Side Effects of talimogene laherparepvec injection: A Synthesis of Findings from 3 Studies

  1. Home
  2. Side Effects of talimogene laherparepvec injection
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of talimogene laherparepvec injection: A Synthesis of Findings from 3 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of talimogene laherparepvec injection: A Synthesis of Findings from 3 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Findings

Talimogene laherparepvec (TVEC) is an FDA-approved oncolytic herpes virus used to treat unresectable stage IIIB to IV metastatic melanoma via intralesional injection. 3 This study aimed to characterize the efficacy of TVEC in patients with unresectable stage IIIB to IV melanoma. 3

Melanoma is a serious type of cancer. Many different treatments are available, but they often have side effects. 2 New ways to deliver drugs are being developed to improve treatment effectiveness and reduce side effects. 2

Directly injecting cancer treatments into the tumor can be more effective and have fewer side effects than injecting them into the bloodstream. 1 This approach is being studied in both preclinical and clinical settings. 1

Reasons for Side Effects

Side effects of talimogene laherparepvec (TVEC) are caused by the virus infecting and multiplying in tumor cells. 3 The virus can destroy tumor cells but also activate immune cells and cause inflammation. 3

Common Side Effects

Injection Site Reactions

Pain, swelling, redness, and fever can occur at the injection site after receiving talimogene laherparepvec (TVEC). 3

Flu-Like Symptoms

After receiving talimogene laherparepvec (TVEC), people may experience fever, chills, fatigue, muscle aches, and headache. 3

Skin Reactions

Rashes, itching, and swelling can occur on the skin after receiving talimogene laherparepvec (TVEC). 3

Gastrointestinal Symptoms

Nausea, vomiting, abdominal pain, and diarrhea can occur after receiving talimogene laherparepvec (TVEC). 3

Side Effects Management

Injection Site Reactions

To reduce injection site reactions, applying ice packs and taking pain relievers is recommended. 3

Flu-Like Symptoms

To reduce flu-like symptoms, taking fever-reducing pain relievers is recommended. 3

Skin Reactions

To reduce skin reactions, applying steroid cream is recommended. 3

Gastrointestinal Symptoms

To reduce gastrointestinal symptoms, taking anti-nausea medications is recommended. 3

Comparison of Studies

Commonalities

All three studies aimed to evaluate the safety and effectiveness of talimogene laherparepvec (TVEC). 3 2 1

Differences

3 aimed to characterize the efficacy of TVEC in patients with unresectable stage IIIB to IV melanoma. 3 2 discussed the role of TVEC in melanoma treatment and the development of novel drug delivery systems. 2 1 provided a comprehensive review on the safety and efficacy of intratumoral immunotherapy. 1

Real-World Applications

Talimogene laherparepvec (TVEC) is a promising oncolytic herpes virus used to treat unresectable stage IIIB to IV metastatic melanoma. 3 It is injected directly into the tumor. 3 TVEC can cause pain, swelling, and fever at the injection site. 3 It can also cause flu-like symptoms, skin reactions, and gastrointestinal symptoms. 3 It is important to consult with your doctor before using TVEC. 3

Limitations of Current Research

The long-term safety and effectiveness of talimogene laherparepvec (TVEC) are still not fully understood. 3 TVEC does not work for all melanoma patients. 3 TVEC can increase the risk of side effects when combined with other treatments. 3

Future Research Directions

Further research is needed to evaluate the long-term safety and effectiveness of talimogene laherparepvec (TVEC). 3 New treatments need to be developed to improve the effectiveness of TVEC and reduce side effects. 3

Conclusion

Talimogene laherparepvec (TVEC) is a promising oncolytic herpes virus used to treat unresectable stage IIIB to IV metastatic melanoma. 3 While TVEC can cause some side effects, these are usually manageable. 3 More research is needed to evaluate the long-term safety and effectiveness of TVEC. 3

Literature analysis of 3 papers
Positive Content
3
Neutral Content
0
Negative Content
0
Article Type
0
0
0
2
3
1.

Delivery routes matter: Safety and efficacy of intratumoral immunotherapy.

Author: De LombaerdeEmily, De WeverOlivier, De GeestBruno G

Anticancer immunotherapy
Reduced systemic toxicity

Intratumoral immunotherapy offers a promising approach for cancer treatment by directly delivering immunostimulatory agents to the tumor site. This review discusses the current state of the art in preclinical and clinical intratumoral immunotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Options of Therapeutics and Novel Delivery Systems of Drugs for the Treatment of Melanoma.

Author: WangHongbin, TranTuan T, DuongKatherine T, NguyenTrieu, LeUyen M

Melanoma treatment
Side effects

Melanoma treatment using FDA-approved drugs has limitations due to side effects and patient non-compliance. Novel drug delivery systems, such as nanoparticles and liposomes, have been developed to improve drug delivery, targeting, and bioavailability, potentially reducing toxicity and enhancing treatment effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Real-World Outcomes of Talimogene Laherparepvec Therapy: A Multi-Institutional Experience.

Author: LouieRaphael J, PerezMatthew C, JajjaMohammad Raheel, SunJames, CollichioFrances, DelmanKeith A, LoweMichael, SarnaikAmod A, ZagerJonathan S, OllilaDavid W

Durable melanoma treatment
Flu-like symptoms

Talimogene laherparepvec (TVEC) is a well-tolerated, durable treatment for unresectable locoregional melanoma, especially in stage IIIB/C disease. TVEC can be safely administered across anatomic sites not amenable to other local therapies.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.