Side Effects of selegiline: A Synthesis of Findings from 27 Studies

  1. Home
  2. Side Effects of selegiline
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of selegiline: A Synthesis of Findings from 27 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of selegiline: A Synthesis of Findings from 27 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Selegiline, a monoamine oxidase B (MAO-B) inhibitor, has been studied for its potential to alter the progression of Parkinson's disease (PD). However, the results of clinical trials on its efficacy have been mixed. 21

While safer and easier-to-use antidepressants like SSRIs and SNRIs have largely replaced MAOIs, selegiline remains relevant in treating challenging cases. 7

The development of selective MAO-B inhibitors, such as selegiline, has led to their therapeutic use in Parkinson's disease. 1

Selegiline, in transdermal form, has been investigated as a treatment for major depressive disorder (MDD). 5

This study examined the effects of selegiline, administered along with levodopa, on blood pressure, heart rate, and norepinephrine levels in patients with Parkinson's disease. 4

Selegiline has been studied for its potential to reduce ADHD symptoms without the undesirable side effects of traditional stimulants. 19

Reasons for Side Effects

Selegiline's side effects are likely due to its inhibition of MAO-B. MAO-B plays a role in breaking down not only neurotransmitters but also other substances. When selegiline inhibits MAO-B, it also hinders the breakdown of these substances, potentially leading to side effects. 3 6

Common Side Effects

Urinary Retention

Selegiline may cause urinary retention. 26

Mental Side Effects

Selegiline can cause mania, anxiety, insomnia, delusions, hallucinations, confusion, and more. 10 3

Other Side Effects

Selegiline can cause headache, nausea, vomiting, constipation, dry mouth, dizziness, weight gain, hypertension, insomnia, fatigue, fever, and more. 10 26 15 20 19 22 25 11 24 2 12

Measures for Side Effects

Urinary Retention

If you experience urinary retention after taking selegiline, consult your doctor. 26

Mental Side Effects

If you experience mental side effects after taking selegiline, consult your doctor. 10

Other Side Effects

If you experience other side effects after taking selegiline, consult your doctor. 10 26 15 20 19 22 25 11 24 2 12

Comparison Between Studies

Common Points of Studies

Many studies have shown that selegiline can improve Parkinson's symptoms. 2 24 14 21 25

Many studies have also shown that selegiline has some side effects. 26 3 6

Differences in Studies

Different studies have reported different results for the frequency and types of side effects of selegiline. 26 3 6

Precautions Regarding Applications in Real Life

Selegiline is used as a treatment for Parkinson's disease and depression, but it's important to remember the risk of side effects. Always follow your doctor's instructions when taking selegiline. 2 24 14 21 25

Current Research Limitations

There is not enough research on the side effects of selegiline. Further research is needed, especially on the long-term effects of selegiline use. 2 24 14 21 25

Future Research Directions

Further research on the side effects of selegiline is needed. In particular, it's necessary to clarify the effects of long-term selegiline use and the mechanisms by which side effects occur. 2 24 14 21 25

Conclusion

Selegiline is used as a treatment for Parkinson's disease and depression, but it's important to remember the risk of side effects. Always follow your doctor's instructions when taking selegiline. 2 24 14 21 25

Literature analysis of 27 papers
Positive Content
23
Neutral Content
2
Negative Content
2
Article Type
5
1
1
11
27
1.

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases.

Author: YoudimMoussa B H

Antidepressant activity
Neuroprotection
Parkinson's disease treatment
Reduced oxidative stress

MAO inhibitors have been used for treating depressive illness and Parkinson's disease, with selective inhibitors offering improved efficacy and safety profiles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

SELEDO: a 5-year long-term trial on the effect of selegiline in early Parkinsonian patients treated with levodopa.

Author: PrzuntekH, ConradB, DichgansJ, KrausP H, KrauseneckP, PergandeG, RinneU, SchimrigkK, SchnitkerJ, VogelH P

Treat Parkinson's disease
Side effects

Early combination of selegiline and levodopa in Parkinson's disease patients significantly delayed the need to increase levodopa dosage compared to levodopa monotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Are metabolites of l-deprenyl (selegiline) useful or harmful? Indications from preclinical research.

Author: YasarS, GoldbergJ P, GoldbergS R

Beneficial metabolites
No abuse potential
No neurotoxicity

This study examines the potential benefits and risks of selegiline's metabolites, concluding that they are unlikely to cause neurotoxicity or lead to drug abuse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

The effects of acute loading with levodopa and levodopa with selegiline on blood pressure and plasma norepinephrine levels in chronic Parkinson's disease patients.

Author: StryjerR, KleinC, TrevesT A, RabeyJ M

Cardiovascular side effects

This study investigated the cardiovascular effects of selegiline in people with Parkinson's disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Selegiline transdermal system for the treatment of major depressive disorder: an 8-week, double-blind, placebo-controlled, flexible-dose titration trial.

Author: FeigerAlan D, RickelsKarl, RynnMoira A, ZimbroffDan L, RobinsonDonald S

Depression treatment
Insomnia

The study investigated the efficacy, safety, and tolerability of the selegiline transdermal system (STS) for treating major depressive disorder (MDD). The results showed that STS was significantly more effective than placebo in improving depression symptoms, with a modest treatment effect primarily due to insomnia side effects. The study concluded that STS has an improved margin of safety compared with oral monoamine oxidase inhibitors and represents a useful addition to the existing array of antidepressants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Serotonin toxicity association with concomitant antidepressants and rasagiline treatment: retrospective study (STACCATO).

Author: PanissetMichel, ChenJack J, RhyeeSean H, ConnerJill, MathenaJulie,

No STS
STS risk

In this large retrospective cohort study, concurrent administration of rasagiline and antidepressants was not associated with serotonin toxicity syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Critical appraisal of selegiline transdermal system for major depressive disorder.

Author: CristanchoMario A, ThaseMichael E

Improved depression treatment
Side effects

The selegiline transdermal delivery system, the first antidepressant patch, has a safe profile and may be a viable option for difficult-to-treat conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Translating the evidence on atypical depression into clinical practice.

Author: RapaportMark Hyman, ThaseMichael E

Atypical depression treatment
Cardiovascular side effects
Sexual dysfunction
Weight gain

This abstract discusses the importance of recognizing subtypes of depression and the potential benefits of using MAOIs, particularly selegiline, for treating atypical depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Pre-clinical studies of pramipexole: clinical relevance.

Author: HubbleJ P

Improved activities of daily living
Neuroprotective properties
Reduced Parkinsonian signs
Membranous fibrosis

Pramipexole is a novel dopamine agonist that shows promise for the treatment of early Parkinson's disease. It has a favorable pharmacokinetic profile and may have neuroprotective properties.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Atypical antipsychotics in the treatment of drug-induced psychosis in Parkinson's disease.

Author: FriedmanJ H, FactorS A

Treat psychosis
Worsen motor function

This study reviewed reports of the use of atypical antipsychotics in patients with PD. Clozapine is the only drug with confirmed benefit without worsening parkinsonism. This study suggests that quetiapine may prove to be as effective and better tolerated than clozapine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Assessment of selegiline and trilostane combined therapy efficacy for canine pituitary-dependent hypercortisolism treatment: A pilot randomized clinical trial.

Author: de CarvalhoGuilherme Luiz Carvalho, MeirellesLuana, da SilvaCarolina Castilhos, NetoWaldemir Santiago, FurtadoPriscila Viau, MachadoLetícia, de Moura MartinsFrancisco Sávio, da Silva MelloFabíola Peixoto, de Faria ValleStella, PöpplÁlan Gomes

PDH treatment
Side effects

Trilostane is a medication used to treat pituitary-dependent hypercortisolism (PDH) in dogs. This study investigates whether combining trilostane with selegiline, a medication used to treat Parkinson's disease, can be an effective and safe treatment for PDH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.

Language : English

12.

Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa. Parkinson Study Group.

Author:

Levodopa side effects

Early treatment with deprenyl or tocopherol did not reduce the occurrence of levodopa-associated side effects in patients with Parkinson's disease. About 50% of patients experienced "wearing off," 30% developed dyskinesias, and 25% developed "freezing."

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Selegiline augmentation of antipsychotics for the treatment of negative symptoms in schizophrenia.

Author: GuptaS, DroneyT, KyserA, KellerP

Improved functioning
Improved negative symptoms

This case series describes three patients with schizophrenia who showed significant improvement in negative symptoms and overall functioning after adding selegiline to their antipsychotic regimen.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Transdermal formulations of deprenyl: guinea pig and pig models.

Author: GaálJ, SzebeniG, SzékácsG, FejérE, WágnerO, SzatmáriI, MagyarK, MezeiM

Improved drug delivery
Reduced side effects

This study describes an in vivo test system for evaluating new transdermal delivery systems containing selegiline as an active ingredient. The system uses guinea pigs and domestic pigs to assess the biodisposition of the drug.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

HPLC and HPLC-MS analysis of urinary N(epsilon)-monomethyl-lysine.

Author: KalászH, BenköA, SzücspZ, SzilágyiA, SzarvasT, LengyelJ

Positive side effects

Administration of L-deprenyl to rats results in the urinary elimination of a 14C-labelled compound. This compound was identified as N(epsilon)-monomethyl-lysine. This finding indicates that transmethylation from a well-known drug may have basic importance in the positive side effects of certain drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Sertraline for the treatment of depression in Parkinson's disease.

Author: HauserR A, ZesiewiczT A

Treats depression in PD
Side effects

This study evaluated the safety and efficacy of sertraline for treating depression in Parkinson's disease (PD). Sertraline was generally well tolerated, with significant improvement in Beck Depression Inventory scores.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Placebo-controlled study examining effects of selegiline in children with attention-deficit/hyperactivity disorder.

Author: RubinsteinSuzanne, MaloneMolly A, RobertsWendy, LoganWilliam J

ADHD treatment
No negative side effects

Selegiline, a monoamine oxidase inhibitor, is effective in treating specific symptoms of ADHD, including sustained attention, learning, hyperactivity, and peer interactions, without significant side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Selegiline in adults with attention deficit hyperactivity disorder: clinical efficacy and safety.

Author: ErnstM, LiebenauerL L, JonsP H, TebekaD, CohenR M, ZametkinA J

Reduced ADHD symptoms
Methodological limitations
Side effects

Selegiline was not more effective than placebo in treating ADHD in adults, and high-dose selegiline had more severe side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Monoamine oxidase B inhibitors for early Parkinson's disease.

Author: MacleodA D, CounsellC E, IvesN, StoweR

Levodopa-sparing effect
Reduced motor fluctuations
Increased withdrawals due to side-effects
No significant effect on disease progression

MAO-B inhibitors did not significantly delay disease progression in early Parkinson's disease. However, they may provide a small benefit on motor fluctuations and a levodopa-sparing effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Ropinirole treatment for restless legs syndrome.

Author: MolnarMiklos Zsolt, FornadiKatalin, ShapiroColin M

Restless legs syndrome treatment

Ropinirole is effective in reducing symptoms of restless legs syndrome. It is well-tolerated and safe and can be used in the general population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

MAO inhibitors: risks, benefits, and lore.

Author: WimbiscusMolly, KostenkoOlga, MaloneDonald

Antidepressant effect
Food and drug interactions
Side effects

This review discusses the current status of monoamine oxidase (MAO) inhibitors in clinical medicine. While their use has declined in recent years, renewed interest in these drugs is emerging due to their potential benefits for treating depression and other conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Treatment options for early Parkinson's disease.

Author: StacyM, BrownleeH J

Tremor treatment

Essential tremor and Parkinson's disease tremor are distinct conditions with different treatments. Levodopa is the most effective treatment for Parkinson's disease, while other therapies like dopamine agonists and anticholinergics may be used in early stages. Polypharmacy is often necessary to manage side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine.

Author: PodurgielSamantha J, YohnSamantha E, DortcheKristina, CorreaMerce, SalamoneJohn D

Chorea treatment
Parkinsonism model
Parkinsonian side effects
Tremulous jaw movements

Tetrabenazine (TBZ), used for Huntington's disease-related chorea, can cause Parkinsonian motor side effects. This study investigates the ability of deprenyl, an antiparkinsonian agent, to attenuate TBZ-induced tremulous jaw movements (TJMs) in rats. Deprenyl successfully reduced TJMs and increased dopamine levels in the striatum.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Side effects of selegiline (Eldepryl).

Author: WatersC H

Parkinson's treatment
Elderly risk
Urinary retention

Selegiline can cause urinary retention in elderly patients with Parkinson's disease.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Parkinson's disease: drug therapy.

Author: OertelW H, QuinnN P

Effective treatment
Individualized treatment
Dyskinesias
Fluctuations
Long-term L-dopa syndrome
Neuropsychiatric symptoms

This study provides an overview of the available drug treatments for Parkinson's disease, including their benefits and side effects. The authors highlight the importance of individualized treatment strategies and the need to monitor patients' response to treatment over time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.