Effects of tacrolimus topical: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Main Research Findings

Topical tacrolimus has been shown to be effective in the treatment of various skin conditions, including vernal keratoconjunctivitis 2 , atopic dermatitis 11 , and vitiligo 9 . It may also be effective in treating oral lichen planus 1 and rosacea 3 . However, topical tacrolimus may increase systemic absorption, leading to toxic levels in patients with cutaneous graft-versus-host disease (GVHD) who use occlusive dressings 8 . Additionally, topical tacrolimus preparations for ophthalmic use have been reported to cause eye irritation and adverse effects 13 .

Benefits and Risks

Benefits Summary

Topical tacrolimus has been shown to be effective in treating various skin conditions, including vernal keratoconjunctivitis, atopic dermatitis, and vitiligo. It may also be effective in treating oral lichen planus and rosacea.

Risks Summary

Topical tacrolimus may increase systemic absorption, leading to toxic levels in patients with cutaneous GVHD who use occlusive dressings. Additionally, topical tacrolimus preparations for ophthalmic use have been reported to cause eye irritation and adverse effects. There is also a concern about the potential carcinogenicity of tacrolimus, and clinicians should be cautious when considering it as a second-line treatment for oral lichen planus 1 .

Comparison Across Studies

Similarities Across Studies

Many studies have shown that topical tacrolimus has anti-inflammatory effects on the skin. Some studies suggest that topical tacrolimus is more effective than other treatments.

Differences Across Studies

The effectiveness of topical tacrolimus seems to vary depending on the type and severity of the skin condition. The incidence of adverse effects associated with the use of topical tacrolimus also appears to vary depending on the type and severity of the skin condition.

Consistency and Contradictions in Findings

Topical tacrolimus has been shown to be effective in treating a wide range of skin conditions. However, the safety and effectiveness of topical tacrolimus may vary depending on the type and severity of the condition. Additionally, there is a concern about the potential carcinogenicity of tacrolimus, so it should be used cautiously.

Practical Implications

Topical tacrolimus is a drug that can be effective in treating skin conditions. However, there are potential risks, such as increased systemic absorption in certain patients and potential carcinogenicity. When using topical tacrolimus, it is important to follow the instructions provided by your healthcare provider.

Limitations of Current Research

There is still a need for more research on topical tacrolimus. In particular, further research is needed to understand the long-term effects of topical tacrolimus use.

Future Research Directions

To further investigate the safety and efficacy of topical tacrolimus, more research is needed. In particular, large-scale clinical trials should be conducted to examine the long-term effects of topical tacrolimus use.

Conclusion

Topical tacrolimus is an effective treatment for many skin conditions. However, there are potential risks, such as increased systemic absorption and possible carcinogenicity. It is important to use topical tacrolimus as directed by your healthcare provider. Further research is needed to better understand the long-term effects of topical tacrolimus.

Literature analysis of 13 papers
Positive Content
12
Neutral Content
0
Negative Content
1
Article Type
1
0
0
3
13
1.

The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report.

Author: MoritaMayu, AsodaSeiji, TsunodaKazuyuki, SomaTomoya, NakagawaTaneaki, ShirakawaMasayori, ShojiHirofumi, YagishitaHisao, NishikawaTakeji, KawanaHiromasa

Cancer development

This case report describes a patient who developed squamous cell carcinoma after using tacrolimus ointment to treat oral lichen planus. While the link between tacrolimus and cancer development is rare, clinicians should be cautious when using tacrolimus as a second-line treatment for oral lichen planus.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Efficacy of single dose dermatological 0.1% Tacrolimus Ointment in the treatment of vernal keratoconjunctivitis.

Author: SharjeelMuhammad, IqbalUsama, JabranAamna, MehmoodAsif, MohiuddinMemona

Safe topical application
Vernal keratoconjunctivitis treatment
Mild recurrence

Tacrolimus 0.1% ointment was found to be effective and safe in the treatment of severe refractory vernal keratoconjunctivitis, even when given once a day.

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Tacrolimus effect on rosacea.

Author: BamfordJoel T M, ElliottBarbara A, HallerIrina V

Rosacea treatment
Tacrolimus side effects

A 12-week open-label trial involving 24 patients with erythrotelangiectatic or papulopustular rosacea demonstrated that 0.1% tacrolimus topical ointment significantly improved erythema in both rosacea subtypes. However, it did not reduce the number of papulopustular lesions. Side effects were consistent with those reported in the tacrolimus topical ointment labeling.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of tacrolimus on IFN-γ signaling in keratinocytes: possible mechanisms by which tacrolimus affects IFN-γ-dependent skin inflammation.

Author: TuHong-Qin, LiXin-Yu, TangMei-Yu, GaoJi-Wei, XuLan-Fang, ChenZhi-Qiang, GuHeng

Modulated IFN-γ signaling
Skin inflammation treatment

Tacrolimus, a topical ointment used to treat skin inflammation, was found to down-regulate IFN-γ signaling in keratinocytes, which may contribute to its therapeutic efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Oral lichen planus: update on etiopathogenesis, diagnosis and treatment.

Author: CrincoliVito, Di BisceglieMaria Beatrice, ScivettiMichele, LuccheseAlberta, TeccoSimona, FestaFelice

Lichen planus treatment
Side effects

Oral lichen planus is an inflammatory mucocutaneous disorder that can affect the skin, oral and genital mucosal surfaces, scalp, and nails. It is a complex immunologic disease, and current treatments include immunosuppressive agents, which can have significant side effects. New biological agents are being investigated that provide selective immunological results with fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Toxic tacrolimus levels after application of topical tacrolimus and use of occlusive dressings in two bone marrow transplant recipients with cutaneous graft-versus-host disease.

Author: OlsonKatherine A, WestKathleen, McCarthyPhilip L

Cutaneous GVHD treatment
Toxic tacrolimus levels

This case report described two patients with cutaneous graft-versus-host disease who developed toxic tacrolimus levels after receiving topical tacrolimus ointment with occlusive dressings.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review.

Author: SistiAndrea, SistiGiovanni, OrangesCarlo Maria

Repigmentation
Vitiligo treatment

Tacrolimus ointment monotherapy has shown good efficacy and tolerability in the treatment of vitiligo, with a peak repigmentation rate at 6 months of therapy. The best results were obtained on lesions of the cephalic region, especially the face.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis.

Author: HultschThomas, KappAlexander, SpergelJonathan

AD treatment
Safe alternative

This paper discusses the use of topical calcineurin inhibitors, pimecrolimus and tacrolimus, for treating atopic dermatitis (AD) in children. These medications offer a more selective mechanism of action compared to topical corticosteroids, making them safer for children's developing immune systems. Pimecrolimus is primarily used for mild to moderate AD, while tacrolimus is preferred for more severe cases.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

The efficacy of adding topical 5-fluorouracil to micro-needling in the treatment of vitiligo: A randomized controlled trial.

Author: PazyarNader, HatamiMohammad, YaghoobiReza, ParvarSeyedeh Yasamin, RadmaneshMohammad, HadibarhaghtalabMaryam

Vitiligo treatment

Vitiligo causes white patches on the skin. While there is no cure, different treatments can help. This study will compare a combination of a procedure called microneedling and a medication called 5-fluorouracil (5-FU) to a medication called tacrolimus for treating vitiligo patches.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test.

Author: Pastor-CleriguesAlfonso, SerranoAdela, MilaraJavier, Marti-BonmatiEzequiel, Lopez-PerezFrancisco J, Garcia-MontanesSara, SanfeliuJoan, Saval-VictoriaAna C, CortijoJulio

Autoimmune ocular disorder treatment
Inflammatory ocular disorder treatment
Ocular side effects

This study evaluated the local corneal tolerance and safety profile of three common tacrolimus 0.03% pharmaceutical preparations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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