Side Effects of secobarbital: A Synthesis of Findings from 8 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of secobarbital: A Synthesis of Findings from 8 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Secobarbital has been shown to be effective in the treatment of insomnia in multiple studies. 6 , 8 , 7 Secobarbital has been shown to be more effective than placebo or other hypnotic agents in increasing sleep duration, shortening sleep onset time, and improving sleep quality. 6 , 8 , 7 Secobarbital has also been shown to be effective in treating insomnia in older adults. 5 Secobarbital showed effectiveness in increasing sleep duration and improving sleep quality even in older adults. 5 However, secobarbital has a risk of dependence and abuse and should be used with caution. 3 Secobarbital has also been shown to be effective in preventing nausea and vomiting. 4

Reasons for side effects

Secobarbital is a central nervous system depressant and affects sleep and levels of consciousness. The side effects of secobarbital are believed to be due to its effects on the central nervous system.

Common side effects

Drowsiness

Secobarbital can cause drowsiness and fatigue. 7 This side effect is more common in older adults and individuals with drug sensitivity. 5 Driving or operating machinery should be avoided after taking secobarbital. 7

Dizziness

Secobarbital may cause dizziness and unsteadiness. Secobarbital may disrupt balance. Care should be taken when getting up or walking after taking secobarbital.

Memory impairment

Secobarbital can cause memory impairment. 7 Secobarbital can impair the ability to remember new information or recall past events. Avoid important meetings or events when taking secobarbital.

Dependence

Secobarbital has the potential for dependence. 3 Long-term use of secobarbital can lead to drug dependence. It is important to take secobarbital as directed by your doctor and not stop taking it without consulting your doctor.

Respiratory depression

Secobarbital can cause respiratory depression. Secobarbital can suppress the central nervous system that controls breathing. If breathing becomes shallow or the number of breaths decreases, consult a doctor immediately.

Side effects management

Drowsiness

If you experience drowsiness after taking secobarbital, avoid driving or operating machinery. Get enough sleep and avoid overexertion.

Dizziness

If you experience dizziness after taking secobarbital, be careful when getting up or walking. Get up slowly and use handrails or other supports to prevent falls.

Memory impairment

Avoid important meetings or events when taking secobarbital. Write down important information or ask someone for help to support your memory.

Dependence

It is important to take secobarbital as directed by your doctor and not stop taking it without consulting your doctor. To reduce the risk of dependence, discuss appropriate treatment options with your doctor.

Respiratory depression

If breathing becomes shallow or the number of breaths decreases after taking secobarbital, consult a doctor immediately.

Comparison between studies

Similarities between studies

Multiple studies have shown that secobarbital is effective for sleep. 6 , 8 , 7 Secobarbital has also been shown to increase sleep duration, shorten sleep onset time, and improve sleep quality. 6 , 8 , 7

Differences between studies

The side effects reported for secobarbital varied across studies. 7 Some studies reported a higher risk of drowsiness and fatigue with secobarbital. 5 Other studies reported a potential for memory impairment and dependence with secobarbital. 3 Therefore, it is important to discuss appropriate dosage and administration with your doctor before taking secobarbital.

Note on real-life applications

Secobarbital should be taken under the supervision of a doctor as a treatment for insomnia. Secobarbital has a risk of dependence and abuse, so taking it without a doctor's consent or stopping it without consulting your doctor can be dangerous. When taking secobarbital, be sure to follow your doctor's instructions and consult your doctor immediately if you experience any side effects.

Limitations of current research

Long-term side effects of secobarbital have not been fully investigated. Additionally, the effectiveness and side effects of secobarbital are believed to vary greatly among individuals. Therefore, it is important to discuss appropriate dosage and administration with your doctor before taking secobarbital.

Future research directions

Further research is needed on the long-term effects and side effects of secobarbital. Also, research is needed to determine how the effectiveness and side effects of secobarbital vary by factors such as age, sex, body size, and health status.

Conclusion

Secobarbital is an effective drug for treating insomnia, but it should be used with caution due to its potential for dependence and abuse. When taking secobarbital, be sure to follow your doctor's instructions and consult your doctor immediately if you experience any side effects.

Literature analysis of 8 papers
Positive Content
6
Neutral Content
2
Negative Content
0
Article Type
3
1
0
0
8
1.

Efficacy and safety of roflumilast in patients with stable chronic obstructive pulmonary disease: a meta-analysis.

Author: YanJun-Hong, GuWan-Jie, PanLei

Exacerbation reduction
FEV1 improvement
Diarrhea
Headache
Insomnia
Nausea
Weight loss

Roflumilast significantly reduces the mean exacerbation rate in COPD patients. Although there are insufficient clinical evidence on other clinical endpoints and high risk of some adverse events, roflumilast therapy may benefit COPD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

3.

Barbiturate detection in oral fluid, plasma, and urine.

Author: FritchDean, BlumKristen, NonnemacherSheena, KardosKeith, BuchhalterAugust R, ConeEdward J

Dizziness
Drowsiness
Somnolence

This study found that single, oral therapeutic doses of butalbital, phenobarbital, and secobarbital were excreted in readily detectable concentrations in oral fluid over a period of approximately 2 days. Oral fluid patterns of appearance and elimination were similar to that observed for plasma and urine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The antiemetic efficacy of secobarbital and chlorpromazine compared to metoclopramide, diphenhydramine, and dexamethasone. A randomized trial.

Author: RichardsP D, FlaumM A, BatemanM, KardinalC G

Antiemetic prophylaxis
Anticholinergic effects
Extrapyramidal reactions
Sedation

Metoclopramide, diphenhydramine, and dexamethasone (MDD) were more effective than secobarbital sodium plus chlorpromazine (SC) in preventing cisplatin-induced emesis. 72% of patients experienced good to excellent antiemetic prophylaxis with MDD compared to 17% with SC. MDD was preferred by a significantly greater number of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Midazolam in the treatment of sleep disorders in geriatric patients.

Author: LachnitK S, ProszowskiE, RiederL

Induces sleep
Drug accumulation
Hangover

Midazolam was as effective as the barbiturate combination Vesparax in treating insomnia in elderly patients, but had fewer side effects and less hangover.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

A clinical comparison of triazolam with placebo and with secobarbital in insomniac patients.

Author: OkawaK K, AllensG S

Insomnia treatment
Mild side effects

Triazolam was found to be more effective than placebo and secobarbital in treating insomnia. In double-blind studies, patients reported better sleep onset, duration, and fewer awakenings with triazolam. There were no differences in alertness the next morning, and side effects did not significantly impact function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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