Side Effects of quinupristin and dalfopristin injection: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Major Findings

Quinupristin/dalfopristin is a new injectable streptogramin antibiotic that is active against most strains of vancomycin-resistant Enterococcus faecium (VREF). This study reports on eight children with VREF infections who received quinupristin/dalfopristin under a compassionate use protocol. 1

Reasons for Side Effects

Quinupristin/dalfopristin works by inhibiting bacterial protein synthesis. However, this action can also affect human cells, potentially causing side effects. 1

Common Side Effects

Gastrointestinal

Quinupristin/dalfopristin administration can lead to gastrointestinal side effects such as nausea, vomiting, and abdominal pain. 1

Liver

Quinupristin/dalfopristin administration can cause liver dysfunction. 1

Blood

Quinupristin/dalfopristin administration can cause blood-related side effects such as leukopenia and thrombocytopenia. 1

Side Effect Management

Gastrointestinal

If gastrointestinal side effects occur, measures such as dietary changes and medication may be considered. 1

Liver

If liver dysfunction occurs, measures such as discontinuation of medication and liver function monitoring may be necessary. 1

Blood

If blood-related side effects occur, measures such as blood transfusions and medication may be necessary. 1

Study Comparison

Study Similarities

Quinupristin/dalfopristin is a promising treatment option for VREF infections. 1

Study Differences

This study investigates the effectiveness of quinupristin/dalfopristin for VREF infections in children. 1

Real-Life Application Considerations

While quinupristin/dalfopristin holds promise as a treatment for VREF infections, it's important to acknowledge the risk of side effects. 1

Current Research Limitations

This study reports on the use of quinupristin/dalfopristin in eight children, so the results may not be generalizable to other children. 1

Future Research Directions

Further research is needed with a larger number of children to evaluate the efficacy and safety of quinupristin/dalfopristin for VREF infections. 1

Conclusion

Quinupristin/dalfopristin shows promise as a treatment for VREF infections but must be used with awareness of potential side effects. More research with larger numbers of children is needed. 1

Keywords
Benefit Keywords
Treat VREF infections
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Risk Keywords
Literature analysis of 1 papers
Positive Content
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Neutral Content
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Negative Content
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Article Type
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1
1.

Experience with quinupristin/dalfopristin in treating infections with vancomycin-resistant Enterococcus faecium in children.

Author: GrayJ W, DarbyshireP J, BeathS V, KellyD, MannJ R

Treat VREF infections

The emergence and spread of vancomycin-resistant Enterococcus faecium (VREF) has presented serious therapeutic difficulties. Quinupristin/dalfopristin is a new injectable streptogramin antibiotic that is active against most strains of VREF. This study reports on eight children with VREF infections who received quinupristin/dalfopristin under a compassionate use protocol.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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