Effects of sumatriptan nasal: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Main Research Findings

Several studies have shown that sumatriptan nasal spray may be an effective treatment for migraine and cluster headache. 25 found that intranasal sumatriptan was significantly more effective than placebo in a randomized, placebo-controlled, double-blind study of cluster headache patients. 23 demonstrated the effectiveness of nasal sumatriptan in treating migraine attacks in children and adolescents. Additionally, 11 showed that intranasal sumatriptan had a faster onset of action and a similar sustained effect compared to oral sumatriptan. These findings suggest that sumatriptan nasal spray may be a viable treatment option for acute migraine and cluster headache.

However, the effectiveness of sumatriptan nasal spray has not been confirmed for all patients. 2 found that sumatriptan nasal spray was less effective than subcutaneous injection in treating cluster headache patients in an open-label study. Furthermore, 6 identified factors like young age of onset, psychiatric disorders, and headache location as potential indicators of a negative response to sumatriptan nasal spray.

Benefits and Risks

Benefits Summary

Sumatriptan nasal spray may be a useful treatment option for acute migraine and cluster headache. It may be especially beneficial for patients who find oral administration challenging or those seeking a faster onset of action. 7 found that sumatriptan nasal spray is absorbed more quickly and has a faster onset of action compared to conventional nasal sprays. 26 showed that sumatriptan nasal spray is safe when used in combination with other medications.

Risk Summary

There are some risks associated with using sumatriptan nasal spray. The most common side effects are nasal discomfort and taste disturbances. 7 found that sumatriptan nasal spray is generally well-tolerated, with only a few reported cases of discontinuation due to side effects. However, 21 suggests that long-term use of sumatriptan nasal spray may lead to tolerance in some patients. Also, sumatriptan nasal spray should not be used by people with pre-existing conditions like heart disease or high blood pressure. 20 states that sumatriptan nasal spray is contraindicated in patients with heart disease or high blood pressure. Additionally, sumatriptan nasal spray is not recommended for pregnant or breastfeeding women.

Comparison Across Studies

Similarities Across Studies

Multiple studies suggest that sumatriptan nasal spray may be effective in treating acute migraine and cluster headache. Many studies also show that sumatriptan nasal spray is generally safe and well-tolerated.

Differences Across Studies

Some studies have shown that the effectiveness of sumatriptan nasal spray can vary depending on the patient and the type of headache. 2 found that sumatriptan nasal spray was less effective than subcutaneous injection in treating cluster headache patients. In contrast, 23 showed that sumatriptan nasal spray was effective in treating migraine attacks in children and adolescents. These findings suggest that the effectiveness of sumatriptan nasal spray might vary depending on the patient and the type of headache.

Consistency and Inconsistencies in the Results

While multiple studies suggest that sumatriptan nasal spray may be effective in treating acute migraine and cluster headache, the effectiveness hasn’t been confirmed in all studies. 2 found that sumatriptan nasal spray was less effective than subcutaneous injection in treating cluster headache patients in an open-label study. This finding contradicts some other findings. Further research is needed to clarify the inconsistencies and address these contradictions.

Considerations for Real-World Application

Sumatriptan nasal spray may be a beneficial treatment option for acute migraine and cluster headache, but its effectiveness might vary between patients. Sumatriptan nasal spray has associated risks. It’s important to discuss with your doctor and explore all treatment options to choose the best one for your needs. 10 found that sumatriptan nasal spray is not recommended for treating migraine in children.

Limitations of Current Research

There is still a need for further research on the effectiveness of sumatriptan nasal spray. Specifically, more research is needed to understand the safety of sumatriptan nasal spray in children and pregnant women. Additional research is also needed to evaluate the long-term effects of sumatriptan nasal spray and ways to improve its efficacy.

Future Research Directions

Further research is necessary to address the remaining questions regarding the effectiveness of sumatriptan nasal spray. Research focusing on the safety of sumatriptan nasal spray in children and pregnant women, the long-term effects of sumatriptan nasal spray, and ways to enhance its efficacy are essential for optimizing the use of this medication.

Conclusion

Sumatriptan nasal spray may be a valuable treatment option for acute migraine and cluster headache. However, there are some risks associated with its use. It is important to discuss with your doctor and choose the most appropriate treatment option. Further research is necessary to better understand the effectiveness and safety of sumatriptan nasal spray.

Literature analysis of 28 papers
Positive Content
28
Neutral Content
0
Negative Content
0
Article Type
10
0
2
6
28
1.

Multiple-attack efficacy and tolerability of sumatriptan nasal spray in the treatment of migraine.

Author: DiamondS, ElkindA, JacksonR T, RyanR, DeBusseyS, AsgharnejadM

Migraine treatment
None reported

Sumatriptan hemisulfate nasal spray is a promising therapeutic option for migraine patients who cannot tolerate oral or injectable medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Sumatriptan nasal spray (20 mg/dose) in the acute treatment of cluster headache.

Author: HardeboJ E, DahlöfC

Cluster headache treatment

Sumatriptan nasal spray at its highest commercially available dose (20 mg/dose) was less effective than subcutaneous injection in relieving pain in the great majority of cluster headache sufferers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Effects of sumatriptan nasal spray (Imigran) on human nasal mucosa.

Author: ChengL-H, WuP-C, LinY-Y, ChuY-H, WangH-W

Migraine treatment
Nasal mucosa effects

This study aims to investigate the direct effect of sumatriptan, a commonly used migraine treatment, on human nasal mucosa *in vitro*.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Effects of sumatriptan nasal spray (Imigran) on isolated rat's tracheal smooth muscle.

Author: ChengLi-Hsiang, WuPei-Chuan, LiuShao-Cheng, ChiuFeng-Shiang, ChuYueng-Hsiang, ChangYing-Nan, WangHsing-Won

Asthma treatment

Sumatriptan is a drug used to treat migraines. This study investigated the effects of sumatriptan on isolated rat tracheal smooth muscle. It found that high concentrations of sumatriptan relaxed the muscle, suggesting it could help with asthma attacks by blocking the effects of acetylcholine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

A review of clinical safety data for sumatriptan nasal powder administered by a breath powered exhalation delivery system in the acute treatment of migraine.

Author: SilbersteinStephen D

Effective migraine treatment
Faster absorption
Lower dose
Well tolerated
Abnormal taste
Nasal discomfort

AVP-825 (sumatriptan nasal powder) is an FDA-approved intranasal medication delivery system for the acute treatment of migraine. AVP-825 delivers a lower dose of sumatriptan than oral or injectable formulations, which may translate into a better safety/tolerability profile. AVP-825 was well-tolerated in clinical trials and provides earlier efficacy onset than other sumatriptan formulations.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Early Onset of Efficacy and Consistency of Response Across Multiple Migraine Attacks From the Randomized COMPASS Study: AVP-825 Breath Powered<sup>&#174;</sup> Exhalation Delivery System (Sumatriptan Nasal Powder) vs Oral Sumatriptan.

Author: SilbersteinStephen, WinnerPaul K, McAllisterPeter J, TepperStewart J, HalkerRashmi, MahmoudRamy A, SiffertJoao

Migraine treatment

Label='OBJECTIVE' NlmCategory='OBJECTIVE'>To further characterize the clinical utility of AVP-825 based on additional prespecified outcomes and post hoc analyses of COMPASS, a Phase 3 comparative efficacy trial of AVP-825 vs 100 mg oral sumatriptan (NCT01667679). AVP-825 was approved in January 2016 by the US Food and Drug Administration under the name ONZETRA<sup>&#174;</sup> Xsail<sup>&#174;</sup> (sumatriptan nasal powder) for the acute treatment of migraine with or without aura in adults.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review.

Author: PatniyotIrene R, GelfandAmy A

Headache treatment
Migraine treatment

Ibuprofen, prochlorperazine, and certain triptan medications are the most effective and safe agents for acute management of migraine and other benign headache disorders in the pediatric population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

AVP-825 breath-powered intranasal delivery system containing 22 mg sumatriptan powder vs 100 mg oral sumatriptan in the acute treatment of migraines (The COMPASS study): a comparative randomized clinical trial across multiple attacks.

Author: TepperStewart J, CadyRoger K, SilbersteinStephen, MessinaJohn, MahmoudRamy A, DjupeslandPer G, ShinPaul, SiffertJoao

Acute migraine treatment

This study compared the efficacy, tolerability, and safety of AVP-825, an investigational bi-directional breath-powered intranasal delivery system containing low-dose (22 mg) sumatriptan powder, versus 100 mg oral sumatriptan for acute treatment of migraine.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Pharmacological treatment of acute migraine in adolescents and children.

Author: Wöber-BingölÇiçek

Pain relief
High placebo rates

This review summarizes current knowledge on the treatment of acute migraine in children and adolescents. While evidence for effective treatments is limited, acetaminophen, ibuprofen, and triptans are commonly used, with varying levels of evidence supporting their efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Pharmacokinetics and tolerability of rizatriptan in pediatric migraineurs in a randomized study.

Author: FraserIain P, HanLingling, HanTae H, LiChi-Chung, HreniukDavid, StochS Aubrey, WagnerJohn A, LinderSteven, WinnerPaul

Migraine treatment

A weight-based dosing scheme for rizatriptan ODTs in pediatric migraineurs generated plasma concentrations similar to those observed in adults.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Intranasal sumatriptan powder delivered by a novel breath-actuated bi-directional device for the acute treatment of migraine: A randomised, placebo-controlled study.

Author: DjupeslandP G, DocekalP,

Effective treatment
Pain relief
Metallic taste

Sumatriptan nasal powder administered using a novel bi-directional powder delivery device was effective and well tolerated for treating migraine attacks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Satisfaction with current migraine therapy: experience from 3 centers in US and Sweden.

Author: BigalMarcelo, RapoportAlan, AuroraSheena, SheftellFred, TepperStewart, DahlofCarl

Migraine treatment dissatisfaction

A significant subset of patients, including a large subgroup of patients using triptans, are dissatisfied with their usual care for the acute treatment of migraine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Sumatriptan nasal spray in adolescent migraineurs: a randomized, double-blind, placebo-controlled, acute study.

Author: WinnerPaul, RothnerA David, WootenJohn D, WebsterChris, AmesMichael

Headache relief
Taste disturbance

Sumatriptan nasal spray (20 mg) provided greater headache relief than placebo at 30 minutes and 2 hours postdose in a randomized, placebo-controlled study of 738 adolescent subjects with migraine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Open label study of intranasal sumatriptan (Imigran) for footballer's headache.

Author: McCroryP, HeywoodJ, UgoniA

Headache treatment
Side effects

Intranasal sumatriptan was effective in treating headache in professional footballers, with 86% of migraine with aura attacks and 100% of migraine without aura attacks showing a response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

[Pharmacologic treatment of acute migraine attack in children].

Author: CuvellierJ C, JoriotS, AuvinS, ValléeL

Manage migraine
Reduce headache
Unpleasant taste

Migraine is a common condition in children, affecting 5-10% of them. While acute headache management is crucial, it is only one part of the treatment process. Identifying migraine precipitants, adjusting lifestyle, and using preventive therapy, both non-pharmacologic and pharmacologic, are essential. Ibuprofen and paracetamol are effective for acute migraine attacks, with limited side effects. Dihydroergotamine mesylate may be helpful for severe attacks, but lacks substantial evidence. Among triptans, sumatriptan nasal spray demonstrates the best efficacy, with transitory unpleasant taste as the most common adverse effect.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

19.

Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack.

Author: JuhaszG, ZsombokT, JakabB, NemethJ, SzolcsanyiJ, BagdyG

Reduced headache intensity

This study investigated the effect of sumatriptan on plasma calcitonin gene-related peptide (CGRP) concentration and headache intensity in migraineurs. Sumatriptan treatment effectively decreased plasma CGRP concentration and headache intensity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Long-term tolerability of sumatriptan nasal spray in adolescent patients with migraine.

Author: NatarajanShankar, JabbourJ T, WebsterChristopher J, RichardsonMary S

Migraine treatment
Unpleasant taste

Sumatriptan nasal spray 20 mg was generally well tolerated and effective for long-term use in adolescent migraineurs ages 12 to 17 years. The most common side effect was an unpleasant taste.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

22.

Patterns of use of triptans and reasons for switching them in a tertiary care migraine population.

Author: SheftellFred D, FeleppaMichele, TepperStewart J, VolcyMichel, RapoportAlan M, BigalMarcelo E

Patients switch triptans for a variety of reasons, including incomplete relief, recurrence, side effects, and a desire to try a different triptan.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Nasal sumatriptan is effective in treatment of migraine attacks in children: A randomized trial.

Author: AhonenKati, HämäläinenMirja L, RantalaHeikki, HoppuKalle

Sumatriptan effective for migraines
Sumatriptan well tolerated
Bad taste after sumatriptan

This study investigated the efficacy and safety of nasal sumatriptan in treating migraine attacks in children and adolescents. The results showed that nasal sumatriptan was effective and well-tolerated in children over 8 years of age. Headache relief was achieved twice as often with sumatriptan compared to placebo. The most common side effect was a bad taste.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Parental satisfaction with sumatriptan nasal spray in childhood migraine.

Author: PakalnisAnn, KringDonna, PaolicchiJuliann

Migraine treatment
Sumatriptan side effects

This retrospective chart review explored the use of sumatriptan nasal spray for abortive therapy of acute migraine attacks in children aged 5 to 12 years. Sumatriptan nasal spray was found to be effective and well-tolerated in this pediatric population, providing good to excellent relief in 77% of the families.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study.

Author: van VlietJ A, BahraA, MartinV, RamadanN, AuroraS K, MathewN T, FerrariM D, GoadsbyP J

Cluster headache

Current evidence-based treatments for cluster headache include oxygen inhalation and subcutaneous sumatriptan. Intranasal sumatriptan is a new formulation with better tolerability than the subcutaneous route. Two open-label studies suggested efficacy of intranasal sumatriptan in cluster headache.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

A pharmacokinetic interaction study between butorphanol and sumatriptan nasal sprays in healthy subjects: importance of the timing of butorphanol administration.

Author: VachharajaniN N, ShyuW-C, NicholaP S, BoultonD W

Migraine treatment
Reduced effectiveness

This study found that administering butorphanol nasal spray less than 30 minutes after sumatriptan nasal spray can reduce the effectiveness of butorphanol due to vasoconstriction caused by sumatriptan.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Treatment of acute cluster headache with 20 mg sumatriptan nasal spray--an open pilot study.

Author: Schuh-HoferSigrid, ReuterUwe, KinzeStephan, EinhäuplKarl Max, ArnoldGuy

Treat cluster headache
None reported

Sumatriptan nasal spray has shown potential for the acute treatment of cluster headache attacks. In an open-label study, 50% of attacks were completely aborted and 58% responded to treatment within 30 minutes. Further double-blind studies are needed to confirm its efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Pediatric headache.

Author: LinderS L, WinnerP

Migraine treatment

This review article discusses the diagnosis and treatment of headaches in children and adolescents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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