Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases.

Author: YoudimMoussa B H

Paper Details 
Original Abstract of the Article :
In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933 Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and dopamine. Zeller gave it the name monoamine oxidase (MAO) to distinguish it from the enzyme that oxidatively deaminated diamines...See full text at original site
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引用元:
https://doi.org/10.1007/s00702-018-1942-9

データ提供:米国国立医学図書館(NLM)

Unraveling the Mysteries of Depression and Neurodegenerative Diseases: The Role of MAO Inhibitors and Iron Chelators

Depression and neurodegenerative diseases are complex conditions that affect millions worldwide. This study explores the potential of MAO inhibitors and iron chelators in treating these conditions, examining their role in modulating neurotransmitter levels and reducing oxidative stress in the brain. The study delves into the history of MAO inhibitors, highlighting their discovery and evolution from non-selective inhibitors to selective inhibitors of MAO-A and MAO-B. The study explores the potential of MAO inhibitors for neuroprotection, suggesting that they could slow or even reverse neurodegeneration in Parkinson's and Alzheimer's diseases. It further explores the role of iron chelators in reducing oxidative stress in the brain, a key factor in the progression of neurodegenerative diseases. This study underscores the importance of exploring multi-target drugs that combine MAO inhibitory, iron chelating, and antioxidant activities for the treatment of depression and neurodegenerative diseases.

A Multi-faceted Approach: Combating Depression and Neurodegeneration

This study emphasizes the need for a multi-faceted approach to treating depression and neurodegenerative diseases, focusing not only on symptom management but also on neuroprotection and reducing oxidative stress. It highlights the potential of multi-target drugs, like those combining MAO inhibitors, iron chelators, and antioxidants, to offer a more comprehensive and effective treatment strategy. This research offers hope for the development of new and innovative therapies for these complex and challenging conditions.

A Journey of Discovery: Unlocking the Secrets of the Brain

This study underscores the importance of ongoing research to better understand the complex mechanisms underlying depression and neurodegenerative diseases. The findings encourage continued exploration of novel therapeutic approaches, including multi-target drugs, to improve treatment options and provide hope for patients seeking relief from these debilitating conditions. It reminds us that the journey to unraveling the mysteries of the brain is a continuous process, fueled by scientific curiosity and the pursuit of better health for all.

Dr.Camel's Conclusion

Just as a camel navigates the vast and intricate landscape of the desert, this study explores the complex pathways of the brain in search of new treatments for depression and neurodegenerative diseases. The study highlights the potential of multi-target drugs, offering a more holistic approach to managing these conditions. It's a reminder that the journey to better health is an ongoing exploration, driven by the pursuit of knowledge and the desire to ease human suffering.
Date :
  1. Date Completed 2019-11-11
  2. Date Revised 2019-11-11
Further Info :

Pubmed ID

30341696

DOI: Digital Object Identifier

10.1007/s00702-018-1942-9

SNS
PICO Info
in preparation
Languages

English

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