Effects of simvastatin: A Synthesis of Findings from 8 Studies

  1. Home
  2. Effects of simvastatin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of simvastatin: A Synthesis of Findings from 8 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of simvastatin: A Synthesis of Findings from 8 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Simvastatin is a cholesterol-lowering medication that has been shown to be effective in reducing cholesterol levels, particularly LDL cholesterol. 1 In addition, simvastatin has been found to reduce triglyceride levels and increase HDL cholesterol levels. 1 These effects have been shown to persist over a period of three years. 1 Furthermore, simvastatin has demonstrated antioxidant effects, 6 suggesting its potential role in reducing cardiovascular disease risk. However, some studies indicate that atorvastatin may be more effective than simvastatin in reducing oxidative stress. 6 Simvastatin has also been shown to have a slight effect on platelet count. 1 Overall, simvastatin is generally considered to be safe and well-tolerated. 1 3

Benefits and Risks

Benefit Summary

Simvastatin effectively lowers cholesterol levels, especially LDL cholesterol. 1 It also reduces triglyceride levels and increases HDL cholesterol levels. 1 These effects are sustained over a period of three years. 1 Additionally, simvastatin demonstrates antioxidant effects, 6 potentially contributing to the reduction of cardiovascular disease risk. Simvastatin is generally considered safe and well-tolerated. 1 3

Risk Summary

Simvastatin may have a slight effect on platelet count. 1 Some studies suggest that atorvastatin may be more effective than simvastatin in reducing oxidative stress. 6 Despite this, simvastatin is generally considered safe and well-tolerated. 1 3

Comparison of Studies

Commonalities of Studies

Across various studies, simvastatin has consistently been shown to effectively reduce cholesterol levels, especially LDL cholesterol. 1 6 3 5 4 7 2 Simvastatin is generally considered to be a safe and well-tolerated medication. 1 3

Differences in Studies

Simvastatin has been shown to have a slight effect on platelet count. 1 In comparison to atorvastatin, simvastatin may be less effective in reducing oxidative stress. 6

Consistency and Contradictions of Findings

While these studies consistently demonstrate simvastatin's effectiveness in reducing cholesterol levels, 1 6 3 5 4 7 2 , there are inconsistencies in findings regarding its impact on oxidative stress and platelet count. Further research is necessary to fully understand these effects.

Practical Application and Considerations

While simvastatin is generally considered safe and well-tolerated, 1 3 it's important to remember that individual responses may vary. It is crucial to follow your doctor's instructions when taking simvastatin. Additionally, be aware that simvastatin may interact with other medications, so consult your doctor before taking it.

Limitations of Current Research

Further research is needed to fully understand the effects of simvastatin, particularly its impact on oxidative stress and platelet count. Larger-scale studies are required to obtain more comprehensive data in these areas.

Future Directions for Research

Studies focused on elucidating the effects of simvastatin on oxidative stress and platelet count are necessary. Long-term studies exploring the long-term impact of simvastatin are also valuable.

Conclusion

Simvastatin is an effective medication for reducing cholesterol levels and may help lower cardiovascular disease risk. However, inconsistencies remain regarding its effects on oxidative stress and platelet count. Further research is necessary to gain a complete understanding of its impact in these areas. When considering simvastatin, consult your doctor and follow their instructions.

Literature analysis of 8 papers
Positive Content
8
Neutral Content
0
Negative Content
0
Article Type
8
0
0
0
8
1.

Three-year follow-up of the Oxford Cholesterol Study: assessment of the efficacy and safety of simvastatin in preparation for a large mortality study.

Author: KeechA, CollinsR, MacMahonS, ArmitageJ, LawsonA, WallendszusK, FatemianM, KearneyE, LyonV, MindellJ

Hyperlipidemia treatment
Decreased platelet count
Increased liver enzymes

This study assessed the effects of simvastatin on blood lipids, biochemistry, haematology, and safety in individuals at increased risk of coronary heart disease. Simvastatin significantly reduced total cholesterol, LDL cholesterol, and triglycerides, and was well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Similar effects of atorvastatin, simvastatin and pravastatin on thrombogenic and inflammatory parameters in patients with hypercholesterolemia.

Author: JoukhadarC, KleinN, PrinzM, SchrolnbergerC, VukovichT, WolztM, SchmettererL, DornerG T

cardiovascular event reduction

Statins may have beneficial effects beyond their lipid-lowering effects, potentially including reducing cardiovascular morbidity and mortality. However, further research is needed to determine whether all statins elicit these effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Hemostatic effects of atorvastatin versus simvastatin.

Author: KadikoyluGurhan, YukselenVahit, YavasogluIrfan, BolamanZahit

Hypercholesterolemia treatment
Hemostatic effects

Atorvastatin was more effective than simvastatin in lowering lipid levels, while simvastatin had more significant effects on hemostatic parameters. Both drugs were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans.

Author: LandmesserUlf, BahlmannFerdinand, MuellerMaja, SpiekermannStephan, KirchhoffNina, SchulzSvenja, ManesCostantina, FischerDieter, de GrootKirsten, FliserDanilo, FaulerGünter, MärzWinfried, DrexlerHelmut

Ezetimibe
Statins

The study tested the hypothesis that similar LDL cholesterol reductions achieved with simvastatin and ezetimibe, a cholesterol absorption inhibitor, would result in different effects on endothelial function, exploring the pleiotropic effects of statins.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients.

Author: KohKwang Kon, QuonMichael J, HanSeung Hwan, LeeYonghee, KimSoo Jin, ParkJeong Beom, ShinEak Kyun

Reduced cholesterol levels
Metabolic side effects

This study investigates the hypothesis that lipophilic and hydrophilic statins may have different metabolic effects in hypercholesterolemic patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease.

Author: LiJia, SunYan-Ming, WangLan-Feng, LiZhu-Qin, PanWei, CaoHong-Yan

Atorvastatin antioxidant

The study found that atorvastatin reduces oxidative stress more effectively than simvastatin in patients with coronary heart disease (CHD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin.

Author: PesaroAntonio Eduardo P, SerranoCarlos V, FernandesJuliano L, CavalcantiAlexandre B, CamposAlexandre H, MartinsHerlon S, MaranhãoRaul C, de LemosJames A, SouzaHeraldo P, NicolauJosé C

LDL-C Reduction
Platelet Inhibition

Ezetimibe 10mg/simvastatin 20mg (E10/S20) was equally effective in reducing LDL-C compared to simvastatin 80 mg (S80) in patients with stable coronary artery disease (CAD). However, E10/S20 was more effective than S80 in inhibiting platelet aggregation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

An experimental medicine study of the effects of simvastatin on emotional processing, reward learning, verbal memory, and inflammation in healthy volunteers.

Author: De GiorgiRiccardo, QuintonAlice M G, WatersShona, CowenPhilip J, HarmerCatherine J

Potential depression treatment

Clinical studies suggest that simvastatin, an anti-inflammatory molecule, could be repurposed for treating depression. However, the neuropsychological effects of simvastatin are unknown and need further investigation to understand its influence on mood and cognition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.