Research Similarities

Many studies suggest that pyridoxine may affect sleep and dreams. 10 Studies also indicate that pyridoxine can impact hippocampal function, monoamine levels, and hippocampal neurogenesis. 8

Research Differences

While some studies show that pyridoxine improves dream vividness, bizarreness, and color, others find no such effect. 10 The effects of pyridoxine may vary depending on factors such as dosage, administration method, and characteristics of study participants.

Consistency and Contradictions in Findings

Research on the effects of pyridoxine hasn't yielded consistently clear results. Some studies have shown that pyridoxine increases the amount of dream content recalled and enhances dream vividness, bizarreness, emotionality, and color scores. 10 However, other studies have found no impact on dream vividness, bizarreness, or color. 10 These contradictions could be attributed to factors such as study design, participant characteristics, and pyridoxine dosage.

Cautions for Real-Life Applications

It's essential to follow a doctor's advice when taking pyridoxine. Excessive intake can lead to neurological damage. 8 Pyridoxine can also worsen tissue damage and oxidative stress caused by high-intensity interval training (HIIT). 4

Limitations of Current Research

Research on the effects of pyridoxine is still insufficient, particularly regarding long-term effects and safety. Further research is needed in these areas.

Future Research Directions

More research is needed to further understand the effects of pyridoxine. Research should focus on determining the optimal dosage, administration methods, and long-term effects and safety of pyridoxine.

Conclusion

Pyridoxine may affect sleep and dreams. However, research on its effects is still in its early stages. Always consult a doctor before taking pyridoxine supplements.

Literature analysis of 12 papers
Positive Content
11
Neutral Content
1
Negative Content
0
Article Type
6
0
1
1
12
2.

Can Pyridoxine Successfully Reduce Behavioral Side Effects from Levetiracetam?: A Critically Appraised Topic.

Author: ChhabraNikita, VanoodAimen, HoerthMatthew T, SanchezCristina Valencia, O'CarrollCumara B

Neuropsychiatric symptom improvement

Levetiracetam is a common anti-seizure medication, but it can cause neuropsychiatric side effects. Preliminary evidence suggests that pyridoxine (vitamin B6) may improve these symptoms, particularly in children. However, more randomized controlled trials are needed to confirm this relationship.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review.

Author: BesagFrank M C, VaseyMichael J, SenArjune

NPAEs Improvement
Neuropsychiatric Adverse Events

Pyridoxine (vitamin B6) supplementation may improve neuropsychiatric adverse events associated with levetiracetam, but more research is needed.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

The 6-week Effects of HIIT on Biomarkers of Tissue and Oxidative Damage in Wistar Rats Previously Supplemented with Pyridoxine.

Author: Dos SantosJessica Denielle Matos, AidarFelipe J, DE MatosDihogo Gama, DE OliveiraJosé Uilien, JúniorAilton Santos Sena, Dos SantosJymmys Lopes, MarçalAnderson Carlos, DE AraújoSilvan Silva

Attenuated tissue injury
Reduced oxidative stress

This study found that pyridoxine supplementation attenuated oxidative stress and tissue injuries induced by long high-intensity interval training (HIIT) in rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Amelioration of Levetiracetam-Induced Behavioral Side Effects by Pyridoxine. A Randomized Double Blind Controlled Study.

Author: MahmoudAdel, TabassumSadia, Al EnaziShoaa, LubbadNahed, Al WadeiAli, Al OtaibiAli, JadLamya, BeniniRuba

Neuropsychiatric side effect reduction

This study investigated the potential benefit of pyridoxine in attenuating the neuropsychiatric side effects of levetiracetam in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on palmar-plantar erythrodysesthesia (PPE) induced by capecitabine or pegylated liposomal doxorubicin (PLD).

Author: CharalambousAndreas, TsitsiTheologia, AstrasGeorge, PaikousisLefkios, FilippouElena

PPE management

This study investigates the efficacy of a pyridoxine (B6) treatment protocol for managing Palmar-Plantar Erythrodysesthesia (PPE), a common side effect of capecitabine and Pegylated Liposomal Doxorubicin-PLD treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70.

Author: JungHyo Young, KimWoosuk, HahnKyu Ri, KwonHyun Jung, NamSung Min, ChungJin Young, YoonYeo Sung, KimDae Won, YooDae Young, HwangIn Koo

Monoamine levels
Novel object recognition memory
Cognitive impairment

Pyridoxine deficiency in mice resulted in impaired novel object recognition memory, reduced levels of 5-HT and DA in the hippocampus, and decreased neurogenesis. Proteomic analysis revealed altered levels of specific proteins, suggesting that pyridoxine plays a critical role in cognitive function and hippocampal neurogenesis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.

Author: Adventure-HeartDenholm J, MaddenNatasha A, DelfabbroPaul

Increased dream recall
Increased tiredness
Lower sleep quality

Vitamin B6 is a nutrient that is important for many functions in the body. This study found that taking vitamin B6 before bed increased the amount of dream content that people remembered.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Pyridoxine Add-On Treatment for the Control of Behavioral Adverse Effects Induced by Levetiracetam in Children: A Case-Control Prospective Study.

Author: MarinoSilvia, VitalitiGiovanna, MarinoSimona Domenica, PavonePiero, ProvvidentiSimona, RomanoCatia, FalsaperlaRaffaele

LEV-induced BAE control

Pyridoxine supplementation was safe and effective in controlling levetiracetam-induced behavioral adverse effects in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial.

Author: AskariGholamreza, NasiriMorteza, Mozaffari-KhosraviHassan, RezaieMasod, Bagheri-BidakhavidiMahdieh, SadeghiOmid

Reduced migraine duration
Reduced migraine frequency
Reduced migraine severity

Folic acid combined with pyridoxine significantly decreased headache severity, attack frequency, and headache diary results in migraine patients with aura compared to placebo. Folic acid alone did not show a significant effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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