Side Effects of tamsulosin: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Major Research Findings

Tamsulosin has been shown to be effective in treating lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH), as demonstrated in studies such as 22 and 19 . Additionally, 21 suggests tamsulosin's potential as a medical expulsive therapy for children with ureteric stones.

However, tamsulosin can cause various side effects, as reported in studies like 14 and 2 . These side effects can include dizziness, headache, erectile dysfunction, ejaculatory dysfunction, gastrointestinal issues, and kidney dysfunction.

Reasons for Side Effects

The side effects of tamsulosin are believed to be caused by its action of blocking alpha-1 adrenergic receptors. These receptors are essential for regulating vasoconstriction, increasing heart contractility, and bladder sphincter contraction. By inhibiting these receptors, tamsulosin can lead to vasodilation, decreased heart rate, and relaxation of the bladder sphincter.

Common Side Effects

Dizziness

Studies like 4 and 5 have reported dizziness as a side effect of tamsulosin.

Headache

Studies like 4 and 5 have reported headache as a side effect of tamsulosin.

Erectile Dysfunction

Studies such as 10 and 6 have linked tamsulosin to erectile dysfunction. This is thought to be due to tamsulosin's vasodilatory properties, which can reduce blood flow to the penis.

Ejaculatory Dysfunction

Studies such as 6 and 3 have reported ejaculatory dysfunction as a potential side effect of tamsulosin. This may be caused by tamsulosin's relaxation of the bladder sphincter, making ejaculation more challenging.

Gastrointestinal Symptoms

Tamsulosin can potentially lead to gastrointestinal issues, including constipation and diarrhea, as reported in studies like 15 .

Kidney Dysfunction

A study by 12 suggests that tamsulosin might contribute to kidney damage in elderly patients with benign prostatic hyperplasia.

Other Side Effects

Beyond the mentioned side effects, tamsulosin could also cause dizziness, nausea, fatigue, nasal congestion, and rash, as reported in studies like 16 . Additionally, 8 suggests that tamsulosin might increase the risk of erectile dysfunction in individuals with psychiatric conditions.

Side Effect Management

Dizziness

If you experience dizziness while taking tamsulosin, consult your doctor. They may adjust your dosage, switch to a different medication, or suggest other management strategies.

Headache

If you develop a headache while taking tamsulosin, talk to your doctor. They may prescribe pain relievers or suggest alternative solutions.

Erectile Dysfunction

If you experience erectile dysfunction while taking tamsulosin, discuss it with your doctor. They may lower your dose, switch to a different medication, or prescribe erectile dysfunction medication.

Ejaculatory Dysfunction

If you experience ejaculatory dysfunction while taking tamsulosin, consult your doctor. They may consider adjusting your dosage, switching to a different medication, or exploring other options.

Gastrointestinal Symptoms

If you experience gastrointestinal side effects while taking tamsulosin, consult your doctor. They may recommend dietary modifications, medication, or other treatments.

Kidney Dysfunction

If you experience kidney dysfunction while taking tamsulosin, it is crucial to consult your doctor immediately. They may advise discontinuing tamsulosin or exploring other management strategies.

Other Side Effects

If you experience any other side effects while taking tamsulosin, be sure to talk to your doctor.

Comparison Across Studies

Commonalities

Many studies have consistently shown that tamsulosin is effective in treating LUTS.

Differences

Studies have presented varying results regarding the side effects associated with tamsulosin. For example, 10 suggests a potential link between tamsulosin and worsening erectile dysfunction, while 19 indicates that combining tamsulosin with tadalafil might be beneficial for improving erectile dysfunction.

Real-World Application Notes

While tamsulosin is an effective treatment for LUTS, it's important to be aware of the potential side effects. It's particularly crucial for individuals with pre-existing conditions, such as advanced age, heart disease, liver disease, or kidney disease, to consult their doctor before starting tamsulosin therapy.

Current Research Limitations

Current research on tamsulosin's side effects is limited. Further research, particularly long-term studies, is needed to fully understand the potential long-term consequences of tamsulosin use.

Future Research Directions

To gain a comprehensive understanding of tamsulosin's side effects, future research should include long-term observational studies and studies involving diverse populations.

Conclusion

Tamsulosin is a valuable medication for treating LUTS but comes with the possibility of side effects. If you are considering taking tamsulosin, it's essential to consult your doctor and make informed decisions about the best treatment approach for you.

Literature analysis of 28 papers
Positive Content
19
Neutral Content
2
Negative Content
7
Article Type
6
1
2
8
26
1.

Absence of clinically relevant cardiovascular interaction upon add-on of mirabegron or tamsulosin to an established tamsulosin or mirabegron treatment in healthy middle-aged to elderly men.

Author: van GelderenMarcel, TretterReiner, MeijerJohn, DorrepaalCaroline, Gangaram-PandayShanti, BrooksAshley, KrauwinkelWalter, DickinsonJames

No clinically relevant changes

Co-treatment with tamsulosin and mirabegron did not result in clinically relevant changes in cardiovascular safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Priapism - A rare side effect of alpha blockers: Report of 2 cases and literature review.

Author: UnalSelman, MicoogullariUygar, OkuluEmrah, KayigilOnder

Priapism

This case report describes two patients who developed priapism, a prolonged unintended erection, after initiating treatment with alpha blockers (silodosin and tamsulosin). While this adverse effect is rare, it emphasizes the need for healthcare providers to inform patients about the potential risks of alpha blocker therapy, including priapism.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Adverse Effects of Pharmacological Therapy of Benign Prostatic Hyperplasia on Sexual Function in Men.

Author: StojanovićNebojša, IgnjatovićIvan, DjenićNebojša, BogdanovićDragan

BPH treatment
Ejaculation dysfunction

Pharmacological therapy of BPH improved voiding symptoms producing different effects on male sexual function. The main adverse effect on sexual function in men is the deterioration in ejaculation or the absence thereof.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Safety of Tamsulosin: A Systematic Review of Randomized Trials with a Focus on Women and Children.

Author: KaplanSteven A, ChughtaiBilal I

Treatment of BPH

A systematic review of randomized studies assessed the overall safety of tamsulosin in women and children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

A first case of fixed drug eruption due to Tamsulosin.

Author: MontazerFatemeh, Jahani AmiriKousar, MofarrahRamina, AhmadiAlborz, NouripourBehzad, MofarrahRamin

Fixed drug eruption

This case report describes a patient with fixed drug eruption (FDE) after taking tamsulosin, an alpha-1 adrenergic receptor blocker.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Impact of medical treatments for male lower urinary tract symptoms due to benign prostatic hyperplasia on ejaculatory function: a systematic review and meta-analysis.

Author: GacciMauro, FicarraVincenzo, SebastianelliArcangelo, CoronaGiovanni, SerniSergio, ShariatShahrokh F, MaggiMario, ZattoniFiliberto, CariniMarco, NovaraGiacomo

Ejaculatory dysfunction

Alpha-blockers and 5ARIs are associated with a higher risk of ejaculatory dysfunction (EjD) than placebo. Combination therapy with both drug classes results in a 3-fold increased risk of EjD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Cognitive and mood side effects of lower urinary tract medication.

Author: MuderrisogluA Elif, BecherKlaus F, MadersbacherStephan, MichelMartin C

Treat urinary tract symptoms
Cognitive impairment
Dementia
Depressive symptoms

This review examines the evidence for adverse effects of muscarinic receptor antagonists, 5α-reductase inhibitors, and α1-adrenoceptor antagonists on cognitive function, mood, and other functions of the central nervous system. The authors recommend careful monitoring of mental status before and after prescribing these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Priapism: What cause: mental illness, psychotropic medications or poly-substance abuse?

Author: KhanQaiser S, TuckerPhebe, LokhandeAkshay

priapism

Priapism is a serious medical condition that can be caused by various factors, including medications, substance abuse, and pre-existing medical conditions. This case report highlights the importance of considering all potential causes of priapism, especially in patients with a history of mental health conditions and substance abuse. It emphasizes the need for clinicians to be aware of the potential side effects of medications and their interactions, particularly in patients with multiple comorbid conditions.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.

Author: OsmanNadir I, ChappleChristopher R, CruzFrancisco, DesgrandchampsFrançois, LlorenteCarlos, MontorsiFrancesco

Improved cardiovascular safety
Lower urinary tract symptom relief

This review discusses silodosin, a uroselective alpha-blocker for treating lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Silodosin is effective and well-tolerated, offering similar efficacy to existing alpha-blockers with improved cardiovascular safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

[Comprehensive pharmacologic management of overactive bladder].

Author: KrivoborodovG G, TurE I

OAB treatment
Frequent urination
Urgency

This article provides an overview of the evidence on pharmacotherapy for neurogenic and idiopathic overactive bladder (OAB). Selective M3 receptor blockers are the preferred medications, and solifenacin 10 mg is often used as a starting dose. Mirabegron, a 3-adrenergic receptor agonist, is an effective alternative for patients who are refractory to anticholinergics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Russian

13.

Prescription pattern of alpha-blockers for management of lower urinary tract symptoms/benign prostatic hyperplasia.

Author: MoonHyong Woo, YangJong Hyup, ChoiJin Bong, BaeWoong Jin, ChoHyuk Jin, HongSung-Hoo, LeeJi Youl, KimSae Woong, ParkSang-Hyun, HanKyungdo, HaU-Syn

BPH management
Side effects

Tamsulosin, an alpha-blocker, has demonstrated the highest persistence rate and return rate among alpha-blockers used for treating benign prostatic hyperplasia (BPH). This suggests patient satisfaction with its effectiveness and tolerability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Adverse events related to alpha-blockers: analysis of real-life data from Eudra-Vigilance.

Author: CicioneAntonio, NacchiaAntonio, BaldassarriValeria, TemaGiorgia, RovestiLorenzo M, ManciniElisa, GuarnottaGiorgio, VoglinoOlivia A, FrancoAntonio, D'AnnunzioSimone, LombardoRiccardo, TubaroAndrea, DE NunzioCosimo

Alfuzosin safety
Ejaculatory disorders
Orthostatic hypotension

This study analyzed real-life data on neuro-vascular and sexual adverse events (AEs) associated with alpha-blockers (ABs) reported to the Eudra-Vigilance database. The study found that silodosin had a significantly higher risk of ejaculatory disorders, while tamsulosin and silodosin had a lower risk of orthostatic hypotension compared to other ABs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

A Case of Mucosal Fixed Drug Eruption Caused by Tamsulosin Administration.

Author: ChoiHoon, KimYong Il, NaChan Ho, KimMin Sung, ShinBong Seok

FDE risk

This case report describes a patient with mucosal fixed drug eruption (FDE) caused by tamsulosin, an alpha-1 adrenergic receptor blocker. This case expands the known adverse effects of tamsulosin and highlights the need for further investigation into the potential for this drug to cause mucosal FDE.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

19.

Efficacy and Safety of a Fixed-Dose Combination Therapy of Tamsulosin and Tadalafil for Patients With Lower Urinary Tract Symptoms and Erectile Dysfunction: Results of a Randomized, Double-Blinded, Active-Controlled Trial.

Author: KimSae Woong, ParkNam Cheol, LeeSeung Wook, YangDae Yul, ParkJong Kwan, MoonDu Geon, YangSang-Kuk, LeeSung Won, MoonKi Hak, AhnTai Young, KimSoo Woong, ParkKwangsung, MinKweon Sik, RyuJi-Kan, SonHankil, JungJina, HyunJae Seog

ED treatment
LUTS improvement
Patient compliance

This randomized, double-blinded, active-controlled trial assessed the efficacy and safety of fixed-dose combinations (FDCs) of tamsulosin and tadalafil compared with tadalafil monotherapy in patients with comorbid BPH-associated LUTS and ED. The FDC 0.4/5 mg demonstrated superiority in LUTS improvement and non-inferiority in ED treatment compared with tadalafil 5 mg. No clinically significant adverse events were observed during the 24-week period.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Silodosin versus Tamsulosin as Medical Expulsive Therapy for Children with Lower-Third Ureteric Stones: Prospective Randomized Placebo-Controlled Study.

Author: SolimanMohamed G, El-GamalOsama, El-GamalSamir, Abdel RaheemAli, Abou-RamadanAhmed, El-AbdAhmed

Reduced pain
Shorter expulsion time
Stone expulsion rate
Drug safety in younger children

This prospective single-blind placebo-controlled randomized study compared the efficacy and safety of silodosin and tamsulosin as medical expulsive therapy for distal ureteric stones (DUS) in 167 children. The study found that silodosin resulted in a significantly better stone expulsion rate and shorter expulsion time compared to tamsulosin. Both medications showed good safety profiles in children.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Effectiveness of Solifenacin and Trospium for Managing of Severe Symptoms of Overactive Bladder in Patients With Benign Prostatic Hyperplasia.

Author: KosilovKirill Vladimirovich, LoparevSergay A, IvanovskayaMarina A, KosilovaLiliya V

Overactive bladder treatment

Combining trospium and solifenacin is an effective and safe way to manage severe symptoms of overactive bladder in patients with benign prostatic hyperplasia who are taking tamsulosin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

A review of animal and human studies for management of benign prostatic hyperplasia with natural products: perspective of new pharmacological agents.

Author: AzimiHanieh, KhakshurAli-Asghar, AghdasiIman, Fallah-TaftiMehrnaz, AbdollahiMohammad

BPH treatment
Unclear mechanisms

There are numerous plants that have beneficial influence on BPH although the mechanisms of action in some plants are not well understood yet. Active ingredients of some of these plants are known and can be used as lead components for development of new effective and safe drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

[Combination drug therapy in patients with BPH].

Author: KuzmenkoA V, KuzmenkoV V, GyaurgievT A

BPH management
LUTS treatment

This introduction highlights the role of infravesical obstruction, most commonly caused by benign prostatic hyperplasia (BPH), as a risk factor for lower urinary tract symptoms (LUTS). BPH symptoms arise from a combination of static (mechanical), dynamic, and impaired bladder function. Medical treatments include alpha-blockers, which reduce outflow obstruction, and 5-alpha reductase inhibitors, which target the static component of BPH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

25.

A Comparison of Boron Supplement and Tamsulosin as Medical Expulsive Therapy for Urinary Stones After Extracorporeal Shock Wave Lithotripsy: a Randomized Controlled Clinical Trial.

Author: JalaliSaba, BorumandniaNasrin, BasiriAbbas, NagieeMohammadreza, AmiriFahimeh Bagheri, TavasoliSanaz, KheirolahkhaniYashar, TaheriMaryam

Stone expulsion

Alpha-blockers are often used to help with stone clearance after shock wave lithotripsy (ESWL), but their effectiveness compared to other therapies is unclear. This study compared the use of boron supplement (anti-inflammatory) with tamsulosin (alpha-blocker) in patients after ESWL. Both treatments led to similar stone expulsion rates and time to clearance, suggesting that boron supplement could be a viable alternative with no significant side effects.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

'Tamsulosin and Darifenacin' Versus 'Tamsulosin Monotherapy' for 'BPH with Accompanying Overactive Bladder'.

Author: SinghIqbal, AgarwalVivek, GargGaurav

BPH treatment
OAB treatment
Urinary retention

Treatment with tamsulosin and darifenacin for 8 weeks is an effective and safe treatment modality in select patients of BPH with accompanying OAB symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

[Do benign prostatic hyperplasia drugs affect mood or cognition?]

Author: BecherK F, MadersbacherS, MichelM C

BPH treatment
Cognitive impairment
Depressive symptoms

This article discusses the risk of central nervous system side effects, such as reduced cognition, dementia, and depressive symptoms, associated with drugs used to treat lower urinary tract symptoms suggestive of benign prostatic hyperplasia. It highlights the documented risks associated with muscarinic antagonists and the recently discovered risks associated with 5α-reductase inhibitors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

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